CGH as an Alternative to PCR-based Detection of Deletions in C ...
CGH as an Alternative to PCR-based Detection of Deletions in C ...
CGH as an Alternative to PCR-based Detection of Deletions in C ...
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Our ProjectF<strong>in</strong>d a better way <strong>to</strong> normalize this data• robust lowess normalization (iterative approach)• subset <strong>of</strong> probes for normalization <strong>to</strong> decre<strong>as</strong>e the proportion <strong>of</strong> outliers(probes <strong>to</strong> the X chromosome only; probes <strong>to</strong> genes for which mut<strong>an</strong>ts arelethal)• “Supersmoother” variable-sp<strong>an</strong> smooth<strong>in</strong>g (not very super)• r<strong>an</strong>k <strong>in</strong>vari<strong>an</strong>t method• sequence <strong>in</strong>formation
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