New Hires - Human Nutrition Research Center on Aging - Tufts ...

HNRCA Director’s <strong>New</strong>sletter
Summer 2012
Dear Colleagues,
With the summer
nearing its end, I am
excited about
expanding the
HNRCA’s
collaborations across
the University. We
continue to work
closely with the Friedman School, teaching
many courses and advising, supporting the
doctoral research work of several students and
forging research and training collaborations
with faculty. We are also working with the
Cummings School, the Friedman School and
the Medical School to prepare our first joint NIH
grant application that bridges the study of
human health and agricultural challenges. We
envision that this will be the first of many fruitful
opportunities for collaboration moving forward.
This year’s HNRCA seminar series is organized
around the theme of Aging <strong>Research</strong> at Tufts
University. This series will showcase the exciting
aging research being conducted across all of
the university’s schools and institutions, and will
provide all of us with a unique opportunity to
discover new opportunities for collaboration
across Tufts. We are also pleased to announce
that the Director of the National Institute on
Aging, Richard Hodes, will be delivering the
keynote speech for this initiative on Friday,
October 5.
Summer 2012
1
This year, five of the Tufts Collaborates, Tufts
Innovates and CTSI pilot grants had PIs or Co-Is
from the HNRCA. HNRCA scientists also serve
on multiple University-wide committees. For
example, Sarah Booth serves on the Graduate
Education Committee; Nirupa Matthan is a
member of the President’s Diversity Council;
Alice Lichtenstein chairs the CTSI Scientific
Advisory Committee; Xiang-Dong Wang and
Joel Mason direct the <strong>Nutrition</strong> Core of the Tufts
Cancer <strong>Center</strong>, just to name a few.
Our research clusters also are offering new and
exciting collaborative opportunities for scientists
at the HNRCA. We are planning a cluster
retreat in the fall, where I look forward to
hearing the progress and discussing the next
steps for the clusters in 2013.
Last, but certainly not least, we are so grateful
to Dick Doolin and Deena Strabone for their
support of the HNRCA this summer during a
time of administrative transition. Their excellent
contributions have helped us ensure that all the
gears continued to turn with ease. Many
thanks to Dick and Deena, and to the
University, for lending that support.
I look forward to a productive fall at the
HNRCA.
Sincerely,
Simin Nikbin Meydani, D.V.M., Ph.D.

Summer 2012
Physician Training Conference to
be Held at HNRCA in October
Drs. Joel Mason and Ed Saltzman are hosting a
conference for trainees and practicing
physicians at the HNRCA on October 11-12,
2012. “<strong>Nutrition</strong> and Exercise in the
Management of Outpatients: Important
Advances You Need to Know” will provide a
forum for nationally- and internationallyrecognized
experts to communicate
theoretical and practical information that is
most critical for state-of-the-art excellence in
clinical care.
Lectures pertaining to commonly encountered
conditions such as obesity, diabetes, cancer,
osteoporosis, HIV positivity, and liver disease will
be presented. Additional discussions will
explore the latest insights regarding the benefits
and risks associated with questions commonly
posed by patients to their primary care
physician, such as the worthiness of vitamin
supplementation and the use of probiotics.
Conference partners include the American
Society for <strong>Nutrition</strong> and the Boston Claude D.
Pepper Older Americans Independence
<strong>Center</strong>. Financial Support is being provided by
Abbott <strong>Nutrition</strong> Health Institute.
Vegetables are at their peak enjoyment right now
2
Scientist Spotlight:
Dr. Susan Roberts and the iDiet
Program
Dr. Susan Roberts, Director of the Energy
Metabolism Laboratory at the HNRCA, has
developed a new group dieting program, the
results of which have been shown to exceed
those of the biggest names in the dieting
industry. Her iDiet program, which is based on
her 2011 book, The “I” Diet, is currently being
scaled by a corporate backer, Instinct Health
Science, Inc. (IHS) to national levels, with an
emphasis on workplace groups.
“I’m a full time employee here at the HNRCA. I
can do so much research in my labs but it’s not
going to help America unless it gets out there,”
says Roberts. Herself a successful dieter – she
was once about 50 pounds heavier than she is
today – she notes that studies of national
programs like Weight Watchers report an
average weight loss of only 6.5 pounds. “They
have a small percentage of participants who
do really well, but the majority does poorly. In
one research study, people who stayed in the
program for six months lost an average of just
10 pounds.”
Dr. Roberts’ research began by compiling
“every study ever done on obesity.” She read
nearly 3,000 studies for the book and
synthesized them down. But still, her book was

Summer 2012
initially four times its published length. “It was a
major process turning this from wonky science
into simple stuff. It was a review on a very large
scale,” she says.
“My publisher said, ‘Sue, you’ve got to put
some people through the program.’ I had put
together all the best weight loss
recommendations but we needed to test it,”
she recounts. So, she put an ad in her local
newspaper for a free weight loss program in
Weston, MA. Participants met in the room
above her garage every Saturday for eight
weeks. “The group format is excellent,” she
says, “but eight weeks wasn’t long enough, so I
converted the program into a 16 week and
then a 32 week program.”
Dr. Roberts has pilot tested the weight loss
groups in four Boston area workplaces. She
says that of the original participants in the
program sites, 89% stayed with the program for
16
14
12
10
8
6
4
2
0
week
1
Participants in the HNRCA iDiet group
HNRCA iDiet group weight loss in pounds
week
2
week
3
week
4
week
6
week
7
week
8
week
9
week
10
week
11
3
6 months and almost all lost weight – and
average weight loss was greater than any
previous published worksite program.
As a community service project for Tufts, Dr.
Roberts offered the program to the HNRCA. A
trainer from IHS has been meeting with
participants weekly since April. The average
loss in the group is 14.3 pounds in eleven weeks,
and the group continues to meet. “They’ve
done so very well and they are so enthusiastic
about achieving their goals,” she says.
Dr. Roberts continues to run community groups
even as she continues her research for nextgeneration
help. “I usually run one group a
week myself for the grounding it gives me in
real-life problems. It’s helpful to see what they
struggle with and what they need. I really like
helping these people. There isn’t any dieter I
can’t relate to.”
<strong>New</strong> National Appointments for
<strong>Center</strong> Scientists
Dr. Bess Dawson-Hughes was recently selected
to join the first Board of Directors of the new
<strong>Center</strong> for Advancement of Science in Space
(CASIS).
Dr. Roger Fielding will become a new Associate
Editor for Journals of Gerontology Medical
Sciences, effective January 1, 2013.
<strong>New</strong>
Administrative
Director, Mark
Wesley
Mark Wesley joined the
HNRCA in July as Senior
Director for Administration

Summer 2012
and Finance. He comes to us from the Broad
Institute of MIT and Harvard where he held the
position of Director of Financial Planning and
Budgets. Mark has over 25 years of experience
in financial and administrative management,
including budgeting and financial reporting,
human resources administration, governmentregulated
contracting and procurement,
planning, and facilities management.
Prior to the Broad Institute, he was the Director
of Budgeting at the Berklee College of Music
for five years, and prior to that, was Business
Manager for the Air and Missile Defense
Technology Division at the federally-funded MIT
Lincoln Laboratory in Lexington, MA. Mark
holds a Bachelor of Science from Northeastern
University.
At the HNRCA, Mark sees tremendous
opportunity to apply his background to the
<strong>Center</strong>’s essential work in improving the quality
of life for aging populations, research that he
sees as having truly universal application.
As he gets established at the HNRCA, Mark’s
top priorities in the coming months are to
ensure that administrative, computing and
grant management services are fully responsive
to the needs of the <strong>Center</strong>’s scientific staff; to
enhance and maintain excellent working
relationships with our USDA/ARS and University
stakeholders; and to help identify and manage
financial resources to support the <strong>Center</strong>’s vital
research into healthy aging through nutrition
and physical activity.
Mark looks forward to meeting and working
with the <strong>Center</strong>’s scientific and support staff,
and extends an open invitation everyone at
the HNRCA to stop by and say hello.
4
Fall Seminar Series to Highlight
Healthy Aging Work at Tufts
University.
The upcoming fall session of the HNRCA
seminar series, “Collaborations on Healthy
Aging at Tufts (CHAT),” was initiated after
compiling a list of almost one hundred Tufts
faculty, staff and scientists whose research has
an age-related component.
The HNRCA will host 12 speakers, each from a
different discipline, school and/or campus at
the University for a one-hour seminar followed
by an afternoon of exploration on future
collaboration.
The first seminar will be “<strong>Nutrition</strong>al modulation
of cardiac disease in dogs and cats,” given by
Lisa M. Freeman, DVM, PhD, Professor at the
Cummings School of Veterinary Medicine. The
seminar will be held in the HNRCA mezzanine
auditorium on September 10 at 12 noon.
In addition to the Tufts speakers, Dr. Richard
Hodes, Director of the National Institute on
Aging, will give a keynote address on Friday,
October 5 th at the HNRCA.
A complete listing of speakers and seminar
topics is available at:
http://hnrca.tufts.edu/events/seminars/
HNRCA in the <strong>New</strong>s
HNRCA scientific expertise and original
research continues to be prominently featured
in the popular press in the U.S. and abroad.
Well over 100 original stories have covered our
work in 2012. Some recent HNRCA-related
headlines include:
- WorldHealth.net. Dr. Aron Troen,
Neuroscience and Aging Laboratory. B
Vitamins Linked to Cognitive Function. July 30,
2012.

Summer 2012
- El Mundo (Spain). Dr. Jose Ordovas, ‘No creo
en la medicina personalizada tal y como se
practica hoy’ (‘I do not believe in personalized
medicine as practiced today’). July 20, 2012.
- Los Angeles Times, Dr. Alice Lichtenstein, <strong>New</strong>
York trans fat ban has cut consumption, study
finds. July 16, 2012
- The Wall Street Journal. Dr. Bess Dawson-
Hughes, Dutifully Taking Your Calcium Pill? It
May Be Too Much. July 2, 2012
- WNYC-FM (<strong>New</strong> York City Public Radio). Dr.
Jeffrey Blumberg, Debating the Pros and Cons
of Vitamin Supplements. June 11, 2012
<strong>New</strong>s from the HNRCA Employee
Recreation Association
Over the summer the ERA has been compiling
your favorite recipes for an HNRCA cookbook.
They want to thank everyone who submitted
recipes and anticipate the book being ready
this fall.
Anyone interested in an HNRCA book club,
please let the ERA know by emailing them at
hnrca_employeerecreationassociation@tufts.e
du. If there is enough interest the ERA will help
get the club started.
The group encourages everyone to get
involved! If you are interested in learning more
about the ERA, attend a meeting. The group
meets monthly on the third Tuesday of the
month at 2:00pm. Look for notices regarding
the next meeting. They are always looking for
new members!
5
Welcome <strong>New</strong> <strong>Hires</strong>
We welcome the following new members of
the HNRCA family.
Cheng Ngo,Chi - Budget & Admin Coord
Kristo,Aleksandra- Postdoctoral Associate
Pham,Lucia - <strong>Research</strong> Asst
Power,Stephanie - Postdoctoral Associate
Rice,Nicholas - Sr <strong>Research</strong> Technician
Sagliani,Kristen - <strong>Research</strong> Asst
Sloan,Sarah - Biostatistician
Smith,Tanisha R. - Processing Coordinator
Wesley,Mark R. - Administrative Director
Yopchick,Jennelle E. - Postdoctoral Associate
Recent Publications from HNRCA
Scientists
The recent publications listed below reflect
submissions to the Director’s office through May 31,
2012. We will continue to collect new publications
from all labs and include them in future newsletters.
Thank you!
Ronchi CF, et. al (including HNRCA Scientist Yeum
KJ). Biomarkers for oxidative stress in acute lung
injury induced in rabbits submitted to different
strategies of mechanical ventilation. J Appl Physiol.
2012 Apr;112(7):1184-90. Epub 2012 Feb 2. PubMed
PMID: 22302956.
Vishwanathan R, et. al (including HNRCA Scientist,
Johnson EJ). Macular lutein and zeaxanthin are
related to brain lutein and zeaxanthin in primates.
Nutr Neurosci. 2012 Jul 9. [Epub ahead of print]
PubMed PMID: 22780947.
El-Qudah JM, Qin J and Tang G, 2011. Mallow
Carotenoids Determined by High-performance
Liquid Chromatography. Journal of Applied
Sciences, 11: 3797-3801.
Yu J, et. al (including HNRCA Scientists Johnson EJ
and Shang F). Measurement of macular pigment

Summer 2012
optical density in a healthy Chinese population
sample. Invest Ophthalmol Vis Sci. 2012 Apr
24;53(4):2106-11. Print 2012 Apr. PubMed PMID:
22427543.
Poulose SM, et. al. (Including HNRCA Scientists Fisher
DR, Bielinski DF, Carey AN, and Shukitt-Hale B)
Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit
pulp fractions attenuate inflammatory stress
signaling in mouse brain BV-2 microglial cells. J Agric
Food Chem. 2012 Feb 1;60(4):1084-93. Epub 2012
Jan 20. PubMed PMID: 22224493.
Miller MG, Shukitt-Hale B. Berry Fruit Enhances
Beneficial Signaling in the Brain. J Agric Food Chem.
2012 Feb 3. [Epub ahead of print] PubMed
PMID:22264107.
Koo BB, et. al. (Including HNRCA Scientists Scott T,
and, Rosenberg I). Clinical Prediction of Fall Risk and
White Matter Abnormalities: A Diffusion Tensor
Imaging Study. Arch Neurol. 2012 Feb 13. [Epub
ahead of print] PubMed PMID: 22332181.
Troen AM, et. al. (Including HNRCA Scientists Scott
TM, Moorthy D, Dobson B, Rogers G, Dallal GE,
Jacques PF, Selhub J, Rosenberg IH; FACT Study
Investigators.) Cognitive dysfunction and depression
in adult kidney transplant recipients: baseline
findings from the FAVORIT Ancillary Cognitive Trial
(FACT). J Ren Nutr. 2012 Mar;22(2):268-76.e1-3. Epub
2011 Dec 6. PubMed PMID: 22153382.
Rabin BM, et. al. (Including HNRCA Scientists Joseph
JA and Shukitt-Hale B)Interaction between age of
irradiation and age of testing in the disruption of
operant performance using a ground-based model
for exposure to cosmic rays. Age (Dordr). 2012
Feb;34(1):121-31. Epub 2011 Mar 22. PubMed PMID:
21424788; PubMed Central PMCID: PMC3260355.
Sorensen EP et. al. (Including HNRCA Scientists Scott
T)The Kidney Disease Quality of Life Cognitive
Function Subscale and Cognitive Performance in
Maintenance Hemodialysis Patients. Am J Kidney
Dis. 2012 Mar 14. [Epub ahead of print] PubMed
PMID: 22425261.
Karastergiou K, et al. (Including HNRCA Scientist
Andrew Greenberg). Sex differences in human
adipose tissues – the biology of pear shape. Biol Sex
Differ. 2012 May31:3(1):13. PMCID: PMC3411490
6
Sakakeeny L, et al. (Including HNRCA Scientist Martin
Obin). Plasma Pyridoxal-5-Phosphate Is Inversely
Associated with Systemic Markers of Inflammation in
a Population of U.S. Adults. J Nutr. 2012 May 23.
Fried SK, et al. (Including HNRCA Scientist Andrew
Greenberg). Lipocalin 2: a “sexy” adipokine that
regulates 17β-estradiol and obesity. Endocrinology.
2012 Apr;153(4):1582-4.
Kwon J, et al. (Including HNRCA Scientist Martin
Obin). Assurance of mitochondrial integrity and
mammalian longevity by the p62-Keap1-Nrf2-Nqo1
cascade. EMBO Rep. 2012 Feb; 13(2):150-6. PMCID:
PMC3271336
Al Rajabi A, et al. (Including HNRCA Scientists Sang
Woon Choi and Sarah Booth). Deuterium-labeled
phylloquinone has tissue-specific conversion to
menaquinone-3 among Fischer 344 male rats. J
Nutr. 2012 May;142(5):841-5. PMCID: PMC3327742
Friso S, et al. (Including HNRCA Scientis Sang Woon
Choi). Promoter methylation in coagulation F7 gene
influences plasma FVII concentrations and relates to
coronary artery disease. J Med Genet. 2012
Mar;49(3):192-9.
Huang T, et al. (Including HNRCA Scientists Jimmy
Crott and Jose Ordovas). MAT1A variants modulate
the effect of dietary fatty acids on plasma
homocysteine concentrations. Nutr Metab
Cardovasc Dis. 2012 Apr;22(4):362-8. PMCID:
PMC3117050
Park LK et al. (Including HNRCA Scientist Sang Woon
Choi). <strong>Nutrition</strong>al influences on epigenetics and agerelated
disease. Proc Nutr Soc. 2012 Feb;71(1):75-83
Pojednic RM, et al. (including HNRCA Scientists
Rachele Pojednic, Kieran Reid, and Roger Fielding).
The specific contributions of force and velocity to
muscle power in older adults. Exp Gerontol. 2012
Aug;47(8):608-13. Epub 2012 May 22.
Haran PH, et al. (including HNRCA Scientists
Prashanth Haran, Donato Rivas, and Roger Fielding).
Role and potential mechanisms of anabolic
resistance in sarcopenia. J Cachexia Sarcopenia
Muscle. 2012 May 16. [Epub ahead of print].

Summer 2012
Mulligan K, et al. (including HNRCA Scientist Roger
Fielding). Low Bone Mass in Behaviorally HIV-
Infected Young Men on Antiretroviral Therapy:
Adolescent Trials Network Study 021B. Clin Infect Dis.
2012 Aug;55(3):461-468. Epub 2012 May 9.
Reid KF, et al. (including HNRCA Scientists Kieran
Reid and Roger Fielding). Skeletal muscle power: a
critical determinant of physical functioning in older
adults. Exerc Sport Sci Rev. 2012 Jan;40(1):4-12. doi:
10.1097/JES.0b013e31823b5f13. Review.
Choi SJ, et al. (including HNRCA Scientist Roger
Fielding). Eccentric contraction-induced injury to
type I, IIa, and IIa/IIx muscle fibers of elderly adults.
Age (Dordr). 2012 Feb;34(1):215-16. Epub 2011 Mar
24.
Clark DJ, Fielding RA (HNRCA Scientist Roger
Fielding). Neuromuscular contributions to agerelated
weakness. J Gerontol A Biol Sci Med Sci.
2012 Jan;67(1):41-7. Epub 2011 Mar 17. Review
Shang F and Taylor A. Roles for the ubiquitinproteasome
pathway in protein quality control and
signaling in the retina: implications in the
pathogenesis of age-related macular
degeneration. Mol Aspects Med. 2012 Aug; 33(4)
446-66.
Shang, F. and Taylor, A. Role of the Ubiquitin-
Proteasome in Protein Quality Control and Signaling:
Implication in the Pathogenesis of Eye Diseases.
Prog Mol Biol Transl Sci. 2012; 109:347-96.
Taylor, A. Introduction to the issue regarding
research regarding age related macular
degeneration. Mol Aspects Med. 2012 Aug; 33(4):
291-4.
Uchiki T, et al. (including HNRCA scientists Fu Shang
and Allen Taylor). Glycation altered proteolysis as a
pathobiologic mechanism that links dietary
glycemic index, aging, and age related diseases in
non-diabetics. 2012 Feb. Aging Cell11(1): 1-13
Shang, F. and Taylor, A. Role of the Ubiquitin-
Proteasome in Protein Quality Control and Signaling:
Implication in the Pathogenesis of Eye Diseases.
Prog Mol Biol Transl Sci. 2012; 109:347-96.
7
Weikel, KA, Chiu CJ, and Taylor, A. <strong>Nutrition</strong>al
Modulation of Age-Related Macular Degeneration.
Mol. Aspects Medicine. 2012 Aug; 33(4): 318-75.
Wu, M. et al (including HNRCA Scientists Allen Taylor,
Fu Shang and Qinging Bian) Oligomerization with wt
αA- and αB-crystallins reduces proteasomemediated
degradation of C-terminally truncated
αA-crystallin. Invest Opthalmol Vis Sci. 2012 May; 53(
6): 2541-50.
Wang J, (including HNRCA Scientists Munkyong Pae,
Simin Meydani and Dayong Wu). Epigallocatechin-
3-gallate inhibits expression of receptors for T cell
regulatory cytokines and their downstream signaling
in mouse CD4 + T cells. J. Nutr., 2012, 142: 566–571.
Wang J, (including HNRCA Scientists Zhihong Ren,
Yanmei Xu, Simin Meydani and Dayong Wu).
Epigallocatechin-3-gallate ameliorates
experimental autoimmune encephalomyelitis by
altering balance among CD4 + T cell subsets. Am J
Pathology. 2012, 180: 221-234.
Zingg J-M et al. (including HNRCA Scientists Syeda T
Hasan, Danica Cowan, Angelo Azzi and Mohsen
Meydani). Regulatory effects of curcumin on lipid
accumulation in monocytes/macrophages. J. Cell
Biochem, 2012, 113: 833-840.
Zingg J-M et al. (including HNRCA Scientists Mohsen
Meydani M and Angelo Azz)i. -Tocopheryl
phosphate – an activated form of vitamin E
important for angiogenesis and vasculogenesis?
Biofactors, 2012, 38: 24–33.
Bolling BW, et al. (including HNRCA Scientists, Kamil
AG, Chen C-YO). Assay dilution factors confound
measures of total antioxidant capacity in
polyphenol-rich juices. J Food Sci 2012;77:H69-75.
Kamil A, Chen CYO. Nuts for diabetes prevention
and management. J Food Drug Analyl 2012;20:323-
7.
Kamil A, Chen CYO. Health benefits of almonds
beyond cholesterol reduction. J Agric Food Chem
2012;60:6694-6702.
Maki KC. et al. (including HNRCA Scientists, Chen
CYO, McKay DL, Blumberg JB). Digestive and
physiologic effects of a wheat bran extract,

Summer 2012
arabino-xylan-oligosaccharide, in breakfast cereal.
<strong>Nutrition</strong> doi:10.1016/j.nut.2012.02.010
Das SK, Roberts SB. 2012. Chapter 5 Energy
Metabolism in fasting, fed, exercise and re-feeding
states. Present Knowledge in <strong>Nutrition</strong>, 10 th edition.
Hoboken, NJ. Wiley-Blackwell. p. 58-68
Elder S, et al. (including HNRCA scientists Susan
Roberts, Alice Lichtenstein, Andrew Greenberg, and
Edward Saltzman). Genetic and environmental
influences on eating behavior – a study of twin pairs
reared apart or reared together. The Open <strong>Nutrition</strong>
Journal. 2012 Mar. 6: 59-70.
Elder S, et al (including HNRCA scientists Susan
Roberts, Alice Lichtenstein, Andrew Greenberg and
Edward Saltzman). Effect of Body Composition
Methodology on Heritability Estimation of Body
Fatness. The Open <strong>Nutrition</strong> Journal. 2012 Feb: 6:48-
58.
Sen S, et al (including HNRCA scientist Susan
Roberts). <strong>Nutrition</strong>, weight gain and eating behavior
in pregnancy: A review of experimental evidence
for long-term effects on the risk of obesity in
offspring. Physiol Behav. 2012 Apr 23. [Epub ahead
of print.]
Kelley G, et al. (including HNRCA scientist Susan
Roberts). Comparison of aerobic exercise, diet or
both on lipids and lipoproteins in adults: a metaanalysis
of randomized controlled trials. Clin Nutr.
2012 Apr; 31(2)156-67.
Kelley G, et al. (including HNRCA scientist Susan
Roberts). Combined effects of aerobic exercise
and diet on lipids and lipoproteins in overweight
and obese adults: a meta-analysis. J Obes. 2012;
2012:985902. Epub 2012 Mar 4.
Racette S, et al. (including HNRCA scientists Sai
Krupa Das, Susan Roberts). Approaches for
quantifying energy intake and % calorie restriction
during calorie restriction interventions in humans: the
multicenter CALERIE study. Am J Physiol Endocrinol
Metab. 2012 Feb; 302(4): E441-8.
Sen S, et al (including HNRCA scientist Susan
Roberts). <strong>Nutrition</strong>, weight gain and eating behavior
in pregnancy: A review of experimental evidence
for long-term effects on the risk of obesity in
8
offspring. Physiol Behav. 2012 Apr 23. [Epub ahead
of print.]
Ordovas JM, et. al. Plasma HDL cholesterol and risk
of myocardial infarction: a mendelian
randomisation study. Lancet. 2012 Aug
11;380(9841):572-80. Epub 2012 May 17.
Ordovas JM, et. al. Assessment of the value of a
genetic risk score in improving the estimation of
coronary risk. Atherosclerosis. 2012 Jun;222(2):456-63.
Epub 2012 Mar 30.
Ordovas JM, et. al. Genetic predisposition to
coronary heart disease and stroke using an additive
genetic risk score: a population-based study in
Greece. Atherosclerosis. 2012 May;222(1):175-9.
Epub 2012 Feb 28.
Ordovas JM, et. al. Report of the National Heart,
Lung, and Blood Institute Working Group on
epigenetics and hypertension. Hypertension. 2012
May;59(5):899-905. Epub 2012 Mar 19. Review. No
abstract available.
Ordovas JM, et. al. (including HNRCA Scientists
Caren E. Smith and Yu-Chi Lee). Perilipin
polymorphism interacts with saturated fat and
carbohydrates to modulate insulin resistance. Nutr
Metab Cardiovasc Dis. 2012 May;22(5):449-55. Epub
2010 Dec 30.
Ordovas JM, et. al. The PPAR alpha gene is
associated with triglyceride, low-density cholesterol
and inflammation marker response to fenofibrate
intervention: the GOLDN study. Pharmacogenomics
J. 2012 May 1. doi: 10.1038/tpj.2012.9. [Epub ahead
of print]
Ordovas JM, et. al. (including HNRCA Scientists
Jimmy Crott, Caren E. Smith, and Yu-Chi Lee).
MAT1A variants modulate the effect of dietary fatty
acids on plasma homocysteine concentrations. Nutr
Metab Cardiovasc Dis. 2012 Apr;22(4):362-8. Epub
2010 Dec 24.
Ordovas JM, et. al. Genetic variation in fatty acid
elongases is not associated with intermediate
cardiovascular phenotypes or myocardial
infarction. Eur J Clin Nutr. 2012 Mar;66(3):353-9. doi:
10.1038/ejcn.2012.2. Epub 2012 Feb 1.

Summer 2012
Ordovas JM, et. al. The effect of CYP7A1
polymorphisms on lipid responses to fenofibrate. J
Cardiovasc Pharmacol. 2012 Mar;59(3):254-9.
Ordovas JM, et. al. A genome-wide association
study of inflammatory biomarker changes in
response to fenofibrate treatment in the Genetics of
Lipid Lowering Drug and Diet Network.
Pharmacogenet Genomics. 2012 Mar;22(3):191-7.
doi: 10.1097/FPC.0b013e32834fdd41.
Ordovas JM, et. al. Novel loci for adiponectin levels
and their influence on type 2 diabetes and
metabolic traits: a multi-ethnic meta-analysis of
45,891 individuals. PLoS Genet. 2012
Mar;8(3):e1002607. Epub 2012 Mar 29.
Ordovas JM, et. al. (including HNRCA Scientists
Caren E. Smith and Yu-Chi Lee). SIRT1 and CLOCK
3111T>C combined genotype is associated with
evening preference and weight loss resistance in a
behavioral therapy treatment for obesity. Int J Obes
(Lond). 2012 Feb 7. doi: 10.1038/ijo.2011.270. [Epub
ahead of print]
Ordovas JM, et. al. A Polymorphism in a gene
encoding Perilipin 4 is associated with height but not
with bone measures in individuals from the
Framingham Osteoporosis Study. Calcif Tissue Int.
2012 Feb;90(2):96-107. doi: 10.1007/s00223-011-9552-
7. Epub 2011 Dec 31.
Ordovas JM, et. al. Cholesterol, Inflammasomes,
and Atherogenesis. Curr Cardiovasc Risk Rep. 2012
Feb 1;6(1):45-52.
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