Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer

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Familial Polyposis Coli
Multiple Gene Mutations inColorectal CancerNormal Early adenoma Intermediate Late adenoma CancerAPC K-RAS SMAD2, 4 TP53Adapted from Ilyas et al. Eur. J. Cancer 1999; 35:335-351 and Kelloff et al. Oncology 1996; 10:1471-1484
Page 1: Cellular Mechanismsin Hereditary Ca
Page 4 and 5: A Dominantly Inherited Cancer
Page 6 and 7: Retinoblastoma
Page 8: Two Hits in Retinoblastoma
Page 11 and 12: Germline Deletion in RB Patient
Page 13 and 14: G1pRb PathwaypRbppRbSCdk4/D1p16Cdk4
Page 15 and 16: Hereditary CancerMultiple TumorsHer
Page 17 and 18: CancerIncreased cell birth rate-RB-
Page 19 and 20: Smart DNA VirusesDNAVirusAdSV40HPVV
Page 21: Neurofibromatosis Type 1
Page 25 and 26: Phakomatoses Network
Page 27 and 28: Human Chromosomes
Page 29 and 30: Breakage-Fusion-Bridge Cycle
Page 31 and 32: DSBs and Mutationsby Radiation1 Gy
Page 33 and 34: BLOOM SYNDROMETwin SpotsCourtesy: D
Page 35 and 36: Bloom SyndromeHomologous Recombinat

Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer

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