Synthesis of Tyrosinase Inhibitors: Designing Chalcones
Synthesis of Tyrosinase Inhibitors: Designing Chalcones
Synthesis of Tyrosinase Inhibitors: Designing Chalcones
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Saint Mary’s College <strong>of</strong> California Summer Research 2009G. DiazExperimental Section Solid <strong>Chalcones</strong> (Table 1)+23. 2’ , 4’ , 2 - Trichlorochalcone: 0.005mol each <strong>of</strong> 2’ , 4’-dichloroacetophenone and 2-chlorobenzaldehydewere mixed together with 1mL 15M NaOH. White solid formed which was recystallized in acetone. The final yieldwas 0.702g; 45.08%. Melting point values were recorded and spectroscopy analysis needs to be done.+24. 4’ , 4-Dimethoxychalcone: 0.005mol each <strong>of</strong> 4’-methoxyacetophenone and 4-methoxybenzaldehydewere dissolved in ethanol and refluxed at 70ºC. 1mL 15M NaOH was added and solid formed instantaneously; thereaction was stopped. Yellow powder was isolated after recrystallization from acetone. The final yield was 1.295g;96.34%. IR: 2964.32cm -1 , 2841.12cm -1 , 1651.78cm -1 .+25. 2’ , 4’ -Dichloro-4’-hydroxychalcone: 0.005mol each <strong>of</strong> 2’ , 4-dichloroacetophenone and4-hydroxybenzaldehyde were combined and mixed together with 2mL <strong>of</strong> 15M NaOH. Crystals formed uponmixing; brown solid was recrystallized from acetone. The final yield was 1.153g; 78.70%. IR: 3155.73cm -1 ,1667.25cm -1 .22
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