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5000400030002000conferenceuntil 2004 1990 continous but slow growth•• • ••6-6500 att.Major limitations: Ionization techniques only forsmall, thermally stabile compounds= widespread use of GC-<strong>MS</strong> no robust and universal couplingbetween HPLC and <strong>MS</strong>1000•1950 1960 1970 1980 1990 2000
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