Scalable approaches for analysis of human genome-wide ...

AcknowledgmentThanks are due to my supervisors, Professor Justin Zobel and Dr Adam Kowalczyk. Justintaught me how to think about scientific questions, encouraged me to dig deeper in interpretingthe work of my own and others, and helped me communicate science better. Adam’s deeptechnical knowledge, experience, and determination were invaluable lessons to me and inspiredme in my work. Thanks also to Dr Michael Inouye. Mike’s wide-ranging knowledge, drive, andgenerosity have helped shape both my work and my approach to science in general. Thanksto Dr Izhak Haviv, whose passion for science is obvious to all who know him, and who wasalways willing to help and provide advice, at any time of the day (or night). Thanks to thehead of my PhD committee, Professor Peter Stuckey, for patiently guiding me in my PhDprocess towards better research and a better thesis.Thanks also go to my fellow students: Raj Gaire, Fan Shi, Gerard Wong, Ben Goudey,Shanika Kuruppu, Geoff Macintyre, and Justin Bedo. They have provided me outlets fromthe sometimes isolating PhD process, and made the process much more enjoyable.Thanks to Matthias Reumann from IBM Research and David Bannon from the VictorianLife Sciences Computing Initiative (VLSCI) for supporting my work, and thanks toVLSCI (project VR0126) and the Victorian Partnership for Advanced Computing (VPAC)for providing high-performance computing facilities. Thanks to NICTA and the University ofMelbourne for scholarship funding and travel grants. Thanks to David A. van Heel (QueenMary, University of London) for generously supplying the celiac disease data used in thisthesis.Finally, thanks are due to my family, and especially to my wife Laura, and my children Oriand Abigail, for their endless patience and love that have allowed me to complete this thesis.Funding StatementThis work was supported by the Australian Research Council, and by the NICTA VictorianResearch Laboratory. NICTA is funded by the Australian Government as represented by theDepartment of Broadband, Communications, and the Digital Economy, and the AustralianResearch Council through the ICT Centre of Excellence program. This work was made possiblethrough Victorian State Government Operational Infrastructure Support and Australianix