Page 14<strong>Adult</strong> <strong>ADHD</strong>: Fact or Fiction?© 2010 Pharmaceutical <strong>Education</strong> Consultants, Inc. unless otherwise noted. All rights reserved.Reproduction in whole or in part without permission is prohibited.Side Effects of Alpha AgonistsClonidine and Guanfacine• Headache• Nausea• Dizziness• Decreased heart rate• Decreased blood pressure• Sedation/somnolence• Fainting• Must taperExtended Release Alpha AgonistsIntuniv (guanfacine)FDA Max/dayStarting Dose1 – 4mg tabs 0.2mg/kg/day 0.005mg-0.08mg/kg/dayStart with 1 mg/day.Increase weekly by 1mg/day until reach 4mg/day.Kapvay (clonidine)FDA Max/dayStarting Dose0.1, 0.2mg tabs 0.4mg/day 0.1mg/dayStart with 0.1 mg/day.Increase weekly by 0.1mg until reach 0.4mg/day.PharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> educationPharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> educationTreatment Refractory <strong>ADHD</strong>• Combine stimulants with atomoxetine orbupropion• Add modafinil to non-stimulant• Try TCA (alone or with stimulant)• Add alpha-agonist• MAO-I (alone)Pearls with <strong>Adult</strong> <strong>ADHD</strong>• Keep the diagnosis in mind• Evaluate thoroughly• Assess for comorbidity, especially affectivedisorders and substance abuse• Treat what’s worst, first• Identify strengths• Enhance resiliencePharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> educationPharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> education
Page 15<strong>Adult</strong> <strong>ADHD</strong>: Fact or Fiction?© 2010 Pharmaceutical <strong>Education</strong> Consultants, Inc. unless otherwise noted. All rights reserved.Reproduction in whole or in part without permission is prohibited.References• JAACAP, Practice Parameter for the Assessment and Treatment ofChildren and Adolescents with <strong>ADHD</strong>, 46:7, July 2007,894-917.• IntJ of Clinical Practice, Clinical Assessment and Treatment of <strong>ADHD</strong> inChildren, 2007; 61(10) 1730-1738.• www.nimh.hin/gov/health/publications/attention-deficit-hyperactivitydisorder/adhd_booklet.pdf• www.surgeongeneral.gov/library/mentalhealth/chapter3/sect6• Reiff, Michael, “<strong>ADHD</strong> A Complete and Authoritative Guide,” AAP, 2004.• Jensen, P. et al, “Evolution and Revolution in Child Psychiatry: <strong>ADHD</strong> asa Disorder of Adaptation,” JAACAP, 36(12:1572-1679), 1997.• Biederman, J., “Practical Considerations in Stimulant Drug Selection forthe <strong>ADHD</strong> Patient-Efficacy, Potency and Titration,” Today’s TherapeuticTrends, 20(4):311/238, 2002.• http://www.additudemag.com/adhd/article/print/3142.html-Exercise:A Med Without Side Effects, Ratey, J.PharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> educationReferences• Kessle RC, et al, Am J Psychiatry, 2006; 163:716-723.• Barkely RA, et al, <strong>ADHD</strong> in <strong>Adult</strong>s: What the Science Says, New York,NY: Guildford Press 2007.• Faraone, S. et al “The worldwide prevalence of <strong>ADHD</strong>: is it anAmerican condition?” World Psychiatry, June 2003; 2(2), 104-113.• Levy F., et al, JAACAP, 1997; 36-737-744.• Faraone SV, et al Bioll Psychiatry, 2005; 57:1313-1323.• Biederman J, et al , Am J Psychiatri, 1995; 152: 431-435.PharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> educationResourcesNotes• CHADD: www.chadd.org• American Academy of Child and Adolescent Psychiatry:www.aacap.org• National Institute of Mental Health: www.nimh.nih.gov/• American Academy of Pediatrics: www.aap.orgPharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> educationPharmCon is accredited by the Accreditation Council for Pharmacy <strong>Education</strong> as a provider of continuing <strong>pharmacy</strong> education