Medical Treatment of Hepatorenal Syndrome - AASLD

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Who Develops HRS?•Cirrhotic patients with ascites• May be preceded by precipitating factor• Spontaneous bacterial peritonitis (SBP)• Sepsis• Total paracentesis• Upper GI hemorrhage•Patients with acute alcoholic hepatitis•Patients with acute liver failure
Risk <strong>of</strong> Developing RenalDysfunction in Patients with50Cirrhosis403027%33%20107%0After GIbleedingAlcoholichepatitisCardenas A, et al. Hepatology. 2001;34:671–676Akriviadis E, et al. Gastroenterology. 2000;119:1637–1648Sort P, et al. N Engl J Med. 1999;341:403–409.Spontaneousbacterialperitonitis
Page 1 and 2: Thomas D. Boyer, MDHepatorenal Synd
Page 3 and 4: Conflicts of interest• Member adv
Page 5 and 6: Pathogenesis of Ascites in Cirrhosi
Page 7 and 8: 7060504030252015105Neurohumoral Sys
Page 9 and 10: Type and Frequency of Injury inAcut
Page 11: Workup of Renal Dysfunction in Pati
Page 14 and 15: Hepatorenal syndromeAdditional Crit
Page 16 and 17: Type 1 HRS Is Associated WithVery P
Page 20 and 21: Prevention of HRS
Page 22 and 23: Antibiotic Prophylaxis in VaricealB
Page 24 and 25: Prostaglandin Inhibition andEffects
Page 26 and 27: Treatment of HRS General• Stop al
Page 28 and 29: Site of Action of CurrentTherapies
Page 30 and 31: TIPS and HRSGut 47:166; 2000
Page 32 and 33: Treatment of HRS:Pharmacologic Ther
Page 34 and 35: Background (II)• Synthetic 12-ami
Page 36 and 37: Reversal of HRS40HRS Reversal (%)30
Page 38 and 39: Survival DistributionFunction1.00.9
Page 40 and 41: Adverse EventsTerlipressinN=56Place
Page 42 and 43: Impact of OLTx on RenalGlomerular f
Page 44 and 45: HRS conclusions continued• Exclus

Medical Treatment of Hepatorenal Syndrome - AASLD

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