Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer

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Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer

Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer

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TP53 AlarmsONCOGENE(e.g., MYC)DNADAMAGEp14 ARFInactiveATM, CHK2mdm2p53ApoptosisCell Cycle Arrest

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Chiara F. Sugrue, MBA, MS, SCT(ASCP)

EXHIBITOR PROSPECTUS - 61st Annual Scientific Meeting

Dorothy L. Rosenthal, MD, FIAC

TP53 AlarmsONCOGENE(e.g., MYC)DNADAMAGEp14 ARFInactiveATM, CHK2mdm2p53ApoptosisCell Cycle Arrest

<strong>Cancer</strong>Increased cell birth rate-RB-1Decreased cell death rate-TP53

Page 1: Cellular Mechanismsin Hereditary Ca
Page 4 and 5: A Dominantly Inherited Cancer
Page 6 and 7: Retinoblastoma
Page 8: Two Hits in Retinoblastoma
Page 11 and 12: Germline Deletion in RB Patient
Page 13 and 14: G1pRb PathwaypRbppRbSCdk4/D1p16Cdk4
Page 15: Hereditary CancerMultiple TumorsHer
Page 19 and 20: Smart DNA VirusesDNAVirusAdSV40HPVV
Page 21 and 22: Neurofibromatosis Type 1
Page 23 and 24: Multiple Gene Mutations inColorecta
Page 25 and 26: Phakomatoses Network
Page 27 and 28: Human Chromosomes
Page 29 and 30: Breakage-Fusion-Bridge Cycle
Page 31 and 32: DSBs and Mutationsby Radiation1 Gy
Page 33 and 34: BLOOM SYNDROMETwin SpotsCourtesy: D
Page 35 and 36: Bloom SyndromeHomologous Recombinat