ADP doc - Supplements - Haematologica

Haematologica2000; vol. 85 – The Platelet ADP Receptors –supplementContents(indexed by Current Contents/Life Sciences and in Faxon Finder and Faxon XPRESS, also available on diskette with abstracts)FOREWORDMarco Cattaneo, Christian Gachet . . . . . . . . . . . . . . . . . . . 1HISTORICAL OVERVIEW OF THE ROLE OF PLATELETS INHEMOSTASIS AND THROMBOSISGiovanni de Gaetano . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3HISTORICAL OVERVIEW OF THE ROLE OF ADP IN PLATELETFUNCTIONDavid C. B. Mills . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11P2Y RECEPTORSJean-Marie Boeynaems, Didier Communi, NathalieSuarez-Huerta, Rodolphe Janssens, Bernard Robaye . . . . . . 15LIGAND SPECIFICITY, REGULATION AND CROSS-TALKOF HUMAN PLATELET ADP RECEPTORSJörg Geiger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22INTERPLAY OF P2 RECEPTOR SUBTYPESIN PLATELET FUNCTIONSatya P. Kunapuli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27ADP: AN IMPORTANT COFACTOR OF PI 3-KINASEACTIVATION IN HUMAN BLOOD PLATELETSBernard Payrastre, Marie-Pierre Gratacap, Catherine Trumel,Karine Missy, Hugues Chap, Christian Gachet,Monique Plantavid. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32CONGENITAL DISORDERS OF PLATELET FUNCTIONKenneth J. Clemetson, Jeannine M. Clemetson . . . . . . . . . 37CONGENITAL DEFECTS OF ADP RECEPTORS ON PLATELETSPaquita Nurden, Bruno Gauthier, Christel Poujol,Jean-Max Pasquet, Alan T. Nurden . . . . . . . . . . . . . . . . . . 46HUMAN ECTO-ADPASE/CD39: THROMBOREGULATIONVIA A NOVEL PATHWAYAaron J. Marcus, M. Johan Broekman, Joan H.F. Drosopoulos,Naziba Islam, Richard B. Gayle III,David J. Pinsky, Charles R. Maliszewski . . . . . . . . . . . . . . 53PHARMACOLOGY OF THE PLATELET ADP RECEPTORS:AGONISTS AND ANTAGONISTSS.M.O. Hourani . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58PHARMACOLOGY OF AR-C69931MX AND RELATEDCOMPOUNDS: FROM PHARMACOLOGICAL TOOLSTO CLINICAL TRIALSR.G. Humphries. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66PHARMACOLOGY OF TICLOPIDINE AND CLOPIDOGRELPierre Savi, Jean M. Herbert. . . . . . . . . . . . . . . . . . . . . . . 73CLINICAL TRIALS WITH ADP RECEPTOR ANTAGONISTSF. Violi, V.N. Di Lecce, L. Loffredo. . . . . . . . . . . . . . . . . . . 78CLOSING REMARKSMarco Cattaneo, Christian Gachet . . . . . . . . . . . . . . . . . . 81