detailed programme - IEB 2013 50th Inner Ear Biology Workshop

P-31 A novel splice-site mutation in the GJB2 gene causing mildpostlingual hearing impairmentMarta Gandía, Francisco J. del Castillo, Francisco J. Rodríguez-Álvarez, Manuela Calderón, Gema Garrido, Miguel A. Moreno-Pelayo, Manuela Villamar, Felipe Moreno and Ignacio del CastilloP-32 EPS8 is necessary for the normal expression of cochlear,but not vestibular hair cell K+ channelsIvo Prigioni, Elisa Tavazzani, Giancarlo Russo, JacopoMagistretti, Donatella Contini, Paolo Spaiardi, Teresa Soda andSergio MasettoP-33 Different expression of histone modification in the spiralganglion of Mn-SOD knock out miceKen-ichi Watanabe and Wilhelm BlochP-34 WBP2-deficient mice show progressive high-frequencyhearing loss and abnormal cochlear innervationAnnalisa Buniello, Andreea Huma, Raquel Martinez-Vega, NeilIngham and Karen SteelP-35 Is a connexin delition associated hearing loss treatable?Ryosei Minoda, Toru Miwa, Takao Yamada, Momoko Ise andEiji YumotoP-36 Mouse models of deafness that suggest impaired calciummobilization in inner ear cells: possible pathways thatdifferentiate the phenotype according to the molecular natureof the mutationsOsamu Minowa, Hiromi Motegi, Hideaki Toki, Maki Inoue,Yoichi Gondo and Tetsuo NodaP-37 Hearing phenotype of the conditional inducible mapk14-null mouseLourdes Rodríguez- de la Rosa, Silvia Murillo-Cuesta, MaríaArechederra, Ana Cuenda, Almudena Porras and Isabel Varela-NietoOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es9.-

16:00 Sessions 3 and 4: Genetics of Hearing Impairment in Humanand MouseChairs: Karen P. Steel and Hannie Kremer16:00 - 16:30 Target Lecture 1:Genetics of monogenic deafness unraveled at fast paceHannie Kremer (UMC, Nijmegen, NL)16:30 - 17:00 Target Lecture 2:Mouse models for human hereditary deafness DFNA8/12 andDFNB21Guy Richardson (US, Sussex, UK)17:00 - 18:30 Oral presentations:O-12 A nonsense mutation in CLIC5 causes autosomal recessivesensorineural hearing impairment with vestibular dysfunctionCelia Zazo Seco, Anne Oonk, Jaap Oostrik, Ronald Admiraal,Hannie Kremer and Margit SchradersO-13 Novel genetic tools to screen for deafness-causing mutations inthe tandemly-duplicated region that contains the STRC(stereocilin) gene and its pseudogeneLaura Ruiz-Palmero, Marta Gandía, Elena Gómez-Rosas,Manuela Villamar, Felipe Moreno, Ignacio del Castillo andFrancisco J. del CastilloO-14 Identification of rare variants in Mt-ND1 and LARS humangenes in Meniere’s disease suggest a two-hit modelTeresa Requena, Sonia Cabrera, Irene Gázquez and José AntonioLópez-EscamezO-15 Disturbance of axonal microtubules in the auditory nerveand outer hair cell degeneration accompanied byprogressive hearing loss in the Pmn/Pmn mouseKristen Rak, Silke Frenz, Johannes Völker, Andreas Radeloff,Rudolf Hagen, Sibylle Jablonka and Robert MlynskiOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es10.-

O-16 Correction of hearing in the mouse model of hereditarydeafness by Gjb2 gene transfer using adeno-associatedviral vectorsKatsuhisa Ikeda, Takashi Iizuka, Kazusaku Kamiya and OsamuMinowaO-17 Developmental changes of epithelial Na + channelexpression and function in the inner ear of pendrin knockoutmouse as a perspective of development ofendolymphatic hydropsSung Huhn Kim, Bo Gyung Kim, Jin Young Kim and Jae YoungChoi18:30 End of Poster Session I19:30 - 21:00 Guided visit to the old historic city center of Alcalá de HenaresStarting from:Facultad de Ciencias Económicas y EmpresarialesUniversidad de AlcaláDe la Victoria Square, 2Alcalá de Henares (Madrid), SpainOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es11.-

Thursday, September 12 th08:00 RegistrationPoster Session II09:00 Session 5: Ototoxic damage and Vestibular diseasesChairs: Agnieszka J. Szczepek and Giovanni Paludetti09:00 - 09:30 Target Lecture:Deep phenotyping of vestibular disorders for next generationsequencingJosé Antonio López Escámez (UGR, Granada, SP)09:30 - 11:00 Oral presentations:O-18 Modulation of copper transporters in protection againstcisplatin-induced cochlear hair cell damageDalian Ding and Richard SalviO-19 Effect in vivo of dimethyl sulphoxide (DMSO) in theototoxicity by cisplatin, an animal modelAmaya Roldán-Fidalgo, Almudena Trinidad Cabezas and RafaelRamírez-CamachoO-20 Co-treatment with ototoxic nitriles and CYP2E1 inhibitors:a new mouse model for vestibular hair cell loss with limitedsystemic toxicityJordi Llorens, Sandra Saldaña-Ruíz, Lara Sedó-Cabezón andPere Boadas-VaelloO-21 Ubiquinone rescues auditory hair cells from the cisplatininducedtoxicityAgnieszka J. Szczepek, Elisabeth Gerschner, Heidi Olze, OlgaHegend and Birgit MazurekO-22 Local delivery of brain-derived-neurotrophic factor on theperforated round window membrane: a possible clinicalapplicationSarah Havenith, HuibVersnel, Sjaak F.L. Klis and Wilko GrolmanOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es12.-

11:00 - 11:30 Coffee breakPoster Session II11:30 Session 6: Noise-induced hearing lossChairs: Lukas Rüttiger and Anna Fetoni11:30 - 12:00 Target Lecture:ACEMg in the prevention and treatment of hearing impairmentJosef M. Miller (UMICH, Ann Arbor, USA)12:00 - 13:30 Oral presentations:O-23 Acute antioxidant response and apoptosis regulation in ratsafter noise exposurePedro Melgar-Rojas, Juan Carlos Alvarado, Verónica Fuentes-Santamaría, M. Cruz Gabaldón and José Manuel JuizO-24 Adenosine amine congener as a cochlear rescue agent: anupdateSrdjan M. Vlajkovic, Song Y. Paek, Howard H-T. Chi, HaoChang and Peter R. ThorneO-25 Autophagy is a defense mechanism against noise-inducedhearing lossSu-Hua Sha and Hu YuanO-26 The early onset of oxidative stress processes in the organ ofCorti after intense noise exposure: the role of membrane fluidityA.R. Fetoni, G. Maulucci, S.L.M. Eramo, M. De Spirito, F.Paciello, D. Troiani and G. PaludettiO-27 Hyperacusis and tinnitus studies in the aging ratDorit Möhrle, Ksenia Varakina, Marlies Knipper and Lukas RüttigerO-28 C-RAF deficiency causes cochlear abnormalities and profoundsensorineural deafness in the mouseMarta Magariños, Rocío de Iriarte, Ulf R. Rapp and Isabel Varela-NietoOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es13.-

13:30 - 13:45 Group photo.Venue: Cloister of the Facultad de Ciencias Económicas yEmpresariales13:45 - 15:00 Lunch15:00 - 16:00 Poster Session II :P-38 Temporary dysfunction of outer hair cells afterintratympanic application of Pseudomonas aeruginosaexotoxin AAdnan Lidian, Birgitta Linder, Barbara Canlon and Matti AnnikoP-39 Ototoxic effects of Mefloquine in cochlear organotypic culturesHaiyan Jiang, Dalian Ding and Richard SalviP-40 Otoacoustic emissions and cochlear functionality in workersexposed to styreneR. Sisto, L. Cerini, M.P. Gatto, M. Gherardi, A. Gordiani,E. Paci, F. Sanjust, T. Botti, G. Tranfo and A. MoletiP-41 Afferent pathology and repair associate with vestibulardysfunction and recovery during chronic ototoxicity in the ratLara Sedó-Cabezón and Jordi LlorensP-42 Oncostatin M - induced protection against cisplatin ototoxicityis mediated via STAT3Elisabeth Gerschner, Olga Hegend, Heidi Olze, Birgit Mazurekand Agnieszka SzczepekP-43 Protective role of edaravone against neomycin-inducedototoxicity in zebrafishJiwon Chang, Kang Woo Kim, Gi Jung Im, Hak Hyun Jung andJune ChoiOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es14.-

P-44 Systemic treatment with resveratrol and N-acetylcysteineprevents from local ototoxicity with kanamycin andfurosemide in ratsF. García-Alcántara, S. Murillo-Cuesta, R. Martínez-Vega,J. Contreras, L. Sanz, I. Varela-Nieto and T. RiveraP-45 Ear in a dish: development of an in vitro assay for ototoxicand otoprotective drugs screeningAurélie Dos Santos, Andreas Eckhard, Ngoc-Nhi Luu, MarcusMüller and Hubert LöwenheimP-46 Deiters cells regulate the remodelling of aminoglycosideinjuredorgan of Corti, through the release of HMGB1Sabine Ladrech, Marc Mathieu, Hassan Boukhaddaoui, Jean-LucPuel and Marc LenoirP-47 Preliminary results with the NMDA antagonist memantine insalicylate-induced tinnitusM. Ralli, R. Salvi, F. Paciello, S.L.M. Eramo, D. Troiani, A.R. Fetoniand G. PaludettiP-48 Effects of the calyx on the apparent properties of vestibular typeI hair cells K + currentsElisa Tavazzani, Giancarlo Russo, Jacopo Magistretti, PaoloSpaiardi, Teresa Soda, Ivo Prigioni and Sergio MasettoP-49 Proteomic analysis of vestibular schwannomaJae-Hyun Seo, Kyoung-Ho Park and Seong-Cheon BaeP-50 Suddens sensorineural hearing loss, inflammatory disease &TNF-alphaElias Q. Scherer, Andreas Knopf and Elmar OestreicherOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es15.-

P-51 Polymorphisms in genes involved in the free-radicalprocess in patients with Ménière’s disease and suddensensorineural hearing lossMasaaki Teranishi, Yasue Uchida, Naoki Nishio, Ken Kato,Hironao Otake, Tadao Yoshida, Michihiko Sone, Saiko Sugiura,Fujiko Ando, Hiroshi Shimokata and Tsutomu NakashimaP-52 Reducing noise-induced hearing loss by peptides targetingtransforming growth factor‐β1Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, LorenaSanz, Carlos Avendaño, Teresa Rivera and Isabel Varela-NietoP-53 IGF-I deficit predisposes to noise-induced hearing loss in miceAdelaida Celaya, Silvia Murillo-Cuesta, Lourdes Rodríguez-dela Rosa, Rafael Cediel, Carlos Avendaño, Julio Contreras andIsabel Varela-NietoP-54 Functional and anatomical correlation in noise-inducedhearing loss mouse modelL. Sanz, C. Avendaño, S. Murillo-Cuesta, R. Cediel, F. García-Alcántara, P. Cobo, I. Varela-Nieto and T. RiveraP-55 Protective effect of rosmarinic acid in noise inducedhearing loss: a functional and morphological studyF. Paciello, S.L.M. Eramo, R. Rolesi, A.R. Fetoni, D. Troianiand G. PaludettiP-56 Role of p66shc in noise induced hearing loss: a functionaland morphological study in mice and ratsS.L.M. Eramo, A.R. Fetoni, F. Paciello, D. Troiani, G. Paludettiand G. PaniP-57 Analysis of vulnerability of hearing loss over agesubsequent to the deletion of BDNF or Cav1.2 in thecochleaS.C. Lee, D. Campanelli, K. Varakina, D. Bing, A. Zuccotti, W.Singer, L. Rüttiger, T. Schimmang and M. KnipperOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es16.-

P-58 Analysis of acute stress on long-term vulnerability after anacoustic injury in a mature rat modelK. Kasini, I. Köpschall, K. Rohbock, L. Rüttiger, M. Knipper andM. JaumannP-59 Lack of BDNF in the cochlea but not in the brain influencessound processingDario Campanelli, Sze Chim Lee, Annalisa Zuccotti, WibkeSinger, Katja Gutsche, Lukas Rüttiger, Thomas Schimmang andMarlies KnipperP-60 Hearing and comorbidities in patients with professionalhearing lossNatalia N. Petrova and Viya S. PanshinaP-61 Synergistic effect of Styrene exposure and acoustic trauma:a functional and morphological study in a model of noiseinduced hearing loss (NIHL)R. Rolesi, F. Paciello, S.M.L. Eramo, D. Troiani, A.R. Fetoni andG. PaludettiP-62 Review of TNF blockers and other biological therapy agents inautoimmune inner ear diseaseDavid Lobo, José Ramón García-Berrocal, José María Verdaguerand Rafael Ramírez-CamachoP-63 Efficacy of etanercept in an animal model of autoimmunelabyrinthitisDavid Lobo, José Ramón García-Berrocal, Almudena Trinidadand Rafael Ramírez-CamachoP-64 Guidance of spiral ganglion cell neurites using ananomatrix in vitroClaudia Frick, Marcus Müller, Ute Wank, Karl-HeinzWiesmüller and Hubert LöwenheimOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es17.-

P-65 Methylprednisolone injection to the inner ear: analternative to the systemic therapyJeanette Sáenz-Piñones, José Ramón García-Berrocal, IthzelVillarreal, Emilia T. Martin-Mata, Almudena Trinidad andRafael Ramírez-CamachoP-66 Fibrin-collagen coating of cochlea implant electrodes fortransplantation of adipose-derived stem cellsPhilipp Schendzielorz, Agmal Scherzed, Kristen Rak, JohannesVölker, Thomas Gehrke, Christian Ginzkey, Rudolf Hagen andAndreas RadeloffP-67 A novel method for transplantation of terminally differentiatedneurons derived from pluripotent stem cells into the cochleaHiroe Ohnishi, Takayuki Nakagawa, Masaaki Ishikawa, YousukeTona, Nakarin Asaka and Juichi ItoP-68 Survival of human iPS cell-derived neurons aftertransplantation into guinea pig cochleaeMasaaki Ishikawa, Takayuki Nakagawa, Hiroe Onishi, YosukeTona, Nakarin Asaka, Yoshitaka Kawai and Juichi ItoP-69 Molecular optical imaging enables visualization of exogenousstem cells in the intact guinea pig cochleaJohn C.M.J. de Groot, Laura Mezzanotte, TimoSchomann,Clemens W.G.M. Löwik, Johan H.M. Frijns and Margriet A.HuismanP-70 Mondini dysplasia: conceptual new and new electrodedesigned for cochlear implantationMª José Lavilla Marti de Valmaseda, Silvia V. DomínguezOvejas, Daniella Laguado Bulgheroni, Javier Cervera Escario,José Marcos Calle and M. AparicioOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es18.-

P-71 Application of new generation technologies (NGS and aCGH)to the integral diagnosis and investigation of inherited hearinglossMatías Morín, Lucia Borreguero, Maria Palomares, Ángeles Mencía,Luciana S. Serrao de Castro, Fernando Mayo, Julián Nevado, PabloLapunzina, Ignacio del Castillo, Javier Santoyo, Felipe Moreno andMiguel Ángel Moreno-PelayoP-72 Highly efficient diagnostic testing in patients with hereditaryhearing loss using Panel-based Next Generation SequencingSarah Fehr, Moritz Menzel, Saskia Biskup, Konstanze Hörtnagel,Tim Scheurenbrand, Andrea Sprecher, Anke Tropitzsch and HubertLöwenheimP-73 SVT-AP-99: Inhibition of Apaf-1 as a potential therapeuticstrategy to prevent cisplatin-induced hearing lossSandra Marchán, Celia Casares, Estefanía Traver, AlmudenaTrinidad, José Ramón García Berrocal, Natividad García Villar,Javier Sanagustín, Carmen Herrero, Carmen Lagunas and RafaelRamírez-CamachoP-74 Plucked human scalp hair follicles may serve inner earcell- based therapyCoen Gho, Suzy Varderesyan, Johan H.M Frijns, Marcelo N.Rivolta and Margriet A. HuismanP-75 Analysis of the effect of stimulated cGMP cascade on thevulnerability for hearing loss after noise exposure duringagingKsenya Varakina, Mahdieh Alinaghikhani, Dan Bing, Sze ChimLee, Iris Köpschall, Marlies Knipper and Lukas RüttigerOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es19.-

P-76 Preventive effect of polyphenols on hearing loss comparingevoked potentials hearing of brain stem responses and stablestate hearing in experimental animals age-relatedR. Sanz-Fernández, Carolina Sánchez-Rodríguez, J. Esteban-Sánchez, E. Martín-Sanz, L. Rodrigáñez, L. De Toro Gil and E.Durio-CaleroP-77 Autoantibodies and sudden hearing lossJohanna Rebholz, Kerstin Ratzlaff, Reinhild Klein and MarkPraetoriusP-78 Methods for hearing threshold measurements with ABR inguinea pigsJohannes Fischer, Jochen Steinhoff and Thomas StarkP-79 Influence of cochleostomy and implant insertion on druggradients following intratympanic application in guineapigsE.B. King, J.J. Hartsock, S.J. O’Leary and A.N. SaltP-80 Change in endocochlear potential during experimentalinsertion of a simulated cochlear implant electrode in theguinea pigHidetoshi Oshima, Ryoukichi Ikeda, Kazuhiro Nomura, MuneharuYamazaki, Hiroshi Hidaka, Takeshi Oshima, Tetsuaki Kawase andToshimitsu KobayashiP-81 Functional and histological outcomes following cochlearimplantation in the mouseNina Mistry, Lisa S. Nolan, Andrew Forge, Shakeel R. Saeed andRuth R. TaylorP-82 Laser assisted cochleostomy in guinea pigsDigna M.A. Kamalski, Jeroen P.M. Peters, Tjeerd de Boorder,Rudolf M. Verdaasdonk, Sjaak F.L. Klis and Wilko GrolmanOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es20.-

P-83 A comparison of two vasoactive/vasodilative agents incombination with corticosteroid for treatment of suddensensorineural hearing lossŠpela Kordiš, Miha Žargi and Saba BattelinoP-84 High speed imaging in laser-assisted stapedotomyDigna M.A. Kamalski, Tjeerd de Boorder, H.P.M. (Jeroen)Peters, Huib Versnel, Rudolf M. Verdaasdonk and WilkoGrolmanP-85 Characterization of neural stem cells in the rat cochlearnucleusJ. Voelker, K. Rak, R. Hagen and R. MlynskiP-86 Study of the role of miRNAs in the development of theauditory portion of the inner earP. Van Den Ackerveken, A. Huyghe, R. Sacheli, F. Rogister,P.P. Lefebvre, L. Nguyen and B. MalgrangeP-87 First steps towards a gapless interface between auditoryneurons and multi-electrode arrays in vitroStefan Hahnewald, Marta Roccio, Pascal Senn, Anne Tscherter,Jürg Streit, Julien Brossard, Herbert Keppner and Hans RudolfWidmerP-88 Autophagy is required for apoptotic cell clearance andneural differentiation in early otic developmentRocío de Iriarte, Marta Magariños, María Rodríguez Aburto,Hortensia Sanchez-Calderón, Juan M. Hurlé and Isabel Varela-NietoP-89 TIS21 is involved in the development of spiral ganglioncellsTakao Yamada, Ryosei Minoda, Momoko Ise and Eiji YumotoOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es21.-

P-90 Inhibition of matrix metalloproteinase-2 but notmetalloproteinase-9 influences spiral ganglion neurons in vitroCristian Setz, Eric Wei, Michael Sung, Soledad Levano, DanielBodmer and Yves BrandP-91 The regulation of Hes/Hey factors during sensorydevelopment of the chicken inner earJelena Petrovic, Gina Abelló, Héctor Gálvez, Joana Neves andFernando GiraldezP-92 Netrin-4 promotes and modulates inner ear spiral ganglionneurite outgrowth in vitroYves Brand, Michael Sung, Eduardo Chavez, Kwang Pak, EricWei, Soledad Levano, Vesna Radojevic, Daniel Bodmer andAllen F. RyanP-93 Spiral ganglion-derived fibroblast cell cultureAnnett Anacker, Karl-Heinz Esser, Thomas Lenarz and GerritPaascheP-94 Rolipram improves survival of spiral ganglion cells in vitroKatharina Kranz, Athanasia Warnecke, Kirsten Wissel, ThomasLenarz and Verena ScheperP-95 Extracellular matrix from human mesenchymal stem cellsfor cell-based drug delivery into the inner earKirsten Wissel, Athanasia Warnecke, Thomas Lenarz, MarinaPrewitz and Carsten WernerP-96 Differentiation of Boettcher's cells during postnataldevelopment of rat cochleaMarie Cloes, Thomas Renson, Nicolas Johnen, Nicolas Thelenand Marc ThiryOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es22.-

16:00 Session 7: Novel therapies and diagnostic toolsChairs: Anneliese Schrott-Fischer and Allen Ryan16:00 - 16:30 Target Lecture:Exploring disrupted cochlear homeostasis: a second youth for"old" diagnostic tools?Paul Avan (UdA, Clermont-Ferrand, FR)16:30 - 18:00 Oral presentations:O-29 Auditory threshold estimation using short-pulse DPOAEinput-output functionsDennis Zelle, Anthony W. Gummer and Ernst DalhoffO-30 Video head impulse test may represent a method for highfrequency vestibular function and compensation phenomenaassessmentHayo A. Breinbauer, Karina Aracena, José L. Anabalón, DiegoNazal and Jorge CaroO-31 Visualization of internal structures in the vestibule and thesemicircular canals using optical coherence tomography(OCT)Tatsunori Sakamoto, Yosuke Tona, Akiko Taura, TakayukiNakagawa and Juichi ItoO-32 Probing auditory nerve fiber loss using round-windowneural noiseCharlène Batrel, Jing Wang, Marc Lenoir, Jean-Luc Puel andJérôme BourienO-33 Intratympanic administration of triamcinolone-acetonide: Invivorelease and proof of oto-compatibilityElisabeth Engleder, Clemens Honeder, Gottfried Reznicek,Michael Wirth, Christoph Arnoldner and Franz GaborOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es23.-

O-34 Targeting the somatostatin receptors as a therapeutic approachfor the preservation and protection of the mammalian cochleafrom excitotoxicityDaniel Bodmer, Yves Brand, Soledad Levano, Cristian Setz andVesna Radojevic18:00 - 18:45 Plenary Conference: 50 years of IEB ScienceChair: Ignacio del CastilloInner ear biology at fifty - a science timelineJonathan Ashmore (UCL, London UK)18:45 - 19:15 Spoendlin Award LectureChair: Marcelo N. Rivolta19:15 - 19:30 Spoendlin Award21:00 Workshop dinnerVenue: Parador de Alcalá de HenaresColegios Street, 8Alcalá de HenaresOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es24.-

Friday, September 13 th08:00 Registration09:00 Session 8: Molecular bases of inner ear development andregenerationChairs: Brigitte Malgrange and Takayuki Nakagawa09:00 - 09:30 Target Lecture:Translating development into regeneration for the earMarcelo N. Rivolta (UoS, Sheffield, UK)09:30 - 11:00 Oral presentations:O-37 Function and regulation of Hey1 and Hey2 in cochleadevelopmentAna Benito González and Angelika DoetzlhoferO-38 Effect of IGF-1 for spiral ganglion afferent dendrite andsynapse regenerationNakarin Asaka, Takayuki Nakagawa, Norio Yamamoto, TomokoKita, Akiko Taura, Masaaki Ishikawa, Yushi Hayashi and JuichiItoO-39 Transcriptional regulation of the Pou4f3 geneAllen F. Ryan, Yan Li, Kwang Pak, Eduardo Chavez, MasatsuguMasuda and Ryoukichi IkedaO-40 Translational research of cell-based therapy for restorationof spiral ganglion neuronsTakayuki Nakagawa, Hiroe Ohnishi, Masa-aki Ishikawa, YosukeTona, Nakarin Asaka, Yoshitaka Kawai and Juichi ItoO-41 Electrophysiological properties of stem-cell derived sensoryneuronsBryony A. Nayagam, Tomoko Hyakumura, Mirella Dottori andKarina NeedhamOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es25.-

O-42 Derivation of otic progenitor and inner ear cells fromnormal or pathological human induced pluripotent stemcells for modeling hereditary hearing lossGrobarczyk Benjamin, Laurence Borgs, Audrey Purnelle,Philippe Lefebvre, Laurent Nguyen and Brigitte Malgrange11:00 - 11:30 Coffee breakPoster Session II11:30 - 12:15 Closing conference:Chair: Miguel Angel MorenoInsights into deafness from new mouse mutantsKaren P. Steel (King´s College, London, UK)12:30 - 13:30 Business MeetingClosing CeremonyEnd of Poster Session IIEnd of WorkshopOrganized by:Organising Secretariat:Fundación General de la Universidad deAlcaláC/ Imagen, 1-328801 Alcalá de Henares (Madrid)Phone: +34 91 879 74 36 Fax: +34 91 879 74 55E-mail: ieb2013@fgua.es26.-