<strong>Clinical</strong>THYROIDOLOGYVOLUME 25 • ISSUE 2 FEBRUARY <strong>2013</strong>Clin <strong>Thyroid</strong>ol <strong>2013</strong>;25:28–30.Editor-in ChiefJerome M. Hershman, MDDistinguished Professor of MedicineUCLA School of Medicineand VA Greater Los Angeles Healthcare SystemEndocrinology 111D, 11301 Wilshire Blvd.Los Angeles, CA 90073Email: jhershmn@ucla.eduAssociate Editors:Albert G. Burger, MDProfessor, University of GenevaGeneva, SwitzerlandEmail: agburger@bluewin.chJorge H. Mestman, MDProfessor of <strong>Clinical</strong> Medicine and OB/GYNUniversity of Southern California,Keck School of MedicineLos Angeles, CAEmail: mestman@usc.eduElizabeth N. Pearce, MD, MScAssociate Professor of MedicineBoston University School of MedicineBoston, MAEmail: Elizabeth.pearce@bmc.orgWendy Sacks, MDCedars-Sinai Medical CenterDepartment of MedicineHealth Sciences Assistant <strong>Clinical</strong> ProfessorUniversity of California, Los Angelesemail: wendy.sacks@cshs.orgStephen W. Spaulding, MDProfessor of MedicineDepartment of MedicineUniversity at Buffalo, SUNYEmail: medspaul@buffalo.eduCord Sturgeon, MDAssociate Professor of SurgeryDirector of Endocrine SurgeryNorthwestern UniversityFeinberg School of MedicineChicago, ILEmail: csturgeo@nmh.orgPresidentBryan R. Haugen, MDSecretary/Chief Operating OfficerJohn C. Morris, MDTreasurerDavid H. Sarne, MDPresident-ElectHossein Gharib, MDPast-PresidentJames A. Fagin, MDTreasurer-ElectGregory W. Randolph, MDExecutive DirectorBarbara R. Smith, CAE<strong>American</strong> <strong>Thyroid</strong> Association6066 Leesburg Pike, Suite 550Falls Church, VA 22041Telephone: 703-998-8890Fax: 703-998-8893Email: thyroid@thyroid.orgDesigned ByKaren Durland (kdurland@gmail.com)<strong>Clinical</strong> <strong><strong>Thyroid</strong>ology</strong>Copyright © <strong>2013</strong><strong>American</strong> <strong>Thyroid</strong> Association, Inc.Printed in the USA. All rights reserved.Meta-analysis of Studies of<strong>Thyroid</strong>ectomy Specimens Showsa Positive Correlation betweenPapillary <strong>Thyroid</strong> Carcinoma andHashimoto’s <strong>Thyroid</strong>itisKaren T. Le, Bojana Jankovic,and Jerome M. HershmanLee JH, Kim Y, Choi JW, Kim YS. The association between papillarythyroid carcinoma and histologically-proven Hashimoto’s thyroiditis: ameta-analysis. Eur J Endocrinol. December 4, 2012 [Epub ahead of print].SUMMARYBackgroundHashimoto’s thyroiditis (HT) is found in a high proportion of resected thyroidspecimens. There has been considerable controversy as to whether having HTpredisposes a patient to papillary thyroid cancer (PTC). This study is a metaanalysisdesigned to clarify the relationship between PTC and histologicallydemonstrated HT and to investigate the clinical and pathologic features of PTCwith coexistent HT.MethodsThe authors performed an extensive literature search for articles that hadprimary data showing an association of PTC and “classical HT” based on histopathologicexamination of thyroid specimens. Articles lacking pathologic datawere excluded. On the basis of these criteria, 38 studies were selected for themeta-analysis.Odds ratios (OR) with 95% confidence intervals (CI) were calculated andcombined using a random-effects model.continued on next pageBack to Contents28
Meta-analysis of Studies of <strong>Thyroid</strong>ectomy SpecimensShows a Positive Correlation between Papillary<strong>Thyroid</strong> Carcinoma and Hashimoto’s <strong>Thyroid</strong>itisLee JH, et al.ResultsThe 38 studies consisted of 37 case–control studiesand one cohort study. The number of patients in eachstudy ranged from 6 to1788, with a total of 10,648PTC cases. Only 11 studies compared the frequencyof HT in cases of PTC and benign thyroid disease. HTwas found in 938 of 2317 (40.5%) of PTC cases and in634 of 3019 (21%) of benign cases (OR, 2.77;95% CI,1.95 to 3.93; P