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Translating Guidelines and Clinical Trial Data to and ... - Amazon S3

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Age at Diagnosis Correlates withOutcomeProbability1.00.908 0.80.70.60.50.40.31-9 Years (n=598)>15 Years (n=78)0.210-15 Years (n=153)0.150 chromosomes39 9.56±3.59 (5-20) 1.59±2.49 (0-11) 11.13±5.0 (5-27)B-ALL TCF3-PBX1 17 1.59±0.62 (1-3) 2.12±1.17 (1-4) 3.7±1.53 (2-7)B-ALL ETV6-RUNX1 47 0.89±1.51 (0-8) 6.0±4.63 (1-21) 6.68±4.8 (0-21)B-ALL rMLL 11 0.09±0.3 (0-1) 0.91±1.81 (0-6) 1±1.79 (0-6)B-ALL BCR-ABL1 9 4±5.3 (0-12) 4.2±4.15 (0-12) 6.8±4.52 (0-13)B-ALLHyperdiploidy with47-50 chromosomes23 1.70±1.55 (0-7) 3.5±3.12 (0-12) 5.1±4.31 (0-15)B-ALL Hypodiploid 10 1.1±1.91 (0-6) 6.0±4.42 (3-18) 7.1±6.12 (3-24)B-ALL Other 36 1.06±3.21 (0-19) 4.64±5.14 (0-20) 5.58±6.57 (0-23)B-ALL Total 192 2.97±4.28 (0-20) 3.83±4.2 (0-21) 6.63±5.56 (0-27)T-ALL 50 0.9±1.98 (0-9) 4.9±6.21 (0-30) 5.8±7.12 (0-39)All Cases 242 2.54±4.0 (0-20) 4.06±4.69 (0-38) 6.46±5.90 (0-39)*Range is shown in parentheses.B-ALL = acute B-lymphoblastic leukemia; T-ALL = acute T-lymphoblastic leukemia.Mullighan CG, et al. Nature. 2007;446(7137):758-764.

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