Virus-Host Interactions
Virus-Host Interactions
Virus-Host Interactions
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History• 1882- Adolf Mayer:Transmission of tobacco mosaicdisease by plant extract– Infectious agent could not beisolated• 1892- Dimitri Ivanofsky:Causative agent of tobacco isnot retained by filters– Cannot be cultivated in vitro• 1898 Martinus Beijerinck:Causative agent can becultivated in live tissue