Case Study - Alliance for Risk Assessment

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23Figure 1-2Conclusion The proposed 24-h, health-protective AMCV for acrolein is 1.2 ppb (2.7 µg/m 3 ). This value falls between the TCEQ acute 1-h ReV of 4.8 ppb (11 µg/m 3 ) (TCEQ 2010)and the chronic noncarcinogenic ReV of 0.22 ppb (0.50 µg/m 3 ) (TCEQ 2010), and is lessthan the ATSDR acute (14 days or less) MRL of 3 ppb (6.9 µg/m 3 ) (1-hr study).It is sufficiently conservative for the adequate protection of public health for the exposureduration and adverse effects considered and would significantly complement TCEQhealth effect evaluations of ambient air data, which currently utilize 1-h and chronic (i.e.,lifetime) health-protective and welfare-based (i.e., odor, vegetation) AMCVs.
24References1. Agency for Toxic Substances and Disease Registry (ATSDR). 2007. Toxicological profile foracrolein. U.S. Department of Health and Human Services. Atlanta, GA.2. Beauchamp, R.O., Jr., D. A. Andjelkovich, A.D. Kligerman, K.T. Morgan, and H. Heck. 1985.A critical review of the literature on acrolein toxicity. CRC Crit Rev Toxicol 14:309-380.3. Cassee, F.R., J.P. Groten, and V.J. Feron. 1996. Changes in the nasal epithelium of ratsexposed by inhalation to mixtures of formaldehyde, acetaldehyde, and acrolein. Fundam ApplToxicol 29(2):208-218.4. Dorman, D.C., M.F. Struve, B.A. Wong, M. W. Marshall, E.A. Gross, and G. A. Willson.2008. Respiratory tract responses in male rats following subchronic acrolein inhalation. InhalToxicol 20(3): 205-216.5. Hazardous Substances Database (HSDB). 2005. Acrolein.6. Roemer, E., H.J. Anton, and R. Kindt. 1993. Cell proliferation in the respiratory tract of the ratafter acute inhalation of formaldehyde or acrolein. J Appl Toxicol 13(2):103-7.7. Texas Commission on Environmental Quality (TCEQ). 2010. Development support documentAcrolein, CAS registry numbers: 107-02-8.Texas Commission on Environmental Quality,Toxicology Division, Chief Engineer’s Office, available athttp://www.tceq.state.tx.us/implementation/tox/dsd/final.html8. Texas Commission on Environmental Quality (TCEQ). 2012. Guidelines to develop toxicityfactors. RG-442.9. United States Environmental Protection Agency (USEPA). 2008. Reregistration EligibilityDecision Acrolein. Prevention, Pesticides, and Toxic Substances. Washington, DC.10. United States Environmental Protection Agency (USEPA). 2013. Technical Report forSchool: Assessing Outdoor Air Near Schools: Additional Monitoring at Temple ElementarySchool (Diboll, TX). February 5, 2013. Available at www.epa.gov/schoolair/11. Weber-Tschopp, A., T. Fischer, R. Gierer, and E. Grandjean. 1977. [Experimentally inducedirritating effects of acrolein on men (author’s transl)]. Int Arch Occup Environ Health 40(2):117-30.
Page 4: 1INTERPRETATION OF 24-HOUR SAMPLING
Page 7 and 8: 1,3-Butadiene concentration parts p
Page 9 and 10: 24-Hour Benzene Concentrations (ppb
Page 11 and 12: 8mortalityresponse relationship of
Page 13: 10Section 4 Twenty-Four Hour Refere
Page 17 and 18: 14Haber’s rule is dependent on th
Page 19 and 20: 161, which is considered to be cons
Page 21 and 22: 18Viluksela, M, Stahl, BU, Birnbaum
Page 23 and 24: 20Example 1: Development of a 24-Ho
Page 25: Log Concentration (µg/m 3 )22Total
Page 29 and 30: 26The TCEQ has historically develop
Page 31 and 32: 28Three subacute mouse studies iden
Page 33 and 34: 30higher than the multiple-day LOAE
Page 35 and 36: Log Concentration (µg/m 3 )32A UF
Page 37 and 38: 34This value is sufficiently conser
Page 39 and 40: 36Example 3: Development of a 24-Ho
Page 41 and 42: difficulty focusing; Human; (E)DecB
Page 43 and 44: 40Figure 3-2 Schematic of BD Metabo
Page 45 and 46: 42Table 3-1: Derivation of the 1-Hr
Page 47 and 48: 1,3-Butadiene concentration parts p

Case Study - Alliance for Risk Assessment

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