08Lec-COMPLICATIONS OF PNEUMONIA.pdf - Pediatric Infectious ...

Pediatric CAPPediatric CAPPossible PathogenEmpiric TherapyPossible PathogenEmpiric TherapyMild, Nontoxicpharyngitis,rhinorrhea ordiarrheaProbably viralNoneBilateral, severeLobar or segmentalconsolidation,moderate - severeS pneumoniaeS pyogenesS aureusM pneumoniaeCefuroxime, ceftriaxone,cefotaximeNafcillin, oxacillin,cefazolin, clindamycinMacrolideModerate toxicityno hospitalizationLobar or segmentalconsolidation, mildS pneumoniaeS pyogenesH influenzaeM pneumoniaeInfluenza A and BAmoxicillinCo-amoxiclavCefprozil, Cefdinir,Cefpodoxime,Cefuroxime,CeftriaxoneMacrolideWith pleural fluid,empyema ornecrotizingS pneumoniaeS pyogenesS aureusH influenzaeAnaerobeCeftriaxone, cefotaximeNafcilllin, oxacillin,cefazolin, clindamycinVancomycinMeropenem, imipenemBL-BIBIBradley JS. Pediatr Infec Dis J 2002;21(6):592-598.Bradley JS. Pediatr Infec Dis J 2002;21(6):592-598.Predictors of Mortality in CommunityAcquired Pneumonia in ChildrenMaria Liza B. Zabala and Alexander O. Tuazon. UP-PGH 2001Predictors of Mortality in CommunityAcquired Pneumonia in ChildrenMaria Liza B. Zabala and Alexander O. Tuazon. UP-PGH 2001Variable Survivor Mortality p OR 95% CIPre-existing illness 27/74 32/46 0.0004 3.98 1.68-9.54Temp 38.5 27/74 26/46 0.009 2.26 1-5.15Altered mental status 60/74 45/46 0.007 10.5 1.47-453.64Mechanical ventilation 20/74 46/46 0.0000Variable Survivor Mortality p OR 95% CIHemoglobin (m+SD) 111+ 20 94+ 28 0.0002WBC < 5 x 10 9 /L 1/74 7/43 0.002 15.37 1.9-690.98WBC > 28 x 10 9 /L 6/74 7/43 0.033 3.15 0.94-11.33Platelet < 150x10 6 /mm 3 5/70 15/43 0.0003 6.5 1.98-24.6O2 supplementation 46/74 46/46 0.0000