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The systolic pressure is determined by the amount of blood being forced into the aorta andarteries with each ventricular contraction, i.e. the stroke volume, and also by the force ofcontraction. An increase in either will increase the systolic pressure. Similarly, if the arterialwall becomes stiffer, as happens in arteriosclerosis, the vessels are not able to distend with theincreased blood volume and so the systolic pressure is increased.Diastolic pressure is also influenced by several factors. The diastolic pressure providesinformation on the degree of peripheral resistance: if there is increased arteriolarvasoconstriction, this will impede blood flowing out of the arterial system to the capillaries, andthe diastolic pressure will rise. Conversely, if the peripheral resistance is reduced byvasodilation, more blood will flow out of the arterial system and thus diastolic pressure will fall.Drugs that modify the degree of arterial vasoconstriction and alter the peripheral resistancewill obviously affect the diastolic pressure, and vasodilator drugs, for example hydralazinehydrochloride (Apresoline), minoxidil (Loniten), are sometimes used in the treatment ofsevere hypertension.Thelevel ofarteriesin thediastolicgreaterand vicediastolic pressure also depends on thethe systolic pressure, the elasticity of theand the viscosity of the blood. Alterationsheart rate will also affect diastolicpressure: with a slower heart rate, thepressure will be lower as there is atime for blood to flow out of the arteries,versa.PULSEinitiatesarteriesand overPRESSURE AND MEAN ARTERIALPRESSURE. Each ventricular contractiona pulse, or wave, of pressure through theand these pulses can be palpated (felt)wherever an artery passes near the skina bony or firm surface.Figure. 3 to the left shows thecommon sites where the pulse is felt.1. Temporal artery at the temple aboveand tothe outer side of the eye2. External maxillary (facial) artery atthepoint of crossing the mandible(lowerjaw)3. Carotid artery on the side of the neck4. Brachial artery on the inner side ofthebiceps5. Radial artery on the radial bone side
of the wrist6. Femoral artery in the groin7. Popliteal artery behind the knee8. Posterior tibial pulse behind the inner ankle9. Dorsalis pedis artery on the upper front part (anteriosuperior aspect) of the footThere is one pulse per heart beat, and so the pulse rate is used as an easy method for countingthe heart rate. These palpable pulses represent the difference between the systolic anddiastolic pressures and this difference is known as the pulse pressure, e.g. the pulse pressurein an individual whose blood pressure is 130/80 mmHg is(130-80) = 50 mmHg.Two of the main factors that alter the pulse pressure are the stroke volume and decreasedarterial compliance.It is sometimes useful to have an average, or mean, value for the arterial pressure, rather thanmaximum and minimum (systolic and diastolic) pressures, as it is the mean pressure thatrepresents the pressure driving blood through the systemic circulation.The mean arterial pressure is not a simple arithmetical mean; it is estimated by addingone-third of the pulse pressure to the diastolic pressure. So, for a blood pressure of 130/80mmHgmean arterial pressure is80 + (1/3 x 50) = 96.67 mmHgFrom the point of view of actual tissue perfusion, it is generally the mean arterial pressure thatmatters, rather than the precise values of systolic and diastolic pressures.<strong>Blood</strong> pressure values. There is no such value as a 'normal' blood pressure for thepopulation as a whole; there is a usual or 'normal' value for any particular individual, but eventhat value varies from moment to moment under different circumstances and over longerperiods of time. Many factors, both physiological and genetic, have an influence on bloodpressure and thus it is not surprising that individuals have significantly different, but 'normal',blood pressure values. Therefore it is more appropriate to refer to a normal range of bloodpressure than to a single value.Normal blood pressures are said to range from 100/60 mmHg to 150/90 mmHg.Age (years) Systolic pressure Diastolic pressure
Page 5: • Arteries and veins are composed
Page 13 and 14: • Is relatively constant when at
Page 16 and 17: Blood pressure in the pulmonary sys
Page 20 and 21: (mmHg)(mmHg)New-born 80 4610 103 70
Page 22 and 23: Catheters can be inserted directly
Page 24 and 25: should be used each time as in some
Page 26 and 27: • Baroreceptors (pressure-sensiti
Page 28 and 29: arterioles feeding its capillaries
Page 30: • Capillary colloid osmotic press

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