2013 Re: T.R.U.E Test and gold Dear Health Care Professional ...

tixocortol-21-pivalate may be used to assist in the diagnosis of allergic contact dermatitis due to corticosteroids in Group A, based on the classificationof topical corticosteroids by cross-reactivity.Gold Sodium Thiosulfate (GST) (Position 28):Gold sodium thiosulfate (purity ≥ 90%) is a fairly common sensitizer with elicitation of symptoms linked to gold in jewelry, occupational exposure togold, previous rheumatoid arthritis treatment, dental restorations, and gold-plated intracoronary stents. The gel vehicle is hydroxypropyl cellulose andthe product is formulated to contain 75 mcg/cm 2 of gold sodium thiosulfate, which corresponds to 23 mcg of gold per patch.Imidazolidinyl Urea (IMID) (Germall ® 115) (Position 29):Imidazolidinyl urea is a complex mixture. The gel vehicle is povidone. The product is formulated to contain 600 mcg/cm 2 of imidazolidinyl urea, whichcorresponds to 486 mcg of imidazolidinyl urea per patch. Imidazolidinyl urea is a preservative found in cosmetics.Budesonide (BUD) (Position 30):Budesonide, USP (purity ≥98.0%) is a corticosteroid. The gel vehicle is povidone. The product is formulated to contain 1 mcg/cm 2 of budesonide,which corresponds to 0.8 mcg of budesonide per patch. Budesonide is found in topical medicinal and anti inflammatory products. Patch testing withbudesonide may be used to assist in the diagnosis of allergic contact dermatitis due to corticosteroids in Group B and to certain esters in Group D,based on the classification of topical corticosteroids by cross-reactivity.36