Evolution of Translational Omics:

How are Omics Tests Different?• Difficulty in defining the biological rationale underpinning a test• Biological rationale behind single-analyte tests is often evident➠ Examples: HER2, LDL• Biological rationale for an omics-based test is often not well defined• Challenges in data provenance and sharing• Large, complex datasets used to create computational models• Simple data management errors can easily occur• Sharing of data and code is not routine• Difficult for other scientists to replicate and verify findings