Curriculum Vitae Qun Sophia Zang, Ph. D - UT Southwestern

Curriculum VitaeQun Sophia Zang, Ph. DWork AddressDepartment of Surgery, Mail Code 9160UT Southwestern Medical Center5323 Harry Hines BlvdDallas, TX 75390Tel: 214-648-5442E-mail: qun.zang@utsouthwestern.eduEducation and TrainingsUniversity of Science and Technology of China (USTC) B.S 1985-1990City University of New York (CUNY), New York, NY PhD 1991-1996Mentor: David A. Foster, PhD, Rosalyn Yalow ProfessorHarvard Medical School, Boston, MA Postdoctoral 1996-1999Mentor: Timothy A. Springer, PhD, Latham Family ProfessorMember of National Academy of SciencesProfessional PositionsAssistant Professor2010-presentDepartment of Surgery, UT Southwestern Medical Center, Dallas, TXInstructor 2007-2010Department of Surgery, UT Southwestern Medical Center, Dallas, TXResearch Scientist 2003-2006Department of Surgery, UT Southwestern Medical Center, Dallas, TXScientist 2002-2003Reata Pharmaceuticals, Inc., Dallas, TXScientist 1999-2002Biogen-Idec, Cambridge, MAProfessional MembershipsShock SocietySurgical Infection Society (SIS)2005-present2006-present

Society of Critical Care Medicine (SCCM)2006-presentCommittee AssignmentsEarly career reviewer2012-presentNIH, Surgery, Anesthesiology and Trauma (SAT) Study SectionHonors and AwardsAmerican Heart Association (AHA) 2009-2011South Central Affiliate Beginning-in-aid GrantPublications1. Jiang YW, Song J, Zang Q, Foster DA. Phosphatidylcholine-specific phospholipase D activityis elevated in v-Fps-transformed cells. Biochem Biophys Res Commun. 1994 Sep 15;203(2):1195-2003. (PMID: 8093039)2. Zang Q, Frankel P, Foster DA. Selective activation of protein kinase C isoforms by v-Src. CellGrowth Differ. 1995 Nov; 6(11): 1367-73. (PMID: 8562474)3. Jiang Y, Lu Z, Zang Q, Foster DA. Regulation of phosphatidic acid phosphohydrolase byepidermal growth factor-Reduced association with the EGF receptor followed by increasedassociation with protein kinase Cδ. J Biol Chem. 1996 Nov 22; 271(47): 29529-32. (PMID:8939878)4. Zang Q, Lu Z, Curto M, Barile N, Shalloway D, Foster DA. Association between v-Src andprotein kinase Cδ in v-Src-transformed fibroblasts. J Biol Chem. 1997 May 16; 272(20): 13275-80. (PMID: 9148947)5. Lu Z, Hornia A, Jiang YW, Zang Q, Ohno S, Foster DA. Tumor promotion by depleting cells ofprotein kinase C δ. Mol Cell Biol. 1997 Jun; 17(6): 3418-28. (PMID: 9154841)6. Huang C, Zang Q, Takagi J, Springer TA. Structural and functional studies with antibodies tothe integrin β2 subunit. A model for the I-like domain. J Biol Chem. 2000 Jul 14; 275(28):21514-24. (PMID: 10779511)7. Zang Q, Lu C, Huang C, Takagi J, Springer TA. The top of the inserted-like domain of theintegrin lymphocyte function-associated antigen-1 β subunit contacts the α subunit β-propellerdomain near β-sheet 3. J Biol Chem. 2000 Jul 21; 275(29): 22202-12. (PMID: 10781608)8. Lu C, Shimaoka M, Zang Q, Takagi J, Springer TA. Locking in alternate conformations of theintegrin αLβ I domain with disulfide bonds reveals functional relationships among integrindomains. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5): 2393-8. (PMID: 11226250)9. Zang Q, Springer TA. Amino acid residues in the PSI domain and cysteine-rich repeats of theintegrin beta2 subunit that restrain activation of the integrin α(X)β(2). J Biol Chem. 2001 Mar 9;276(10): 6922-9. (PMID: 11096074)

Symposium-Cancer Biology and Therapeutic Opportunities January 2012Hunter College of the City University of New York, New York, NYConference Presentations (past 5 years)1. Zang Q, Maass DL, and Horton JW. Septic Challenge Decreases DNA Content in CardiacMitochondria. Poster presentation at Surgical Infection Society, Toronto, ON, Canada, 04/20072. Zang Q, Tang J, Maass DL, and Horton JW. Septic Challenge Causes Mitochondrial DNADamage in the Heart. Poster presentation at Shock Society. Baltimore, Maryland, 06/2007.3. Zang Q, Tang J, Maass DL, and Horton JW. Septic Challenge Causes Mitochondrial DNADamage in the Heart. Poster presentation at Shock Society, Cologne, Germany, 06/2008.4. Zang Q. (corresponding author), Maass D, Sadek H, Williams N, and Frantz D. ProtectiveEffects of Mitochondria-targeted Vitamin E in Pneumonia-related Sepsis. Poster presentationsat Shock Society, San Antonio, Texas, 06/2009.5. Wang Y, Zang Q, Dulan G, Liu Z, Wu Q, Shaul P, Williams N, Frantz D, and Nwariaku FE. AMitochondria-targeted antioxidant Prevents Endothelial Migration. Poster presentations atShock Society, San Antonio, Texas, 06/2009.6. Wigginton J, Barber R, Zang Q, Simpkins J, Yi W, Gatson J, Lai L, Lu L, Minei J, Arnoldo B,and Idris A. Early Inflammatory Response in Multiple Organs Following Severe Burn Injury isSignificantly Reduced by 17β-estradial. Poster presentations at Shock Society, San Antonio,Texas, 06/2009.7. Maass D, Barber R, Zang Q, Simpkins J, Idris A, Yi W, Gatson J, Goyal V, Minei J, Arnoldo B,and Wigginton J. Single-dose Estrogen Administered Following Severe Burn InjurySignificantly Reduces Circulating Cytokines. Poster presentations at Shock Society, SanAntonio, Texas, 06/2009.8. Zang QS (corresponding author), Maass D, Wigginton J, Barber R, Martinez B, Idris A,Horton JW (deceased), and Nwariaku FE. Burn Serum Causes a CD-14 DependentMitochondrial Damage in Primary Cardiomyocytes. Poster presentations at Shock Society,Portland, Oregon, 06/2010.9. Zang QS (corresponding author), Sadek H, Maass D, Martinez B, Ma L, Kilgore JA, WilliamsNS, Frantz DE, Wigginton J, Nwariaku FE. Specific Inhibition of Mitochondrial OxidativeStress Suppresses Inflammation and Improves Cardiac Function in a Rat Pneumonia-relatedSepsis Model. Poster presentations at Shock Society, Norfolk, Virginia, 06/2011.10. Zang Q (corresponding author), Martinez B, and Maass DL. Sepsis-induced CardiacMitochondrial Deficiency Involves Altered Mitochondrial Localization of Tyrosine Kinase cSrcand Tyrosine Phosphotase Shp2. Plenary presentation at Surgical Infection Society, Dallas,Texas, 04/2012.Current and Past Research Interests• Mitochondrial ROS signaling in secondary organ failure after sepsis and acute injuries

• Therapeutic application of mitochondrial-targeted antioxidants• Function of leukocyte integrins in inflammation• Signal transduction of kinases and phosphatases