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SIDE EFFECTSSravani.Kethireddy* et al. /International Journal Of Pharmacy&Technology• Isoniazid: Some of the side effects of this drug include- rash, abnormal, hepatitis, sideroblasticanemia, peripheral neuropathy, headache, poor concentration, poor memory and depression.• Rifampicin: Certain adverse effects known to be caused by this drug are-Fever,gastrointestinal disturbances, rashes and immunological reactions. Liver damage, associatedwith jaundice, has also been reported and in some rare cases has led to death. At times bodilyfluids, such as urine and tears, are known to become orange-red in color.• Pyrazinamide: The most common side affect of this drug (1%) is joint pains, and the mostdangerous side effect is Hepatitis. Hepatitis is a dose related side effect, and since its dosagehas been reduced, the occurrence of Hepatitis has greatly fallen. Other minor side effectsinclude – nausea, vomiting, anorexia, skin rash, sideroblastic anemia, pruritus, dysuria,hyperuricemia, interstitial nephritis, malaise and fever.• Ethambutol: Optic neuritis, red-green color blindness, peripheral neuropathy and arthralgiaare some of the side effects caused by ethambutol[70].Symptom-basedapproach to manageside-effects of anti-TB drugsSide-effectsMajorSkin rash with orwithout itchingDeafness (no wax onotoscopy)Dizziness (vertigo andnystagmus)Jaundice (other causesexcluded), hepatitisConfusion (suspectdrug-induced acuteliver failure if there isDrug(s) probablyresponsibleManagementStop responsible drug(s) andrefer to clinician urgentlyStreptomycin, Stop anti-TB drugsisoniazid, rifampicin,pyrazinamideStreptomycin Stop streptomycinStreptomycinIsoniazid,pyrazinamide,rifampicinMost anti-TB drugsStop streptomycinStop anti-TB drugsStop anti-TB drugsIJPT | June 2010 | Vol. 2 | Issue No.2 | 206-244Page 229