Methods for handling treatment switching - MRC Network of Hubs for ...
Methods for handling treatment switching - MRC Network of Hubs for ...
Methods for handling treatment switching - MRC Network of Hubs for ...
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P-valueModel: T i (0) = T i<strong>of</strong>f+ exp(ψ) × T ion• When ψ=0 we have T i (0) = T i• So the test statistic is the same as <strong>for</strong> the observeddata• Thus the P-value <strong>for</strong> the RPSFTM is the same as <strong>for</strong> theITT analysis– provided the same test is used <strong>for</strong> both• The estimation procedure is “randomisation-respecting”– it is based only on the comparison <strong>of</strong> groups asrandomised– I’ve suggested the term randomisation-basedefficacy estimator, RBEE (White, 2005)36
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