Automated DPX process - Gerstel

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In this issue News ■ Cooperation: New Solution for Fat Determination 3 Application ■ Determining markers for fatty acid decomposition 4 ■ FAMEs: Automated, Accurate and Reproducible Fatty Acid Derivatization and Determination 8 Innovation ■ Polymer analysis: Efficient Automated Pyrolysis GC 12 ■ Drugs of abuse: Extraction in seconds 14 ■ MAESTRO-Software: Perfectly Synchronized Sample Prep and Analysis 24 Interview ■ Robert J. Collins, Ph.D., President GERSTEL, Inc.: Looking forward to shaping the future of the business 18 Report ■ Archaeology meets chemistry: Peeking into Pharaoh’s wine glass 21 GERSTEL online You can find more information on products, applications and services on the GERSTEL home page at www.gerstel.com. 2 GERSTEL Solutions Worldwide Editorial International Sales under new leadership As of July 2008, Ralf Löscher, Ph.D. has joined GERSTEL as International Sales Manager. A passionate marathon runner with a Ph.D. degree in biology, Dr. Löscher brings new energy to the International Sales team, coupled with extensive experience in the international analytical instrumentation business. Before joining GERSTEL, the frequent flyer was International Sales Manager for a reputable supplier of GC and LC Time of Flight (TOF) Mass Spectrometry systems and had before that worked for a major international corporation, responsible for sales of LC and LC/MS instrumentation in Germany. Among Ralf Löscher’s many activities in his first year in office have been participation in the Analytica China and ArabLab exhibitions, reinvigorating and refocusing GERSTEL activities in growth markets with a stronger presence and forming new contacts and alliances. GERSTEL introduces Automated Disposable Pipette Extraction (DPX) Disposable Pipette Extraction (DPX) is a fast and efficient SPE technique used for a wide range of applications such as drugs of abuse and therapeutic drug monitoring. Only 200 - 250 µL of sample is needed to reach the required limits of detection using a fully automated process. The extraction step is performed in 30 - 60 seconds and the complete process including elution and rinse steps takes 3 - 6 minutes depending on the application. Additionally, automated DPX is performed during the GC or LC run of the preceding sample ensuring maximum throughput and best possible GC/MS or LC/MS system utilization. Elution requires only a small amount of solvent, which means that DPX effectively provides a concentration step. For many applications, such as pesticides in fruit and vegetables, solvent evaporation is not required. For more information on the DPX system, please see article on page 14. Keeping VOCs and SVOCs out of car interiors All leading worldwide car manufacturers and a large number of their suppliers rely on GERSTEL technology. Analyses are regularly performed to ensure that materials used in or near the vehicle interior do not emit dangerous levels of Volatile and Semi-Volatile Organic Compounds (VOCs and SVOCs). A method that is often used world-wide is the VDA Method 278 from the German Automobile Producers Association (VDA). The VDA 278 method specifies thermal desorption/ thermal extraction of materials that are placed directly in thermal desorption tubes followed by GC/MS determination. Some manufacturers have their own methods based on GERSTEL equipment. Recently, two new methods were established by a renowned leading worldwide manufacturer. One method complements the VDA 278 method in the determination of emissions from materials used in car interiors; the other method specifies direct air monitoring inside the passenger cabins of vehicles. As far as GER- STEL Solutions Magazine is informed, the methods are to be used by all world-wide operations including suppliers. Both methods specify the GERSTEL Thermal Desorption System (TDS 3) with Thermal Desorption Autosampler (TDSA) in combination with a GERSTEL Cooled Injection System (CIS 4). News Imprint Published by GERSTEL GmbH & Co. KG Eberhard-Gerstel-Platz 1 45473 Mülheim an der Ruhr Germany Editorial Director Guido Deußing ScienceCommunication Neuss, Germany guido.deussing@t-online.de Translation and editing Kaj Petersen kaj_petersen@gerstel.de Scientific advisory board Eike Kleine-Benne, Ph.D. eike_kleine-benne@gerstel.de Oliver Lerch, Ph.D. oliver_lerch@gerstel.de Malte Reimold, Ph.D. malte_reimold@gerstel.de Contact gerstel@gerstel.com Design Paura Design, Hagen, Germany www.paura.com GERSTEL Solutions Worldwide – March 2009 ISSN 1619-0076
GERSTEL Solution Worldwide News GERSTEL and Büchi in cooperation New Solution for Fat Determination In order to further improve the patented Caviezel ® rapid analysis method for determination of fat in food and feed, the Swiss company Büchi has entered into cooperation with GERSTEL. W hen it comes to the determination of fats in food and feed, the Swiss company Büchi plays a substantial role. This is due to the patented Caviezel method, which is increasingly specified in standardized methods. Examples are the determination of fat contents that must be listed on food products as well as the determination of milk fat in foods. Following the Caviezel method, an internal standard is added to the sample and the fat is extracted before undergoing alka- Complete solution from Büchi and GERSTEL for the determination of fat levels in food and feed products. The system is based on the Büchi Extraction unit B 815, a 7890 GC from Agilent Technologies with a split/splitless inlet and a FID, a GERSTEL MultiPurpose Sampler (MPS) and MAESTRO software. GERSTEL Solutions Worldwide – March 2009 line digestion. The resulting salts are converted to free acids and these are subsequently determined using a gas chromatograph (GC) with flame ionization detection (FID). Leading Büchi managers looked to GERSTEL to provide technical and application know-how in order to fully unlock the potential of the Caviezel method. GERSTEL has provided improved automation and simplified, accelerated GC analysis; in short: a single system that performs three different analyses in one short run, providing the analyst in the laboratory with a simpler, more efficient method. Büchi was faced with the challenge of improving the automation of their fat analysis solution, and they seized the opportunity to team up with outside expertise. The goal of the GERSTEL-Büchi cooperation was to create a comprehensive integrated solution, comprised of the Büchi extraction unit B 815, an Agilent 7890 GC with a split/ splitless inlet and a FID, a GERSTEL MultiPurpose Sampler (MPS), integrated software control as well as a customized report. GERSTEL has exclusive sales and distribution rights world-wide for this solution. MPS provides high throughput Automated sample preparation and sample introduction are among the core competencies of the GERSTEL MPS, making it the ideal candidate for automating all the required steps in the GERSTEL-Büchi fat analysis solution. „The MPS combines high sample capacity with the flexibility to adapt to any sample preparation challenge”, says Ralf Bremer, Managing Director in charge of R&D and Production at GERSTEL. Using the PrepAhead functionality of the GERSTEL MAESTRO software, the MPS can even prepare the next sample or multiple samples while the current analysis is ongoing. This means that the next sample is always prepared and ready for injection as soon as the GC finishes running the previous sample. The GC system never has to be idle; it is always utilized to its fullest capacity providing best possible return on in- vestment. MAESTRO additionally offers an unsurpassed degree of flexibility, which is often sorely needed in a production environment. Priority samples that need to be analyzed as soon as possible, (for example, to release a batch of product or to accept an incoming raw material shipment), can simply be inserted into the running analysis sequence table. 3-in-1 chromatography system Büchi’s pre-GERSTEL solution was based on a GC method using packed columns, an older technology that has limited separation power. Because of this limitation, three different GC runs, each based on a different column was required per sample. The total analysis time needed was of course quite long and the user had to change and condition the columns prior to performing the next analysis. Last, but not least, lack of separation power resulted in wider peaks and less accurate results. “Implementing a method that uses capillary column technology along with the 7890 GC from Agilent Technologies enabled us to improve the separation and provide more accurate peak integration and thus more accurate results”, says Ralf Bremer, “and all three analyses are now performed in one run in just 9 minutes”. There is no longer a need to change columns and this of course improves the stability, performance and productivity of the system. The system provides values for the following: Total fat content, fat profile and butter fat (milk fat) content. According to Jochen Knecht, Ph.D., Managing Director of Büchi Germany and initiator of the cooperation, “This is a big step forward”. GERSTEL delivers the complete system pre-loaded with required analysis method parameters and a reporting tool that delivers all relevant results nicely organized on one page. “To use our system, you don’t have to be a GC expert”, says Ralf Bremer, “the system produces first class results in both production and R&D environments – and it does so much faster than it’s predecessor”. 3
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Page 7 and 8: Analytical conditions Adsorbent: Te
Page 9 and 10: T he more complex the method, the h
Page 11 and 12: Fatty acid methyl esters (FAMEs) Fa
Page 13 and 14: Success all around: The repeatabili
Page 15 and 16: (Bill) E. Brewer, Ph.D. from the Un
Page 17 and 18: THC and metabolites in blood: Total
Page 19 and 20: Why do you think that DPX will be a
Page 21 and 22: Archaeology meets chemistry W ine f
Page 23 and 24: Solid Phase Micro-Extraction (SPME)

Automated DPX process - Gerstel

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