Chair page: - UVM College of Medicine - University of Vermont

Department of Medicine 

ANNUAL REPORT 

July 1, 2010 – June 30, 2011 

Submitted by: 

Polly E. Parsons, MD 

E.L. Amidon Professor and Chair 


Date: September 30, 2011

TABLE OF CONTENTS 

Section Page 

Chair’s Executive Summary.............................................................................. 1 

Department of Medicine Standing Committees ................................................ 3 

Medical Service – FAHC Practice Sites............................................................8 

Department of Medicine Visits and Work RVU’s............................................... 9 

Grants............................................................................................................. 10 

Grad Students/Pre-Doctoral Trainees and Post Doc Assoc./Fellows ............. 13 

Medical Education .......................................................................................... 15 

Cardiovascular Division .................................................................................. 23 

Clinical Pharmacology Division....................................................................... 45 

Dermatology Division...................................................................................... 49 

Endocrinology Division ................................................................................... 55 

Gastroenterology & Hepatology Division ........................................................ 63 

General Medicine Research Division.............................................................. 73 

Geriatrics Division........................................................................................... 81 

Hematology/Oncology Division....................................................................... 85 

Immunobiology Division................................................................................ 105 

Infectious Diseases Division......................................................................... 113 

Nephrology Division...................................................................................... 119 

Primary Care Internal Medicine Division....................................................... 125 

Pulmonary and Critical Care Medicine Division ............................................ 131 

Rheumatology and Clinical Immunology Division ......................................... 159 

i

Chair’s Executive Summary: 


Annual Report 2010-2011 

The Department of Medicine is committed to excellence in all of the 

areas that define our mission: research, clinical care, education and 

service. This past year we welcomed not only new residents, 

postdoctoral fellows, graduate students, and staff but new faculty in 

Cardiology, Dermatology, Gastroenterology, Hematology-Oncology, 

Infectious Disease, Nephrology, Primary Care Internal Medicine, and 

Pulmonary and Critical Care Medicine. 

The Department continues to be a national leader in research This 

year we held the third department-wide Research Day on June 

10, 

2011, which highlighted the strength and breadth of the research enterprise. 

Unfortunately, it is impossible to list each individual accomplishment. In aggregate, the 

Department faculty published nearly 300 manuscripts, reviews, chapters, and books. 

Many faculty members serve on NIH study sections, are editors of journals, and are 

members of editorial boards. Research funding continues to be robust with a total of 

$25.2 million in funding at UVM which includes COBRE awards; PPG, a contract to 

establish and support a Vaccine Testing Center, mentored awards, T32 (training) grants, 

and individual RO1 and R21 awards and $3.45 million in clinical research and grant 

funding at FAHC. This year members of the department were recognized by two 

programs initiated by the University of Vermont Medical Group and FAHC to recognize 

and support research: Dr. Christopher Huston was named the Junior Investigator of the 

Year and Drs. Renee Stapleton and Frederike Keating were PI on the research grants 

selected 

for funding. 

Members of the Department of Medicine are dedicated to teaching and education. The 

faculty participate extensively in the VIC curriculum and more than 100 trainees 

including house officers, chief medical residents, undergraduate students, graduate 

students and post-doctoral fellows (MD and PhD) are actively engaged in research, 

education and clinical care in the Department. The faculty received a number of honors 

and awards this year for their contributions to education. Dr. William Hopkins received 

the Foundations Teaching Award, the Foundations Course Director Award, and the 

AMSA Golden Apple Award from the Class of 2012. The course that he directs, 

Cardiovascular, Respiratory & Renal Systems, won the award for Outstanding 

Foundations Course for the fifth year in a row. Dr. Jan Carney was selected as a 

Frymoyer Scholar for the 2011 and 2012 academic years. Dr. David Kaminsky won the 

Outstanding Teacher of the Year, Subspecialty Medicine Award; and Dr. Jaspinder Sra 

was named the Outstanding 

Teacher of the Year, General Internal Medicine Award, by 

the 

Medicine Housestaff. 

1

In addition to awards for teaching, faculty have also been recognized for their leadership. 

Dr. Theodore Marcy was awarded the 2011 Unsung Heroes’ Award by the American 

Lung Association 

and the C. Everett Koop Foundation and Dr. Amanda Kennedy was 

named 

the 2011 Pharmacist of the year by the Vermont Society of Healthy System 

Pharmacists. 

The Department provides extensive clinical care not only at Fletcher Allen Health 

Care 

but at numerous satellite sites throughout Vermont and New York State. The 

subspecialty providers in the department continue to develop opportunities for 

collaborative interactions with other departments and services to provide 

multidisciplinary care. Examples of new clinical initiatives this year included successful 

roll-out of our electronic medical record (PRISM) to all clinical sites, collaborative 

efforts to bring transcatheter aortic valve implantation techniques to the region, 

recruitment of faculty and equipment to begin advanced GI manometry studies in support 

of further development of a Digestive Disease Center, and co-location of our 

Endocrinology and Cardiology Units to optimize patient care, space, collaborative 

research and teaching. We are also positioning ourselves for the changes in health 

care 

by participating in a Vermont pilot on payment reform for sub-specialty services, 

developing expansion plans for Dermatologic services, furthering our outreach 

relationships, and developing a Thyroid Cancer Multidisciplinary Clinic with 

Otolaryngology, Hem/Onc, and Endocrinology, and introducing ultrasound services in 

Rheumatology. The providers in PCIM expanded their roles in the Vermont Blueprint 

for Health and the Hospitalists increased 

their service to be able to care for virtually all of 

the 

inpatients on the Medicine service as well as to expand their role in the teaching of 

medical 

students and residents. 

Administrative Team: 

Physician Leader and Chair 

Vice Chairs 


Medical Education Mark Levine, MD 

Research Charles Irvin, PhD 

Administrative Director Allen Mead 

Assistant Director Kevin Callahan 

Physician Executive Assistant Laurie St.Gelais 

Financial Administrator Roberta Gilmour 

Grants Manager Eric Gagnon 

Financial Associate Marlene Frank 

Business Associate Gwen Landis 

� New faculty recruited 7/1/06 to present: 60 

o Total faculty: 171 

o By rank – Assistant Professors: 

74 

Associate Professors: 44 

2

Reappointments: 

Promotions: 

Professors: 41 

Research Associates: 

12 

o By gender – 63 female; 108 men 

o By track – Tenured: 40 

Research Track: 21 

Tenure 

Track: 9 

Non Tenure Clinical Track: 101 

Standing 

Committees: 

FALL 2010 – 12 green sheet reappointments; 3 pink sheet reappointments; 5 promotions; 3 tenure and/or tenure and promotion 

SPRING 2011 – 23 green sheet reappointments; 13 pink sheet 

reappointments, (18) part-time faculty reappointments 

Dr. Bonita Libman: promoted to Professor of Medicine 

Dr. Kathy Schwarzenberger: promoted to Professor of Medicine 

Dr. Richard Pinckney: promoted to Associate Professor of Medicine 

Dr. Allen Repp: promoted to Associate Professor of Medicine 

Dr. Jeffrey Spees: promoted to Associate Professor of Medicine (tenure) 

Dr. Anne Dixon, Associate Professor of Medicine was awarded tenure. 

Dr. Sean Diehl: promoted to Research Assistant Professor of Medicine 

Operational E fficiency Committee 

K. Schwarzenberger, 

MD, Chair 

S. Ades, MD 

K. Callahan 

B. Grant, MD 

F. Keating, MD 

B. Libman, 

MD 

T. Marcy, MD 

A. Mead 

L. Polish, MD 

J. Schnure, MD 


MD 

A. Segal, MD 

D. 

Strader, MD 

R. Vincent 

Education Com mittee: 

M. Levine, MD, Chair 

3

G. Allen, MD 

M. Antkowiak, M.D. 

L. Bryan, MD 

R. Christian, MD 

D. Collins, MD 

E. Ganguly, MD 

Z. Gardner, MD 

M. Hockett, MD 

P. Hohl, MD 

F. Keating, MD 

M. Pasanen, MD 

L. Polish, MD 

M. Ramundo, MD 

D. Shelc 

P. 

Slavik, MD 

N. Zakai, MD 

Fellowship Educat ion Committee 


M. Capeless, MD 

R. Christian, 

MD 

N. Ferrentino, MD 

E. Gagnon 

C. Grace, MD 

D. Kaminsky, MD 

B. Libman, MD 

R. Pinckney, MD 

A. 

Segal, MD 

J. Sprague, MD 

Housestaff Evalua tion Committee 



M. Levine, MD 

M. Hockett, 

MD 

Z. 

Gardner, MD 

D. Shelc 

Housestaff Selec tion Committee: 


W. Alston, MD 

M. Antkowiak, MD 

L. Bryan, MD 

W. Hopkins, MD 


K. Pierce, MD 

4


Ms. D. Shelc 

Medical Grand Rounds Education Program Committee 

R. Budd, MD, Chair 

C. Irvin, MD 

M. Levine, MD 

P. Parsons, MD 

T. Jetton, PhD 

S. 

Lidofsky, MD 

M. Wood, MD 

Quality Assur ance Committee - Medicine Health Care Service: 

M. Levine, MD, 

Chair 

S. Ades, MD 

M. Airiodi 

A. Bates, MD 

S. Bellemare 

D. Benway, RN 

T. Berrings, RN 

J. Blondin 

P. Bouchard, RN 

I. Bonin, RN 

M. Capeless, MD 

P. Gagne, RN 

Z. Gardner, MD 

C. Henderson, MD 

M. Hockett, MD 

Y. Mageto, MD 

D. Pepin, RN 

A. Repp, MD 

J. Rimmer, MD 

P. Slavik, MD 

J. Vecchio, MD 

M. Wood, MD 

Quality Assura nce Committee – Cardiac Catheterization Laboratory 

H. Dauerman, MD, 


P. Gogo, MD 

E. Terrien, MD 

M. Watkins, MD 

T. 

Fortner, RN 

H. 

Igneri, RN 

5

Quality Assurance Committee – Dermatology 

T. Holmes, MD 

K. Schwarzenberger, MD 

G. Goldman, MD 

K. 

Schwarzenberger, MD 

T. Stockton 

Resident and Scholarly Activ ity 

V. Hood, MD, Chair 

A. Marney, Associate 


C. Irvin, PhD 

F. Landry, MD 

M. Levine, MD 

R. Pinckney, MD 

C. Holmes, MD 

M. 

Meyer, MD 

A. Marney, MD 

Bylaws and Credenti aling Committee 

Glenn Goldman, 


M. Lazarovich, MD 

E. Leib, MD 

K. Pierce, MD 

D. Schneider, MD 

J. Schure, MD 

R. Solomon, MD 

J. Vecchio, MD 

M. 

Wood, MD 

Social Committee (C lub Med –icine) 

Edward Terrien, Chair 

Nicole Hynes, MD 

Prema Menon, MD 

Farrah Khan, MD 

Annis Marney, MD 

Julie Lin, MD 

Deb Adey, MD 

Cindy 

Noyes, MD 

Tammy 

Stockton, RN 

Department of Medicine, University of Vermont 

Unit Directors 

P.E. Parsons, MD, Chair 

R. Budd, MD, Immunobiology 

6

S. Cooper, MD, Rheumatology 

N. Fukagawa, MD, Geriatrics (acting) 

R. Galbraith, MD, Clinical Pharmacology 

(acting) 

C. Grace, MD, Infectious Diseases 

G. Goldman, MD, Dermatology 

J. Leahy, MD and Joel Schnure, MD, Endocrinology, 

Metabolism, & Diabetes 

B. Littenberg, MD, General Internal Medicine 

M. Wood, MD, Hematology/Oncology (interim) 

A. Dixon, MD, Pulmonary and Critical 

Care Medicine 

C. Schneider, MD, Cardiology Unit 

and Vascular Biology Unit 

R. 

Solomon, MD, Nephrology 

J. Vecchio, MD, Gastroenterology 

Research Comm ittee 

C Irvin, PhD and R. 

Budd, MD, Co-chairs 

R. Pratley, MD 

M. Poynter, PhD 

T. Mazuzan 

D. Schneider, MD 

B. Kirkpatrick, MD 

C. Maclean, MD 

T. Jetton, PhD 


MD 

M. Toth, PhD 

J. Vecchio 

E. Gagnon 

Promotions and Tenure 

G.Davis, MD, 


R. Pratley, MD 

E. Leib, MD 

Assistant Profes sor and Instructor Faculty Actions 

M. Tischler, Chair 

D. Plante, MD 


MD 

P. 

VanBuren, MD 

S. Lidofsky, MD 

Part-time Faculty Actions 

J. Alpert, M.D, Chair 

C. Berger, M.D. 

B. Libman, M.D. 

Scientific Integrity C ommittee 

R. Budd, M.D., Chair 

7

N. Fukagawa, M.D. 

B.E. Sobel, M.D. (ex officio) 

Medical Service 

Patient Days: 47,127 (inpatients and outpatients) 

Ambulatory 

Care Visits: 210,292 (136,223 specialty and 74,069 primary care) 

FAHC Practice Sites: 

Ambulatory Care Center – Medicine has a presence in four Modules: 

-Medicine: Infectious Disease (including Travel 

Medicine), Osteoporosis Center, 

Rheumatology and Clinical Immunology, 

and Pulmonary (including PFTs), Lung 

Cancer Multidisciplinary Clinic, Hepatology 

- Dermatology including Mohs Surgery 

- Cancer Center: Hematology/Oncology and Melanoma Multidisciplinary Clinic 

- Surgery: Gastroenterology, Thrombosis Center [part of Hem/Onc and Vascular 

Surgery], and Gastrointestinal 

Multidisciplinary Center 

University 

Health Center 

- Nephrology 

Tilley Drive, South Burlington 

- Cardiology and Cardiac Rehabilitation 

- Endocrinology and Endocrine 

Clinical Research 

FAHC Outreach Sites: 

Brattleboro (BMH) – Infectious Disease 

Morrisville (Copley Hospital) – Hem/Onc, Dermatology, Rheumatology 

St. Albans (Northwestern Medical Center) – Pulmonary, Rheumatology, 

Endocrinology, Nephrology, Dermatology, and Cardiology 

St. Johnsbury (Northeastern Medical Center) - Infectious Disease 

Barre (Central Vermont) – Rheumatology, Nephrology 

Rutland (Rutland Regional) – Nephrology, 

Cardiology, Infectious Disease 

Newport (Newport Memorial) – Nephrology 

Malone (Alice Hyde) – Cardiology 

Ticonderoga (Moses Luddington Hospital) – Dermatology, Cardiology 

Saranac Lake (Adirondack Medical 

Center) – Cardiology, Hematology/Oncology 

Canton- 

Potsdam – Cardiology 

Massena (MMH) – Cardiology 

Primary Care Sites: 

Aesculapious (Timberlane, South Burlington) 

8

Work RVUs 

600,000 

500,000 

400,000 

300,000 

200,000 

100,000 

Given Essex (Essex Junction) 

Given Burlington (University Health Center) 

Given Williston (Blair Park, Williston) 

0 

Department of Medicine Work RVUs 

07/06-06/07 07/07-06/08 07/08-06/09 07/09-06/10 07/10-06/11 

Data for Medicine Annual Report 

W ork RVUs by Academic Ye ar 

Requested by Allen Mead 7. 28.11 

Academic 

Primary 

Year Specialty 

Care Total 

07/06‐06/07 283,236 107,380 390,616 

07/07‐06/08 307,332 123,130 430,462 

07/08‐06/09 332,038 128,319 460,357 

07/09‐06/10 343,618 126,342 469,960 

07/10‐06/11 343,612 143,192 486,804 

Source: Dataware House Cognos Query 

Academic Year 

Specialty Primary Care 

9

Arrived Visits 

250,000 

200,000 

150,000 

100,000 

50,000 

- 

Specialty Care 

Department of Medicine Arrived Clinic Visits 

2006-2007 2007-2008 2008-2009 2009-2010 2010-2011 

2006- 

2007 

2007- 

2008 

Academic Year 

Specialty Care Primary Care 

2008- 

2009 

2009- 

2010 

2010- 

2011 

110,794 118,880 126,256 130,912 136,223 

Primary Care 81,386 77,875 77,735 74,272 74,069 

Total 192,180 196,755 203,991 205,184 210,292 

10

Graduate Students/Pre-Doctoral Trainees and Post Doctoral Associates/Trainees 

Last First Name System Title Department 

KLAUS JOSEPH Graduate Assistant Med-Immunobiology 

SALIGRAMA NARESHA Graduate Assistant Med-Immunobiology 

VAITHILINGAM ARCHANA Graduate Assistant 

Graduate Rsrch/Teach 

Med-Infectious Disease 

SATERIALE ADAM Asst Med-Infectious Disease 

LATHROP MELISSA Post Doct Fellow/Trainee Med-Pulmonary 

MENON PREMA Post Doct Fellow/Trainee Med-Pulmonary 

SCKOLNICK MARIA Post Doct Fellow/Trainee Med-Cardiology 

SHIMADA ISSEI Post Doct Fellow/Trainee Med-Cardiology 

SMITH BRADFORD Post Doct Fellow/Trainee Med-Pulmonary 

TENEBACK CHARLOTTE Post Doct Fellow/Trainee Med-Pulmonary 

CASE LAURE Post Doctoral Associate Med-Immunobiology 

KREMENTSOV DIMITRY Post Doctoral Associate Med-Immunobiology 

MENON PREMA Post Doctoral Associate Med-Pulmonary 

SHIMADA ISSEI Post Doctoral Associate Med-Cardiology 

SIDELEVA OLGA Post Doctoral Associate Med-Endocrinology 

Med-Hematology 

THEILER SHALEEN Post Doctoral Associate Oncology 

WALL EMMA Post Doctoral Associate 

Pre Doctoral 

Med-Immunobiology 

CURRIL INGRID Fellow/Trainee 

Pre Doctoral 

Med-Cardiology 

GOODWIN MEAGAN Fellow/Trainee 

Pre Doctoral 

Med-Pulmonary 

THARP WILLIAM Fellow/Trainee Med-Endocrinology 

11

Medical Education 

1. Leadership 

Mark A Levine, M.D.,F.A.C.P 

– Program Director 

Mark Pasanen, M.D., F.A.C.P Mary Ramundo, MD 

– Associate Program Director - Associate Program Director 

Dorothy Shelc 

– Program Administrator 

Summary of Program Highlights 2010-2011 

A. A major new initiative in the residency program is the successful transition to 

hospitalist-centered teams in the general internal medicine setting. In doing so 

the overarching goals were to improve supervision of medicine residents and 

to improve the academic educational environment of inpatient medicine. In 

making this transition we aimed to both preserve and when needed optimize 

the following: 

� The balance between resident autonomy and adequate supervision. 

13

� Retention of a strong critical thinking element for residents. 

� The balance between didactic and work rounds teaching. 

� Incorporation of maximum teaching opportunities by hospitalists as 

well as subspecialists 

� Optimizing the work schedule to achieve all of the above. 

B. An equally major undertaking this year was the planning required to meet new 

duty hour rules effective July 2011. As part of this transition the program was 

able to eliminate almost 90% of the overnight call required for interns so that 

interns could abide by the new rule of maximum 16-hour shifts. To allow 

total compliance with all new duty hour rules on July 1,2011the following 

initiatives were undertaken: 

� The hiring of 2 additional preliminary year medicine residents at the 

PGY1 level. 

� The hiring of additional mid-level practitioners in 

hematology/oncology and cardiology. 

� Expansion of non-teaching service capacity. 

� Development of a set of principles to guide the residency remodel 

process. 

C. With the opening of the new Simulation Center in early 2011 the program was 

able to initiate as well as expand upon opportunities inherent in the concept of 

simulation training. Our training of residents in mock code situations has 

been expanded. The opportunities for procedural training have been expanded 

and continue to be developed. Communication skills training occurred during 

intern orientation along with opportunity for team building skills. The 

program continues to use standardized patients for individual resident 

evaluation and remediation efforts. 

D. Improvement in resident’s medical knowledge and Board preparation. 

Faculty are leading Board review sessions as part of morning report twice 

monthly, employing MKSAP Board review questions to build resident 

knowledge, test taking skills, and critical thinking and judgment. 

E. Chief Residents and residents within the program were able to pilot and 

subsequently fully enact a new PRISM-based communication tool for helping 

nursing staff identify which resident to call regarding patient questions that 

arise in the context of patient care. This is especially important in an era of 

increased hand-offs and transitions of care. 

F. The Residency Retreats continue to support the overall competency-based 

residency curriculum in a strong fashion. Numerous new sessions on 

communication skill development have been introduced, many of them led by 

Palliative Care faculty and involving the use of standardized patients. Further 

expansion of sessions in professionalism, research, and empowerment of 

14

G. The Grand Rounds Design Committee continues to be active and the Grand 

Rounds series is as cutting edge and innovative as ever, incorporating 

substantial local expertise and accomplishment. The Departmental Morbidity 

and Mortality conference continues to be highly popular and focuses 

discussions in a competency-based manner that has been both educational and 

constructive. 

2. List of All Residents 

PGY-3 

Antkowiak, MaryEllen University of Vermont 

Bryan, Locke University of Mississippi 

Cobell, William University of Utah 

Gomes, Olubusola UMDNJ – New Jersey Medical 

School 

Jasielec, Jagoda Jagiellonski University, Poland 

Jha, Shalini Royal College of Surgeons, Ireland 

Johnson, Scott Albany Medical College 

Lim, Nicholas University College Cork, Ireland 

Lischke, Stefan Universitat Rostock, Germany 

Rapp, Matthew George Washington University 

Ringwala, Sukit University of Wisconsin 

Rydz, Frederick Jagiellonski University, Poland 

PGY-2 

Amin, Anish University of Dundee, United 

Kingdom 

Bantle, Anne University of Minnesota 

Brazelton, Jason University of South Alabama 

Collins, Dan University of Utah 

Glick, Emily University of Vermont 

Henderson, Carl UMDNJ School of Osteopathic 

Medicine 

Nimmich, Elizabeth University of So. Carolina 

Nimmich, Mitchell University of So. Carolina 

Pontee, Glencora Ben Gurion University 

Prabhu, William SUNY – Upstate 

Stanek, Jadwiga Jagiellonski University, Poland 

Wangensteen, Kirk University of Minnesota 

15

PGY-1 

Categorical 

Bartsch, Jason George Washington University 

Borofsky, Jennifer University of Vermont 

Burke, Michele University of Vermont 

Hill, Elizabeth University of Vermont 

Hohl, Patrick University of New England, 

Osteopathic Medicine 

Lampignano, Daniel University of Colorado 

McMahon, Sean SUNY – Upstate 

Meyer, David East Tennessee State University 

Meyer, Gabriela East Tennessee State University 

Ronaghy, Arash Boston University 

Stinnett-Donnelly, Justin University of Vermont 

Sundaran, Preeth Royal College of Surgeons, Ireland 

Preliminary 

Braaten, Amanda University of Washington 

Gerety, Lyle University of Vermont 

Jenkins, Neil Ohio State University 

Khan, Jenna University of Maryland 

Miller, Jill Creighton University 

Palmadottir, Vala University of Iceland 

Zhang, Catherine Case Western Reserve 

Chief Medical Residents 

Gardner, Zechariah University of Vermont 

Hockett, Mia University of Vermont 

4. Resident Awards 

The Frank L. Babbot, M.D. Award - Dr. MaryEllen Antkowiak and Dr. Nicholas 

Lim 

The Richard E. Bouchard Excellence in Primary Care Award - Dr. Jagoda 

Jasielec 

The Harriet P. Dustan, MD Award - Dr. Sukit Ringwala 

5. Resident presentations at local/national meetings 

ACP Vermont Chapter Meeting, October 22, 2010 

16

William Cobell, MD, Kunal Gupta, MD. 

“GI Bleeding” A Common Complaint with A Not-So-Common Cause. 

Emily Glick, MD, Marc Tischler, MD, Bill Hopkins, MD, et al. 

Sinus Venosus ASD: A Unique “Hole in the Heart.” 

Carl Henderson, DO, Dean Stephens MD, Bonita Libman MD, Ronald Bryant 

MD. 

Massive Bilateral Shoulder Effusions: A Case of Milwaukee Shoulder. 

Mitchell Nimmich, MD, MaryEllen Antkowiak, MD. – Winner of the 

Clinical Vignette Competition Presented at the National ACP Meeting, April 

2011 

NMDA Receptor Encephalitis in a Previously Healthy 27 Year Old Woman. 

William Prabhu, MD, Shalini Jha, MD, Chris Holmes, MD. 

Levamisole Associated Purpura Fulminans Following Cocaine Use. 

Presented at the National ACP Meeting, April 2011 

Matthew Rapp, MD, Jennifer Martino, MD, Gil Allen, MD. 

A 35-Year Old Patient With Spontaneous Hemothorax. 

Sukit Ringwala, MD MPH. Heart Disease in Vermont: Trends in Acute 

Myocardial Infarction Mortality. 

Frederick Rydz, MD, Florian Foerg, MD. 

Blinding Pancreatitis: A Case of Pancreatitis Induced Retinopathy. 

Justin Stinnett-Donnelly, MD, Abigail Trutor, Andrea Vogl, Anne Dixon, MD. 

Winner of the Resident Research/ QI Competition 

Presented at the National ACP Meeting – April 2011 

Vermont’s Academic Medical Center Medical Intensive Care Census Analysis: 

Towards the Quantification of Optimal Intensivist Staffing. 

Kirk Wangensteen, MD PhD, James Boyd, et al. 

Parkinsonism in Patients with Chronic Hepatitis C Treated with Interferon Alpha: 

Case Reports and Review of the Literature. 

Other Publications, Award and Presentations 

Locke Bryan MD, American Society of Hematology Research Training 

Award and ASH Conference Poster Presentation, New Orleans, Louisiana, 

November 19, 2010 

Is Higher Soluble P-Selectin a Risk Factor for Chronic Venous Insufficiency? 

17

Zechariah Gardner MD Grading the Severity of Obstruction in Mixed 

Obstructive-Restrictive Lung Disease. Presented at the American Thoracic 

Society, New Orleans – May 2010 

Jagoda Jasielec MD The Effect of Aspirin Therapy on Circulating Vascular 

Endothelial Growth Factor (VEGF) Levels in Tamoxifen-Treated Women. 

Presented at the American Society of Clinical Oncology in Chicago, June of 

2010 

Scott Johnson MD, Anish Amin MD, Dan Collins MD Non-Traumatic Rib 

Fracture: An Unusual Presentation of Extranodal Marginal Zone Lymphoma. 

Presented by Dr. Johnson at the ACP National Meeting, Toronto, April 2010 

Scott Johnson MD Relationship of Adipokines with Immune Response and 

Lung Function in Obese, Asthmatic, and Non-Asthmatic Women. Presented at 

the American Thoracic Society, New Orleans, May 2010 

Weiss HS, Sher AE, Wenzell W, Johnson SE, Glovinsky PG. “Adherence with 

Positive Airway Pressure Therapy in Patients with Upper Airway Resistance 

Syndrome.” Abstract and Presentation to the SLEEP 2010 24th Annual 

Meeting of the Associated Professional Sleep Societies. Original Manuscript 

submitted for publication to the Journal Sleep, pending publication. 

Johnson SE, Dixon AE, Griffes L, Raymond DM, Ramdeo R, Soloveichik A, 

Cohen RI. “Decreased adipokines in obesity are associated with increased Th2 

chemokines in re-menopausal women.” 2010 American Thoracic Society 

International Conference. Abstract and Poster Discussion Presentation. Am 

J Respir Crit Care Med 181;2010:A4048. 

Johnson SE, Collins D, Amin A, Madsen M, Bambace N, Grant B. Nontraumatic 

rib fracture: An unusual presentation of extranodal marginal zone 

lymphoma. 2010 American College of Physicians National Meeting Abstract 

and Poster Presentation. 2009 American College of Physicians New 

Hampshire and Vermont Regional Scientific Meeting Poster Presentation 

winning submission in clinical vignette category. 

Nicholas Lim MD Hospitalization rates for variceal hemorrhage in the era of 

prophylactic beta blockers and band ligation. Poster Presentation at: Digestive 

Disease Week, Chicago, IL May 2011. 

Ahmed B, Lischke S, Holterman LA, Straight F, Dauerman HL. 

Angiographic predictors of vascular complications among women undergoing 

cardiac catheterization and intervention. J Invasive Cardiology 2010 Nov:22 

(11): 512-6. 

18

Rapp, Matthew MD The Utility of Serum CA 19-9 in Cystic Neoplasia of the 

Pancreas. Poster Presentation at: Digestive Disease Week, Chicago, IL May 

2011 

Sukit Ringwala MD Platelet Suppression with Rivaroxaban in Patients with 

Coronary Artery Disease. Research competition at the ACP National 

Meeting, Toronto, April 2010 

Li F, Liu P, Liu C, Xiang D, Deng L, Li W, Wangensteen K, Song J, Ma Y, Hui 

L, Wei L, Li L, Ding X, Hu Y, He Z, Wang X. Hepatoblast-Like Progenitor 

Cells Derived From Embryonic Stem Cells Can Repopulate Livers of Mice. 

Gastroenterology. 2010 Aug 27. 

He Z, Zhang H, Zhang X, Xie D, Chen Y, Wangensteen KJ, Ekker SC, Firpo M, 

Liu C, Xiang D, Zi X, Hui L, Yang G, Ding X, Hu Y, Wang X. Liver xenorepopulation 

with human hepatocytes in Fah-/-Rag2-/- mice after pharmacological 

immunosuppression. Am J Pathol. 2010 Sep;177(3):1311-9. 

Pálmadóttir VK, Gudmundsson H, Hardarson S, Arnadóttir M, Magnússon T, 

Andrésdóttir MB. 

Incidence and outcome of acute phosphate nephropathy in Iceland. PLoS One. 

2010 Oct 19;5(10):e13484. 

6. Graduating Residents – where are they going/ which fellowships 

Antkowiak, MaryEllen Chief Medical Resident, then Pulm/CC 

Fellowship - FAHC 

Bryan, Locke Chief Medical Resident, then H/O 

Fellowship At Northwestern, Chicago, IL 

Cobell, William GI Fellowship at University of Missouri 

Gomes, Olubusola Hospitalist, New Jersey 

Jasielec, Jagoda Heme Onc Fellowship, University of 

Chicago 

Jha, Shalini Geriatric Fellowship, London, Ontario, 

Canada 

Johnson, Scott Sleep Medicine Fellowship, University of 

Wisconsin 

Lim, Nicholas GI Fellowship – FAHC 

Lischke, Stefan Cardiology Fellowship – FAHC 

Rapp, Matthew Hospitalist – Central Vermont Hospital 

Ringwala, Sukit Cardiology Fellowship- FAHC 

Rydz, Frederick General Internal Medicine Fellowship – 

London, Ontario, Canada 

19

7. MATCH RESULTS 2011-2012 

Categorical 

Robert Disantis Penn State University 

Adedayo Fashoyin University of Wisconsin 

Damon Houghton University of North Carolina 

Timothy Leclair University of Vermont 

Jacqueline Malekirad University of Washington 

Samuel Merrill Washington University 

Benjamin Parkhurst University of Buffalo 

Samreen Rizvi Imperial College – United Kingdom 

Deva Sharma University of Maryland 

Krystine Spiess Kansas City Osteopathic Medicine 

Derinda Trobaugh University of Arkansas 

Heather Viani University of Vermont 

Preliminary 

Mohammed-Ali Babi Weill Cornell – Qatar (Neurology) 

Adam Darby Saint Georges (Neurology) 

Sara Hardy Case Western Reserve (Neurology) 

William Hart University of Toledo (Anesthesia) 

Robert Hieronimus University of Toledo (Anesthesia) 

Veena Kalapatapu Indiana University (Anesthesia) 

Kendra Lesiak University of Nebraska (Dermatology) 

Amy Odefey University of Vermont (Anesthesia) 

Kathryn Richard University of Vermont (Anesthesia) 

20

Cardiovascular Division 

David J. Schneider, MD, Director 

http://www.fletcherallen.org/services/heart_health/specialties/cardiology/ 

During the past year the Cardiovascular Division has grown with the 

addition of several new cardiologists. Drs. Carey, Fitzgerald, and 

Winget have left private practice and joined the division. Efforts 

continue to develop a cohesive network of cardiac care in our region. 

We now provide full time cardiology services at Northwestern Medical 

Center. Dr. Adam Kunin who works primarily for Copley Medical 

Center provides ambulatory care for his patients in Chittenden county 

at our facility on Tilley Drive. Our association with Central Vermont 

Medical Center is enhanced by their hiring of our former fellow Dr. Joachim Mueller. 

Dr. Mueller will perform advanced electrophysiology studies at FAHC. Collaboration 

with the cardiologists employed by Rutland Regional Medical Center has increasd with 

our association with Dr. Chris Higgins who performs invasive cardiovascular 

catheterization procedures at FAHC. The growth of the Vermont network is 

complemented by our New York network with Dr. Elgharib at Alice Hyde Medical 

Center and Dr. Tramontano at Canton Potsdam Hospital. We have experienced 

substantial growth of our ambulatory volume with an increase of more than 20% 

compared with the previous year. With the expansion of the group, we have increased 

our general cardiology training program to 12 fellows. David Schneider was selected by 

the fellows as the teacher of the year, his 3 rd such honor. William Hopkins was selected 

for the fifth consecutive year by the medical students of the College of Medicine as the 

recipient of the Course Director of the year. The course he directs, Cardiovascular, 

Respiratory, and Renal, has been selected as the best course for 5 consecutive year. Dr. 

Hopkins was also the recipient of the best clinical teacher of the year. Key research 

initiaves and accomplishments including the following: In the area of cardiovascular 

intervention, Dr. Dauerman is the national principal investigator for 2 clinical trials -one 

clinical trial testing the utility of selected prophylactic strategies to prevent acute 

kidney injury after cardiac catheterization and the second trial defining optimal 

antiplatelet therapy after coronary stenting. He is also a member of the steering 

committee investigating the utility of coronary intervention compared with surgical 

bypass for the treatment of left main disease, and he is an active participant in a trial 

defining the optimal use of transcatheter aortic valve implantation (TAVI). In the area of 

electrophysiology, Dr. Lustgarten is an investigator in a trial comparing a catheterdelivered 

device that occludes the left atrial appendage. This mechanical therapy is being 

compared with anticoagulation for the prevention of emboli in patients with atrial 

fibrillation. Dr. Lustgarten has developed a method to perform physiologc pacing 

through the HIS bundle and is comparing HIS pacing with traditional biventricular pacing 

in a small multicenter trial. Dr. Spector has developed an interactive model to better 

understand atrial fibrillation that is published in Circulation Arrhythmia and 

Electrophysiology. In the area of heart failure research, the first randomized clinical trial 

performed by the NHLBI Heart Failure Clinical Research Network (Dr. LeWinter is a coauthor 

and one of 9 principal investigators in the US) was published in the New England 

Journal of Medicine. Dr. Ades continued his groundbreaking research designed to 

21

edefine cardiac rehabilitation and the prevention of subsequent cardiac events. In total, 

the Cardiovascular Division published 73 manuscripts and chapters during the past year. 

Faculty 

David Schneider, MD 

Professor of Medicine 

Director, Cardiovascular Division 

Research and Clinical Interests 

� thrombosis 

� platelet Biology 

� atherosclerosis/ischemic heart disease 

� preventive cardiology 

Philip Ades, MD 


Director, Cardiac Rehabilitation 


� cardiac Rehabilitation 


� ischemic heart disease 

Mark Capeless, MD 


Director, Cardiovascular Training Program 


� heart rhythm disturbances 

Kevin Carey, MD 

Assistant Professor of Medicine 


� coronary intervention 

� cardiac catheterization 


Timothy Christian, MD 



� cardiac MRI 

� nuclear Cardiology 

Harold Dauerman, MD 


Director, Cardiovascular Catheterization Laboratory 


22


� peripheral vascular intervention 


� vascular biology 

Nader Elgharib, MD 







John Fitzgerald, MD 





� valvular heart disease 

Prospero Gogo, MD 


Associate Director Interventional Cardiology Training Program 



� percutaneous coronary intervention 

� percutaneous treatment of structural heart disease 

William Hopkins, MD 

Associate Professor of Medicine 

Director, Adult Congenital Heart Disease & Pulmonary Hypertension Program 


� pulmonary hypertension 

� adult congenital heart disease 

� adults with down syndrome 


� echocardiography 

Friederike Keating, MD 


Director, Nuclear Cardiology 

Director, Cardiac Care Unit 


� cardiovascular disease in women 

� cardiovascular imaging 

� thrombosis 

23

� platelet biology 

Robert Kelm, Jr., PhD 


� cardiovascular biology & disease 

� regulation of gene expression 

� protein-nucleic acid interactions 

Martin LeWinter, MD 


Director, Heart Failure & Cardiomyopathy Program 


� heart failure and cardiomyopathy 


� pericardial disease 

Robert Lobel, MD 




Daniel Lustgarten, MD 




Marcus Meyer, MD 



� heart failure 

� cardiovascular imaging 

Burton Sobel, MD 

Distinguished Professor of Medicine 

Director, Cardiovascular Research Institute 


� vascular Biology 

� cardiac response to injury 

Peter Spector, MD 


Director of Electrophysiology 



24

Jeffrey Spees, PhD 


Director, Stem Cell Core Facility 


� adult stem cell biology 

� regenerative medicine 

Edward Terrien, MD 


Director, Ambulatory Cardiovascular Clinic 






Marc Tischler, MD 


Director, Echocardiography Laboratory 




� cardiac magnetic resonance imaging 

Michael Toth, PhD 




� skeletal muscle function 

Anthony Tramontano, MD 






� cardiac magnetic resonance imaging 

Peter Van Buren, MD 


Associate Director Cardiovascular Training Program 




25

Matthew Watkins, MD 


Director of Interventional Cardiology 

Director of Interventional Cardiology Fellowship Training Program 


� interventional cardiology 


Joseph Winget, MD 




Fellows 

Neil Agrawal, MD 

Phil Anderson, MD 

Simon Chu, MD 

Daniel Correa, MD 

David Coyle, MD 

Cameron Donaldson, MD 

Nate Madsen, MD 

Keon Menzies, MD 

Ellie Mueller, MD 

Joachim Mueller, MD 

Mohamad Nawar, MD 

Magdalena Zeglin, MD 

Pierre Znojkiewicz, MD 

Nurse Practitioners and Physician Assistants: 

Elizabeth Carney, APRN 

Gregory Ehle, PA 

Karen Farrell, APRN 

Susan Ann Hamlyn-Prescott, APRN 

Ann Laramee, APRN 

Cheryl McNeil, APRN 

Nancy Strong, APRN 

Graduate Students, Post-doctoral Fellows, MD PhD Students: 


Keon Menzies, MD PhD 


Amy E. Rumora (Biochemistry Program) 

26


Michael Previs 

Donald Selby 

Cameron Donaldson 


Christopher French, MD, PhD 


Annemarie Gallo 


Benjamin Bakondi, Ph.D. 

Charla Poole, B.S. (MD/PhD student) 

Ingrid Curril, M.S. 

Krithika Rao, B.S. 

Mathew LeComte, B.S. (MD/PhD student) 

Issei Shimada, Ph.D. (AHA Research Fellow) 

Leadership in Professional Societies: 


Steering Committee, American Heart Assn Annual Meeting—Interventional 

Cardiology Programming 

Nader Elgharib, MD 

Elected to fellowship in ACC and SCAI 


Ad Hoc Grant Reviewer, NHLBI 

Chair, NHLBI Advisory Panel, Diabetic Cardiomyopathy 

Self-Evaluation Exam Committee, American Board of Internal Medicine 

Chair, Publications and Presentations Committee, NIH Heart Failure Research 

Network 

Chair, Research Committee, Heart Failure Society of America 

David Schneider, MD 

Councilor, Society for Experimental Biology and Medicine 


Master, American College of Physicians 

President, Board of Governors, Society for Experimental Biology and Medicine 

Past President, Society for Experimental Biology and Medicine 

27


Commander Vermont State Guard Medical Corps 

ACC Governor Elect for Vermont 

Editorships and Editorial Boards: 


Associate Editor, Coronary Artery Disease 

Consulting Editor, and Former Editor-in-Chief, Journal of Cardiopulmonary 

Rehabilitation and Prevention 


Editorial Board—Journal of the American College of Cardiology 

Associate Editor—Journal of Thrombosis and Thrombolysis 





Section Editor, Current Treatment Options in Cardiovascular Medicine 

Editor-in-Chief, Clinical Medicine: Cardiology 

Book Review Editor, Circulation 

Myopericardial Disease Section Editor, UpToDate 

David J. Schneider, MD 

Coronary Artery Disease (Associate Editor) 

American Journal of Cardiology (Editorial Board) 

Current Cardiology Reviews (Editorial Board) 


Editor, Coronary Artery Disease 

The Canadian Journal of Cardiology 

Clinical Guides to Medical Management, Series Editor 

Cardiology: International Literature Review Service 

Journal of Clinical Investigation, Associate Editor 

American Journal of Physiology, Associate Editor 


Coronary Artery Disease (Editorial Board) 


Peer Reviewer ACC/AHA Hypertrophic Cardiomyopathy 

28

Marc Tischler, MD 



Editorial Board member, American Journal of Physiology: Endocrinology and 

Metabolism sub-section 

Study Sections and Federal Advisory Boards: 


Recently completed 6 years on clinical Aging Study Section (NIA) 2004-2010 


NHLBI: Data and Safety Monitoring Board (DSMB) for the Immunomodulatory, 

Inflammatory, and Vasoregulatory Properties of Transfused Red Blood Cells as a 

Function of Storage 

Steering Committee, Mission Lifeline/American Heart Association. 


Medtronic Co-Management Council of Advisors 


Member, NHLBI Working Group titled “Guided Antithrombotic Therapy: Current 

Status and Future Research Directions” – 2011 


Physician’s Advisory Board – Biosense Webster, Inc., 2003 – present 


AHA Brain R1 Study Section 

NIH Special Emphasis Panel/Scientific Review Group 2011/10 ZHL1 CSR-S (O2) - 

R24 Center for Gene Transfer 


National Institutes of Health, Center for Scientific Review, 

National Institutes of Aging 

NIA-C Clinical Aging Study Section 

Major Faculty Awards: 


Clinical Teacher of the Year, 2011 

Foundations Course Director Award, 2011 

Outstanding Foundations Course Award, 2011 

29


Cited in “Best Doctors in the Northeast” and “Best Doctors in America” 


NIH R21 Grant, 2009-2011 

Scientist Development Grant, American Heart Association 2007-2011 


Teacher of the year, 2011 – Cardiovascular Training Program 


University Distinguished Professor of Medicine 

Grants 


High-Caloric Expenditure Exercise in Cardiac Rehabilitation of Overweight Patients 

Principal Investigator: Philip A Ades MD 

Agency: The Schwendler Award for Cardiovascular Clinical Research 

Period: 6/1/10 - 5/31/11 PI: 10% time 

The goal of this award is to provide biometry support and salary support to finalize 

obesity-related manuscript preparation and to provide support for the preparation of a 

multi-center RO-1 application to the NHLBI 


EXCEL: International Randomized trial of Drug Eluting stents versus CABG for 

Left Main coronary disease. (Steering Committee) 2010-2012 

BOSS Trial: Randomized trial of normal saline versus bicarbonate for patients at high 

risk of contrast induced kidney injury (National Co-Principal Investigator) 2010 

EDUCATE : Endeavor Drug Eluting Stents: Understanding Care, Antiplatelet Agents 

and Thrombotic Events (EDUCATE) Trial (National Co-Principal Investigator) 2010- 

2011, Grant: $83,970 

Prospero Gogo, MD 

Unrestricted educational grants from SCAI ($42k) and Medtronic ($16k) 

Friederike Keating, MD 

Fletcher Allen Health Care and University of Vermont Medical Group; 

INVESTIGATOR INITIATED RESEARCH AWARD - Contribution of 

microparticles to procoagulant and proinflammatory properties of stored packed red 

blood cell units; PI: Friederike Keating, MD, FACC; Co-PI: Mark Fung, MD, PhD 

30


09GRNT2170060, American Heart Association Founders Affiliate 

Regulation of Vascular Remodeling by Pur Repressors Proteins 

07/01/2009 � 06/30/2012 

$198,000 total costs 


PI – “Advanced Glycated End-Products in Human Myocardium” 

NIH RO1 HL089944, 9/1/08 – 8/31/13 

Current year funding $485,000 

PI, “New England, New York and Quebec Regional Clinical Center” 

NIH UO1 HL084899, 10/1/06 – 9/30/11 

Current year funding $250,000 

PI – “Cardiac Re-Synchronization Therapy in an Animal Model of Ischemic 

Cardiomyopathy” 

Medtronic, Inc. 

Current year funding: $90,000 

PI – “Ranalozine to Treat Rate-Dependent Incomplete Relaxatio: In Vitro Studies in 

Human Myocardium” 

8/1/10-7/31/12 

Gilead Pharmaceuticals 

Current year funding: $84,000 


DIRECT - Direct His Bundle Pacing to Implement CRT Study 

Long Term Follow-Up Ablation – Long-Term follow-up of patients undergoing 

radiofrequency catheter ablation 

ACT V – Vernakalent study 

ADAPTIVE CRT – evaluation of a novel biventricular pacing algorithm to maximize 

CRT response rate 

SLS- System Longevity Study 

Long Term Follow-Up ICD/ PCMKR-Long Term Follow up of Patients Undergoing 

Bi- Ventricular Pacemaker and ICD Implantation 

RESPECT-Reducing Episodes by Septal Pacing Efficacy Confirmation Trial 

(RESPECT) 

ST Detect- ST Segment Detection Study 

PREVAIL: Implantable left atrial occluder study 


NIH R21 Grant, 1 R21 HL 094807-01A1 2009-2011 

Cardiac and Renal Effects of N-Acetylcysteine – 12/01/09-11/30/2011 – PI 20% 

effort. 

31


PI: Burton E. Sobel, M.D. 

Agency: Medtronic, Inc. 

Period: 01/01/06 – indefinite 

$500,000 annually 


Agency: Intrexon, Inc. 

Period: 11/01/07 – 12/31/10 


Agency: Takeda Pharmaceuticals, Inc. 

Period: 07/07/08 – indefinite 

$500,000 annually 


High Resolution Assessment of Atrial Electrophysiology and Ablation for Atrial 

Fibrillation (Biosense Webster) 

Development of Novel Catheters and Computer Assisted (Medtronic) 

Foundations of Clinical Electrophysiology (Medtronic) 

Long-Term Follow-up of Patients Undergoing Radiofrequency Catheter Ablation 

Use of Multi-Site Mapping to Distinguish between Multi-wavelet Reentry and Focal 

Firing as the Underlying Mechanism of Atrial Fibrillation (St. Jude Medical) 


5 P20 RR016435-06 NIH/NCRR (Parsons) 7/1/2006 – 6/30/2011 

(Spees PI of project 3, “Adult bone marrow stem cells for CNS repair”) 

1 R01 HL085210-02 NIH/NHLBI (Spees) 1/1/2008– 12/31/2012 

“Factors Responsible for Cardiac Preservation Conferred by Adult Marrow Stem 

Cells” 


Individual Research Project Grant 7/01/10 to 6/30/15 ($2,023,353) 

NIH R01 AG-033547 PI: Toth 

Title: Muscle Disuse and Contractile Dysfunction in the Elderly 

Peter Van Buren, MD 

GCRC-Based Cardiovascular Research Grant 7/1/10- 6/30/11 Van Buren (PI) 

University of Vermont, College of Medicine 

The Role of the Extracellular Matrix in Obesity Associated Diastolic Dysfunction. 

The hypothesis to be test in this project is that extracellular matrix remodeling in 

obesity leads to decrease myocardial compliance and contributes diastolic 

dysfunction in this patient population. 

32

Role: Principal Investigator 

Medtronic Alliance Grant: 5/1/11- 4/30/12 Van Buren (PI) 

The Impact of Glycemic Control on Cardiac Function and of Cardiac Function on 

Glycemic Control In Patients With Type 2 Diabetes and Heart Failure. The 

hypothesis to be tested is that optimal heart failure management and diabetic control 

are positively correlated with one or both being independent variables reflected 

temporally. If so, simultaneous use of Cardiac Compass and CGM will likely 

optimize disease management and improve outcomes. 

Role: Principal Investigator 

Matthew Watkins, MD 

Trans Radial Artery Clinical Training Course 12/2010 

Course Co-founder and Co-director 

Clinical and didactic training in radial artery access for coronary intervention for 

visiting established Interventional Cardiologists 

Supported by a non-restricted educational grant from TERUMO 

OMEGA Clinical Trial: A prospective multicenter trial to assess the Omega Coronary 

Stent system for the treatment of a single coronary de novo artery lesion 

Boston Scientific multicenter trial, FAHC site PI 

Publications 

Kaminsky DA, Savage PD, Callas P, Ades PA Lung Function and Cardiovascular 

Risk: Effect of Cardiac Rehabilitation. J Cardiopulm Rehabil Prev. 2010 Nov- 

Dec;30(6):384-90. May 3. [Epub ahead of print] 

Ades PA, Savage PD, Harvey-Berino J. The treatment of obesity in cardiac 

rehabilitation. J Cardiopulm Rehabil and Prev. 2010 30(5):289-98. 

Ades PA, Savage PD. The Obesity Paradox: Perception vs. Knowledge. Mayo Clin Proc, 

2010; 85:112-114. 

Toth MJ, LeWinter MM, Ades PA, Matthews DE. Impaired muscle protein anabolic 

response to insulin and amino acids in heart failure patients: relationship to markers of 

immune activation. Accepted pending revision. Clinical Science, 2010 Aug 

17;119(11):467-76. 

Artinian NT, Fletcher G, Mozaffarian D, Kris-Etherton P, Van Horn L, Lichtenstein AH, 

Kumanyika S, Kraus WE, Fleg JL, Redeker NS, Meininger JC, Banks J, Stuart-Shor EM, 

Fletcher BJ, Miller TD, Hughes S, Braun LT, Kopin LA, Berra K, Hayman LL, Ewing 

33

LJ, Ades PA, Durstine L, Houston-Miller N, Burke LE; on behalf of the American Heart 

Association Prevention Committee of the Council on Cardiovascular Nursing. 

Interventions to promote physical activity and dietary lifestyle changes for cardiovascular 

risk factor reduction in adults: a scientific statement from the American Heart 

Association. Circulation 2010 Jul 27;122(4):406-41. 

Miller MS, Vanburen P, Lewinter MM, Braddock JM, Ades PA, Maughan DW, Palmer 

BM, Toth MJ. Chronic heart failure decreases cross-bridge kinetics in single skeletal 

muscle fibers from humans. J Physiol. 2010 Oct 15;588(Pt 20):4039-53. Aug 19. [Epub 

ahead of print] 

Pope E, Harvey-Berino J, Savage PD, Bunn JY, Ludlow M, Oldridge N, Ades PA. The 

impact of high-calorie-expenditure exercise and behavioral weight loss on quality of life 

and exercise enjoyment in older adults with Coronary Heart Disease. Journal of Aging 

and Physical Activity. In Press 2011. 

Hamm LF, Sanderson BK, Ades PA, Berra K, Kaminsky LA, Roitman JL, Williams MA 

Core Competencies for Cardiac Rehabilitation/Secondary Prevention Professionals: 2010 

Update. Position Statement of the American Association of Cardiovascular and 

Pulmonary Rehabilitation J Cardiopulm Rehabil Prev. 2011;31:2-10. 

Savage PD, Shaw AO, Ades PA, Miller MS, VanBuren P, Martin M. LeWinter MM, 

Toth MJ. Directly Measured Physical Function in Chronic Heart Failure: Favorable 

Effects of High Intensity Resistance Training. Med Sci Sports Ex. Accepted, pending 

revisions, 2011. 

Toth MJ, Ward K, van der Velden J, Miller MS, Vanburen P, Lewinter MM, Ades PA 

Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship 

to muscle size and function. J Appl Physiol. Epub ahead of print. 2011. 

Audelin MC, Savage PD, Toth MJ, Harvey-Berino, Schneider DJ, Bunn JY, Ludlow M, 

Ades PA Determinants of Improved Insulin Sensitivity after Lifestyle Interventions in 

Overweight Coronary Patients. Accepted pending revisions, Metabolism, 2011 

Valencia HE, Savage PD, Ades PA. Cardiac Rehabilitation Participation in Underserved 

Populations: Minorities, Low Socioeconomic and Rural Residents. In Press, J 

Cardiopulm Rehabil Prev 2011. 

Ades PA, Savage PD, Lischke S, Toth MJ, Harvey-Berino J, Bunn JY, Ludlow M, 

Schneider DJ. The effect of weight loss and exercise on flow-mediated vasodilatation 

in overweight patients with coronary heart disease: A randomized controlled trial. In 

Press, Chest 2011. 

34

Savage PD, Sanderson BK, Brown TM, Berra K, Ades PA. Clinical Research in Cardiac 

Rehabilitation and Secondary Prevention Programs: Looking Back and Moving 

Forward".Accepted Pending revisions, J Cardiopulm Rehabil 2011. 

Rubin LJ, Hopkins WE. Overview of Pulmonary Hypertension. In: UpToDate, Rose, BD 

(ed), UpToDate, Waltham, MA 2011. 

Rubin LJ, Hopkins WE. Diagnostic Evaluation of Pulmonary Hypertension. In: 

UpToDate, Rose, BD (ed), UpToDate, Waltham, MA 2011. 

Rubin LJ, Hopkins WE. Pathogenesis of Pulmonary Hypertension. In: UpToDate, Rose, 

BD (ed), UpToDate, Waltham, MA 2011. 

Rubin LJ, Hopkins WE. Treatment of Pulmonary Hypertension. In: UpToDate, Rose, BD 

(ed), UpToDate, Waltham, MA 2011. 

Albu JB, Lu J, Mooradian AD, Krone R, Nesto RW, Porter M, Rana JS, Rogers WJ, 

Sobel BE, Gottlieb S, for the BARI 2D Investigators: Relationships of obesity and fat 

distribution with atherothrombotic risk factors: Baseline results from the Bypass 

Angioplasty Revascularization Intervention 2 Diabetes (BARI 2D) trial. Obesity 

18:1046-1054, 2010. 

McBane RD II, Hardison RM, Sobel BE and the BARI 2D Study Group: Comparison of 

plasminogen activator inhibitor-1, tissue-type plasminogen activator antigen, fibrinogen, 

and D-dimer levels in various age decades in patients with type-2 diabetes mellitus and 

stable coronary artery disease (From the Bypass Angioplasty Revascularization 

Investigation 2 Diabetes Trial). Am. J. Cardiol. 105:17-24, 2010. 

Habel N, Znojkiewica P, Thompson N, Muller JG, Mason B, Calame J, Calame S, 

Sharma S, Mirchandani G, Janks D, Bates J, Noori A, Karnbach A, Lustgarten DL, Sobel 

BE, Spector P: The temporal variability of dominant frequency and complex fractionated 

atrial electrograms constrains the valildity of sequential mapping in human atrial 

fibrillation. Heart Rhythm 7:586-593, 2010. 

Miyagawa R, Asakura T, Nakamura T, Okada H, Iwaki S, Sobel BE, Fujii S: Increased 

expression of plasminogen activator inhibitor type-1 (PAI-1) in HepG2 cells induced by 

insulin mediated by the 3’-untranslated region of the PAI-1 gene and its pharmacologic 

implications. Coron. Artery Dis. 21:144-150, 2010. 

French CF,* Zaman AKMT,* Kelm RJ, Sobel BE (* Co-first authors): Vascular rhexis: 

Loss of integrity of coronary vasculature in mice subjected to myocardial infarction. 

Exp. Biol. Med. 235:966-973, 2010. 

Binbrek AS, Rao KN, Van de Werf F, Sobel BE: Meta-analysis of studies of patients in 

the United Arab Emirates with ST elevation myocardial infarction treated with 

thrombolytic agents. Am. J. Cardiol. 106:1692-1695, 2010. 

35

French CJ, Taatjes DJ, Sobel BE: Autophagy in myocardium of murine hearts subjected 

to ischemia followed by reperfusion. Histochem. Cell Biol. 134:519-526, 2010 (DOI 

10.1007/s00418-010-0748-0). 

Lam PH, Anderson III PR, Ahmed B, Sobel BE, VanBuren P, Schneider DJ: Biomarker 

profiles as descriptors of left ventricular remodeling after acute myocardial infarction. 

Coron. Artery Dis., in press. 

Asakura T, Iwaki S, Okada H, Sobel BE, Fujii S: Posttranscriptional regulation of 

plasminogen activator inhibitor type-1 by cAMP in HepG2 liver cells. J. Biochem., in 

press. 

French CJ, Zaman TAKM, Sobel BE: The angiotensin receptor blocker, Azilsartan 

medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator 

inhibitor type-1 (PAI-1) protein potentially facilitating the stabilization of atherosclerotic 

plaques. J. Cardiovasc. Pharm., in press. 

Spector PS, Habel N, Sobel BE, Bates JHT: Emergence of complex behavior: An 

interactive model of cardiac excitation provides a powerful tool for understanding 

electrical propagation. Circulation: Arrhythmia & Electrophysiology, in press. 

Zaman AK, French CJ, Spees JL, Binbrek AS, Sobel BE: Vascular rhexis in mice 

subjected to non-sustained myocardial ischemia and its therapeutic implications. Exp. 

Biol. Med. 236:598-603, 2011 (DOI: 10.1258/ebm.2011.011026). 

Sobel BE, Hardison RM, Genuth S, Brooks MM, McBane RD III, Schneider DJ, Pratley 

RE, Huber K, Wolk R, Krishnaswami A, Frye RL for the BARI 2D Investigators. 

Profibrinoytic, anti-thrombotic, and anti-inflammatory effects of an insulin sensitizing 

strategy in patients in the BARI 2D trial. Circulation, in press. 

Shimada IS, Borders A, Spees JL. Proliferating reactive astrocytes are regulated by 

Notch-1 in the peri-infarct area following stroke. (Accepted and In Press, Stroke 2011) 

Zaman AK, French CJ, Spees JL, Binbrek AS, Sobel BE. Vascular rhexis in mice 

subjected to non-sustained myocardial ischemia and its therapeutic implications. Exp 

Biol Med (Maywood). 2011 May 1;236(5):598-603. Epub 2011 Apr 26. 

Shimada IS, Spees JL. Stem and progenitor cells for neurological repair: minor issues, 

major hurdles, and exciting opportunities for paracrine-based therapeutics. J Cell 

Biochem. 2011 Feb;112(2):374-80. doi: 10.1002/jcb.22963. Review. 

Bakondi B, Shimada IS, Peterson BM, Spees JL. SDF-1α Secreted by Human CD133- 

Derived Multipotent Stromal Cells Promotes Neural Progenitor Cell Survival Through 

CXCR7. Stem Cells Dev. 2011 Jun;20(6):1021-9. Epub 2010 Nov 9. 

36

Kendirci M, Trost L, Bakondi B, Whitney MJ, Hellstrom WJ, Spees JL. Transplantation 

of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve 

growth factor receptor into the penis rescues erectile function in a rat model of cavernous 

nerve injury. J Urol. 2010 Oct;184(4):1560-6. Epub 2010 Aug 21. 

Curril IM, Koide M, Yang CH, Segal A, Wellman GC, Spees JL. Incomplete 

reprogramming after fusion of human multipotent stromal cells and bronchial epithelial 

cells. FASEB J. 2010 Dec;24(12):4856-64. Epub 2010 Aug 19. 

Bakondi B, Spees JL. Human CD133-derived bone marrow stromal cells establish 

ectopic hematopoietic microenvironments in immunodeficient mice. Biochem Biophys 

Res Commun. 2010 Sep 17;400(2):212-8. Epub 2010 Aug 16. 

Shimada IS, Peterson BM, Spees JL. Isolation of locally derived stem/progenitor cells 

from the peri-infarct area that do not migrate from the lateral ventricle after cortical 

stroke. Stroke. 2010 Sep;41(9):e552-60. Epub 2010 Jul 29. 

LeWinter, Martin M, Tischler, Marc T: Pericardial Diseases ; Braunwald’s Heart 

Disease. A Textbook of Cardiovascular Medicine. 2011; 75: 1651-1678. 

Krasnow McEntee R, Coyle D, Meyer M. Severe Dilated Cardiomyopathy After 

Propranolol Treatment in an Undiagnosed Adrenal Pheochromocytoma 

Circ Heart Fail. 2011; 4: 3 e10-e12. 

Toth MJ, Shaw AO, Miller MS, VanBuren P, LeWinter MM, Maughan DW, Ades PA. 

Reduced knee extensor function in heart failure is not explained by inactivity. Int J 

Cardiol. 2010;143:276-82. 

LeWinter MM, Popper J, McNabb M, Nyland L, Stephen SB, Granzier H. 

Extensible behavior of titin in the miniswine left ventricle. Circulation 121:768-774, 

2010. 

LeWinter MM, Granzier H. Titin – A Multifunctional Giant. Circulation 121: 2137- 

45, 2010. 

Donaldson C, Taatjes D, Palmer B, Bishop N, Von Turkovich M, Spinale F, Zile M, 

Maughan D, LeWinter MM. Immunoelectron microscopic detection of the advanced 

glycation end-product carboxymethyl lysine in human myocardium. Histochem Cell Biol 

134:23-30, 2010 

Toth MJ, LeWinter MM, Ades PA, Matthews DE. Impaired muscle protein anabolic 

response to insulin and amino acids in heart failure patients: relationship to markers of 

immune activation. Clin Sci 119:467-76, 2010. 

37

Francis GS, Greenberg BH, Hsu DT, Jaski BE, Jessup M, Lewinter MM, Pagani FD, Piña 

IL, Semigran MJ, Walsh MN, Wiener DH, Yancy CW Jr. 

ACCF/AHA/ACP/HFSA/ISHLT 2010 clinical competence statement on management of 

patients with advanced heart failure and cardiac transplant: a report of the 

ACCF/AHA/ACP Task Force on Clinical Competence and Training. Circulation 

122:644-72, 2010. 

Force T, Adhikari B, Byrne B, Maron B, Seidman C, Molkentin J, Anderson M, LeWinter 

MM, Maron M, Regnier M. Research directions in hypertrophic cardiomyopathy: Report 

of a working group of the National Heart, Lung and Blood Institute. Circulation 

122:1130-3, 2010. 

Savage P, Ades P, LeWinter M, Miller D, Toth M. Muscle strength and physical 

disability in chronic heart failure: Favorable effects of high intensity resistance training. 

Circulation Heart Fail (in press) 

Miller MS, Vanburen P, LeWinter MM, Braddock JM, Ades PA, Maughan DW, Palmer 

BM, Toth MJ. Chronic heart failure decreases cross-bridge kinetics in single skeletal 

muscle fibers from humans. J Physiol 2010;588:4023-53 [E pub ahead of print] 

Savage P, Shaw AO, Miller MS, Vanburen P, Lewinter MM, Ades PA, Toth MJ. Effect 

of rersistance training on physical disability in chronic heart failure. Med Sci Sports 

Exerc. 2011 Jan 12. [Epub ahead of print] 

Selby DE, Palmer B, LeWinter MM, Meyer M. Tachycardia-induced diastolic 

dysfunction and resting tone in myocardium from patients with normal ejection fraction. 

J Amer Coll Cardiol 2011;58:147-54. 

Felker GM, Lee KL, Bull DA, MD, Redfield MM, Stevenson LW, Goldsmith SW, 

LeWinter MM, Deswal A, Rouleau JL, MD, Ofili EO, Anstrom KJ, Hernandez AF, 

McNulty SE, Velazquez EJ, Kfoury AG, Chen HH, Givertz MM, Semigran MJ, Bart BA, 

Mascette AM, Braunwald E, O’Connor CM, For the NHLBI Heart Failure Clinical 

Research Network. A Randomized Controlled Trial of Diuretic Strategies in Patients with 

Acute Decompensated Heart Failure. New Eng J Med 2011;364:797-805. 

Casson PR, Toth MJ, Johnson JV, Stanczyk FZ, Casey CL, Dixon ME. Correlation of 

serum androgens with anthropometric and metabolic indices in healthy non-obese 

postmenopausal women. J Clin Endocrinol Metab 95: 4276-4282, 2010 [PMC 2936067]. 

Debold EP, Saber W, Cheema Y, Bookwalter C, Trybus K, Warshaw DM, VanBuren P. 

Human actin mutations associated with hypertrophic and dilated cardiomyopathies 

demonstrate distinct thin filament regulatory properties in vitro. J Mol Cell Cardiol. 

2010;48:286-92. [PMC2813351] 

VanBuren P, Palmer BM. Cooperative activation of the cardiac myofilament: the pivotal 

role of tropomyosin. Circulation. 2010;121:351-3. [PMC2901860] 

38

Hünlich M, Tremble SM, Begin KJ, Leavitt BJ, Ittleman FP, VanBuren P. Atrial 

contractile protein content and function are preserved in patient with coronary artery 

disease and atrial fibrillation. Coron Artery Dis. 2010;21:357-62. [PMC Journal - In 

Process] 

Rehwinkel AE, Mueller J, VanBuren P. Lustagarten DL. Ventricular Resynchronization 

by Implementation of Direct His Bundle Pacing in a Patient with Congenital Complete 

AV Block and Newly Diagnosed Cardiomyopathy. J Cardiovasc Electrophysiol. In press 

Savage P, Shaw, AO, Miller MS, VanBuren P, LeWinter MM, Ades PA, Toth MJ. 

Muscle strength and physical disability in chronic heart failure: favorable effects of 

resistance training. Med Sci Sports Exerc In press 

VanBuren P, Ma J, Chao S, Mueller E, Schneider DJ, Liew CC. Blood gene expression 

signatures associate with heart failure outcomes. Physiological Genomics 2011;43:392-7 

[PMC Journal - In Process] 

VanBuren P, LeWinter MM. Heart failure as a consequence of diabetic cardiomyopathy. 

In Heart Failure: A Companion to Braunwald’s Heart Disease. Mann DL, editor. 

Elsevier, St Louis, USA 2011;408-418. 

Dauerman HL, Bhatt DB, Smyth SS, French PA, Becker RC. Bridging the gap between 

clinical trials and applications of antiplatelet therapy for the elderly. American Heart 

Journal 2010; 159: pp. 508-517. 

Dauerman HL. PCI, diabetes and death. J Am Coll Cardiol 2010;55: p. 1076-1079. 

Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, 

Dauerman HL, French PA, Smyth SS, Becker RC. Genetic regulation of platelet receptor 

expression and function: application in clinical practice and drug development. 

Arterioscler. Thromb. Vasc. Biol 2010; 30: 2372-2384. 

Solomon RJ, Dauerman HL. Contrast Induced Acute Kidney Injury: A Clinician’s 

Update. Circulation, 2010; 122: 2451-2455. 

Ahmed BA, Lischke S, Straight F, Holterman K, Dauerman HL. Angiographic predictors 

of vascular complications among women undergoing cardiac catheterization and 

intervention. J. Invasive Cardiology 2010; 22: 512-516. 

Anderson P, Gogo PB, Ahmed B, Straight R, Terrien EF, Watkins MW, El Gharib N, 

Dauerman HL. Two hour bivalirudin infusion after PCI for ST elevation myocardial 

infarction. J. Thromb Thrombolysis 2010; 31: 401-406. 

39

Ahmed B, Dauerman HL, Piper WD, Robb JF, Goldberg D, Boss RA Jr, Phillips WJ, 

Fedele F, Ryan TJ Jr, Butzel D, Silver MT, Malenka DJ. Recent changes in practice of 

elective PCI for stable angina. Circulation: Quality and Outcomes 2011: 4: 300-305. 

Dauerman HL, Rao SV, Resnic F, Applegate RG. Bleeding avoidance strategies: 

consensus and controversy. J Am Coll Cardiol June 28, 2011. 

Ahmed BA, Lischke S, Holterman LA, Straight F, Dauerman HL. Gender related 

differences in predictors of vascular complications: role of vessel size and BMI. 

Catheterization and Cardiovascular Interventions 2011, submitted. 

Dauerman HL, Cutlip DC. Rationale, design and 30 day outcomes of the Endeavor Drug 

Eluting Stents: Understanding Care, Antiplatelet Agents and Thrombotic Events 

(EDUCATE) Trial. Am Heart J 2011, manuscript submitted 

Dauerman HL. Reasonable incomplete revascularization. Circulation 2011; 123: 2237- 

2240. 

Dauerman HL. The magic of disappearing stents. J Am Coll Cardiology July, 2011, in 

press. 

Dauerman HL. Inflammation and Arterial Injury. In 1001 Questions: An Interventional 

Cardiology Board Review. Lippincott, Williams and Wilkins, New York, 2011. 

Donaldson C. and Dauerman HL. Acute myocardial infarction in Critical Care Secrets, 

5 th edition (editor. P. Parsons and Wiener-Kronish ) , Elsevier, 2011. 

Spector PS. Circulation Arrhythmia and Electrophysiology (“Emergence of Complex 

Behavior: an Interactive Model of Cardiac Excitation Provides a Powerful Tool for 

Understanding Electrical Propagation”) 

Spector PS. ICU book chapter ("Dysrhythmias and Tachyarythmias", in Critical Care 

Secrets 5 th edition) 

Rumora AE, Steere AN, Ramsey JE, Knapp AM, Ballif BA, Kelm RJ Jr. Isolation and 

characterization of the core single-stranded DNA-binding domain of purine-rich element 

binding protein B (Pur�). Biochem Biophys Res Commun 400:340-345, 2010. PMID: 

20728429 

Malenka DJ, Robb F, Watkins MW, Goldberg D, Boss RA Jr., Kellett M, Ryan T, 

Wiseman A, Ver Lee P, Phillips W, Brown JR. Post-PCI acute kidney injury is 

associated with sheath size. In review AHA 

Keating FK, Schneider DJ, Savage PD, Bunn JY, Harvey-Berino J, Ludlow M, Toth MJ, 

Ades PA. Effect of Exercise Training and Weight Loss on Platelet Reactivity in 

Overweight Patients with Coronary Artery Disease. Manuscript in Preparation. 

40

Scholz KH, Maier SKG, Jung J, Fleischmann C, Werner GS, Olbrich HG, Ahlersmann D, 

Keating FK, Jacobshagen C, Moehlis H, Hilgers R, Maier LS. Reduction in Treatment 

Times Through Formalized Data Feedback: Results from a Prospective Multicenter Study 

of ST Elevation Myocardial Infarction. Manuscript in Preparation. 

Keating FK, Butenas S, Fung MK, Schneider DJ. Platelet-leukocyte interaction, 

leukocyte apoptosis and procoagulant activity in stored red blood cells. Transfusion. 2011 

May;51(5):1086-95. 

41

Division of Clinical Pharmacology 

Richard Galbraith, MD, PhD, Acting Director 

http://www.med.uvm.edu/medicine/pharmacology 

The Clinical Pharmacology Division comprises faculty members who are 

primarily interested in various research agendas within the general field of 

Clinical Pharmacology. Areas of interest include muscle atrophy, 

oxidative stress, appetite regulation, nutrition, and amino acid 

metabolism. 

Dr. Galbraith’s long-term interests concern the clinical management and 

research issues relevant to the porphyrias. He also has worked extensively in the clinical 

pharmacology of metal-substituted porphyrins in the treatment of jaundice, porphyria and 

obesity. 

Dr. Dwight Matthews leads a group of researchers who have used stable isotopically 

labeled tracers and kinetic models to answer questions of human physiology and 

biochemistry. The research program of his group in chemistry focuses on developing 

new methods and techniques of mass spectrometry to measure stable isotopes in 

biological molecules and mathematical and computer models to interpret the stable 

isotope tracer kinetic data obtained from biological samples. 

Faculty 

(list all faculty, Director first, then alphabetically with academic rank (note any medical 

administrative position, i.e. MICU Director), ex: 

Richard Galbraith, MD, PhD 


Acting Director, Clinical Pharmacology 

Associate Dean, Patient Oriented Research 

Director, Center for Clinical and Translational Science 

� Internal Medicine 

� Endocrinology 

� Metabolism 

Dwight Matthews, PhD 

Professor of Medicine and Chemistry 

Chair, Department of Chemistry, College of Arts and Sciences 

43


Galbraith: 

Member, Board of Directors of the Association for the accreditation of Human Research 

Protection Programs. 

Matthews: None 


Galbraith: 

Ad Hoc Reviewer, Pharmacology, Hepatology, European Journal of Clinical 

Investigation, Pediatrics, Pediatric Research, Journal of Coronary Artery Disease 

Reviewer, Clinical Therapeutics and Medical Economics Publications 

Reviewer, The American Journal of Clinical Nutrition 

Matthews: 

Editorial Board, Current Opinion in Clinical Nutrition and Metabolic Care 

Section Editor, Assessment of Nutritional Status and Analytical Methods, Current 

Opinion in Clinical Nutrition and Metabolic Care 

Advisory Board, Sport Sciences for Health 


Galbraith: 

Member, NIH Director’s Pioneer Awards Review Committee 

Chair, Clinical Research Subcommittee of FASEB Science Policy Committee 

Chair, FASEB Symposium of the Engagement of Basic Scientists in Translational 

Research 

Matthews: 

NIH Special Emphasis Panel/Review Group, Shared-Instrument Grant Program – NCRR 

(8/2010) 

NIH Special Emphasis Panel/NIGMS Research Centers in Trauma, Burn & Perioperative 

Injury ZGM1 PPBC-5 (BN) (12/2010) 

Grants – list all active by faculty member, PI 

Galbraith: 

M01 RR000109 Morin (PI) 

03/01/06-02/28/11 

NIH/NCRR 

General Clinical Research Center 

Role: Program Director 

$2,400,000 

44

Matthews: 

P20 RR020165 

8/1/06 - 6/30/11 

Vermont Immunobiology/Infectious Diseases Center 

P.I. Ralph C. Budd, M.D. 

Proteomics Core 

P.I: D.E. Matthews, Ph.D. 

$549,697 

P01 HL046703 

9/1/07-7/31/12 

Surface Dependent Reactions in Thrombosis and Thrombolysis 

P.I. Kenneth G. Mann, Ph.D. 

Co-investigator on two sub-projects of this program project: D.E. Matthews, Ph.D. 

$6,526,204 

NSF grant CHE-0342861 

8/1/08-7/31/11 

MRI: Acquisition of an LCMS for the Chemistry Department at the University of 

Vermont 

P.I: D.E. Matthews, Ph.D. 

$430,735 

R01 HL085646 

8/5/08-4/30/12 

Dual Oxidases in Airway Epithelial Repair and Remodeling 

P.I. Albert van der Vliet, Ph.D. 

co-investigator: D.E. Matthews, Ph.D. 

$1,250,000 

R01 DK082803 

4/1/10-3/31/14 

Palmitate Metabolism and Insulin Resistance 

P.I. Craig Lawrence Kien, M.D., Ph.D. 

co-investigator: D.E. Matthews, Ph.D. 

$2,186,329 

Publications – peer reviewed, chapters, etc. (not abstracts) 

Galbraith: None 

Matthews: 

1. Beauchemin D, Matthews DE. Elemental and Isotope Ratio Mass Spectrometry. 

Oxford, UK: Elsevier, 2010, pp 1-1065. 

2. Echeverria PC, Figueras MJ, Vogler M, Kriehuber T, de MN, Deng B, Dalmasso 

MC, Matthews DE, Matrajt M, Haslbeck M, Buchner J, Angel SO. The Hsp90 co- 

45

chaperone p23 of Toxoplasma gondii: Identification, functional analysis and dynamic 

interactome determination. Mol.Biochem.Parasitol. 2010; 172: 129-140. 

3. Matthews DE. Gas chromatography-pyrolysis-IRMS (GC-P-IRMS) for hydrogen 

and oxygen. In: Beauchemin D, Matthews DE, eds. Elemental and Isotope Ratio 

Mass Spectrometry. Oxford, UK: Elsevier, 2010:784-789. 

4. Matthews DE. Gas chromatography-combustion-IRMS (GC-C-IRMS) for carbon 

and nitrogen. In: Beauchemin D, Matthews DE, eds. Elemental and Isotope Ratio 

Mass Spectrometry. Oxford, UK: Elsevier, 2010:774-783. 

5. Matthews DE. Gas chromatography-combustion-isotope ratio mass spectrometry 

applied to measuring nitrogen-15 in biomedicine. In: Beauchemin D, Matthews DE, 

eds. Elemental and Isotope Ratio Mass Spectrometry. Oxford, UK: Elsevier, 

2010:954-961. 

6. Schoeller DA, Racine N, Shriver TC, Matthews DE. Doubly labeled water 

method in IRMS to measure free living energy expenditure. In: Beauchemin D, 

Matthews DE, eds. Elemental and Isotope Ratio Mass Spectrometry. Oxford, UK: 

Elsevier, 2010:962-967. 

7. Toth MJ, LeWinter MM, Ades PA, Matthews DE. Impaired muscle protein 

anabolic response to insulin and amino acids in heart failure patients: relationship 

with markers of immune activation. Clin.Sci.(Lond) 2010; 119: 467-476. 

8. Krudysz-Amblo J, Jennings ME, Matthews DE, Mann KG, Butenas S. 

Differences in the fractional abundances of carbohydrates of natural and recombinant 

human tissue factor. Biochim.Biophys.Acta 2011; 1810: 398-405. 

46

Division of Dermatology 

Glenn Goldman, MD, Director 

http://www.med.uvm.edu/medicine/Dermatology 

Dermatology at Fletcher Allen Health Care is a division of Medicine with 

three general medical dermatologists, four surgical dermatologists, and 

four experienced physician assistants. We provide basic dermatology care 

to the community as well as highly-specialized care with particular 

strengths in the treatment of psoriasis, cutaneous lupus, dermatomyositis, 

cutaneous lymphoma, and all forms of skin cancer including melanoma. 

We also provide cosmetic services for lasers and fillers in an ever 

growing area of dermatology. In the next year we will be adding one or 

two more general dermatologists and expanding into a separate location within the 

ambulatory care facility. This will increase our ability to see patients with medical 

dermatology needs. Currently Vermont has a substantial shortage of dermatologists, and 

we aim to diminish the waiting period for appropriate care. This year we will have 

approximately 27,000 patient visits producing about 55,000 wRVU. 

Two of our attendings hold national leadership positions. Dr. Kathryn 

Schwarzenberger is a newly-elected member of the Board of the American Academy of 

Dermatology and she is a test writing committee member of the American Board of 

Dermatology. Dr. Glenn Goldman is a member of the Board of the American College of 

Mohs Surgery and also serves as the American Medical Association RUC advisor to the 

ACMS. He just rotated off of the American Board of Dermatology. Dr. Goldman and his 

mentor, Dr. Leonard Dzubow will publish in April of 2012 an expansive and detailed text 

of facial reconstruction with over 1000 clinical operative photos and 60 videos. The video 

editor is Dr. Christopher Yelverton, our current surgical fellow and newest faculty hire. 

Several of our attending physicians are regular participants in Fletcher Allen 

administrative processes. Drs. Goldman and Schwarzenberger are involved in multiple 

committees at the medical center. Dr. Julie Lin is intimately involved with the 

development of the EMR through her participation with PRISM, where she is the PRISM 

representative from the Department of Medicine. 

Our residency and procedural dermatology fellowship programs train 

exceptionally qualified physicians, and we have recently received a five-year ACGME 

residency review cycle with no citations. We have increased our complement of residents 

to two per year starting 7/1/2011. Our residents and fellows have an excellent 

employment track record. Four of our graduates are in private practice in general 

dermatology. Three have gone on to complete fellowships in procedural dermatology. 

These three all went on to take jobs in academic medicine, and Dr. Todd Holmes remains 

on faculty at Fletcher Allen Health Care, and Dr. Melissa Pugliano-Mauro has started a 

new Mohs surgery unit in conjunction with the University of Pittsburgh. We frequently 

host residents from other institutions for rotations in subspecialty areas of dermatology, 

especially in surgery, in which Dr. Goldman is a preceptor for the American Society of 

Dermatologic Surgery. 

47

On average we receive over 250 applications for our residency spots annually, 

and approximately 40 applications are received for our single procedural dermatology 

fellowship slot. Residents and fellows present regularly at our local and regional 

meetings, and in the last three years the procedural dermatology fellows have been first 

author on two major studies published in the dermatologic surgery literature. This year 

our residents were involved in several local skin screenings. Our procedural dermatology 

fellow is the video editor of a major textbook of flap reconstruction surgery being 

authored by Dr. Goldman. Next year our fellow will pursue a study of loop coil MRI for 

cutaneous tumors and Dr. Goldman, Dr. Holmes and the fellow will be performing strain 

/ tension experiments on flap repairs in a porcine model. 

Each month we host several third or fourth year students for rotations in 

dermatology. On average one or two University of Vermont medical students per year 

choose to enter the field of dermatology. Due to the tremendously-competitive nature of 

dermatology as a specialty, each student requires careful guidance and assistance in 

procuring a residency. For the last ten years, every UVM student who has pursued 

dermatology as a career has been able to match for a residency. Sometimes this has 

required the completion of a research fellowship following medical school, but our 

faculty mentors have been able to work with students who did not match directly to find a 

way to achieve their career goals. 

Dermatology at Fletcher Allen Health Care / The University of Vermont is wellknown 

for its continuing medical education. We hold a high-level dermatology 

conference each year which draws participants from around the country. In addition, we 

hold a local dermatology conference for the didactic and hands-on instruction of primary 

care physicians. Both are well-attended, and attendance and response to the latter 

conference has been overwhelming. 

Faculty 

Glenn Goldman, MD 


Director, Dermatology Division 

Director, Procedural Dermatology Program 

Board of Directors, American College of Mohs Surgery 

� Mohs Surgery and Reconstructive Surgery 

� Management of high-risk skin cancers 

� Cosmetic Dermatology 

� Procedural Dermatology Education 

� National Health Care Policy 

� Continuing Medical Education 

Kathy Schwarzenberger, MD 


Residency Director, Dermatology Division 

Board of Directors, American Academy of Dermatology 

48

� Connective Tissue Disease 

� Dermatology Education 

� Health Care Policy 

� Clinical Operations 

� Continuing Medical Education 

Jamie Alpert, MD 


Chair, Part-Time Faculty Actions Committee 

� General Medical Dermatology 

Todd Holmes, MD 


� Surgical Dermatology 

� Mohs and Reconstructive Surgery 

� Resident Education 

Julie Lin, MD 


Department of Medicine PRISM Representative 

� Cutaneous Lymphoma 

� Electronic Medical Records 

� Bioinformatics 

Christine Weinberger, MD 


� Mohs Surgery and Reconstruction 

� Mohs Surgery for Melanoma 

Chistopher Yelverton, MD, MBA 


� Mohs Surgery and Reconstruction 

� General Medical Dermatology 

� Cosmetic Dermatology 

� Residency Education 

� 

Fellows 

Ani Tajirian, MD 

Procedural Dermatology Fellow 2011-2012 

49

Residents 

Judy Wong, MD Chief resident 

Laura McGevna, MD PGY-3 

Ryan Rogers, MD PGY-3 

Elizabeth Zeek, MD PGY-2 

Physician Assistants: 

Deb Roseman, PA: 

Deb has been with us for ten years. She has decades of experience as a 

dermatology physician assistant and has a following of thousands of patients for whom 

she provides care. 

Anne Klein, PA 

Anne is a surgical PA, and works with the dermatologic surgeons daily. She 

trained for years with a plastic surgeon and has exceptional procedural skills. A testament 

to her skill is that physicians refer patients to her regularly for surgical excisions. 

Rich Callahan, PA 

A newer member to our staff, Rich is experienced in dermatology and provides 

both medical and minor surgical dermatology care. He brings with him many patients 

from his former practice. 

Christine Sowle, PA 

Christine trained with us and stayed on as a dermatology PA. She has been 

working with us for almost ten years and has a large following of thousands of patients 

who see her on a regular basis. 

Leadership in Professional Societies 

Boards of Directors 

Dr. Goldman – American College of Mohs Surgery 

Dr. Schwarzenberger – American Academy of Dermatology 

Dr. Schwarzenberger – Test Writing Committee of the American Board of Dermatology 


Dr. Schwarzenberger- Editor of Dermatology MKSAP 15 & 16 

Editorial Board of Archives of Dermatology 

Editorial Board of Journal of the American Academy of Dermatology 

50


American Medical Association 

Dr. Goldman – RUC representative for the American College of Mohs Surgery 


1. Hartford OH, Pothiawala GA, Goldman GD. Ulcerated facial nodules in a renal 

transplant patient. Arch Dermatol 2010;146:81-86. 

2. Pugliano-Mauro, M, Goldman GD. Mohs surgery is effective for high-risk 

cutaneous squamous cell carcinoma. Dermatol Surg 2010;36:1544-53. 

3. Marks MM, Yelverton CB, Williford PM, Teuschler HV, Coloe J, Chen J, 

Feldman SR. A Medicare cost comparison of minor cutaneous procedures by 

surgical setting. J Dermatolog Treat. 2010 Mar;21(2):101-6. 

4. Ray TL, Weinberger CH, Lee PK. Closure of large surgical defects on the 

cutaneous upper lip using an island pedicle flap. Dermatologic Surgery 2010 

Jun;36(6): 931-4. 

5. Eleftheriou LI, Weinberger CH, Endrizzi BT, et al. The Victory stitch: a novel 

running V-shaped horizontal mattress suturing technique. Dermatologic Surgery; 

accepted for publication. 

51

Division of Endocrinology 

Jack Leahy, MD, Co-Director 

Joel Schnure, MD, Co-Director 

http://www.med.uvm.edu/medicine/endocrinology 

The Division of Endocrinology, Diabetes and Metabolism has 6 

physicians, 3 nurse practitioners, 3 certified diabetes educators 

(CDEs). 

The Division performs consultative and ongoing endocrine care for 

Vermonters and upstate New Yorkers. The largest portion of our 

clinical enterprise is delivering diabetes care to both in-patients and out-patients. Our 

mission is to combine cutting edge 

research in basic metabolism and cell biology and physiology while 

establishing an exemplary center for clinically excellent patient care. 

Our goal is to strive to deliver seamless system-wide diabetes care. 

In this regard, we have developed algorithms for intensive in-patient 

management and recently helped develop a clinical pathway for use in 

the Medical Home, in conjunction with PCIM and Family Care. This 

pathway will allow for state of the art diabetes management to reach more patients with 

diabetes in our catchment area. We also provide more intensified regimens for the 

growing cohort of individuals on insulin infusion pumps. Our diabetes care team offers 

classes to individuals, families and groups to assist in achieving targeted glycemic control 

for all patients with diabetes. The Vermont Regional Diabetes Center is an American 

Diabetes Association accredited diabetes education program. 

Five of our attendings participate in thyroid ultrasonography and have developed a 

thyroid fine needle aspiration (FNA) biopsy clinic. Together with the cytopatholgy 

faculty and trainees, this service has had overwhelming success in the early diagnosis and 

treatment of thyroid cancer 

Other areas of clinical interest include metabolic bone disease and osteoporosis, 

hypogonadism, as well as pituitary and adrenal disease. Overall, the clinic is flourishing 

in our new Tilley Drive setting with 12,000 visits per year – fourth in the Department of 

Medicine 

The Division’s research efforts have focused on beta cell function, intracellular 

metabolism and life cycle. Dr Leahy’s work in this area is world renown. We are also 

involved in clinical research and clinical trials involving incretin biology, new product 

development, hypertension, obesity, insulin resistance and cardiovascular outcomes. 

Our education mission continues to expand. There are two Fellows in Endocrinology. 

We have had approximately 30 students rotating through the service and the number of 

residents electing endocrinology is on the increase. 

53

Faculty 

Jack Leahy, MD 


Co-Director, Endocrinology, Diabetes and Metabolism Division 

� Diabetes mellitus 

Joel Schnure, MD 


Co-Director, Endocrinology, Diabetes and Metabolism Division 

Member, DOM Operations and Efficiency Committee 

Lead, Task Force on In-Patient Diabetes Education 

Member, In-Patient Diabetes Initiative 

� Diabetes care, type 1 & 2 

� Diabetes in pregnancy 

� Thyroid disease 

� Pituitary disease 

Rose Christian, MD 


Director, Endocrinology Fellowship Program 

� Osteoporosis 

� Metabolic bone disease 

� Hereditary and genetic bone diseases 

� Post-transplant bone disease 

Matthew P Gilbert, DO, MPH 


� Diabetes mellitus 

� Thyroid disorders 

� Thyroid cancer 

� Male hypogonadism 

Thomas Jetton, PhD 


� Regulation of glucose homeostasis 

� β-cell biology 

� Nutrient regulation of β-cell growth 

Annis Marney, MD, MSCI 


Associate Director, Endocrinology Fellowship Program 

Director, Medical Student and Residency Endocrine Elective 

Chair, Resident Research and Scholarly Activity Committee 

Patient Care and Operations Committee 

Clinical Research Center Scientific Advisory Committee 

54

� General endocrinology 

Muriel Nathan, MD, PhD 


� Diabetes, including use of insulin pumps 

� Thyroid cancer, nodules and disorders 

� Pituitary tumors and dysfunction 

� Adrenal disorders 

I have been actively working on inpatient improvement projects funded by the James M. 

Jeffords Institute for Quality ~ SQ and IV insulin forms, insulin pump, DKA 

Mina Peshavaria, PhD 

Research Assistant Professor of Medicine 

� Biochemical, physiology and molecular biology of islet transcription factors 

� Transcription factor regulation of beta cell mass 

� Beta cell mass compensation mechanisms 

Richard Pratley, MD 

Professor of Medicine (7/1/10-4/1/11) 

Director, Diabetes and Metabolism Translational Medicine Unit 

� Diabetes 

� Clinical research 

Fellows 

Alison Schneider, MD (F5 starting July 1, 2011) 

Vanessa Escobar Barboza, MD (F4 starting July 1, 2011) 

Nurse Practitioners and Certified Diabetes Educators 

Margaret Costello, NP 

Maureen Dwyer, NP 

Ann Gotham, NP 

Kristen Bolton, CDE 

Rhonda Lapidow, CDE 

Linda Tilton, CDE 

Graduate Students, Post-doctoral Fellows, MD PhD Students 

William Diaz (Graduate Student) 

William Tharp (MD, PhD Student) 


Thomas Jetton 

� Organizer and Senior Member: Boston-Ithaca Islet Club 

55

Jack Leahy 

� Founding Member and Member, Editorial Board for BetaCellsinDiabetes.org in 

partnership with The Endocrine Society 

� Councilor for Society of Experimental Biology and Medicine 

Richard Pratley 

� Program Committee: American Diabetes Association Annual Scientific Meetings 

� American Diabetes Association: Older Americans Work Group 


Thomas Jetton 

� Reviewer: Diabetes, Endocrinology, PNAS, Metabolism, Diabetologia, American 

Journal of Physiology 

Mina Peshavaria 

� Editorial Advisory Board Member: The Open Endocrinology Journal, Reviews 

and Letters 


� Associate Editor: Diabetes Care 

� Section Editor: Current Diabetes Reports 


Thomas Jetton 

� ADA Research Grant Study Section (*retired in December 2010) 

� NIH/MMPC MicroMouse Grant Review Panel Member 

� Ad Hoc Member, Juvenile Diabetes Research Foundation International, 

Generating Beta Cell Source Grants Study Section 

Jack Leahy 

� Ad Hoc Reviewer for Cellular Aspects of Diabetes and Obesity (CADO) NIH 

Study Section June 2010 

� Ad Hoc Reviewer for NIH-NIDDK, Diabetes, Endocrinology, and Metabolic 

Diseases B Sub-Committee (DDK-B) Study Section March 2011 


� NIDDK CIDO Ad Hoc Reviewer Oct 2010 

� NIDDK ZDK1 GRB-9 (O1) 

� NIDDK ZDK1 GRB-N (O5) 

56

Grants 

Thomas Jetton 

ß-cell Compensation in Partial Pancreatectomy Mice (Leahy, PI) 

9/1/10 – 8/31/14 

Jetton, Co-I (24% effort) 

NIH/NIDDK R01 DK56818-10 

Beta-cell PPAR gamma signaling in fat fed mice (Leahy, PI) 

1/1/10-12/31/12 


ADA Basic Research Award 

Pdx1 dependent and independent mechanisms in adaptive ß-cell growth (Peshavaria, PI) 

3/3/08-7/31/11 


Juvenile Diabetes Research Foundation International 

Role of AMPK in ß-cell growth and survival (Peshavaria, PI) 

1/1/11-12/31/11 

Jetton, Co-I (3.5% effort) 

Iacocca Foundation Research Award 

PPARy and uterine vascular dysfunction in diabetic pregnancy (Gokina, PI) 

9/1/2008-7/30/12 


NIH/NHLBI R01 HL088245 

Additive effects of TZD and DPP-4 inhibitor therapy on beta-cell mass and function 

(Leahy, PI) 

9/1/10-2/25/13 

Jetton, Co-I (22.5% effort) 

Takeda Pharmaceuticals Research Grant 

Jack Leahy 

Β-cell compensation in partial pancreatectomy mice (PI) 

9/1/10-8/31/14 

NIH/NIDDK R01 DK56818-10 

Beta-cell PPAR-gamma signaling in fat fed mice (PI) 

1/1/10-12/31/12 

American Diabetes Association Research Grant 

Additive Effects of TZD and DPP-4 inhibitor therapy on beta-cell mass and function (PI) 

57

9/1/10-2/25/13 

Takeda Pharmaceuticals Research Grant 

Annis Marney 

Effect of Sitagliptin on short-term metabolic dysregulation of oral glucocorticoid therapy 

(PI) 

08/11-07/13 

Merck (Investigator Initiated Study) 

Mina Peshavaria 

Pdx1 dependent and independent mechanisms in adaptive β-call growth (PI) 

3/3/08-7/31/11 

Juvenile Diabetes Research Foundation International 

Pdx1-mediated mechanism regulating β-cell growth 

6/16/08-8/15/10 


Role of AMPK in β-cell growth and survival (PI) 

1/1/11-12/31/11 


Mechanisms mediating β-cell adaptation in partial hepatectomy mice (PI) 

1/1/11-12/31/11 

Diabetes Action Research and Education Foundation 


Adipokines in cardiovascular disease (Virend Somers, PI) 

9/09-8/11 

Pratley, Co-I 

Mayo Clinic 

Effects of aliskiren and valsartan on adipocyte proliferation and differentiation in murine 

diet-induced obesity (PI) 

11/10-10/11 

Novartis Pharmaceuticals Corp. 

Effects of Pioglitazone on the incretin axis in patients with type 2 diabetes mellitus (PI) 

2/08-2/11 

Takeda Pharmaceuticals North America 

Effects of Sitagliptin on markers of bone turnover in patients with type 2 diabetes (PI) 

8/08-12/10 

58

Merck & Co., Inc. 

Publications 

Bode B, Brett J, Falahati A, Pratley RE. Comparison of the efficacy and tolerability 

profile of liraglutide, a once-daily human GLP-1 analog, in patients with type 2 diabetes 

≥65 and

Leahy J, Pratley R. What is type 2 diabetes mellitus? Crucial role of maladaptive changes 

in beta cell and adipocyte biology. Translational Endocrinology and Metabolism 2011; 

2:9-42. 

Marney AM, Kunchakarra S, Byrne L, Brown NJ. Interactive hemodynamic effects of 

DPP-4 inhibition and ACE inhibition in humans. Hypertension 2010; 56:728-733. 

McMillian WD, Trombley BJ, Charash WE, Christian RC. Phentolamine continuous 

infusion in a patient with pheochromocytoma. Am J Health-Syst Pharm 2011; Jan 15; 

68(2):130-134. 

Power M, Pratley R. Alternative and Complementary Treatments for Metabolic 

Syndrome. Curr Diab Rep 2011; Feb 19. [Epub ahead of print] 

Pratley R, Nauck M, Bailey T, Montanya E, Cuddihy R, Filetti S, Garber A, Thomsen 

AB, Hartvig H, Davies M; for the 1860-LIRA-DPP-4 Study Group. One year of 

liraglutide treatment offers sustained and more effective glycaemic control and weight 

reduction compared with sitagliptin, both in combination with metformin, in patients with 

type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract 2011; Apr; 

65(4):397-407. 

Schneider A, Pratley RE. Does the Metabolic Syndrome Carry Additional Risk for 

Myocardial Infarction? Curr Diab Rep 2011; Feb 19. [Epub ahead of print] 

She P, Zhang Z, Marchionini D, Diaz WC, Jetton TL, Kimball SR, Vary TC, Lang CH, 

Lynch CJ. Molecular characterization of skeletal muscle atrophy in the R6/2 mouse 

model of Huntington’s disease. Am J Physiol Endocrinol Metab 2011; 301:E49-E61. 

Singh PP, Abbott JD, Lombardero MS, Sutton-Tyrrell K, Woodhead G, Venkitachalam 

L, Tsapatsaris NP, Piemonte TC, Lago RM, Rutter MK, Nesto RW. Bypass Angioplasty 

Revascularization Investigation 2 Diabetes Study Group. The prevalence and predictors 

of an abnormal ankle-brachial index in the Bypass Angioplasty Revascularization 

Investigation 2 Diabetes (BARI 2D) trial. Diabetes Care 2011; Feb; 34(2):464-467. 

Winters R, Christian RC, Sofferman R. Thyrotoxicosis due to ectopic lateral thyroid 

tissue presenting five years after total thyroidectomy. Endocr Pract 2011; Jan-Feb; 

17(1):70-73. 

Zhou Y, Jetton TL, Goshorn S, Lynch CJ, She P. Transamination is required for αketoisocaproate 

but not leucine to stimulate insulin secretion. J Biol Chem 2010; 

285:33718-33726. 

60

Division of Gastroenterology and Hepatology 

James Vecchio, MD, Director 

http://www.med.uvm.edu/medicine/gastroenterology 

The Gastroenterology and Hepatology Unit at the University of 

Vermont College of Medicine/FAHC has eight full-time Faculty 

members, three GI Fellows and two Ph.D.’s. Clinical care, teaching, 

and both basic science and clinical research are all major elements of 

the GI Unit. 

Cutting edge clinical care and state of the art endoscopy are just two 

components of the Faculty’s responsibility. A newly constructed 

modern 8-room Endoscopy Center is equipped with the latest HD endoscopes, to allow 

the performance of over 12,000 procedures per year. All aspects of diagnostic and 

therapeutic GI endoscopy are performed. Advanced procedures including EUS 

(endoscopic ultrasound) with on site cytopathology, and all modes of ERCP (endoscopic 

retrograde cholangiopancreatograhy) with portable fluoroscopy are performed daily. A 

new motility center and esophageal pH laboratory is being launched. A dedicated nursing 

staff and ancillary personnel of the Endoscopy Center ensure a seamless flow of patients 

each day. 

In the Rowell Building of the University of Vermont there is a Simulation Center. At the 

Simulation Center, GI Fellows may practice endoscopy on newly designed and highly 

sophisticated computerized models of the GI tract. 

A daily clinical office setting is shared with General Surgery in the Digestive Disease 

Center located on the 5 th floor of the new Ambulatory Care Center. There is a very close 

working relationship with the Colorectal Surgery and General Surgery division. There are 

dedicated liver clinics, and each aspect of luminal gastroenterology is represented in the 

various clinics. All this is accomplished with an integrated out-patient and in-patient 

electronic medical record. 

All members of the GI Unit are actively involved in a variety of aspects of medical 

teaching. The members of the GI Faculty have very active roles in lectures in the 

Vermont Integrated Curriculum of the UVM College of Medicine. UVM medical 

students are team members on the consult service and in the clinical office setting. The 

members of the GI Faculty are responsible for the vast majority of the teaching in the GI 

Fellowship Program. Members of the GI Faculty give lectures to both medical and 

surgical residents, review at Residents’ Morning Report and are part of the integrated 

Teaching Attending Service at FAHC. A weekly clinical GI Conference is held and led 

by GI Faculty and guest speakers from other divisions. Two Journal Clubs occur each 

month where an in-depth analysis and review of recent articles is accomplished. A 

monthly Quality Care Review Committee Meeting enables a constant improvement of 

clinical care and endoscopic practices. And finally, a monthly GI Research Meeting of 

all the GI Faculty and Fellows meets to review present and future research endeavors. 

61

Each Faculty member and each GI Fellow is actively engaged in an academic research 

pursuit. Research projects to date span the field of gastroenterology and hepatology from 

eosinophilic esophagitis, to new therapy for Barrett’s esophagus with radiofrequency 

ablation (RFA), to all aspects of chronic liver disease, new therapies for hepatitis C, new 

medications for inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), 

and exploring methods for early detection of pancreatic cancer. 

The Gastroenterology and Hepatology Unit at the University of Vermont fosters a close 

cooperation, collaboration and interaction with other research departments throughout 

UVM which allows an unique opportunity to explore translational research as it pertains 

to future aspects of clinical care. 

Faculty 

James Vecchio, MD 


Director, Gastroenterology and Hepatology Division 

� GERD 

� Celiac Disease 

� Inflammatory Bowel Diseases – Crohn’s and Ulcerative Colitis 

� Therapeutic Endoscopy 

Nicholas Ferrentino, MD 


Director, GI Fellowship Program 

� Chronic Viral Hepatitis 

� Management of Cirrhosis 

� General Gastroenterology and General Hepatology 


Eric Ganguly, MD 


� Endoscopic Ultrasound and GI Malignancies 

� Barrett’s Esophagus and Radiofrequency Ablation for Barrett’s Esophagus 


� General Gastroenterology 

Allen Lee, MD 


� Esophageal Manometry and pH Monitoring 

� Motility Disorders 

� GERD 

� Small Bowel Endoscopy 

62

Steven Lidofsky, MD, Ph.D. 

Professor of Medicine and Pharmacology 

Director, Hepatology Section 

Director, Gastrointestinal Research 

Director, MD-Ph.D. Program 

� Liver Cell Biology 

� Portal Hypertension 

� Hepatocellular Carcinoma 

� Viral Hepatitis 

� Metabolic Syndrome and the Liver 

Gary Mawe, Ph.D. 

Professor 

Anatomy & Neurobiology 

� Neural Regulation of the Digestive Tract 

(understanding changes in enteric neural circuits that contribute to altered gut 

function in inflammatory bowel disease and irritable bowel syndrome) 

Peter Moses, MD 


� Inflammatory Bowel Disease 

� Irritable Bowel Syndrome 


� Translational research with Human Microbiota 

Doris Strader, MD 


� Hepatitis C 

� Eosinophilic Esophagitis 

� General Hepatology and General Gastroenterology 

André-Denis Wright, Ph.D. 

Associate Professor 

Chair, Department of Animal Science 

� Human Gut Microbiology 

a) Determination of bacterial and methanogen profiles in individuals 

from five major colonic groups: healthy colon, diverticulosis, 

inflammatory bowel disease, colon polyps and colorectal cancer. 

b) The dynamics of the methanogen population, and methane production 

in humans. 

c) Determination of the dietary effects on different microbial populations in 

the gut. 

d) The link between gut microorganisms and obesity. 

Richard Zubarik, MD 


63

Director, Endoscopy 

� Pancreatic Disorders 

� Endoscopy Quality 


� Endoscopic Ultrasound 

Fellows 

Kunal Gupta, MD 

GI Fellow 

Nick Lim, MD 

GI Fellow 

Neeraj Sardana, MD 

GI Fellow 


� Sue Ishaq (Ph.D. Student) 

� Anjas Samsudin (Ph.D. Student) 

� Paul Evans (Ph.D. Student) 

� Sarah Hook (Ph.D. Student) 



� Editorial Board, Clinical Therapeutics 

� Ad hoc Grants Reviewer for: Burroughs Wellcome Foundation, Medical 

Research Council of Canada, Natural Sciences and Engineering Research 

Council of Canada 

� Vice Chair of Joint Awards Review Committee, American Association for the 

Study of Liver Diseases and American Liver Foundation 

� Ad hoc Reviewer for the following selected Journals: American Journal of 

Medicine, American Journal of Physiology, American Journal of Transplantation, 

British Journal of Pharmacology, Gastroenterology, Hepatology, Journal of 

Biological Chemistry, Journal of Cellular Physiology, Journal of Clinical 

Investigation, Journal of Critical Illness, Journal of Hepatology, Journal of 

Membrane Biology, Journal of Physiology, Molecular and Cellular Biochemistry, 

Molecular and Cellular Biology, Pediatrics, Nature Medicine, New England 

Journal of Medicine, Proceedings of the National Academy of Sciences, U.S.A. 


� Associate Editor, Autonomic Neuroscience: Basic & Clinical 

� Associate Editor, Frontiers in Enteric Neuroscience 

� Editorial Board Member, American Journal of Physiology: Gastrointestinal and 

Liver Physiology 

� Editorial Board Member, Neurogastroenterology and Motility 

64

� Editorial Board Member, Frontiers in Autonomic Neuroscience 

� Editorial Board Member, Frontiers in Gastrointestinal Sciences 


� Editorial Board Member, The Journal of Clinical Gastroenterology (Yale) 

� Editorial Board Member, The World Journal of Gastroenterology (China) 

� Reviewer, The American Journal of Gastroenterology 

� Reviewer, Gastroenterology 

� Reviewer, Alimentary Pharmacology 

� Reviewer, Neurogastroenterology and Motility 

� Grant Reviewer, Study Section of the NIH at the National Institute of Biomedical 

Imaging and Bioengineering (NIBIB) 


� Editor, Zootaxa (Protozoa) 

� Associate Editor, Current Microbiology 

� Editorial Board Member, Microbial Ecology 

� Editorial Board Member, Journal of Camelid Science 

� Editorial Board Member, Journal of Eukaryotic Microbiology 



� Member, NIH ZRG1 DKUS E10 Study Section 


� Advisory Board, The International Foundation for Functional Gastrointestinal 

Disorders 


� FDA Advisory Committee for Anti-Viral Drugs 


� USDA 

� NSF 



� Apokeronopsis wrighti n.sp., a new species named after Dr. Wright in recognition 

of his contributions to the phylogenetics and evolution in ciliates (see J. Eukaryot. 

Microbiol.) 


Eric Ganguly, MD 

� A Multicenter National Prospective Study of Pregnancy and Neonatal 

Outcomes in Women with Inflammatory Bowel Disease 

� HALO Patient Registry: Ablation of Barrett’s Esophagus 

65

Kunal Gupta, MD 

� Analysis of Methanogenic Microorganisms in Stool Compared to Exhaled Breath 

Methane Concentration in Humans 


� NIH/NIDDK R01 DK56644 

Mechanisms of Cell Volume Regulation in Liver 

� A Randomized Trial of Telaprevir, Peginterferon, and Ribavirin versus 

Peginterferon and Ribavirin for Treatment of Genotype 1 Hepatitis C Virus with 

Host Interleukin 28B CC Polymorphism 


� NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 

“Neuronal Excitability and Motility in Colitis” 

� NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 

“Neural Control of the Gallbladder” 


� A Phase II Randomized, Placebo-Controlled, Double-Blind, Dose Ranging Study 

to Assess the Immunogenicity and Safety of a Clostridium Difficile Toxoid 

Vaccine (ACAM-CDIFF) in Subjects with Clostridium Difficile Infection 

(CDI) 


� Treatment of Eosinophilic Esophagitis with High-Dose Proton Pump Inhibition 

and Swallowed Fluticasone 

James Vecchio, MD 

� Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial 

Comparing REMICADE® (infliximab) and Placebo in the Prevention of 

Recurrence in Crohn’s Disease Patients Undergoing Surgical Resection Who Are 

at an Increased Risk of Recurrence (PREVENT) 

� SECURE / A Non-Interventional Long-term Post-Marketing Registry of Patients 

Treated with Certolizumab Pegol (Cimzia ® ) for Crohn’s Disease 


� Vermont Agency of Agriculture 

� Vermont Dairy Center of Excellence 

Richard Zubarik, MD 

� Can Endoscopic Ultrasound (EUS) Stigmata of Chronic Pancreatitis Predict the 

Response to Pancreatic Enzymes 

� International Registry for Intraductal Papillary Mucinous Neoplasms 

66

� Prospective Study of Bacteremia and the Infection Rates Following 

Cholangioscopy with the Spyglass Cholangioscope 


Kuntz WB, Ferrentino N, Strader DB, Lidofsky SD. Vitamin D status and extrahepatic 

symptoms in chronic hepatitis C (submitted). 

Ganguly EK, Najarian KE, Vecchio JA, Moses PL. Endoscopic occlusion of cystic duct 

using N-butyl cyanoacrylate for postoperative bile leakage. Dig Endosc. 2010 

Oct;22(4):348-50. 

Costedio MM, Coates MD, Brooks EM, Glass LM, Ganguly EK, Blaszyk H, Ciolino AL, 

Wood MJ, Strader D, Hyman NH, Moses PL, Mawe GM. Mucosal serotonin signaling is 

altered in chronic constipation but not in opiate-induced constipation. Am J 

Gastroenterol. 2010. 105(5):1173-80. 

Parikh A, Gupta K, Wilson AC, Fields K, Cosgrove NM, Kostis JB. The effectiveness of 

outpatient appointment reminder systems in reducing no-show rates. Am J Med. 

123(6):542-8. 

Lidofsky SD. 2010. Jaundice. In Feldman M, Friedman LS, Brandt LJ. (eds.) Sleisenger 

and Fordtran’s Gastrointestinal and Liver Disease, 9 th ed., pp. 323-335. 

Barfod ET, Moore AL, Van de Graaf BG, Lidfosky SD. Myosin light chain kinase and 

Src control membrane dynamics in volume recovery from cell swelling. Mol Biol Cell 

22:634-650. 

Lavoie B, Balemba C, Godfrey C, Watson G, Vassileva C, Corvera C, Nelson MT, Mawe 

GM. Bile acid receptor GPBAR1 stimulation decreases gallbladder smooth muscle 

activity by activating KATP channels. Journal of Physiology, 588:3295-3305. 

Accompanied by a Perspective’s article in the same issue. Chosen as an “Editor’s 

Choice” article for that issue. 

Wood MJ, Hyman N, Mawe GM. The Effects of Dia-kenchu-to (DKT) on Propulsive 

Motility in the Colon. Journal of Surgical Research. 164:84-90. 

Balemba OB, Bhhattarai Y, Stenkamp-Strahm C, Lesakit MSB, Mawe GM. The 

traditional anti-diarrheal remedy, Garcinia buchananii stem bark extract, inhibits 

propulsive motility and fast synaptic potentials in the guinea pig distal colon. 

Neurogastroenterology and Motility. 22:1332-1339. 

Faure C, Patey N, Gauthier C, Brooks EM, Mawe GM. Serotonin signaling is altered in 

irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age 

patients. Gastroenterology. 139:249-258. 

67

Hoffman JM, McKnight ND, Sharkey KA, Mawe GM. The relationship between 

inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig 

distal colon. Neurogastroenterology and Motility. In press. 

D’Autreaux F, Margolis KG, Roberts J, Li Z, Karamooz N, Stevanovic K, Ahuja A, 

Mawe GM, Morikawa Y, Cserjesi P, Setlick W, Gershon MD. Levels of Hand2 

expression influence the specification of enteric neurons and function of the gut. 

Gastroenterology. In press. 

Hons IM, Storr MA, Mackie K, Lutz B, Pittman QJ, Mawe GM, Sharkey KA. Plasticity 

of mouse enteric synapses mediated through retrograde endocannabinoid and purinergic 

signaling. Submitted. 

Mawe GM, Lavoie B, Nelson MT, Pozo MJ. Neuromuscular Function in the Gallbladder 

and Sphincter of Oddi. In Physiology of the Gastrointestinal Tract, 4 th edition. LR 

Johnson, ed., Elsevier. Submitted/In press. 

Strader DB. Chapter 26 in Zakim & Boyers ‘Textbook of Hepatology’ 6 th Edition: 

Hepatotoxicity of Herbal Preparations. In press. 

King EE, Smith RP, St-Pierre B, Wright ADG. Differences in the rumen methanogen 

population exist between Jerseys and Holsteins dairy cows in Vermont. Appl. Environ. 

Microb. (Accepted) 

Hook SE, Steele MA, Northwood KS, Wright ADG, McBride BW. Impact of highconcentrate 

feeding and low ruminal pH on methanogens and protozoa in the rumen of 

dairy cows. Microbial Ecol. (Accepted) 

Wright ADG, Klieve AK. Does the complexity of the rumen microbial ecology preclude 

methane mitigation? Animal Feed Sci. Technol. (In press) 

Hook SE, Wright ADG, McBride B. Methanogens: methane producers of the rumen and 

mitigation strategies. Archaea 2010: 1-11. 

Glad T, Kristiansen VF, Nielsen KM, Brusetti L, Wright ADG, Sundset MA. Ecological 

characterization of the colonic microbiota in arctic and sub-arctic seals. Microb. Ecol. 

60:320-330. 

Grainger C, Williams R, Clarke T, Wright ADG, Eckard RJ. Supplementation with whole 

cottonseed causes long-term reduction of methane emissions from lactating dairy cows 

offered a forage and cereal grain diet. J Dairy Sci. 93:2612-2619. 

Tabatabaei M, Rahim RA, Abdullah N, Wright ADG, Shirai Y, Sakai K, Sulaiman A, 

Hassan MA. Methanogens: the success of anaerobic treatment of wastewaters. Process 

Biochem. 45:1214-1225. 

68

Tabatabaei M, Zakaria MR, Rahim RA, Abdullah N, Wright ADG, Shirai Y, Shamsara 

M, Sakai K, Al Hassan M. Comparative study of methods for extraction and purification 

of environmental DNA from high-strength wastewater sludge. African J. Biotechnol. 

9:4926-4937. 

Zubarik RS. Screening for Pancreatic Cancer in a High Risk Population with Serum CA 

19-9 and Targeted Endoscopic Ultrasound: A Feasibility Study. Gastrointestinal 

Endoscopy. (In press) 

69

Division of General Medicine Research 

Benjamin Littenberg, MD, Director 

http://www.med.uvm.edu/medicine/gim 

The division consists of seven faculty, two faculty fellows on loan from 

other departments, and two PhD students in the Clinical and 

Translational Science Program. Four physician faculty members 

practice in the Fletcher Allen Primary Care Internal Medicine Group 

and one serves as the Medical Director for the Division of Vermont 

Health Access (Medicaid). The division is largely responsible for the 

education programs of the Center for Clinical and Translational Science 

and includes the Director, two Associate Directors and many of the core 

faculty from the PhD, Masters, and graduate certificate programs in CTS. Our faculty 

also contains the Associate Dean for Primary Care and the Associate Director of 

Ambulatory Education for the Internal Medicine Residency. 

The research activities of the division include: investigations into the role of information 

systems in improving quality of care, patient safety in the use of pharmaceuticals in the 

outpatient setting, the role of compassion in the medical encounter, the epidemiology of 

narcotic abuse and the management of chronic pain, the use of the medical record to 

develop new insights in pathophysiology and epidemiology, and the role of the built 

environment in determining health, including obesity and incidents of cancer. The 

division’s research is funded by grants from NIH, the State of Vermont, AHRQ, and 

Fletcher Allen. The total amount in the current fiscal year is $1,841,474. 

Fellows include: 

Connie van Eeghen, MHSA, MBA, Lecturer, College of Nursing and Health Sciences 

Rodger Kessler, PhD, Research Assistant Professor of Family Medicine 

Benjamin Littenberg, MD 

Professor of Medicine and Nursing 

Director, General Internal Medicine 

� Methodologies for Technology Assessment 

Clinical trials; Meta-analysis of diagnostic test assessments; Instruments to 

assess patients' preferences 

� Clinical Technology Assessment 

Common problems in Primary Care; Diagnostic tests; Decision support 

systems Informatics 

� Public health surveillance for chronic disease; Value-added laboratory 

reporting; Patient registries 

� Quality Improvement and Patient Safety 

Breast cancer; Diabetes; Cardiovascular Risk; Medical error; Outpatient 

prescriptions, chronic kidney disease 

71

E. Graduate Students, post-doctoral Fellows, MD/PhD Students 

� Rodger Kessler, PhD 

� Connie van Eeghen 

� Kairn Kelley 

� Rhonda Kost 

F. Endowed Professorships 

� Henry and Carleen Tufo Professor of Medicine 

K. Grants 

� A Curriculum for Clinical Research Training in Vermont 

2K30 RR022260 (Benjamin Littenberg) 6/1/05 - 5/30/13 Program 

Director 

National Center for Research Resources (NCRR) $873,762 total 

This grant supports developing a curriculum in clinical research at the University of 

Vermont to effectively and efficiently transform clinicians and other young academics 

into successful independent clinical investigators. 

� Collaborative National Network Examining Comparative Effectiveness Trials 

(CONNECT) 

1R24 HS019462 (PI: Benjamin Miller, PsyD) 8/1/2010 - 7/31/12 Consultant 

Agency for Health Research and Quality (AHRQ) $963,121 

total 

This project establishes a national network of primary care patient centered medical 

homes with integrated behavioral and psychological services. The goal is to determine 

the determinants of high quality care in such settings. 

L. Publications 

� Johnson AJ, Chen MYM, Zapadka ME, Lyders EM, Littenberg B. Radiology 

report clarity: a cohort study of structured reporting compared with 

conventional dictation. J Am Coll Radiol 2010; 7:501-506. 

� Witherby S, Johnson J, Demers L, Mount S, Littenberg B, MacLean CD, 

Wood M, Muss H. Topical Testosterone for Breast Cancer Patients with 

Vaginal Atrophy Related to Aromatase Inhibitors: A Phase I/II Study. 

Oncologist 2011; 16:424-431. PMID: 21385795 

� Sinclair N, Littenberg B, Geller B, Muss H. Accuracy of Screening 

Mammograms in Older Women. AJR - Am J Roentgenology 2011; (In press). 

Elizabeth S. Chen, PhD 

Assistant Professor 

Associate Director of Biomedical Informatics, Center for Clinical and Translational 

Science 

Assistant Professor, Computer Science 

72

� Biomedical Informatics, electronic health records, clinical decision support, 

clinical data mining, natural language processing 

G. Leadership in Professional Societies 

� Member, Meetings Committee, American Medical Informatics 

� Member, Education Committee, AMIA 

� Member, Scientific Program Committee, AMIA 2011 Summit on Clinical 

Research Informatics 

� Primary UVM Representative, AMIA Academic Forum 

� Member, Program Committee (Health Informatics Track), IEEE Conference 

on Healthcare Informatics, Imaging, and Systems Biology 

K. Grants 

� 2K30 RR022260 (Benjamin Littenberg) 6/1/05 - 5/30/13 Faculty 

National Center for Research Resources (NCRR) $873,762 

A Curriculum for Clinical Research Training in Vermont 

This grant supports developing a curriculum in clinical research at the 

University of Vermont to effectively and efficiently transform clinicians and other 

young academics 


� Wright A, Chen ES, Maloney FL. An Automated technique for identifying 

associations between medications, laboratory results and problems. J Biomed 

Inform. 2010 Dec;43(6):891-901. 

� Chen ES, Melton GB, Engelstad M, Sarkar IN. Standardizing clinical 

document names using the HL7/LOINC Document Ontology and LOINC 

codes. AMIA Annual Symp Proc. 2010:101-5. 

� Chen ES, Sarkar IN. Towards structuring unstructured GenBank metadata for 

enhancing comparative biological studies. AMIA Summits Transl Sci Proc. 

2011-6-10. 

Amanda G. Kennedy, PharmD 

Assistant Professor of Medicine (Research Track) 

� Patient and Medication Safety 

� Pharmacoepidemiology 

� Health Services Research 

� Academic Detailing 

E. Graduate Students, post-doctoral Fellows, MD/PhD Students 

� Helen Smith 

� Jennifer Libous 

� Sarah Gillett 

� Kristi Johnson 

73

� Sarah Bryce 

� Abigail Crocker 

I. Study Sections 

� Health Care Technology and Decision Science, October 27-28, 2010 

� Health Care Technology and Decision Science, June 23-24, 2011 

J. Major Awards 

� Pharmacist of the Year, Vermont Society of Health-System Pharmacists 

K. Grants 

(Kennedy) 7/1/10-6/30/11 Principal 

Investigator 

Vermont Department of Health $200,000 

The Vermont Academic Detailing Program 

This program develops and delivers Academic Detailing to providers and 

practices in Vermont. 

2K30 RR022260 (Benjamin Littenberg) 6/1/05 - 5/30/13 Faculty 

National Center for Research Resources (NCRR) $873,762 

A Curriculum for Clinical Research Training in Vermont 

This grant supports developing a curriculum in clinical research at the University 

of Vermont to effectively and efficiently transform clinicians and other young academics 


L.Publications 

� Pinckney RG, Helminski AS, Kennedy AG, Maclean CD, Hurowitz L, Cote E. 

The Effect of Medication Samples on Self-Reported Prescribing Practices: A 

Statewide, Cross-Sectional Survey. J Gen Intern Med 2010 Aug 31. PMID: 

20809157. 

� Kennedy AG, Littenberg B, Callas PW, Carney JK. Evaluation of a modified 

prescription form to address prescribing errors. Am J Health Syst Pharm. 

2011;68:151-157. 

Charles D. MacLean, MD 


Associate Dean for Primary Care 

Research Director, Area Health Education Center 

74

D. NPs and Pas 

� Sarah Bushweller, PA 

G. Leadership in Professional Societies 

� Fellow, American College of Physicians 

K. Grants 

� NIAAA 1R01AA018658-01A1 (Rose) 10%(Co-I) 7/1/10-6/30/15 

National Institute of Alcohol $606,918 (annual) 

Automated Alcohol Screening and Brief Intervention in Primary Care using IVR 

This grant is a randomized controlled trial of alcohol screening and brief 

intervention (SBI) administered using a telephone-based Interactive Voice 

Response (IVR) system. 

� HHSH P50HP 20996 -01-01 (MacLean) 10% (PI) 10/1/10-9/30/11 

Health Resources and Services Administration $131,000 

Planning Vermont’s Healthcare Workforce Future 

This planning grant assembles a wide array of stakeholders including the 

Vermont DOL and Workforce Investment Board to plan for healthcare workforce 

needs. 

� HHSH 2502009000510 (MacLean) 10% (PI) 10/1/09-8/31/12 

Health Resources and Services Administration $730,316 

The Vermont Student/Resident Experiences and Rotations in Community 

Health Program (Vermont SEARCH). This program develops and promotes 

primary care experiences in federally qualified health centers. 

� Vermont Department of Health (Kennedy) 5% (Co-I) 7/1/10-6/30/11 

The Vermont Academic Detailing Program $200,000 

This program develops and delivers Academic Detailing to providers and 

practices in Vermont. 

� U77 HP03624 (MacLean) 10% (PI) 9/1/10-8/31/12 

Health Resources and Services Administration $1,435,616 total 

Model State Supported Area Health Education Centers 

The Vermont AHEC Program is a statewide network of community and 

academic partners working together through three AHEC centers and a Program 

Office to improve the health of Vermonters. Through community-based 

initiatives, Vermont AHEC works to promote rural health educational 

opportunities and address health care workforce challenges unique to specific 

areas of the state. 



Director 

75


This grant supports developing a curriculum in clinical research at the University 

of Vermont to effectively and efficiently transform clinicians and other young 

academics into successful independent clinical investigators. 


� Rose G, MacLean CD, Skelly J, Badger GJ, Ferraro TA, Helzer JE. Interactive 

Voice Response Technology Can Deliver Alcohol Screening and Brief 

Intervention in Primary Care. J Gen Int Med 2010;25(4):340-4. 

� Khan S, MacLean CD, Littenberg B. The Effect of the Vermont Diabetes 

Information System on Inpatient and Emergency Department Use: Results from a 

Randomized Trial. Health Outcomes Research in Medicine 2010; Jul;1(1):e61e66. 

� Pinckney R, Helminski AS, Kennedy A, MacLean CD, Hurowitz L, Cote E. “The 

effect of medication samples on self-reported prescribing practices: a statewide, 

cross-sectional survey”. JGIM 2011; 26(1): 40-4. 

� Rose G, Skelly J, Badger GJ, MacLean CD, Malgeri M, Helzer J. Automated 

Screening for At-Risk Drinking in a Primary Care Office Using IVR. J Studies 

Alcohol and Drugs 2010; 71: 734-8. 

Richard G. Pinckney, MD, MPH 


K. Grants 

� Title: A compassion training program for clinicians 

Role: Principal investigator 

Source: Frymoyer Scholarship 

Dates: 09/01/09 – 08/31/11 



Director 





L.Publications 

� Pinckney RG, Helminski AS, Kennedy AG, Maclean CD, Hurowitz L, Cote E. 

The effect of medication samples on self-reported prescribing practices: a 

statewide, cross-sectional survey 

JGIM. 2011;26:40-44. 

76

� Khan S, Pinckney RG, Keeney D, Frankowski B, Carney JK. Prevalence of Food 

Insecurity and Utilization of Food Assistance Program: An Exploratory Survey of 

One Vermont Middle School. J Sch Health 2011;81:15-20. 

Alan S. Rubin, MD 

Research Associate Professor of Medicine and Psychiatry 

E. Graduate Students, post-doctoral fellows, MD/PhD 

� Tim Tourville 

� Peter Durda 

� William Tharp 

� Carole McBride 

K. Grants 



Director 





77

Division of Gerontology 

Naomi K. Fukagawa, MD PhD 

Acting Director, Gerontology 

http://www.med.uvm.edu/medicine/gerontology 

Service: Not applicable 

Education – Department of Medicine Research Seminar Series 

Research – Recent research focus is on the impact of air pollution on health, comparing 

the effects of emissions from petrodiesel and biodiesel combustion. Work is being done 

in collaboration with the U.S. Environmental Protection Agency in Research Triangle 

Park, NC. In addition, research in human volunteers continues and focuses on the effect 

of beta-alanine supplementation on exercise endurance. 

Faculty 

Naomi K. Fukagawa, MD PhD 


Acting Director, Gerontology 

� Health Effects of Petro- and Biodiesel Exhaust 

� Protein/Amino Acid and Energy Metabolism 

� Oxidative Stress in Aging and Disease 

� Metabolic Regulation 

Muyao Li, PhD 

Research Associate 

� Human genetic diseases 

� Gene structure, Function and Mutation, Gene Expression Profile 

� Basic cell and molecular mechanisms in human diseases associated with advanced 

age and obesity 

� Mechanisms for toxicity of pathogenic particles 


Nutrition Reviews (2010 Impact Factor 4.077) – Editor in Chief 

American Journal of Clinical Nutrition (2010 Impact Factor 6.606) - Associate Editor 

Journal of Nutritional Biochemistry (2010 Impact Factor 4.538) – Editorial Board 

79


NIDDK Training Grant (T32) Review 

Vice-Chair, 2010 USDA/HHS Dietary Guidelines Advisory Committee 

International: Member of External Review Committee for the Singapore Institute for 

Clinical Sciences Grant Call, Singapore 

Foundation for Polish Science, Warsaw Poland 


NIEHS 1 RC1 ES018053-01 (Fukagawa, PI) 

12/1/2009 – 8/31/2012 

NIH/AARA Mechanisms for Cardiovascular Effects of Air Pollutants: Effect of Age 

and Sex 

The goal is to determine the mechanisms responsible for the effects of petrodiesel and 

biodiesel exhaust emissions on cardiovascular disease. Annual Direct Cost $330,256 

NIH NCRR M01 RR00109 (R.Morin, PI) 12/01/2006– 02/28/2011 

General Clinical Research Center 

The major goal of this project is to create and sustain specialized institutional resources in 

which clinical investigators can observe and study human physiology as well as treat 

disease with innovative approaches. Dr. Fukagawa is the Associate Director (salary 

only). Annual Direct Cost $2,097,086 

Ajinomoto Amino Acids Research Program (Fukagawa, PI) 10/01/2009 – 09/31/2012 

Synergistic Effects of the Branched Chain Amino Acids and Camosine Precursors on 

Exercise-induced Muscle Damage and Performance in Humans 

The goal is to determine the effects of amino acid supplementation on exercise 

performance. Annual Direct Cost $50,000 

NIH NIEHS R03ES017860-01 (Fukagawa, PI) 

Tlp2/COT Regulation of ERK1/2 and NF-kB in Response to Particulates 01/01/2010- 

12/31/2012 

The goal is to determine whether Tlp2/COT is the upstream signal for ERK1/2 and NFkB 

activation as a component of cellular responses to exposure to particles generated by 

combustion of petrodiesel or biodiesel fuels. Annual Direct Cost $45,000 

NIH NIDDK R01DK082803-01 (Kien, PI) 

Palmitate Metabolism and Insulin Resistance 12/01/2009-11/30/2014 

The goal is to determine the mechanisms through which palmitate metabolism influences 

insulin resistance in human volunteers. (Role-Co-investigator) Annual Direct Cost 

$427,731 

80


1. Kien CL, Everingham KI, Stevens R, Fukagawa NK, Muoio DM. Short-term effects of 

dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human 

subjects. Obesity 2010 June 17 [Epub ahead of print] PMID: 20559306. 2011. 19(2): 

305-311. 

2. Hillegass JM, Shukla A, Lathrop SA, MacPherson MB, Fukagawa NK, Mossman BT. 

Assessing nanotoxicity in cells in vitro. Wiley Interdiscip Rev Nanomed 

Nanobiotechnol. 2010 May-Jun;2(3):219-31. Review. PMID: 20063369 

3. Shukla A, Barrett TF, Macpherson MB, Hillegass JM, Fukagawa NK, Swain WA, 

O'Byrne KJ, Testa JR, Pass HI, Faux SP, Mossman BT. An ERK2 Survival Pathway 

Mediates Resistance of Human Mesothelioma Cells to Asbestos-Induced Injury. Am J 

Respir Cell Mol Biol. 2011 Mar 31. [Epub ahead of print] PMID: 21454801 

4. Li M, Fukagawa NK. Age-related changes in redox signaling and VSMC function. 

Antioxidants & Redox Signaling. 2010 Mar 1; 12(5): 641-655. 

5. Below JE, Cox NJ, Fukagawa NK, Hirvonen A, Testa JR. Factors that impact 

susceptibility to fiber-induced health effects. J Toxicol Environ Health B Crit Rev. 

2011;14(1-4):246-66. PMID: 21534090 

81

Division of Hematology/Oncology 

Claire Verschraegen, MD, Director 

http://www.med.uvm.edu/medicine/hemonc 

Executive Summary 

This is a combined hematology and oncology division with 16 full and 

part time and emeritus faculty, 6 fellows, 5 post doctoral fellows, 5 

midlevel providers, 15 nurses and 20 staff. The group has embodied the 

mission of the COM and FAHC with high quality of care, cutting edge 

research and dedication to all aspects of teaching. 

Clinical efforts for 2010/11 include a heavy clinical load with 23,532 

outpatient visits (including 1,173 new patients) and 5,014 inpatient visits for a total of 

32,805 RVU’s. Services offered include multidisciplinary clinics where at a single visit 

patients may be seen by a number of oncologic or specialty providers. Establilshed MDC 

clinics exist for breast, upper GI, ENT, lung cancer and melanoma. In 2010/11 385 new 

patients were seen through the MDC clinics and the ENT MDC clinic was established 

with Steven Grunberg, M.D. as the leader. Site specific tumor boards exist for patients 

with the above cancers as well as lower GI, GU, brain tumors, sarcomas, leukemia’s and 

lymphomas. Our specialty services also include a hemophilia and thrombosis center, a 

familial cancer and high risk breast programs. Activities of the cancer patient support 

program (CPSP) provide nutrition, psychological and social work support to any patient 

in Vermont in need of these services. 

Research within the division is done in several ways (clinical trials, basic science 

research and epidemiology) covering a number of broad themes (cancer treatment and 

prevention, supportive care of cancer patients and cancer and coagulation). Faculty in the 

hematology/oncology division are principal investigators for the majority of the over 300 

cancer related studies at the University of Vermont, with 60% of these studies being 

investigator initiated. Approximately 1,000 cancer patients are put on clinical trials 

annually with about 3/4 th being accrued to medical oncology studies. Approximately 7% 

of patients are enrolled on clinical trials at FAHC which is higher than the 6% national 

average. Available trials include Phase I-III treatment trials, supportive care and 

translational studies, with the majority of the later (supportive care and translational 

studies) being investigator initiated. Investigators within the division receive funding 

from clinical trials (cooperative group and pharmaceutical trials), NIH (NCI, NHLBI), 

ACS, and private groups (LCCRO, etc.) for research funds for 2010/11 being 2,285,106. 

The faculty in the hematology/oncology division support the education mission in many 

ways. They teach medical students both in classroom sessions and small group settings 

for the ICDM, attacks and defenses and generation courses. Faculty also teach 3 rd and 4 th 

year students on the inpatient hematology/oncology team either as the teaching attending 

or giving didactic lectures. Faculty often lecture medical and other specialty residents 

and fellows. The Hematology/Oncology fellowship is quite strong having recently been 

credentialed for 5 years by the ACGME. The fellowship accepts 2 fellows per year for a 

83

3 year fellowship. All fellows are expected to sit for both hematology and oncology 

boards with all fellows in the past 12 years passing. Graduating fellows pursue careers in 

academic medicine and join private practices. Our 2011 graduates are both pursuing 

academic careers. 

Faculty in hematology/oncology provide a great amount of service to the local (UVM) 

and national communities. They serve on a number of important local committees 

including DOM operations and research committees, P&T committee, IRB and PRC. 

Several faculty serve in leadership roles for a number of hematology and oncology 

related societies including ASCO, ATS, ASH, MAASC, NEECOS. 

In 2011 Dr. Claire Verschraegen joined our faculty as the permanent division chief and 

clinical director of the VCC. Under her leadership all cancer services will be unified 

under the VCC and the FAHC Cancer Service line to optimally serve the cancer 

population and the people of Vermont at risk for cancer. Her strategic vision will 

encompass all aspects of basic and clinical cancer research, delivery of cancer treatment 

and services, and cancer prevention into an integrated enterprise that will help UVM 

apply for new NCI Cancer Center Designation. 

Faculty 

Steven Ades, M.D. 


� Associate Director, Hematology/Oncology Fellowship Program 

� Leader, Fletcher Allen Health Care GI Multidisciplinary Clinic 

� Research interests include: GI and GU cancers & thrombosis 

Richard F. Branda, M.D. 

Emeritis Faculty 

� Medical School Admissions Committee 

� Advisor for Hematology/Oncology Fellowship 

Mary Cushman, M.D., MSc 

Professor of Medicine and Pathology 

� Director, Thrombosis and Hemostasis Program 

� Research interests include: Etiology of vascular disease and other chronic 

diseases. Care of Patients with venous thrombosis and related disorders. 

Epidemiology of venous thrombosis atherosclerotic diseases. Venous thrombosis 

and post-thrombotic syndrome 

Kim Dittus, M.D. 


� Research interests include: Cancer survivorship, energy balance 

Steven Emmons, M.D. 

� Assistant Professor of Medicine 

84

� Leader, Fletcher Allen health Care Melanoma Multidisciplinary Clinic 

� Research interests include: CNS cancer and melanoma 

Barbara Grant, M.D. 


� Director, Stem Cell Program 

� Research interests include: Lymphoma 

Marc Greenblatt, M.D. 


� Research interests include: Molecular genetics of mutation in cancer genes, and 

gastrointestinal cancers 

Steven Grunberg, M.D. 

Professor of Medicine and Pharmacology 

� Leader, Fletcher Allen Health Care ENT Tumor Multidisciplinary Clinic 

� Research interests include: Lung cancer, head and neck tumors, antiemetics 

Chris E. Holmes, M.D., PhD 


� Director, Vermont Hemophilia Treatment Center 

� Assistant Director, Thrombosis and Hemostasis Program 

� Research interests include: Venous thrombosis, post-thrombotic syndrome 

and platelet function 

Farrah Khan, M.D. 

Attending Physician 

Patricia O’Brien, M.D. 


� Director, Lymphedema Program 

Julie Olin, M.D. 

Attending Physician 

Julian Sprague, M.D. 


� Director, Hematology/Oncology Fellowship Program 

Research interests include: Leukemia and neurotoxicity 

Claire F. Verschraegen, M.D. 

Professor of Internal Medicine 

� Director, Hematology/Oncology Unit 

Marie E. Wood, M.D. 


� Director, Familial Cancer Program 

85

� Research interests include: Molecular markers of breast cancer risk, attitudes of 

primary care physicians regarding cancer genetics, breast cancer screening and 

prevention 

Neil Zakai, M.D., MSc 


� Research interests include: Epidemiology and novel risk factors of venous 

thrombosis and cardiovascular disease. Epidemiology, causes, and consequences 

of anemia in diverse populations. Venous thrombosis causes and prevention, post 

thrombotic syndrome 

Fellows 

N. Brad Adams, M.D. – third year fellow 

Deb Abrams, M.D. – third year fellow 

Nadia Bambace, M.D., - third year fellow (completing fellowship 8/30/2011) 

M. Mansoor Alam, M.D. – second year fellow 

Edress Othman, M.D. – second year fellow 

John Winters, M.D. – first year fellow 

Julia Moukharskaya, M.D. – first year fellow 

NP’s and PA’s 

Penelope Gibson, PA 

Jamie Kelly, PA 

Paul Larson, NP 

Janet Ely, NP 

Steve Rolleri, NP 

Graduate students, post-doctoral fellows, MD PhD students 

Marissa Engbers, M.D. (Leiden University) – PhD student 

– Mary Cushman, M.D., M.Sc 

Locke Bryan, M.D. – Postdoctoral fellow – Mary Cushman, M.D., M.Sc 

Irina Arkipova-Jenkins (University of Vermont) - Medical Student 

- Neil Zakai, M.D., MSc 

Catherine Mygatt (University of Vermont) – Medical Student 

- Neil Zakai, M.D., MSc 

Sarah Gillett (University of Vermont) MD., PhD candidate 

- Mary Cushman, M.D., MSc 

Leadership in Professional Societies 

Mary Cushman, M.D., MSc - faculty 

Chair, Subcommittee on Quality, American Society of Hematology. 

Chair, Nominating Committee, American Heart Association Council on 

Epidemiology and Prevention 

Leadership Cabinet, Leadership Committee and Immediate Past Chair, American 

Heart Association Council on Epidemiology and Prevention 

86

Panel Member, American College of Chest Physicians Evidence-Based Clinical 

Practice Guidelines on Antithrombotic Therapy (9 th Edition) 

Member, Scientific Committee on Thrombosis and Vascular Biology, American 

Soceity of Hematology 

Member, Council Operations Committee, American Health Association 

Marc S. Greenblatt, M.D. – faculty 

Co-Chair, Working Group on Assessment of Pathogenicity, Collaborative Group 

of the Americas on Inherited Colorectal Cancer (CGA-ICC) 

Chair, Panel Discussion, "Implementing IHC and MSI Testing on Incident 

Colorectal Cancers", 2010 Annual Meeting of CGA-ICC 

Interim Scientific Advisory Council, Human Variome Project 

Council Member, Human Genome Variation Society (HGVS) 

Co-Chair, Organizing Committee, 2010 Annual Meeting of HGVS 

International Society for Gastrointestinal Hereditary Tumors (InSiGHT), 

Interpretation Committee, and Moderator of Basic Science Paper Session, 2011 

InSIGHT Meeting 

Steven Grunberg, M.D. – faculty 

President- Elect/Board of Directors – Multinational Association of Supportive 

Care in Cancer 

Immediate Past President/Board of Directors – Northern New England Clinical 

Oncology Society (NNECOS) 

Chris E. Holmes, M.D., PhD – faculty 

Member, Platelet Scientific Subcommittee, American Society of Hematology 

Council Member, American College of Physicians, Vermont Chapter 

Patricia O’Brien, M.D. – faculty 

Vermont Lymphedema Network – continue to serve as an advisor for state board 

and to assist with educational events in this area of professional education 

Marie E. Wood, M.D. – faculty 

Appointed member: ASCO Integrated Technology and Media Committee (July 

2010 -- June 2013) 

Vice Chair: CALGB Prevention Subcommittee (ongoing) 

Appointed member: ASCO Prevention Committee (6/2009 - 6/2012) 

Appointed member: ASCO Annual Meeting Program committee (2008 -- 2011) 

Editorships and Editorial Boards 


Senior Guest Editor, Circulation. 

87

Associate Editor, Journal of Thrombosis and Haemostasis, the Journal of the 

International Society on Thrombosis and Haemostasis 

Co-Editor, Prevention Series, Circulation. 

Editorial Board, Clinical and Translational Science 

Editorial Board, Archives of Internal Medicine 

Editorial Board, Thrombosis and Thrombolysis 

Marc S. Greenblatt, M.D. 

Communicating Editor, Human Mutation 


Proceedings Editor, American Society of Clinical Oncology (10-year term 

ended November 2010) 


Guest Editor – Circulation 2011 

Abstract Reviewer: 

2011 American Heart Association Council on Epidemiology and 

Prevention, Atlanta, GA 

2011 International Society on Thrombosis and Haemostasis Congress, 

Kyoto, Japan 

Study Sections and Federal Advisory Boards 


Chartered Member, NIH Cardiovascular and Sleep Epidemiology Study Section 

(Chair, Veronique Roger, MD). 


Ad hoc member, National Cancer Institute Initial Review Group Subcommittee 

G-Education 

Chair, National Cancer Institute Special Emphasis Panel – R25 Grants 

Member, National Cancer Institute Symptom Management and Quality of Life 

Committee Drug Development Task Force 

Marie E. Wood, M.D. - Invited Reviewer: PAR 10-283 “Core Infrastructure and 

Methodological Research for Cancer Epidemiology 

Cohorts” July 2011. 

- Invited Reviewer: RFA CA-10-006 “Transdisciplinary 

Research in Energetics and Cancer (TREC)”. July 2010 


Ad hoc reviewer National Institutes of Health NINDS NSD-K 

March 3, 2010; June 21 st , 2010, March 10-11, 2011 

Major faculty awards 


Crystal Heart Award. American Heart Association Vermont. For volunteer 

service. 

Finalist, Senior Researcher of the Year. Fletcher Allen Health Care 

88


Finalist, Junior Researcher of the Year, Department of Medicine, UFAHC 

Grants – list all active grants by faculty member, PI 

Steven Ades, M.D. 

S Ades, PI, - “Impact of Rosuvastatin on Risk Markers of Venous 

Thromboembolism During Systemic Therapy for Advanced Cancer” 

UVM Hematology/Oncology Research Pilot Project 

Funding – 4/1/2011 – 4/1/2013 

Year 1 - $46,944 

Year 1 - $43,109 

Matching funds from DOM 


M Cushman, Co-I. Multiethnic Study of Atherosclerosis: Special Laboratory 

Center, N01HC95166. 

M Cushman, Subcontract PI. Etiology of Geographic and Racial Differences in 

Stroke Mortality, U01 NS041588 

M Cushman, Subcontract PI. Epidemiology of Venous Thrombosis and 

Pulmonary Embolism, R01 HL59367 

M Cushman, Subcontract PI. The Incidence and Progression of Peripheral Venous 

Disease, R01 HL084229 

M Cushman, Subcontract PI. Aging, abdominal fat, inflammation and 

cardiovascular disease, R01 HL088451 

M Cushman, Co-I. Molecular Epidemiology of MI and Stroke in Older Adults 

R01 HL071862 

M Cushman, Subcontract PI. Genetic contributors to diabetes and dyslipidemia in 

African-Americans R01 DK084350 

M Cushman, Co-I. Reasons for racial disparities in venous thromboembolism, 

RC1HL099460 . 

. 

Funding anticipated. 

M Cushman, Subcontract PI. Exceptional Aging: 12 year trajectories to function. 

RO1 AG0236290-1 

Kim Dittus, M.D., PhD 

K Dittus, PI, - “Translational Studies of Muscle Atrophy/Dysfunction in 

Individuals with Cancer Cachexia” 

UVM Hematology/Oncology Research Pilot Project 

Funding – 4/1/2011-4/1/2013 

$99,190 for 2 years with matching funds from DOM 

Steven Grunberg, M.D. , PI – Randomized Phase II Pilot Study of Loratadine for the 

Prevention of Pain Caused by the Granulocyte Colony Stimulating Factor 

Pegfilgrastim – NCI/CALGB 

89

Chris E. Holmes, M.D., PhD – American Cancer Society, “Platelet Modulation in 

the Control of Angiogenesis” (PI) 

Marie E. Wood, M.D. – 1 R21 CA137650-01A2, “Vitamin D and Breast Cancer 

Biomarkers” (PI) Funding: 4/1/2010-3/31/2012 


NHLBI Reasons for Racial Disparities in Venous Thromboembolism 

RC1 Neil A. Zakai, PI 

Funding 09/2009 - 09/2011 

NHLBI Regional and Racial Differences in Hemostasis and Risk of 

K08 Stroke and Heart Disease (K-award) 

Neil A. Zakai, PI, 

Funding : 04/01/10-04/01/15 

HTRS Venous Thrombosis in Medical Inpatients 

Mentored Research Award 

Neil A. Zakai, PI 

Funding 7/01/08 - 12/31/11 

NATF Venous Thrombosis Prevention in Medical Inpatients 

North American Thrombosis Forum project grant. 

Neil A. Zakai, PI 

Funding 2/01/11 – 2/01/12 



Cushman M, Callas PW, Denenberg JO, Bovill EG, Criqui MH. Risk factors for 

peripheral venous disease resemble those for venous thrombosis: the San Diego 

Population Study. J Thromb Haemost 2010;8:1730-5. (PMCID: PMC2937057) 

Allison MA, Cushman M, Callas PW, Denenberg JO, Jensky NE, Criqui MH. 

Adipokines are associated with lower extremity venous disease: the San Diego 

Population Study. J Thromb Haemost 2010;8:1912-18. (PubMed - in process) 

Allison MA, Peralta CA, Wassel CL, Aboyans V, Arnett DK, Cushman M, Eng J, 

Ix J, Rich SS, Criqui MH. Genetic ancestry and lower extremity arterial disease in 

the Multi-Ethnic Study of Atherosclerosis. Vascular Med 2010;15:351-9. 

(PubMed - in process) 

Yan R, Fernandes V, Bahrami H, Vogel-Claussen J, Bluemke D, Redhuil A, 

Cushman M, Tracy RP, Lima J. Fibrinogen and left ventricular myocardial 

systolic function: the Multi-Ethnic Study of Atherosclerosis. Am Heart J 

2010;160:479-86. (PMCID: PMC2937158) 

90

Kizer JR, Arnold AM, Strotmeyer ES, Ives DG, Cushman M, Ding J, Kritchevsky 

SP, Chavez PHM, Hirsh CH, Newman AB. Change in circulating adiponectin in 

adults surviving into advanced old age: determinants and impact on functional 

outcome and mortality. The Cardiovascular Health Study All Stars Study. J 

Gerontol Med Sci 2010;65:1208-14. (PMCID: PMC2954239) 

Tang W, Basu S, Kong X, Pankow J, Aleksic N, Tan A, Cushman M, Boerwinkle 

E, Folsom A. Genome-wide association study identifies novel loci for plasma 

levels of protein C: the ARIC study. Blood 2010;116:5032-6. (PMCID: 

PMC3012596) 

Lakoski SG, Cushman M, Siscovick DS, Blumenthal RS, Palmas W, Burke G, 

Herrington DM. The relationship between inflammation, obesity and risk for 

hypertension in the Multi-Ethnic Study of Atherosclerosis. J Hum Hypertension 

2011;25:73-9. (PubMed - in process) 

Douketis J, Tosetto A, Marcucci M, Baglin R, Cushman M, Eichinger S, Palareti 

G, Poli D, Tait RC, Iorio A. Patient-level meta-analysis: effect of measurement 

timing, threshold and patient age on ability of D-dimer testing to assess 

recurrence risk after unprovoked venous thromboembolism. Ann Intern Med 

2010;153:523-31. 

Baglin T, Douketis J, Tosetto A, Marcucci M, Cushman M, Kyrle P, Palareti G, 

Poli D, Tait RC, Iorio A. Does the clinical presentation and extent of venous 

thrombosis predict likelihood and type of recurrence? A patient-level metaanalysis. 

J Thromb Haemost 2010;8:2436-42. (PubMed - in process) 

Criqui MH, Kamineni A, Allison MA, Ix JH, Carr JJ, Cushman M, Detrano R, 

Post W, Wong ND. Risk factor differences for aortic versus coronary calcified 

atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb 

Vasc Biol 2010;30:2289-96. (PMCID: PMC2959146) 

Glasser SP, Judd S, Basile J, Lackland D, Halanych J, Cushman M, Prineas R, 

Howard V, Howard G. Prehypertension, racial prevalence and its association with 

risk factors: analysis of the REasons for Geographic And Racial Differences in 

stroke (REGARDS) study. Am J Hypertens 2011;24:194-9. (PubMed - in process) 

Nelson TL, Kamineni A, Psaty BM, Cushman M, Jenny NS, Hokanson J, Furberg 

C, Mukamal KJ. Lipoprotein-associated phospholipase A2 (Lp-PLA2) and future 

risk of subclinical disease and cardiovascular events in individuals with type 2 

diabetes: The Cardiovascular Health Study. Diabetologia 2011;54:329-33. 

(PubMed - in process) 

Shih RA, Griffin BA, Salkowski N, Jewell A, Eibner C, Bird CE, Liao D, 

Cushman M, Margolis HG, Eaton CB, Whitsel EA. Ambient particulate matter air 

pollution and venous thromboembolism in the Women’s Health Initiative 

91

hormone therapy trials. Environ Health Perspect 2011;119:326-31. (PubMed - in 

process) 

Rossouw J, Bray P, Liu J, Kooperberg C, Hsia J, Lewis C, Cushman M, Bonds D, 

Hendrix S, Papanicolaou G, Howard T, Herrington D. Estrogen receptor 

polymorphisms and vascular effects of hormone therapy. Atheroscler Thromb 

Vasc Biol 2011;31:464-9. (PubMed - in process) 

Dubin R, Cushman M, Folsom AR, Fried LF, Palmas W, Peralta CA, Wassel C, 

Shlipak MG. Kidney function and multiple hemostatic markers: cross-sectional 

associations in the Multi-Ethnic Study of Atherosclerosis. BMC Nephrol 

2011;12:3. (PubMed - in process) 

Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, Lopez 

LM, Shin SY, Baumert J, Vitart V, Bis JC, Wild SH, Rumley A, Yang Q, 

Uitterlinden AG, Stott DJ, Davies G, Carter AM, Thorand B, Polasek O, 

McKnight B, Campbell H, Rudnicka AR, Chen MH, Buckley BM, Harris SE, 

Peters A, Pulanic D, Lumley T, de Craen AJ, Liewald DC, Gieger C, Campbell S, 

Ford I, Gow AJ, Luciano M, Porteous DJ, Guo X, Sattar N, Tenesa A, Cushman 

M, Slagboom PE, Visscher PM, Spector TD, Illig T, Rudan I, Bovill EG, Wright 

AF, McArdle WL, Tofler G, Hofman A, Westendorp RG, Starr JM, Grant PJ, 

Karakas M, Hastie ND, Psaty BM, Wilson JF, Lowe GD, O'Donnell CJ, 

Witteman JC, Jukema JW, Deary IJ, Soranzo N, Koenig W, Hayward C. Genetic 

predictors of fibrin D-dimer levels in healthy adults. Circulation 2011;123:1864- 

72. 

Levine DA, Calhoun DA, Prineas RJ, Cushman M, Howard VJ, Howard G. 

Moderate waist circumference and hypertension prevalence: the REGARDS 

study. Am J Hyperten 2011;24:482-8. (PubMed - in process) 

Smith NL, Rice KM, Bovill EG, Cushman M, Bis JC, et al. Genetic variation 

associated with plasma von Willebrand factor levels and the risk of incident 

venous thrombosis. In press, Blood. (PubMed - in process) 

Douketis J, Tosetto A, Marcucci M, Baglin T, Cushman M, Kyrle P, Cosmi B, 

Poli D, Tait RC, Iorio A. Risk for recurrence after venous thromboembolism in 

men and women: a patient-level meta-analysis. BMJ 2011;342:d813. 

Howard VJ, Kleindorfer DO, Judd SE, McClure LA, Safford MM, Rhodes JD, 

Cushman M, Moy CS, Soliman EZ, Kissela BM, Howard G. Disparities in stroke 

incidence contributing to disparities in stroke mortality. Ann Neurol 2011;69:619- 

27. 

Rajpathak SN, Kaplan RC, Wassertheil-Smoller S, Cushman M, Rohan TE, 

McGinn AP, Wang T, Strickler HD, Scherer PE, Mackey R, Curb D, Ho GYF. 

92

Resistin, but not adiponectin and leptin, is associated with the risk of developing 

ischemic stroke among postmenopausal women. In press, Stroke. 

Kan H, Folsom AR, Cushman M, Rose KM, Rosamond WD, Liao D, Lurmann F, 

London SJ. Traffic exposure and incident venous thromboembolism in the 

Atherosclerosis Risk in Communities (ARIC) Study. J Thromb Haemost 

20119:672-8. (PubMed - in process) 

Wang T, Xue X, Rohan TE, Gunter M, Scherer P, Smoller S, Kaplan R, Strickler 

H, Cushman M, Rajpathak SN, Ho GYF. A prospective study of inflammation 

markers and endometrial cancer risk in postmenopausal hormone nonusers. 

Cancer Epi Biomarkers Prev 2011;20:971-7. 

Matthews JC, You Z, Wadley V, Cushman M, Howard G. Association of selfreported 

tooth loss with cognitive function in the REGARDS study: assessment of 

potential pathways. J Am Dental Assoc 2011;142:379-90. 

Shastri S, Katz R, Shlipak MG, Kestenbaum B, Peralta CA, Kramer H, Jacobs Jr 

DR, de Boer IH, Cushman M, Siscovick D, Sarnak MJ. Cystatin C and 

albuminuria as risk factors for development of chronic kidney disease stage 3: the 

Multi-Ethnic Study of Atherosclerosis. Am J Kidney Dis 2011;57:832-40 

Lakoski SG, Cushman M, et al. Adiposity, inflammation, and risk of death in 

black and white men and women in the US: The REasons for Geographic And 

Racial Differences in Stroke (REGARDS) Study. J Clin Endocrinol Metab 

2011;96:1805-14. 

Vaidya D, Szklo M, Cushman M, Holvoet P, Polak J, Bahrami H, Jenny NS, 

Ouyang P. Association of endothelial and oxidative stress with metabolic 

syndrome and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis. 

In press Eur J Clin Nutrition. 

Shiffman D, O’Meara ES, Rowland CM, Louie JZ, Cushman M, Tracy RP, 

Devlin JJ, Psaty BM. The contribution of a 9p21.3 variant, a KIF6 variant, and Creactive 

protein to predicting risk of myocardial infarction in a prospective study. 

In press, BMC Cardiovasc Disord. 

Folsom AR, Yatsuya H, Nettleton JA, Lutsey PL, Cushman M for the ARIC 

Study investigators. Community prevalence of ideal cardiovascular health by the 

American Heart Association definition, and relationship with cardiovascular 

disease incidence. J Am Coll Cardiol 2011;57:1690-6. 

McKnight KK, Wellons MF, Sites CK, Roth DL, Szychowski JM, Halanych JH, 

Cushman M, Safford MM. Racial and regional differences in age at menopause in 

the United States: findings from the Reasons for Geographic and Racial 

Differences in Stroke (REGARDS) study. In press, Am J Obstet Gynecol. 

93

Blaha MJ, Rivera JJ, Budoff MJ, Blankstein M, Agatston A, O’Leary DH, 

Cushman M, Lakoski S, Criqui MH, Szklo M, Blumenthal RS, Nassir K. 

Association between obesity, high-sensitivity C-reactive protein ≥2 mg/L and 

subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study 

of Atherosclerosis. Arteroscler Thromb Vasc Biol 2011;31:1430-8. 

Fornage M, Debette S, Bis JC, Schmidt H, Ikram MA, Dufouil C, Sigurdsson S, 

Lumley T, Destefano AL, Fazekas F, Vrooman HA, Shibata DK, Maillard P, 

Zijdenbos A, Smith AV, Gudnason H, de Boer R, Cushman M, Mazoyer B, Heiss 

G, Vernooij MW, Enzinger C, Glazer NL, Beiser A, Knopman DS, Cavalieri M, 

Niessen WJ, Harris TB, Petrovic K, Lopez OL, Au R, Lambert JC, Hofman A, 

Gottesman RF, Garcia M, Heckbert SR, Atwood LD, Catellier DJ, Uitterlinden 

AG, Yang Q, Smith NL, Aspelund T, Romero JR, Rice K, Taylor KD, Nalls MA, 

Rotter JI, Sharrett R, van Duijn CM, Amouyel P, Wolf PA, Gudnason V, van der 

Lugt A, Boerwinkle E, Psaty BM, Seshadri S, Tzourio C, Breteler MM, Mosley 

TH, Schmidt R, Longstreth WT, Decarli C, Launer LJ. Genome-wide association 

studies of cerebral white matter disease burden: the CHARGE Consortium. Ann 

Neurol 2011;69:928-39. 

McClellan WM, Warnock DG, Judd S, Muntner P, Kewalrami R, Cushman M, 

McClure L, Newsome B, Howard G. Albuminuria and racial disparities in the 

incidence of end-stage renal disease. In Press J Am Soc Nephrol. 

Zweifler RM, McClure LA, Howard VJ, Cushman M, Hovater MK, Safford MM, 

Howard G, Goff DC. Racial and geographic differences in prevalence, awareness, 

treatment and control of dyslipidemia: the Reasons for Geographic and Racial 

Differences in Stroke (REGARDS) study. In Press, Neuroepidemiology. 

Soliman EZ, Howard G, Meschia JF, Cushman M, Muntner P, Pullicino PM, 

McClure LA, Judd S, Howard VJ. Self-reported atrial fibrillation and risk of 

stroke in the Reasons for Geographic and Racial Differences in Stroke 

(REGARDS) study. In Press, Stroke. 

Garg PK, McClelland R, Jenny NS, Criqui MH, Liu K, Polak JH, Jorgensen N, 

Cushman M. Association of lipoprotein-associated phospholipase A2 and 

endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA). In 

Press, Vascular Med. 

Lutsey PL, Cushman M, Heckbert SR, Tang W, Folsom AR. Longer legs are 

associated with greater risk of incident venous thromboembolism. The 

Longitudinal Investigation of Thromboembolism Etiology. In Press, Thromb 

Haemost. 

Kizer JR, Arnold AM, Jenny NS, Cushman M, Strotmeyer ES, Ives DG, Ding J, 

Kritchevsky SB, Chaves PHM, Hirsch CH, Newman AB. Longitudinal Changes 

94

in Adiponectin and Inflammatory Markers and Relation to Survival in the Oldest 

Old: The Cardiovascular Health Study All Stars Study. In press J Gerontol Med 

Sci. 

Tamura MK, Muntner P, Wadley V, Cushman M, Zakai NA, Bradbury B, Kissela 

B, Unverzagt F, Howard G, Warnock D, McClellan W. Albuminuria, kidney 

function and the incidence of cognitive impairment among adults in the United 

States. In Press, Am J Kidney Dis. 

DeFilippis AP, Blaha MJ, Ndumele C, Budoff MJ, Lloyd-Jones DM, McClelland 

RL, Lakoski SG, Cushman M, Wong ND, Blumenthal RS, Lima J, Nasir K. The 

Association of Framingham and Reynolds Risk Scores with Incidence and 

Progression of Coronary Artery Calcification in the Multi-Ethnic Study of 

Atherosclerosis. In Press, J Am Coll Cardiol. 

Saposnik G, Barinagarrementeria F, Brown RD, Bushnell CD, Cucchiara B, 

Cushman M, deVeber G, Ferro JM, Tsai FY on behalf of the American Heart 

Association Stroke Council and Council on Epidemiology and Prevention. 

Diagnosis and management of cerebral vein thrombosis: a statement for 

healthcare professionals from the American Heart Association/American Stroke 

Association. Stroke 2011;42:1158-92. 

Jaff MR, McMurtry MS, Archer SL, Cushman M, Goldenberg N, Goldhaber SZ, 

Jenkins JS, Kline JA, Michaels AD, Thistlethwaite P, Vedantham S, White RJ, 

Zierler BK. Management of massive and submassive pulmonary embolism, 

iliofemoral deep vein thrombosis and chronic thromboembolic pulmonary 

hypertension. A Scientific Statement from the American Heart Association 

Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, 

Council on Peripheral Vascular Disease, and Council on Arteriosclerosis, 

Thrombosis and Vascular Biology. Circulation 2011;123;1788-1830. 

C-reactive protein Coronary Heart Disease Genetics Consortium. Association 

between C-reactive protein and coronary heart disease: Mendelian randomization 

analysis based on individual patient data. BMJ 2011;342:d458. 

Emerging Risk Factors Collaboration. Diabetes mellitus, fasting glucose, and the 

risk of cause-specific death. N Engl J Med 2011;364:829-41. 

Cushman M. Patch instead of pill: a safer menopausal estrogen? [editorial]. 

Arterioscler Thromb Vasc Biol 2010;30:136-7. PMID 20089948. 

Franklin BA, Cushman M. Recent advances in preventive cardiology and lifestyle 

medicine: a Themed Series. Circulation 2011;123:2274-83. 

95

Marc S. Greenblatt, M.D. 

Povey S, Al Aqeel AI, Cambon-Thomsen A, Dagleish R, den Dunnen JT, Firth 

HV, Greenblatt MS, Isaacson Barash C, Parker M, Patrinos GP, Savige J, 

Sobrido M-J, Winship I, Cotton RGH, Practical guidelines addressing ethical 

issues pertaining to the curation of human locus-specific variation databases 

(LSDBs), Hum Mutat. 2010 Nov;31(11):1179-84. epub Aug 3, 2010, PMID: 

20683926,. 

Kohonen-Corish M, Al-Aama J, Auerbach A, Axton M, Bernstein I, Béroud C, 

Burn J, Cunningham F, Cutting G, den Dunnen J, Greenblatt MS, Kaput J, Katz 

M, Lindblom A, Macrae F, Maglott D, Möslein G, Povey S, Ramesar R, Richards 

CS, Seminara D, Tavtigian SV, Taylor G, Vihinen M, Winship I, Cotton RHG, 

How to catch all those mutations – The Report of the third Human Variome 

Project Meeting; UNESCO Paris, 10th – 14th May 2010, Hum Mutat. 2010 

Dec;31(12):1374-81. PMID: 20960468 

Kohonen-Corish, MRJ, Macrae F, Genuardi M, Aretz S, Bapat B, Bernstein IT, 

Burn J, Cotton RGH, den Dunnen JT, Frebourg T, Greenblatt MS, Hofstra R, 

Holinski-Feder E, Lappalainen I, Lindblom A, Maglott D, Møller P, Morreau H, 

Möslein G, Sijmon R, Spurdle AB, Tavtigian S, Tops CMJ, Weber TK, de Wind 

N, Woods MO, on behalf of Contributors to the InSiGHT-HVP Workshop, 

Deciphering the Colon Cancer Genes - Report of the InSiGHT-Human Variome 

Project Workshop, UNESCO, Paris 2010, Hum Mutat, 2011 32:491-494. PMID: 

21387463 

Miller PJ, Duraisamy S, Newell JA, Chan PA, Tie MM, Rogers AE, Ankuda CK, 

von Walstrom GM, Bond JP, Greenblatt MS, Classifying Variants of CDKN2A 

Using Computational and Laboratory Studies, Hum Mutat 2011 in press. PMID: 

21462282 


Avritscher EBC, Shih Y-CT, Sun CC, Gralla RJ, Grunberg SM, Xu Y, Elting LS: 

Cost-Utility Analysis of Palonosetron-Based Therapy in Preventing Emesis 

among Breast Cancer Patients. J Support Oncol 8:242-251, 2010. 

Grunberg SM, Chua D, Maru A, Dinis J, DeVandry S, Boice JA, Hardwick JS, 

Beckford E, Taylor A, Carides A, Roila F, Herrstedt J: Single Dose Fosaprepitant 

for the Prevention of Chemotherapy-Induced Nausea and Vomiting Associated 

with Cisplatin Therapy: A Randomized, Double-Blind Study – Protocol 017 

EASE. J Clin Oncol 29:1495-1501, 2011. 

Boccia RV, Gordan LN, Clark G, Howell JD, Grunberg SM, on behalf of the 

Sancuso Study Group: Efficacy and Tolerability of Transdermal Granisetron for 

the Control of Chemotherapy-Induced Nausea and Vomiting Associated with 

Moderately and Highly Emetogenic Multi-Day Chemotherapy: A Randomized, 

Double-Blind Phase III Study. Support Care Cancer (In Press) 2011. 

96

Salsman JM, Grunberg SM, Beaumont JL, Rogers M, Paul D, Clayman ML, Cella 

D: Communicating about Chemotherapy-Induced Nausea and Vomiting: A 

Comparison of Patient and Provider Perspectives. J Natl Compr Canc Netw (In 

Press) 2011. 

Einhorn LH, Grunberg SM, Rapoport B, Rittenberg C, Feyer P: Antiemetic 

Therapy for Multiple Day Chemotherapy and Additional Topics Consisting of 

Rescue Antiemetics and High-Dose Chemotherapy with Stem Cell Transplant: 

Review and Consensus Statement. Support Care Cancer 19 (Suppl 1):S1-S4, 

2011. 

Kris MG, Tonato M, Bria E, Ballatori E, Espersen B, Herrstedt J, Rittenberg C, 

Einhorn LH, Grunberg S, Saito M, Morrow G, Hesketh P: Consensus 

Recommendations for the Prevention of Vomiting and Nausea Following High- 

Emetic-Risk Chemotherapy. Support Care Cancer 19 (Suppl 1):S25-S32, 2011. 

Grunberg SM, Warr D, Gralla RJ, Rapoport BL, Hesketh PJ, Jordan K, Espersen 

BT: Evaluation of New Antiemetic Agents and Definition of Antineoplastic 

Agent Emetogenicity – State of the Art. Support Care Cancer 19 (Suppl 1):S43- 

S47, 2011. 

Olver I, Molassiotis A, Aapro M, Herrstedt J, Grunberg S, Morrow G: Antiemetic 

Research: Future Directions. Support Care Cancer 19 (Suppl 1):S49-S55, 2011. 

Grunberg SM, Adams NB, Gralla RJ: Management of Nausea and Vomiting. In: 

Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (eds). Cancer 

Management: A Multidisciplinary Approach – 13 th Edition, London England, 

UBM Medica, 2010, pp 939-950. 

Chris E. Holmes, M.D., PhD 

Bambace N, Holmes CE. The platelet contribution to cancer progression. J 

Thromb Haemostasis 2010, DOI: 10.1111/j.1538-7836.2010.04131.x 

Snoep JD, Gaussem P, Eikenboom JCJ, Emmerich, J, Zwaginga JJ, Holmes 

CE, Vos HL, de Groot PG, Rosendaal FR, van der Bom JG. The minor 

allele of GP6 T13254C is associated with decreased platelet activation and a 

reduced risk of recurrent cardiovascular events and mortality: results from 

the SMILE-platelets project. J Thromb Haemostasis 2010, in 

DOI: 10.1111/j.1538-7836.2010.04018. 

Bambace NM, Levis JE, Holmes CE. The Effect of P2Y-Mediated Activation 

on VEGF and Endostatin Release from Platelets. Platelets 2010; 21: 85-93. 

97

Holmes CE, Ramos-Nino ME, Littenberg B. An Association between Anti- 

Platelet Drug Use and Reduced Cancer Prevalence in Diabetic Patients: Results 

from the Vermont Diabetes Information System. BMC Cancer. 2010; 10: 289. 

Masanori Mori, M.D. (3 rd year Fellow) 

Articles 

Mori M, Parsons HA, De La Cruz M, et al. Changes in symptoms and inpatient 

mortality: a study in advanced cancer patients admitted to an acute palliative care 

unit in a comprehensive cancer center. J Palliat Med. In Press. 

Mori M, Elsayem A, Reddy SK, et al. Unrelieved pain and suffering in patients 

with advanced cancer. Am J Hosp Palliat Med. In Press. 

Hui D, Mori M, Parsons HA, Kim SH, LiZ, Damani S, Bruera E. The lack of 

standard definitions in the supportive and palliative oncology literature. J Pain 

Symptom Manage in April 2011. 

Oral Presentations 

Mori M, Kuwama Y, Parsons HA, Ashikaga T, Grunberg SM, Miyashita M. 

Acculturation and beliefs about end-of-life (EOL) cancer care among individuals 

of Japanese ancestry living in America. Presented at the MASCC/ISOO 2011 

International Symposium on 6/24/11. 

Mori M, Ellison D, Ashikaga T, McVeigh U, Ramsay A, Ades S. Code status 

(CS) on admission and the quality of inpatient end-of-life (EOL) cancer care: 

perspectives of bereaved primary caregivers (PCGs). Presented at the 

MASCC/ISOO 2011 International Symposium on 6/24/11. 

Mori M, Kuwama Y, Parsons HA, Ashikaga T, Grunberg SM, Miyashita M. 

Acculturation and perceptions of good cancer death among individuals of 

Japanese ancestry living in America. Presented at the MASCC/ISOO 2011 

International Symposium in Athens, Greece, on 6/25/11. 2011 MASCC Young 

Investigator Award. 

Mori M, Ellison D, Ashikaga T, McVeigh U, Ramsay A, Ades S. In-advance endof-life 

(EOL) discussions and the quality of inpatient EOL cancer care: 

perspectives of bereaved primary caregivers (PCG). Presented at the 

MASCC/ISOO 2011 International Symposium in Athens, Greece, on 6/25/11. 

“Cultural disparity and end-of-life cancer care among Japanese Americans.” 

Presented as an invited lecturer at the Japanese American Association Senior 

Week in the New York City, 9/15/10. 

Poster Presentations 

Mori M, Sprague J. The long-term effect of sorafenib in a FLT3-ITD-positive 

patient with a refractory acute erythroid leukemia. Poster presentation at 

Northern New England Clinical Oncology Society Annual Meeting on 10/29/10. 

98

Mori M, Ellison D, McVeigh U, Ramsay A, Ashikaga T, Ades S. Advanced care 

planning and the quality of inpatient end-of-life care of cancer patients: 

challenges in an after-death survey study among bereaved primary caregivers. 

Post presentation at the Vermont Cancer Center 2010 Clinical and Translational 

Research Symposium on 11/5/10. 

Metzelder S, Finck A, Fey M, Scholl S, Kröger M, Reiter A, Salih HR, Götze K, 

Meyer, RG, Giagounidis A, Brugger W, Vöhringer M, Müller L, Ching LY, 

Dreger P, Mori M, Basara N, Schaefer-Eckart K, Schultheis B, Baldus C, 

Neubauer A, Burchert A. Sorafenib monotherapy is effective in relapsed and 

refractoryFlt3-ITD positive acute myeloid leukemia, particularly after allogenic 

stem cell transplantation. Poster presentation at the 52 nd American Society of 

Hematology Annual Meeting and Exposition on 12/6/10, #3314. 

Mori M, Ellison D, McVeigh U, Ramsay A, Ashikaga T, Ades S. Quality 

improvement in the inpatient end-of-life cancer care: Preliminary results of the 

after-death survey study among bereaved primary caregivers. (Poster presentation 

at the 6 th Annual Quality Forum at Fletcher Allen Health Care / University of 

Vermont College of Medicine on 1/12/11.) 

Mori M, Ashikaga T, Grunberg SM. Phase II trial of subcutaneous 

methylnaltrexone in the treatment of severe opioid-induced constipation in cancer 

patients. Poster to be presented in the Trials in Progress Poster Session at 2011 

ASCO Annual Meeting on 6/6/10. 

Patricia O’Brien, M.D. 

Poster presentation at NECCO meeting. Title: Recalcitrant lymphedema after 

treatment of breast cancer; poster submitted to ASCO Breast Cancer Symposium; 

Poster submitted to San Antonio Breast Cancer Conference for December 2011 

(all are case reports using MRI data, body maps, interdisciplinary data). 

Community Service 

Annual Breast Cancer Conference 

Medical student advising on lymphedema research projects 

Medical student advising on global health program 

Admissions substitute interviewer 

Susan G. Komen Grant board member 

Vermont Cancer Network board member 

Victoria Buffum Foundation board member 

Marie E. Wood, M.D. 

Bordeleau L, Lipscombe L, Lubinski J, Ghadirian P, Foulkes WD, Neuhausen S, 

Ainsworth P, Pollak M, Sun P, Narod SA; Hereditary Breast Cancer Clinical 

Study Group (Wood, ME). Diabetes and breast cancer among women with 

BRCA1 and BRCA2 mutations. Cancer. 2011 May 1;117(9):1812-8. 

99

Witherby, S, Johnson, J, Demers, L, Mount, S, Littenberg, B, Maclean, C, Wood, 

M, Muss, H. Topical testosterone for breast cancer patients with vaginal atrophy 

related to aromatase inhibitors: A phase I/II study. The Oncologist. 

2011;16(4):424-31 

Metcalfe K, Lubinski J, Lynch HT, Ghadirian P, Foulkes WD, Kim-Sing C, 

Neuhausen S, Tung N, Rosen B, Gronwald J, Ainsworth P, Sweet K, Eisen A, 

Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group (Wood, ME). 

Family history of cancer and cancer risks in owmen in BRCA1 or BRCA2 

mutations. J Natl Cancer Inst. 2010 Dec 15;102(24):1874-8. 

Flynn BS, Wood ME, Ashikaga T, Stockdale A, Dana GS, Naud S. Primary care 

physicians' use of family history for cancer risk assessment. BMC Family 

Practice. 2010 June 3; 11(1): 

Vicus, D, Finch, A, Rosen, B, Fan, I, Bradley, L, Cass, I, Sun, P, Karlan, B, 

McLaughlin, J, Narod, SA. Hereditary Ovarian Cancer Clinical Study Group 

(Wood, ME): Risk factors for carcinoma of the fallopian tube in women with and 

without a germline BRCA mutation. Gynecol Oncol. 2010; 118(2): 155-159. 

Pal, T, Keefe, D, Sun, P, Narod, S.A.: Hereditary Breast Cancer Clinical Study 

Group (Wood, ME): Fertility in women with BRCA mutations: a case-control 

study. Fertil Steril. 2010; 93(6): 1805-1808. 


Kabagambe EK, Judd SE, Howard VJ, Zakai NA, Jenny NS, Hsieh M, Warnock 

DG, Cushman M. Inflammation Biomarkers and Risk of All-Cause Mortality in 

the REasons for Geographic and Racial Differences in Stroke (REGARDS) 

Cohort. American Journal of Epidemiology 2011. In Press 

Nalls MA*, Couper DJ*, Tanaka T*, van Rooij FJA*, Chen MH*, Smith AV*, 

Toniolo D*, Zakai NA*, Yang Q, Greinacher A, Wood AR, Garcia M, 

Gasaprini P, Liu Y, Lumley T, Folsom AR, Reiner AP, Geiger C, LagouV, 

Felix JF, Volzke H, Gouskova NA, Biffi A, Doring A, Volker U, Chong S, 

Wiggins K, Rendon A, Dehghan A, Moore M, Taylor K, Wilson JG, Letre G, 

Hofman A, Bis, JC, Pirastu N, Fox CS, Meisinger C, Sambrook J, Arepalli 

S, Nauck M, Prokish H, Stephens J, Glazer NL, Cupples LA, Okada Y, 

Takahashi A, Kamatani Y, Matsuda K, Tsunoda T, Tanaka T, Kubo M, 

Nakamura Y, Yamamoto K, Kamatani N, Stumvoll M, Tonjes A, Prokopenko I, 

Illig T, Patel K, Garner S, Kuhnel B, Mangino M, Oostra BA, Thein SL, Coresh J, 

Wichmann HE, Menzel S, Lin JP, Pistis G, Uitterlinden AG, Spector TD, Teumer 

A, Eriksdottir G, Bandinelli S, Frayling T, Chakravarti A, van Duijn CM, Melzer 

D, Ouwehand WH, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo 

100

DL, Soranzo N, Witteman JCM, Psaty BM, Ferrucci L, Harris TB, O’donnell CJ, 

Ganesh SK. Multiple loci are associated with white blood cell phenotypes. Plos 

Genetics 2011; In Press. *Co-first author. 

Whitson HE, Thielke S, Diehr P, O’Hare AM, Chaves PHM, Zakai NA, Arnold 

A, Chaudhry S, Ives D, Newman AB. Patterns and Predictors of Recovery from 

Exhaustion in Older Adults: The Cardiovascular Health Study. Journal of the 

American Geriatrics Society 2011; 59; 207-13. 

Peralta CA, Shlipak MG, Judd S, Cushman M, McClellan W, Zakai NA, Safford 

MM, Zhang X, Muntner P, Warnock D. Detection of chronic kidney disease 

with creatinine, cystatin C and urine albumin-to-creatinine ratio and association 

with progression to end-stage renal disease and mortality. JAMA 2011; 305: 

1545-52. 

Zakai NA, Lange L, Longstreth WT, O'Meara ES, Kelley JL, Fornage M, 

Nikerson D, Cushman M, Reiner AP. Association of coagulation and 

inflammation related genes and factor VIIc levels with stroke: the cardiovascular 

health study. J Thromb Haemost. 2011;9:267-74. 

Zakai NA, McClure LA. Race and Venous Thrombosis. Journal of Thrombosis 

and Haemostasis 2010. Under Review 

Levine GN, D'Amico AV, Berger P, Clark PE, Eckel RH, Keating NL, Milani 

RV, Sagalowsky AI, Smith MR, Zakai N. Androgen-deprivation therapy in 

prostate cancer and cardiovascular risk: a science advisory from the American 

Heart Association, American Cancer Society, and American Urological 

Association: endorsed by the American Society for Radiation Oncology. 

Circulation. 2010; 121: 833-40. 

Levine GN, D'Amico AV, Berger P, Clark PE, Eckel RH, Keating NL, Milani 

RV, Sagalowsky AI, Smith MR, Zakai N. Androgen-deprivation therapy in 

prostate cancer and cardiovascular risk: a science advisory from the American 

Heart Association, American Cancer Society, and American Urological 

Association: endorsed by the American Society for Radiation Oncology. CA 

Cancer J Clin. 2010; 60: 194-201. 

Zakai NA, Lutsey PL, Folsom AR, Heckbert SR, Cushman M. Total tissue factor 

pathway inhibitor and venous thrombosis. The Longitudinal Investigation of 

Thromboembolism Etiology. Thromb Haemost. 2010; 104: 207-12. 

Warnock DG, Muntner P, McCullough PA, Zhang X, McClure LA, Zakai NA, 

Cushman M, Newsome BB, Kewalramani R, Steffes MW, Howard G, McClellan 

WM. Kidney function, albuminuria, and all-cause mortality in the REGARDS 

(Reasons for Geographic and Racial Differences in Stroke) study. Am J Kidney 

Dis. 2010; 56: 861-71. 

101

Meschia JF, Merrill P, Soliman EZ, Howard VJ, Barrett KM, Zakai NA, 

Kleindorfer D, Safford M, Howard G. Racial disparities in awareness and 

treatment of atrial fibrillation: the REasons for Geographic and Racial 

Differences in Stroke (REGARDS) study. Stroke. 2010; 41: 581-7. 

Kurella Tamura M, Wadley VG, Newsome BB, Zakai NA, McClure LA, Howard 

G, Warnock DG, McClellan W. Hemoglobin concentration and cognitive 

impairment in the renal REasons for Geographic And Racial Differences in 

Stroke (REGARDS) Study. J Gerontol A Biol Sci Med Sci. 2010; 65: 1380-6. 

102

Division of Immunobiology 

Ralph Budd, MD, Director 

http://www.med.uvm.edu/medicine/immunobiology 

http://www.med.uvm.edu/vcii 

The Immunobiology Program was established in the Department of 

Medicine in 1995 in recognition of the growing strength in this area 

of research from various departments. Although established in one 

department, it was intended from the start that this program should 

evolve to span several departments to include the various interests 

in genetic regulation of autoimmune and infectious diseases, basic 

mechanisms of T cell signaling of cytokine genes and cell death 

(Medicine), viral immunology (Pathology), transplantation 

immunology (Surgery), and maternal/fetal immunology (Ob-Gyn). Dr. Ralph Budd has 

directed this program since its inception. It currently includes 4 core faculty (Drs. Budd, 

Botten, Rincón, and Teuscher) whose research interests are detailed below. 

In 2006 the Immunobiology faculty partnered with faculty in Infectious Diseases and 

Microbiology and Molecular Genetics to successfully compete for a Center of 

Biomedical Research Excellence (COBRE) Award from NIH (NCRR). This allowed the 

formation of the Vermont Center for Immunology and Infectious Diseases (VCIID), 

which now numbers 21 faculty in 8 departments in 4 colleges and is in close alliance with 

the Vermont Vaccine Trial Center, headed by Dr. Beth Kirkpatrick, one of the VCIID 

faculty. The VCIID has a weekly joint Research-in-Progress meeting, seminar series, and 

a journal club. This provides a weekly forum for students and postdoctoral fellows to 

present their research progress as well as for faculty to review hypotheses and specific 

aims of planned grants. During the first 5 years of Phase I COBRE funding, VCIID 

faculty published 213 articles and received nearly $48 million in funding, excluding the 

COBRE funds. 

In 2011 the COBRE grant was renewed for a second 5 years. This will provide funds to 

allow the College of Medicine to build a new BSL3 facility in partnership with the 

Vermont Department of Health, and to recruit new faculty to the theme of the host 

response to infection. 

Faculty 

Ralph Budd, MD 


Director, Vermont Center of Immunology & Infectious Diseases 

� Key Research Interests: Death receptors, caspases and metabolism in T cell 

growth, gamma/delta T cells in Lyme arthritis 

103

Jason Botten, PhD 

Assistant Professor of Medicine, Adjunct in Microbiology and Molecular Genetics 

� Key Research Interests: Virology, Cellular Microbiology, Immunology, 

Proteomics 

Sean A. Diehl, PhD 


� Key Research Interests: Molecular immunology, human immunology, allergic 

disease, autoimmune disease, T cells, B cells 

Oliver Dienz, PhD 


� Key Research Interests: T cell signaling, memory T cell function, influenza, lung 

inflammation, cytokines and their transcriptional regulation 

Karen Fortner, PhD 


� Key Research Interests: Regulation of T lymphocyte homeostasis and 

autoimmunity 

Mercedes Rincon, PhD 


Director, Transgenic/Knockout Mice Facility 

� Key Research Interests: T cell activation, allergy/asthma, influenza infection, T 

cell development, breast cancer, cancer and inflammation. 

Cuixia Shi, PhD 

Research Associate, Medicine 

� Key Research Interests: identify gamma delta T cells role in immunity 

Cory Teuscher, PhD 

Professor of Medicine and Pathology 

� Key Research Interests: The major focus of the research effort in my laboratory is 

the identification and characterization of non-classical immune response genes 

controlling susceptibility and resistance to immunopathologically mediated 

diseases. 

Tina Thornton, PhD 

Research Associate, Medicine 

� Key Research Interests: The major focus is on understanding the interactions of 

signaling pathways that control early thymocyte development and survival, and is 

currently exploring the interaction of the p38 MAPK pathway and GSK3 in cells 

from the immune system and central nervous system under normal and 

pathological conditions. 

104


Laure Case, PhD 

Roxana del Rio, PhD 

Joseph Klaus (graduate student) 

Andreas Koenig, PhD 

Dimitry Krementsov, PhD 

Jonathan Rud, PhD 

Naresha Saligrama (graduate student) 

Phan Thai (MD/PhD student) 

Emma Wall, PhD 


(Budd) Editor for “Textbook of Rheumatology”, Elsevier 

(Rincon) J. Immunology; International Journal of Biological Sciences 


(Budd) Chairman of the Immunity and Host Defense NIH study section (207-2009) 

(Teuscher) Charter member, Hypersensitivity, Autoimmune, and Immune-mediated 

diseases NIH study section 

(Rincon) Charter member, Cellular and Molecular Immunology A 


(Budd) University Scholar designation by UVM Graduate College for 2009-2010 


Grant Awards 07/01/10 – 06/30/11 

Budd: 

NIH funding update: 

1 – P01 renewal through ARRA Funding 

3 – ARRA Supplements 

1 – Non ARRA Supplement 

Non – competitive continuations of Immunobiology’s R01’s, R21’s, T32, 

COBRE. 

Foundation funding update: 

1 – New Postdoctoral Fellowship 

Title: Role of Fas in T Cell Development and Function 

105

Dates of Award: 09/01/2006 – 05/31/2012 

Role: PI 

Current Yr funding: $0 (no cost extension) 

Source: NIH/NIAID 

Title: Role of Fas in T Cell Development and Function (Supplement) 

Dates of Award: 09/29/09-5/31/12 

Role: PI 



Title: Gamma Delta Cells in Lyme Arthritis 


Role: PI 

Current Yr funding: $315, 284 

Source: NIH/NIAMS 

Title: Gamma Delta Cells in Lyme Arthritis (ARRA Supplement) 


Role: PI 

Current Yr funding: $240,800 


Title: Vermont Immunology / Infectious Diseases Center 


Role: PI 

Current Yr funding: $2,166,699 

Source: NIH/NCRR 

Title: Vermont Immunology / Infectious Diseases Center (Pilot ARRA 

Supplement) 


Role: PI 

Current Yr funding: $393,646 (no cost extension, effective 09/17/11) 


Title: Vermont Immunology / Infectious Diseases Center (BSL3 ARRA 

Supplement) 


Role: PI 



Title: Regulation of Effector CD4 T Cells During Infection 


Role: PI 

106

Current Yr funding: $1,683,578 (no cost extension, effective 08/01/11) 


Botten: 

Title: Identification of Novel Arenavirus Protein-Host Celluar 


Role: PI 



Diehl: 

Title: H1R Signaling and Immune Deviation in EAE 


Role: Co-PI (PI, Teuscher) 


Source: NIH/ NINDS 

Rincón: 

Title: p38 MAP Kinase during Early Thymocyte Development 


Role: PI 



Teuscher: 

Title: Susceptibility and Resistance Loci in EAE 


Role: PI 


Source: NIH/NINDS 

Title: Molecular Genetics of Arthritis in Murine Lyme Disease 


Role: Co-PI 


Source: University of Utah 

Title: Histamine Receptor Signaling in CNS Autoimmune Disease 


Role: PI 


Source: NIH/NINDS 

107

Title: Sex Chromosomes in Fetal Programming and Susceptibility in EAE 


Role: PI 



Title: H1R Signaling and Immune Deviation in EAE 


Role: PI (Diehl, Co-PI) 



Title: p38 MAPK as a Female-Specific Druggable Target in Autoimmune 

Disease of the CNS 


Role: Mentoring PI 


Source: National Multiple Sclerosis Society (postdoctoral fellowship) 


Aktan I, Chant A, Borg ZD, Damby DE, Leenstra PC, Lilley GW, Petty J, Suratt BT, 

Teuscher C, Wakeland EK, Poynter ME, Boyson JE. Slam haplotypes modulate the 

response to lipopolysaccharide in vivo through control of NKT cell number and function. 

J Immunol. 2010 Jul 1;185(1):144-56. Epub 2010 Jun 7. PMID: 20530260 

Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, 

Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, 

Guzman CA, Spits H. Generation of human antigen-specific monoclonal IgM antibodies 

using vaccinated "human immune system" mice. PLoS One. 2010 Oct 4;5(10). pii: 

e13137. PMID: 20957227 

Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi MF, 

Sette A, Buchmeier MJ. A multivalent vaccination strategy for the prevention of Old 

World arenavirus infection in humans. J Virol. 2010 Oct;84(19):9947-56. Epub 2010 Jul 

28. PMID: 20668086 

Case LK, Del Rio R, Bonney EA, Zachary JF, Blankenhorn EP, Tung KS, Teuscher C. 

The postnatal maternal environment affects autoimmune disease susceptibility in A/J 

mice. Cell Immunol. 2010;260(2):119-27. PMID: 19914609 

del Rio R, Sun Y, Alard P, Tung KS, Teuscher C. H2 control of natural T regulatory cell 

frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced 

108

autoimmune disease. J Immunol. 2011 Jan 1;186(1):382-9. Epub 2010 Dec 6. PMID: 

21135167 

Fortner KA, Bouillet P, Strasser A, Budd RC. Apoptosis regulators Fas and Bim 

synergistically control T-lymphocyte homeostatic proliferation. Eur J Immunol. 2010 

Sep 21. PMID: 20979227 



Nov;40(11):3043-53. doi: 10.1002/eji.201040577. Epub 2010 Oct 27. PMID: 21061436 

Fortner KA, Lees RK, MacDonald HR, Budd RC. Fas (CD95/APO-1) limits the 

expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC 

contacts. Int Immunol. 2011 Feb;23(2):75-88. Epub 2011 Jan 25. PMID: 21266499 

Goodwin M, Sueblinvong V, Eisenhauer P, Ziats NP, Leclair L, Poynter ME, Steele C, 

Rincon M, Weiss DJ. Bone Marrow Derived Mesenchymal Stromal Cells Inhibit Th2- 

Mediated Allergic Airways Inflammation in Mice. Stem Cells. 2011 May 4. doi: 

10.1002/stem.656. PMID: 21544902 

Janssen-Heininger YM, Aesif SW, van der Velden J, Guala AS, Reiss JN, Roberson EC, 

Budd RC, Reynaert NL, Anathy V. Regulation of apoptosis through cysteine oxidation: 

implications for fibrotic lung disease. Ann N Y Acad Sci. 2010 Aug;1203:23-8. Review. 

PMID: 20716279 

Lu C, Diehl SA, Noubade R, Ledoux J, Nelson MT, Spach K, Zachary JF, Blankenhorn 

EP, Teuscher C. Endothelial histamine H1 receptor signaling reduces blood-brain barrier 

permeability and susceptibility to autoimmune encephalomyelitis. Proc Natl Acad Sci 

U S A. 2010 Nov 2;107(44):18967-72. Epub 2010 Oct 18. PMID: 20956310 

Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis 

RJ, Rincon M, Boyson JE. Translational control of NKT cell cytokine production by 

p38 MAPK. J Immunol. 2011 Apr 1;186(7):4140-6. Epub 2011 Mar 2. PMID: 

21368234 

Neveu WA, Bernardo E, Allard JL, Nagaleekar V, Wargo MJ, Davis RJ, Iwakura Y, 

Whittaker LA, Rincon M. Fungal Allergen {beta}-glucans Trigger p38 MAPKmediated 

IL-6 Translation in Lung Epithelial Cells. Am J Respir Cell Mol Biol. 2011 

Jun 3. PMID: 21642586 

Norton MT, Fortner KA, Oppenheimer KH, Bonney EA. Evidence that CD8 T-cell 

homeostasis and function remain intact during murine pregnancy. Immunology. 2010 

Nov;131(3):426-37. doi: 10.1111/j.1365-2567.2010.03316.x. PMID: 20553337 

Shi, C., Sahay, B., Russell, J.Q., Fortner, K.A., Hardin, N., Sellati, T.J., and Budd, R.C. 

Reduced Immune Response to Borrelia burgdorferi in the Absence of γδ T cells. In Press. 

109

Spach KM, Case LK, Noubade R, Petersen CB, McElvany B, Zalik N, Hickey WF, 

Blankenhorn EP, Teuscher C. Multiple linked quantitative trait loci within the 

Tmevd2/Eae3 interval control the severity of experimental allergic encephalomyelitis in 

DBA/2J mice. Genes Immun. 2010 Dec;11(8):649-59. Epub 2010 Sep 23. PMID: 

20861860 

Wheeler K, Tardif S, Rival C, Luu B, Bui E, Del Rio R, Teuscher C, Sparwasser T, 

Hardy D, Tung KS. Regulatory T cells control tolerogenic versus autoimmune response 

to sperm in vasectomy. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7511-6. Epub 

2011 Apr 18. PMID: 21502500 

110

Division of Infectious Diseases 

Christopher Grace, MD, FACP, Director 

http://www.med.uvm.edu/medicine/id 

The Infectious Diseases (ID) Unit is a dynamic group of individuals 

dedicated to the diagnosis, management and prevention of infectious 

diseases. This past year we provided over 1,500 new inpatient 

consultations and 6,000 outpatient visits yearly. This effort includes the 

care of over 400 patients with HIV in four federally funded clinics in 

Vermont, international traveler’s clinic and refugee clinic. The ID unit 

works collaboratively with the Vermont Department of Health for 

diagnosis and treatment of tuberculosis and biological and pandemic 

influenza preparedness. In addition the ID unit is a resource to all providers throughout 

Vermont and upstate New York. We currently have outreach contracts set up with several 

hospitals throughout Vermont and upstate New York to act as a resource for infection 

prevention, and other infectious disease expertise. The ID staff includes the FAHC 

Hospital Epidemiologist and infection control officer, the Department of Medicine’s 

Associate Director of Residency Training and the medical student Clerkship Director. 

In addition to daily teaching rounds with medical students, residents and fellows, the 

physicians are actively involved in the Attacks and Defenses, Neural Sciences, 

Generations, Connections, Convergence and Doctoring in Vermont, medicine clerkships 

and acting internships sections of the Vermont Integrated Curriculum. The ID unit is the 

home of a two year fellowship training program. The graduating fellows have a 100% 

board certification pass rate over the past 10 years. This program includes a year of 

research that has resulted in abstract presentations at the national ID meetings. 

Within our unit we have two active research laboratories which support a number of 

projects by PhD students, research associates, attending physicians, and the 2 nd year ID 

Fellow. Research is a vital component of the unit’s work. Investigations center on the 

molecular biology and pathogenesis of Entamoeba histolytica, Cryptosporidium species, 

Salmonella enterica serovar Typhi, Campylobacter jejuni as well as Phase I clinical trials 

developing live attenuated Dengue virus vaccines. Clinical research efforts include 

epidemiologic investigations into Clostridium difficile infection and risks; HIV service 

delivery models and outcomes; and exploration of the biologic rationale of oral polio and 

rotavirus vaccine failure in an international field trial setting. Over this past year the unit 

has published 7 peer reviewed articles and 3 book chapters. Our fellow’s research into 

health care related C. difficile will be presented at the IDSA in Boston, 2011. 

In addition to clinical revenues, financial support is provided by grants from the NIH, 

NIAID, Health Services Research Administration (HRSA), Bill and Melinda Gates 

Foundation, contracts with regional hospitals and FAHC directorships totaling more than 

2.7 million dollars. 

Our unit will increase to eight physicians in September of 2011 when Dr Cindy Noyes 

joins the faculty. 

111

Faculty 

Christopher Grace, MD FACP 


� Director, Infectious Diseases 

� Director, ID Fellowship Training Program 

� Director at FAHC Title III HRSA grant for HIV care 

� Director at FAHC title II HRSA grant for HIV care (Vermont Dept. of Health) 

� Consultant: Pandemic Influenza and Bioterrorism, Vermont Department of Health 

W. Kemper Alston, MD MPH 


� Chair, Infection Prevention Committee 

� Hospital Epidemiologist 

� Consultant: Tuberculosis, State of Vermont 

� Consultant for Food and Drug Evaluation and Research 

� Hospital Infections, Tuberculosis 

Christopher D. Huston, MD 


� Research Interests: Intestinal protozoan infections including E. Histolytica hostparasite 

infections, Cryptosporidium drug development 

� Institutional Biosafety Committee 

Beth D. Kirkpatrick, MD 


� Director, Vaccine Testing Center 

� Research Interests: Vaccine Development, enteric infections , Dengue Fever 

� Institution Review Board 

Janet Lindlow, PhD 


� Research Interests: Human Immunology to infectious pathogens, Dengue Fever, 

Typhoid Fever 

� Institutional Biosafety Committee 

Kristen K. Pierce, MD 


� Associate Program Director, ID Fellowship Training Program 

� Research Interests: Dengue Fever vaccine development study 

Louis B. Polish, MD 


� Director, Department of Medicine Clerkship Program 

� Chair, Infectious Disease Practice Committee 

� Director, AIDS Education Training 

112

Mary B. Ramundo, MD 


� Associate Program Director, College of Medicine Residency Program 

� Department of Medicine, Medical Education Committee 

� Chairman, Housestaff Evaluation Committee 

Jose Teixeria, PhD 


� Interests: Intestinal protozoan infections including E. Histolytica host-parasite 

infections, Cryptosporidium drug development 

Fellows 

Sarah Mooney, MD 

Infectious Disease 1 st Year Fellow 

� Infectious Disease Fellowship Training Program July 1, 2010 – June 30, 2012 

Cindy Dion Noyes, MD 

Infectious Disease 2 nd Year Fellow 

� Infectious Disease Fellowship Training Program August 1, 2009-Aug 31, 2011 

� Research Year: Clostridium difficile in Health Care Workers 


Deborah Kutzko, FNP 

Nurse Manager, Comprehensive Care clinic 

� Travel health 

� AIDS Comprehensive Care Clinic 

Hella Douglas, PsychNP 

Comprehensive Care clinic, HIV patient 

� HIV Patient Care, mental health 


Kelly Fimlaid – PhD Student, (Kirkpatrick Laboratory) 

Kovi Bessos – MD, PhD Student (Huston Laboratory) 

Adam Sateriale – PhD Student (Huston Laboratory) 

Archina Vaithilingan – PhD Student (Huston Laboratory) 


W. Kemper Alston, MD 

o External reviewer 

� Annals of internal Medicine, 

113

� Clinical Infectious Diseases 

� Infection Control and Hospital Epidemiology 

Christopher Huston, MD 

o Editorial Board Member – Infection and Immunity 

o External reviewer 

� Complexity in biology: molecular aspects of infectious Diseases 

� French-Israel Scientific and Technological Cooperation Agreement 

� Ministry of Science and Technology, Israel 

o Ad-Hoc Reviewer 

� National Institutes of Allergy and Infectious diseases 

� ZRG1DM-B(02) Pathoghens and Symbiotes 

� ZRG1DM-P(02) Parasites and vectors study section 



2011 Junior Researcher of the Year, University of Vermont 


Beth D. Kirkpatrick MD. Co-Principal Investigator 

Exploration of the biologic cases for the underperformance of oral polio and rotavirus 

vaccination in Bangladesh and India 

$1,450,000 Bill and Melinda Gates Foundation 

Total award $17,000,000 

Beth Kirkpatrick, MD 

The Operation of a Facility for the Study of infectious agents, vaccines and 

antimicrobials in adult and pediatric human subjects 

RFP #NIHAO2008011 Subaward 

04/01/2009 – 03/31/13 

$4,400,000 


Ryan White Part C Grant for HIV Care 

Non- competing grant award 

July 1, 2010 – June 30, 2011 

$580,506 Federal HRSA 

Christopher Grace,MD FACP 

Ryan White Care Act Part B 

July 1, 2010 – June 30, 2011 

$165,420 Federal 

114


TB Control and Surveillance, Public Health Preparedness & Response for Bioterrorism 

Centers for Disease Control and Prevention Investigations and Technical Assistance 

08/01/2010-06/30/2011 

$25,000.00 Federal 

Louis Polish, MD 

New England AIDS Education Training 

Subaward from UMASS 

7/1/2010 – 6/30/2011 

Direct Costs $66,000 


NIH COBRE 

Vermont Immunobiology/ Infectious Diseases Center 

Mechanism of Entomoeba histolytica phagocytosis 

Annual direct costs $146,061 


NIH/ NIAID 

Molecular Mechanism of Entamoeba histolytica phagocytosis 

Annual direct costs $200,000 


The Campbell Foundation 

Targeting human proteins for treatment of cryptosporidiosis 

Annual Direct Costs $63,636 


Typanosoma brucei infection in a HIV positive Ugandan male 

Dill EA, Renault C, Kirkpatrick BD 

Clin lab Sci 2011 Spring; 24(2): 85-88 

Antibodies in Action: Role of Human Opsonins in Killing Salmonella Enterica Serovar 

Typhi 

Lindow JC, Fimlaid KA, Bunn JY, Kirkpatrick BD 

Infect Immun. 2011 Aug; 78(8): 3188-94 

Epub May 31 

PMID: 21124212 

A Sequential Model of Host Cell Killing and Phagocytosis and Entomoeba histolitica 

Sateriale A, Huston CD 

J. Parasitol Res. 2011; 2011:926706 e-pub 2011 Jan 20 

PMID: 21331284 

115

Evidence for a novel Entamoeba histolytica lectin activity that recognizes carbohydrates 

present in ovalbumin 

Heron BT, Sateriale A, Teixeira JE, Huston CD 

Int J. Parasitol. 2011 Feb;41(2): 137-44 epub 2010 Aug 31 

PMID: 20807536 

A sequential model of host cell killing an phagocytosis by Entomoeba histolytica 

Sateriale A, Huston CD 

Journal of Parasitology Research 2011 

PMID 21331284 

The pitfalls of public reporting 

Alston WK 

Infection Control and Hospital Epidemiology, 2010; 31:985 

The complexity, relative value, and financial worth of curbside consultations in an 

academic infectious diseases unit 

Grace C, Alston WK, Ramundo M, Polish L, Kirkpatrick B, Huston C 

Clin Infect Dis 2010 Sep 15;51(6): 651-5 

PMID: 20687842 

Pharmacokinetics, Practical Application to Antimicrobial Therapy 

Ahern J, Pierce K 

Infect Dis Clin Pract 2011 January, 19(1):16-24 

Protozoan, Intestinal 

Huston CD 

Book Chapter in Eukaryotic Microbiology 

Editor: Schaechter, M 

San Diego, CA. Elsvier, Inc (in press) 

Entamoeba genetic diversity and virulence. 

Sing U, Huston CD 

Book Chapter in Evolution of Virulence of Eukaryotic Microbes 

Editors: Sibley D, Howlett B, Heitman J 

New York, NY Wiley-Blackwell (in Press) 

Meningitis and Encephalitis 

Noyes C, Huston CD 

Book Chapter in: Critical Care Secrets, 5 th ed. 

Editors: Parsons PE, Wiener-Kronish JP 

Philadelphia, PA. Elsvier, Inc. (in Press) 

116

Division of Nephrology 

Richard Solomon, MD Director 

http://www.med.uvm.edu/medicine/nephrology 

Clinical Care: 

The primary responsibility of the Division is patient care. As the only 

Nephrologists in practice in the entire State of Vermont, this means 

outpatient outreach programs as well as hospital coverage throughout 

much of the State. In addition to FAHC, members of the Division have 

outpatient clinics in St. Albans, Barre, Newport, and Rutland and are on the consulting 

staff at the respective hospitals – Northwestern, Central Vermont Hospital, North 

Country Hospital and Rutland Regional Medical Center. As consulting staff, members of 

the Division perform in-patient and outpatient consults and are available by phone to 

support local physicians. Chronic dialysis patients (n=270) at five satellite dialysis 

facilities (the above 4 hospitals and South Burlington) are cared for by Division staff. An 

active kidney transplant program and home dialysis program also are primary 

responsibilities of the Division staff. This year, Dr. Dana Negoi joined our faculty 

allowing us to expand our outreach to St. Albans. Both Dr. Alan Segal and Dana Negoi 

have started a home dialysis program which is staffed by two RN’s and to which one of 

our four renal fellows participates weekly. The home dialysis program has nearly doubled 

in size (# of patients) over the past year because of their involvement. We also expanded 

our clinical footprint at Rutland Regional Medical Center with Dr. Wolfgang Weise 

spending the majority of his time there. 

Teaching: 

Members of the Division play an active role in medical education. Faculty teach in first 

and second year medical school core curriculum courses as well as third year student 

rotations in Medicine. Members of the Division provide 10-12 lectures to the Medical 

House staff each year and participate in the weekly Subspecialty Attending Roundings 

and monthly in morning report. The Division has an active 2 year fellowship program (2 

fellows each year). We have been fortunate in having excellent fellows – 100% pass rate 

for Nephrology Boards over the past 10 years with approximately 50% of graduates 

becoming faculty in academic medicine groups. 

Research: 

The Division conducts investigator initiated and participates in multicenter clinical trials 

in areas of dialysis care, chronic kidney disease, hypertension, and acute kidney injury. 

Our faculty have presented their work at national meetings including: 

Virginia Hood, MD 

The almost impossible to control BP. II Congresso International de Medicina 

Interna, Santiago, Dominican Republic, September 4, 2010 

117

Desequilibrio Acido-Base: Casos clinicos. II Congresso International de Medicina 

Interna, Santiago, Dominican Republic, September 4, 2010 

Defining Moments: ACP Alaska Chapter and WWAMI Medical Student 

Program, Anchorage, Alaska, September 16, 2010 

Lactic Acidosis. American Society of Nephrology Renal Week, Denver, CO, 

November 17, 2010 

Other agents and toxins in the pathogenesis of metabolic acidosis. American 

Society of Nephrology Renal Week, Denver, CO, November 17, 2010 

My Life in Medicine. David Roger’s Colloquium, Cornell, New York, NY, 

February 23, 2011 

Blood pressure: goals and how to achieve them for individuals and groups of 

patients. Society of Medicine of Santiago and ACP Chile Chapter, Santiago, 

Chile, May 9, 2011 

Managing disorders of sodium, water, and potassium in heart failure. Society of 

Medicine of Santiago and ACP Chile Chapter, Santiago, Chile, May 10, 2011 

Managing disorders of sodium, water, and potassium in heart failure. Uruguay 

Society of Internal Medicine, Montevideo, Uruguay, May 13, 2011 

Dana Negoi, MD 

Negoi D. Volume Overload and Mortality in Peritoneal Dialysis. 31 th Annual 

Dialysis Conference. Phoenix, Arizona. February 21, 2011 

Faculty 

Negoi D. Culture Negative Peritonitis and other Causes of cloudy Dialysate. 31 th 

Annual Dialysis Conference. Phoenix, Arizona. February 21, 2011 

Richard Solomon, MD 


Director of Division, Medical 

Director Dialysis Services North Country Hospital 

Deb Adey, MD 


Director Transplant Nephrology 

John Gennari, MD 

(Professor, Emeritus) 



Medical Director Dialysis Services, Central Vermont Hospital 

118



Medical Director Dialysis Services Northwestern Hospital 

Jeffrey Rimmer, MD 


Medical Director Dialysis Services Chittenden County Dialysis Center and MCHC 

Alan Segal, MD 


Medical Director Dialysis Services, Home Training Unit, Chittenden Country Dialysis 

Center, 

Director, Nephrology Fellowship Program 

Wolfgang Weise, MD 


Medical Director Dialysis Services Rutland Regional Medical Center 

Fellows 

Michael Duque (2) 

Samer Diab (2) 

Neil Ybanez (1) 

Panupong Lisawat (1) 

Nurse Practitioners 

Caroline Tassey, NP 

Endowed Professorships 

Patrick Chair in Nephrology (Dr. Solomon) 


Deb Adey, MD 

� UNOS/OPTN 

� Region 9, Ethics Committee 

2010-current 


� President-Elect of ACP (April 2010-2011) 

� President of the ACP (April 2011-2012) 

� DOM Finance Committee – 2010-2013 

� Member, Vermont Office of Health Access (Medicaid) Drug Utilization Review 

Board – 1999-present 

119

� Member, Vermont Program for Quality Healthcare, Inc, Diabetes 

Steering Committee 1998-present 

Alan Segal, MD 

� Chair, UVM COM Student Affairs Committee 

� Member, Executive Council of Faculty Senate, UVM COM 

� Research Review Committee, UVM COM 

Study Sections and Federal Advisory Boards 

Richard Solomon MD 

� Member, Renal Safety Board of the Biomarker Consortium of the Foundation for 

NIH. 

Member DSMB of the Clinical Translation Study Group at Massachusetts General 

Hospital (currently involved in new therapies for diabetes). 

Grants 


Keryx Biopharmaceuticals “ A 3 – Period 58 – Week Safety and Efficacy trial of 

KRX – 0502 ( ferric citrate ) in Patients with End – Stage Renal Disease ( ESRD) 

on Dialysis – Principal Investigator 

Richard Solomon, MD 

2005-present CORAL: NIH 

Medical vs interventional treatment of renal artery stenosis 

2008-present Novartis 

ALTITUDE trial: long term benefits of Aliskirein added to angiotensin 

receptor antagonism. 

PI 

2009-present Luitpold, Inc 

Comparison of Venofer and Carboxymaltose for intravenous iron 

replacement therapy in patients with chronic kidney disease. 

2009-present MDS, Inc 

Comparison of sodium bicarbonate to saline for prevention of contrast 

induced kidney injury in patients with eGFR < 30 ml/min undergoing 

coronary or peripheral angiography. 

Trial PI 

PI 

120

2010-present NIH 2RO1HL071944-06 (4%) Project 025215 

Prepregnancy phenotype and predisposition to preeclampsia, Ira Bernstein 

(PI) 

Wolfgang Weise, MD 

Evaluation of cinacalcet therapy to lower cardiovascular events 

(EVOLVE), 2007-present, 

Principal Investigator 

Publications (2010-2011) 

Co-investigator 

Gennari FJ, Hussain-Khan S, Segal A. An unusual case of metabolic alkalosis: A window 

into the pathophysiology and diagnosis of this common acid-base disturbance. American 

J Kid Disease .2010;55:1130-1135. 

Gennari FJ. Very low and high pre-dialysis serum [HCO3-]: Risk factors for mortality. 

What are the appropriate interventions? Seminars in Dialysis 2010;23:253-257. 

Gennari, FJ. Metabolic alkalosis. In: Comprehensive Clinical Nephrology, Floege J, 

Johnson RJ, Feehally J (eds). 4th Edition, Elsevier Science, Philadelphia, In press, 2010 

Li J, Solomon R. Creatinine increases following intravenous contrast: incidence and 

impact. Invest Radiol. 2010, 45: 471-476. 

Mitnick S, Leffler C, Hood VL. “Family Caregivers, Patients and Physicians: Ethical 

Guidance to Optimize Relationships”. J Gen Intern Med 25(3):255–60, 2010 

Qunibi W, Winkelmayer WC, Solomon R, Moustafa M, Kessler P, Ho CH, Greenberg J, 

Diaz-Buxo JA. A randomized, double-blind, placebo-controlled trial of calcium acetate 

on serum phosphorus concentrations in patients with advanced non-dialysis-dependent 

chronic kidney disease. BMC Nephrology, 2011, 12: 9-23. 

Segal, A. Potassium and the Dyskalemias. in Suki and Massry’s Therapy of Renal 

Diseases, Vol. New York (Springer, 2010). 

Solomon R. Contrast-induced acute kidney injury and long-term outcomes: are they 

connected? J Invas Cardiol (accepted) 2010. 

Brown JR, Robb JF, Block CA, Schoolwerth AC, Kaplan AV, O’Connor GT, Solomon, 

RJ, Malenka DJ. Does safe dosing of iodinated contrast prevent contrast-induced acute 

kidney injury? Circ Cardiovasc Interven 2010, 3: 346-350. 

121

Solomon R. Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney 

disease and diabetes mellitus undergoing coronary angiographic procedures. Am Heart J 

2010, 159: e7. 

Solomon R. and Dauerman H. Contrast-induced acute kidney injury: Clinician Update, 

Circulation, 2010, 122: xx-xx. 

122

Division of Primary Care Internal Medicine 

Jonathan Hayden, Director 

http://www.fletcherallen.org/services/primary_care/specialties/primary_care_internal_me 

dicine/ 

Primary Care Internal Medicine (PCIM) is active in the delivery of both outpatient and 

inpatient general internal medicine care to adults. Our primary service area is Chittenden 

and the surrounding counties of Vermont. We have 70 members in our health care 

service including 40 faculty practice physicians, 18 community physicians, and 14 nurse 

practitioners and physician assistants. 

The majority of our effort is directed to the primary care of adults in 

the office setting where patients are seen for a variety of acute and 

chronic medical problems, preventive care, health maintenance and 

preoperative exams. During 2011 the faculty practice physicians and 

associate staff had about 110,000 patient visits at our 4 practice sites 

and the hospital. Our physicians are the primary providers for many 

geriatric patients in Chittenden County as well, attending to senior 

citizens living independently, in assisted living, and over 150 individuals residing in 

local nursing homes. 

PCIM has been actively involved in the Vermont Blueprint for Health program in 

conjunction with the Vermont Department of Health. All of our practices have 

worked to improve office systems for delivering care to patients with chronic medical 

problems. This program has been recognized both regionally and nationally for its 

innovative work. Our four practices at Aesculapius, Burlington, Williston and Essex 

have been evaluated and recognized by NCQA as Patient Centered Medical Homes. 

The Aesculapius practice continues innovative work with the community care team – 

integrating the services of nurses, dieticians, social workers and other health 

professionals to improve the care of patients with chronic medical conditions using a 

patient centered medical home model. 

PCIM has an active hospitalist and consultation service at Fletcher Allen with a 

typical census of 75 patients. In 2010 we expanded this service to accommodate the 

patients of all interested community primary care physicians which has provided 

enhanced care to inpatients at Fletcher Allen. The service will exceed 24,000 inpatient 

encounters in fiscal year 2011. We have continued our active medical consultation 

service, our hip fracture co-management service with Orthopedics, and a busy nonteaching 

service. In addition, the PCIM hospitalists have assumed responsibility for 

teaching attending on all of the four general medicine teaching services, a total of 48 

months annually. This change has been well received by residents and students and 

allows integration of the teaching programs with a team-based approach to patient care. 

We provide 24x7 clinical supervision to the medicine residents, physician leadership of 

the rapid response team (CATS Team), and direct care to patients admitted to the 

medicine service without resident coverage. In addition to our core hospitalist program, 

123

we continue to provide expert medical consultation at the Fanny Allen Rehabilitation 

Center and the inpatient psychiatry unit. 

Active involvement in the teaching programs of the UVM College of Medicine 

continues to be an important part of the mission of Primary Care Internal Medicine. 

With the completion of the UVM Affiliation Agreement all PCIM faculty physicians 

have full-time medical school faculty appointments in the Department of Medicine. 

Many community physician members of the PCIM Health Care Service have part-time 

faculty status. Members are involved in curriculum development, program 

administration and teaching in all 4 years of medical school both in the hospital and in the 

outpatient setting. Many physicians precept residents at the Given Burlington practice 

which houses the medical resident clinic. Thirty-five medical residents practice in the 

clinic under the supervision of our preceptors providing care to general medicine patients 

in a busy clinic environment. PCIM physicians direct a variety of educational programs 

including Doctoring in Vermont, the Medicine outpatient clerkship, the Convergence 

program, and the Internal Medicine residency program. 

Faculty 

Aesculapius Medical Center 

Jennifer Gilwee, MD (Site Clinical Leader) 


Jennifer Ayer, MD 


Dennis Beatty, MD 


Alicia Cunningham, MD 


Kim Fodor, MD 


Jason Gramling, MD 


Jonathan Hayden, MD 

� Associate Professor of Medicine 

Marie Sandoval, MD 


David Ziegelman, MD 


Given Health Care Center Burlington 

Claudia Berger, MD (Site Clinical Leader) 


Jaina Clough, MD 


Mia Hockett, MD 


Robert Karp, MD 

� Associate Professor in Medicine 

124

� PCIM Director of Area Nursing Homes 

Benjamin Littenberg, MD 

� Professor of Medicine 

Scott Luria, MD 


John Miller, MD 


Mark Pasanen, MD 


Richard Pinckney, MD 


Halle Sobel, MD 


Given Health Care Center Essex 

Patricia King, MD (Site Clinical Leader) 


Nathan Ayer, MD 


Tania Bertsch, MD 


Diane Haddock, MD 


Mark Levine, MD 


� Residency Program Director 

Charles MacLean, MD 


Roberta O’Brien, MD 


Given Health Care Center Williston 

Dennis Plante, MD (Site Clinical Leader) 


Marvin Klikunas, MD 


Lucy Miller, MD 


PCIM Hospitalists Service 

Allen Repp, MD - (Director) 


Mireille Anawati, MD 


Paul Crainich, MD 


Florian Foerg, MD 


125

Zechariah Gardner, MD 


Steve Grant, MD 


Mohit Jindal, MD 


Nicholas Kuhn, MD 


Carrie Lyon, MD 


Sadie Mills, MD 


Chad Mitchell, MD 


Shuw Siew, MD 


Paul Slavik, MD 


Jaspinder Sra, MD 


� Osler Teacher of the Year 2011. 

Dennis Woods, MD 



Aesculapius Medical Center 

Tara Abele, NP 

Tristan Adie, NP 

Diane Bell, NP 

Given Health Care Center Burlington 

Gabrielle Mikula, NP 

Tracey Niquette, NP 

Helen Osborne Linseisen, NP 

Given Health Care Center Essex 

Sarah Bushweller, PA 

Given Health Care Center Williston 

Nancy Berg, NP 

Darla Witmer, NP 


Mark Levine, MD 

� Governor, Vermont Chapter of American College of Physicians 


Patricia King, MD 

126

� Federation of State Medical boards Advisory Panel 



Charles MacLean, MD 

� Health Resources and Services Administration/DHHS – 

1) Planning Vermont’s Healthcare Workforce Future $131,786 

2) Vermont Student/Resident Experiences and Rotations in Community Health 

(SEARCH) $378,369 

3) Model State-Supported Area Health Education Centers $297,045 


Mireille Anawati, MD 

� Kolski BC, Khadivi B, Anawati M, Daniels LB, Demaria AN, Blanchard DG. 

The dilated coronary sinus: utility of coronary sinus cross-sectional area and 

eccentricity index in differentiating right atrial pressure overload from persistent 

left superior vena cava. Echocardiography. 2011;28(8):829-32 

Jaspinder Sra, MD 

� Prasad, H; Sra, J; Levy, WC; Stapleton, DD. Influence of Predictive Modeling in 

Implementing Optimal Heart Failure Therapy. Am J Med Sci 341(3):185-190 

(2011) 

Steven Grant, MD, Allen Repp, MD, Charles MacLean MD, Benjamin Littenberg MD 

� Morris, NS., Grant, S., Repp, A., MacLean, C., Littenberg, B. Prevalence of limited 

health literacy and use of compensatory strategies among hospitalized patients. Nursing 

Research 60(5):361-366 (2011) 

127

128

Division of Pulmonary and Critical Care Medicine 

Anne Dixon, MD, Director 

http://www.med.uvm.edu/medicine/pulmonary 

The Pulmonary Critical Care Division has maintained and expanded a 

busy clinical service during the last 12 months. The Division is 

responsible for managing critically ill patients in the Medical Intensive 

Care unit, inpatient pulmonary and critical care consults, and has a 

number of sub-specialty clinics including in interstitial lung disease, 

cystic fibrosis, lung cancer, asthma and cancer survivorship. The Division 

also provides a full range of pulmonary diagnostic services including 

bronchoscopy, pulmonary function testing and other services; evaluation 

of sleep disorders; and outpatient pulmonary rehabilitation. 

In the last 12 months there were over 5000 outpatient visits, an approximate 10 % 

increase over the previous year. The Division totaled approximately 17 000 inpatient and 

outpatient consults during this period. Major new initiatives include the expansion of the 

endobronchial ultra-sound service which has becomes increasingly important in the 

diagnosis and staging of lung cancer. 

The Division has a national and international reputation in research, especially in the 

areas of asthma, stem cell research and more recently obesity and lung disease. The 

Division brought in $5.8 million in external research support in 2010. The Division is 

home to an American Lung Association Asthma Clinical Research Center, one of 18 such 

centers in the country, and the only one in New England. Much of the ’s research takes 

place at the Vermont Lung Center, funded by an NIH Center of Biomedical Research 

Excellence grant, now entering its third five year cycle. 

Currently Division members are involved in 29 clinical research projects, including in 

asthma, idiopathic pulmonary fibrosis, critical care, cystic fibrosis and other topics. 

Basic science and translational research focuses on airway disease biology and animal 

modeling of asthma and other airway diseases. 

Daniel Weiss, MD, PhD received a prestigious $4.26 million Opportunity Grant from the 

NIH to support his work on a novel approach to use stem cells to engineer new lungs for 

patients with end-stage lung disease. This summer, UVM will again host more than 120 

experts from around the world for the biannual “Stem Cells and Cell Therapies in Lung 

Biology and Lung disease. The Division will also host the first international conference 

on obesity and lung disease at Stowe this fall. 

As it maintains a busy clinical practice and successful research program, the Division has 

been equally committed to education and training over the last year. Members have a 

leadership role in the medical school curriculum, including running the respiratory 

section of the award winning Cardiovascular Respiratory and Renal Foundations Course. 

Dr. Gil Allen has taken a leadership role in the implementation of training in the 

placement of central lines using the new Simulation Center, a course that has led to a 

129

dramatic decrease in the incidence of this serious complication on the clinical services. 

The Division has two fellows each year in a three year pulmonary and critical care 

training program. Over the last two years graduates of this program have chosen to take 

a fourth year for research in the hopes of pursuing their own careers in academic 

medicine. 

The last year has been a busy and successful year for the Division as outlined in detail for 

all members of the Division below. 

Faculty 

Anne E. Dixon, MD 


Director, Pulmonary Disease and Critical Care Medicine 

� Asthma 

� Chronic Obstructive Pulmonary Disease 

Gilman Allen III, MD 


� Acute Lung Injury (ALI) 

Jason H.T. Bates, PhD Sc. 


Department of Molecular Physiology & Biophysics 

Interim Director, School of Engineering 

� Monitoring of lung function in patients and animals 

� Automatic control of ventilatory support 

� Mechanical determinants of bronchial responsiveness 

Gerald S. Davis, MD 


� Occupational Lung Disease 

� Asthma 

� Pulmonary Fibrosis 

� Silicosis 

� Sarcoidosis 

� Bronchoalveolar Lavage 

Susan Dunning, MD 


� Sleep Apnea 

� Sleep Disorders 

� Chronic Respiratory Failure 

Charles Irvin, PhD 

Professor Pulmonary Sciences and Critical Care Medicine 

130

Professor Department of Molecular Physiology & Biophysics 

Director, Vermont Lung Center 

� Asthma 

� Pulmonary Physiology 

� Animal Models of Lung Disease 

David Kaminsky, MD 


Director, Pulmonary Disease Fellowship Program 

� Asthma 

� Pulmonary Function Testing 

Laurie Whittaker Leclair, MD 


Adult CF Program Director, FAHC CF Center Member 

� Adult Cystic Fibrosis (CF) 

Lennart Lundblad, PhD 

Research Assistant Professor 

� Lung mechanics in human as well as in laboratory animals 

� Asthma 

� COPD 

� Thoracic gas volume 

� Airway pharmacology 

Yolanda Mageto, MD, MPH 


� Epidemiology of Interstitial Lung Diseases 

� Pathophysiology, diagnosis and management of Idiopathic pulmonary Fibrosis 

� Asthma community outreach and outcomes 

Theodore Marcy, MD, MPH 


� Tobacco use and dependence treatment 


E.L. Amidon Professor of Medicine 

Chair, Department of Medicine 

Medicine Health Care Service Leader 

� Acute Lung Injury 

� Critical Care 

Matthew Poynter, PhD 


131

� Airway Biology 

Renee Stapleton, MD, PhD 


� Nutrition in Critical Care 


� End of Life Care 

Benjamin Suratt, MD 


� Chemotherapy and hematopoietic stem cell transplantation complications 

Charlotte Teneback, MD 

Clinical Instructor 

� Cystic fibrosis, pulmonary rehabilitation 

Daniel Weiss, MD, PhD 



� Gene and cell therapies for lung diseases 

Fellows 

Ali Al-Alwan, MD 

Krishnendu Bhadra, MD 

Alexey Knyazhitskiy, MD 

Jenny Martino, MD 

Prema Menon, MD 

Binh Nguyen, MD 

Tatsiana Palvinskaya, MD 


Katie Bird, NP 

Lily Sender, PA 


Niki Ubags, BS, Masters Student 

MaryEllen Antikowiak, MD, Resident 

Rebecca Martin, MD, PhD Student 

Timothy Leclair, MSIV 

Baoshun Ma, PhD Research Associate 

Bradford Smith, PhD post-doctoral fellow 

Joshua Pothen, BS PhD student in Bioengineering 

Keryn Palmer, BS Masters student in Biomedical Engineering 

132

Martin Wollmer, exchange med. student from Lund University, Sweden 

Johan Helgeson, exchange med. student from Lund University, Sweden 

Meagan Goodwin CMB graduate student 

Melissa Lathrop, PhD post-doctoral fellow 

Laura Wangensteen, MD post-doctoral fellow 


Anne Dixon, MD 

� Chair, Membership Committee, American Thoracic Society 

� Executive Steering Committee American Lung Association Asthma Clinical 

Research Center Network 

Gilman Allen, MD 

� Website Director, Respiratory Structure and Function (RSF) Assembly, American 

Thoracic Society 

� Planning Committee, RSF Assembly, American Thoracic Society 

� Nominating Committee, RSF Assembly, American Thoracic Society 

Jason Bates, PhD 

� Chair of the Program Committee, Respiratory Structure & Function Assembly of 

the American Thoracic Society 


� Chairman, Education Committee, RSF Assembly 

� Nominating Committee, American Thoracic Society (Elected by ATS Board of 

Directors) 

� Chairman, RSF Assembly Nominating Committee, Assembly of Respiratory 

Function, ATS (appointed by Assembly Chairman) 

� Chairman, Executive Steering Committee for NIH NCRR NISBRE 

� Co-chair working group on mentoring NIH NHLBI 

� Member, Awards Committee Society of Experimental Medicine & Biology 

� Member Finance Committee Society of Experimental Medicine & Biology 

� Councilor, Society of Experimental Medicine & Biology 


� Cystic Fibrosis Foundation 

Therapeutic Development Network Steering Committee 


� Member of the Program Committee of the Respiratory Structure and function 

assembly, American Thoracic Society. 

� Officer, board of the Pulmonary Research Group 

133


� American Thoracic Society: 

Program and Budget Committee: member 2007-present 

Members in Transition and Training Committee: member 2008-present 

Publications Policy Committee: member 2011-present 

� Association of Professors of Medicine: 

Education Committee: member: 2008-present; Chair: 2010-2011 

IM-ITE test writing committee: 2008-2011 

Board of Directors: 2010-present 

� Alliance for Academic Internal Medicine: 

Fellowship Requirements Task Force: 2009-2010 

Accreditation Committee: Chair 2011-present 

� Multisociety National Task Force to Develop a Critical Care Research Agenda 

Chair: 2009 - present 


� American Thoracic Society 

Committee for Members in Transition and Training 

Member 2006-present 

Chair-Elect, 2009-2010 

Chair, 2010-present 

� Critical Care Assembly Planning Committee 

Member, 2009-present 

Chair, 2011-present 

� International Conference Critical Care Program Committee, 2009-present 

� Career Development Task Force, 2009-present 

� Canadian Critical Care Nutrition Clinical Practice Guidelines Committee, 

External Panel Member, 2008-present 

� Data Safety Monitoring Board, “Randomized trial of an interdisciplinary 

communication intervention to improve patient and family outcomes in the ICU,” 

PI JR Curtis and RA Engelberg, University of Washington, 2009-present. 


� Member of Planning Committee, AII/ATS 


� Chairman, American Thoracic Society Stem Cell Working Group 

134

� Chairman, International Society for Cell Therapy (ISCT) Lung Disease 

Committee 

� Symposium, Mini-Symposium Chair, 2010, 2011 ATS meetings 

� Respiratory Tract Committee, American Society of Gene and Cell Therapy 

� American Lung Association Research/Scientific Advisory Board 



� Ad Hoc Reviewer for journals American Journal of Physiology, Critical Care 

Medicine, and Chest 


� Associate Editor, Journal of Applied Physiology 


� Editorial Board, Journal of Applied Physiology 

� Editorial Board, Respiratory Research 

� Editorial Board, American Journal Respiratory Cell and Molecular Biology 


� Proceedings Editor, the Pulmonary Research Group 


� Ad Hoc reviewer for the following journals: Preventive Medicine, and Chest 


� Up-to-Date: Editor-in-Chief, Critical Care Section 2004-present 

� American Journal of Respiratory and Critical Care Medicine, 

Editorial Board 2005-present 

� CHEST, Editorial Board 2005-present 

� Proceedings of the American Thoracic Society Editorial Board 2006-present 


� Associate Editor, Journal of Parenteral and Enteral Nutrition (JPEN), January 

2009-2010 


� Editorial Board, Molecular Therapy 

135



� Ad Hoc member Lung Cellular and Molecular Immunobiology study section, 

NIH 

� Special Emphasis Panel: NHLBI‐ Patient Oriented Research (K23, 24, and 25's) Career 

Enhancement Awards 

� Special Emphasis Panel: NHLBI – Lung Tissue Research Consortium 


� External Grant Reviewer for Canadian Cystic Fibrosis Foundation 

Gerald Davis, MD 

� Chair, Data & Safety Monitoring Board “Idiopathic Pulmonary Fibrosis 2006- 

Clinical Research Network” [IPFNet] 

(NHLBI Multicenter Trials Network) 

� Member, ad hoc Study Section for “Asthma & Allergic Diseases 2011 

Cooperative Research Centers” 

(NIAID RFA ZAI1 PA-I (M1)) 

� Member, ad hoc Panel to review National Institutes of Health NHLBI 2011 

Loan Forgiveness Program for Academic Medicine 


� Charter Member, Standing Study Section, (COBRE and RCMI) NCRR, National 

� Ad Hoc RC4 National Institutes of Health 

� Ad Hoc RIBT study Section, Nation Institutes of Health 

� Chairman, ZRG1 CVRS G(03) Study Section, National Institutes of Health 

� Ad Hoc R34 and U01 grants, NIAID, National Institutes of Health 

� Ad Hoc Chairman for a P01 grant and K08 grants, NIAID, National Institutes of 

Health 


� Risk, Prevention, and Health Behavior (RPHB) IRG on July 1-2, October 14-15, 

and March 3-4. 


� NHLBI - ARDS Clinical Trials Network II Protocol Review Committee: member 

2006 to present 

� Special Emphasis Panel: NIH Loan Repayment program: 2007 – 2011 

� NHLBI Institutional Training (T32) Mechanism Review Group 2009-2010 

� Scientific Council of the Francis Families Foundation: 2007-2011 

136

� US Critical Illness and Injury Trials Group: Organizing Committee, member: 

2007-present 

� NHLBI Scientific Advisory Council: member 2011-present 


� Ad Hoc member of LCMI Study Section reviewing R01 applications 

� Standing member of Special Emphasis Panel of NHLBI reviewing K08 

applications 

� Ad Hoc member of CounterACT Study Section reviewing applications to mitigate 

toxic threats 


� World Health Organization Respiratory Working Group for development of ICD- 

11, 2010- present 


� NIH LCMI Section, ad hoc, October 2010 


� NHLBI LIRR, K18, SBIR reviewer 

� NHLBI K18 Study section Chief 5/11 

� ALA Research Grant Study Section Chief 1/11 

� Italian Cystic Fibrosis Foundation 

� Canadian Physicians Service Foundation 

� Raine Foundation at the University of Western Australia 



� Harold and Marilyn Menkes Lectureship, Johns Hopkins University 

� Visiting Professor, Mayo Clinic, Scottsdale AZ 

� Visiting Professor, University of Oregon Health Services Center, Portland 

� Visiting Professor, University of California, Davis, CA 

Theodore Marcy, MD, PhD 

� Pulmonary Teacher of the Year award 2011 

� ALA/ C Everett Koop Foundation Unsung Heroes Award 2011 



137

U01 HL089464 Dixon (PI) 

9/30/09-6/30/14 

Study of Asthma and Nasal Steroids (STAN): 


Simulation Scenario Development; Training Collaboration between FAHC, UVM 

College of Medicine, and Vermont National Guard 

Source: DHHS PI: Ricci, Michael Effort: 16.5% 

Period: 9/01/10-7/31/11 Budget: 471,240 

COBRE Pilot Program Grant PI: Allen, GB Effort: 7.5% 

Period: 1/1/10 – 9/30/10 (no cost extension) Budget: 40,000 

“Endotoxin Burden within the Gut and Airways of Mechanically Ventilated 

Patients in the Intensive Care Unit” 

Allergy and Asthma Foundation PI: Allen, GB Effort: 5% 

Source: AAFA Period: 5/1/11-4/30/12 Budget: 20,000 

“Reflux and Asthma: the mechanisms of acid-induced airways 

hyperresponsiveness” 

RC4 HL106625 PI: D.J. Weiss Effort: 12.5% 

Period: 09/17/10-8/30/13 Budget: 1,230,617 

“Bioengineering New Lungs from Cadaveric Lung Scaffolds” 


R01 HL103405 PI: Bates 07/01/10 – 06/30/13 

NIH/NHLBI A multi-scale approach to airway hyperresponsiveness: from 

molecule to organ. 


Controlled, Parallel Group, Event-Driven, Group Sequential, Phase III 

2008-2010 

Study” (BUILD 3) & open label extension 

Actelion Pharmaceuticals Ltd. 

Gerald S. Davis, M.D. (Principal Investigator for site) 

“A Randomized Double-Blind Placebo-Controlled, Phase 3 Study of the 

2006- 

Safety and Efficacy of Pirfenidone in Patients with Idiopathic Pulmonary 

Fibrosis (PIPF-006 / CAPACITY) & open label extension.(PIPF-0012) 

InterMune Inc. 


“A Phase 2, Multicenter, Multinational, Randomized, Double-Blind, 

2009-2010 

Placebo-Controlled, Parallel-group, Dose-ranging Study Evaluating the 

Efficacy and Safety of CNTO 888 Administered Intravenously in Subjects 

with Idiopathic Pulmonary Fibrosis 

138

Centocor R&D, Inc. 

Yolando Mageto, MD (Co-Principal Investigator for site) 

Gerald S. Davis, M.D. (Co-Principal Investigator for site) 


2010 - 

Placebo-Controlled, Parallel-group, Study Evaluating the Safety and 

Efficacy of Treatment with Ustekinemab or Golimumab in Subjects with 

Chronic Sarcoidosis 



“A Phase 2, Sequential, Ascending Dose Study To Characterize The Safety, 

Tolerability, 2011 - Pharmacokinetic And Biological Activity Of CC-930 In 

Idiopathic Pulmonary Fibrosis (IPF) 2011 - 

Celgene Cooporation 

Yolando Mageto, MD (Principal Investigator for site) 

Gerald S. Davis, MD (Co-Investigator for site) 

“A Phase 2a, Open-Label, Single-Arm Study to Evaluate the Safety, Tolerability, 

and Efficacy of FG-3019 in Subjects with Idiopathic Pulmonary Fibrosis 2011 - 

Fibrogen Inc. 



“A Phase 1, Open Label, Multi-Dose Study to Evaluate the Safety, Tolerability, 

and Biologic Effects of Three Doses of IW001 in Patients with Idiopathic 

Pulmonary Fibrosis (IPF) 2011 - 

Immuneworks 



“PIPF-016 entitled “A Randomized, Double-Blind, Placebo-Controlled, Phase 3 

Study of the Efficacy and Safety of Pirfenidone in Patients with Idiopathic 

Pulmonary Fibrosis” 2011 - 


Gerald S. Davis, MD (Principal Investigator for site) 

Yolando Mageto, MD (Co-Investigator for site) 


2010-2015 National Heart, Lung and Blood Institute (NIH/NHLBI) P30 

RR031158-01 

Translational Research in Lung Biology and Disease 

Principal Investigator: Charles G. Irvin (20% effort) 

3,750.00 total Direct 5,643,750.00 Estimated Total 

139

2009-2014 American Lung Association 

Asthma Clinical Research Center 

Principal Investigator: Charles G. Irvin (10% effort) 

$100,000 year 1 direct cost $500,000 (total award) plus capitation 

4/1/04-3/31/14 National Heart Lung & Blood Institute (NHLBI) T32 

HL076122-01 Multidisciplinary Training in Lung Biology 

Principal Investigator: Charles Irvin (0% effort) 

$299,928 

1/1/11-12/31/15 U13 RR022675 NOT-RR-05-004 

National IDeA Symposium of Biomedical Research Excellence (NISBRE) 


45,391 annual direct costs 

12/10-11/11 National Heart, Lung and Blood Institute (NIH/NHLBI) P30 

RR031158-01) PIP Grant 

Role of DARC, the Duffy antigen receptor, in eosinophil induced airway 

pathology 


$50,000 


Therapeutics and Development network Award 2010 

12/10-12/11 Role on Grant: Co-PI $80,000 Cystic Fibrosis Foundation 

Learning and Leadership Collaborative Adult Quality Improvement (AQI2) 

5/2011-5/2012 Role on Grant: Team leader Cystic Fibrosis Foundation 


Sepracor ASRC312, PI: Lennart Lundblad 

Hoffman La-Roche: PI: Lennart Lundblad 

COBRE PI: Charles Irvin. Lennart Lundblad role: Core Director of the 

Phenotyping facility 


National Institutes of Health / National Cancer Institute 5R21CA134817-2 

Clinical Testing of a CDSS for Tobacco Use Treatment. No cost extension 

through Aug 31, 2011 

Yolanda Mageto, MD, MPH 


2009-2010 

Placebo-Controlled, Parallel-group, Dose-ranging Study Evaluating the 

Efficacy and Safety of CNTO 888 Administered Intravenously in Subjects 

140

with Idiopathic Pulmonary Fibrosis 


Yolando Mageto, MD (Co-Principal Investigator for site) 

Gerald S. Davis, M.D. (Co-Principal Investigator for site) 

“A Phase 2, Sequential, Ascending Dose Study to Characterize the Safety, 

Tolerability, 2011 - Pharmacokinetic and Biological Activity of CC-930 in 

Idiopathic Pulmonary Fibrosis (IPF) 2011 - 

Celgene Cooporation 



“A Phase 2a, Open-Label, Single-Arm Study to Evaluate the Safety, Tolerability, 

and Efficacy of FG-3019 in Subjects with Idiopathic Pulmonary Fibrosis 2011 - 

Fibrogen Inc. 



“A Phase 1, Open Label, Multi-Dose Study to Evaluate the Safety, Tolerability, 

and Biologic Effects of Three Doses of IW001 in Patients with Idiopathic 

Pulmonary Fibrosis (IPF) 2011 - 

Immuneworks 



“PIPF-016 entitled “A Randomized, Double-Blind, Placebo-Controlled, Phase 3 

Study of the Efficacy and Safety of Pirfenidone in Patients with Idiopathic 

Pulmonary Fibrosis” 2011 - 


Gerald S. Davis, MD (Principal Investigator for site) 

Yolando Mageto, MD (Co-Investigator for site) 


“1 R13 HL103080-01 NIH: NHLBI 

Multi-society Strategic Planning for Critical Care Research” 

Polly E. Parsons PI 

3/1/2010 

“IU01HL102547 – M. Boeckh (PI) NIH 

A Randomized Phase II Trial of CMV Prevention in Acute Lung Injury” 

UVM Site PI: P. Parsons 

6/1/10-5/31/13 


R01-HL089177 (Poynter; PI) 

R01 Administrative Supplement (Poynter, PI) 

141

Flight Attendant Medical Research Institute Research grant (van der Vliet; Co-I) 

R01-NS061014 (Teuscher; Co-I) 

NASA EPSCoR Research grant (Lakin & Hill, Co-I) 

RC1 Challenge Grant (Fukagawa; Co-I) 

R01-DK082803 (Kien; Co-I) 

VLC Pilot Project (Poynter & Ckless, PI) 

VCIID Pilot Project (Boyson & Poynter; Co-PI) 


Fletcher Allen Health Care/University of Vermont Medical Group Research 

Award 

“Intravenous Zinc as a Therapy for Severe Sepsis: A Pilot Study” 

12/1/10-11/30/12 $50,000 Role: PI 

National Palliative Care Research Center 

“Changing the paradigm of CPR: Exploring Informed Assent” 

7/1/10-6/30/12 Direct: $140,000 ($70,000 per year) Role: PI 

American Heart Association Clinical Research Program Award 

“The pharmacokinetics of omega-3 fatty acids in patients with sepsis and in 

healthy controls” 

09CRP2230291, 7/1/09-6/30/11Direct: $100,000 ($50,000 per year) Role: PI 

University of Vermont College of Medicine Internal Grant Program Award 

"Zinc and Vitamin D in Patients with Sepsis" 

12/1/09 - 11/30/10 $75,000 Role: PI 

“A Randomized double-Blind Placebo-Controlled Trial of 

Ganciclovir/Valganciclovir for Prevention of Cytomegalovirus Reactivation in 

Acute Lung Injury” 

1U01HL102547-01, 7/01/10-6/30/13 

Per-patient reimbursement Role: Site-Co-PI and Protocol Committee Member 


4th Year Clinical Fellowship, Cystic Fibrosis Foundation 

December 2010 - December 2011. $68,250 

Bejamin Suratt, MD 

Research Project Grant (R01), NHLBI, HL-084200 (Suratt), 

$1,900,000: 2006 – 2011 

"Reciprocal regulation of SDF-1 between marrow and lung during acute lung 

injury” 

Role on grant: PI 

142

Research Project Grant (R01), NHLBI, HL-089177 (Poynter), 

$1,887,500: 2007 – 2012 

"Nitrogen Dioxide in the Sensitization to Allergic Airway Disease” 

Role on grant: Co-investigator 

New Research Initiative, University of Vermont College of Medicine, 

$25,000: 2009 – 2010 

“Obesity and Acute Lung Injury: The effects of hyperleptinemic leptin resistance 

on neutrophil development and behavior in the pathogenesis of ALI” 


R01 Administrative Supplement, NHLBI, HL-084200-04S1 (Suratt) 

$183,286: 2009 – 2011 

"Reciprocal regulation of SDF-1 between marrow and lung during acute lung 

injury” 


UVM COBRE Pilot Project Award, University of Vermont College of Medicine, 

$40,000: 2010 – 2011 

“Obesity and the pathogenesis of acute lung injury” 


UVM COBRE Pilot Project Award, University of Vermont College of Medicine, 

$50,000: 2011 – 2012 

“The role of bone marrow proteases in alpha-one antitrypsin deficiency-related 

lung disease” 


Pilot Award, AlphaOne Foundation, 

$40,000: 2011 – 2012 

“Role of alpha-one antitrypsin in control of neutrophil release and the 

development of lung inflammation” 



NIH RC4HL106625 (DJ Weiss PI) 9/1/10-8/31/13 

NIH/NHLBI $3,600,000 total direct 

Bioengineering Functional Lung Tissue from Cadaveric Scaffolds 

NHLBI R21HL094611 (DJ Weiss PI) 7/1/10-6/30/12 

NIH/NHLBI $275,000 total direct 

Use of 3-D Culture and Stretch to Develop Lung from MSCs, ESCs, and iPS 

NHLBI RC2HL101535 (D Kotton PI, Boston University) 9/30/09-9/29/11 

DJ Weiss Co-Investigator $33,106 direct/yr 1 (subcontract) 

Characterization of human hematopoietic and endodermal progenitors derived 

from iPS free of reprogramming transgenes 

143

NASA EPSCOR Research Grant (PI Jane Hill PhD, VUM College of 

Engineering) DJ Weiss Co-Investigator 

9/1/09-8/31/12 $1,500,000 total direct 

The impact of microgravity-grown Pseudomonas aeruginosa and Haemophilus 

influenzae on human lung cells: integration of virulence, lung cell immune 

responses, and the volatile metabolome 

NCRR COBRE P20 RR-155557 (Irvin) 

Pilot Proposal (DJ Weiss PI) 1/1/10-12/31/10 1.8 calendar 

De-Cellularized Mouse Lungs for Lung Tissue Engineering with Adult and 

Embryonic Stem Cells 

CF Foundation Research Grant (D Kotton PI, Boston University) 

4/1/10- 3/31/12 DJ Weiss Co-Investigator $90,000 direct/yr 

Derivation of Pluripotent Stem Cells for Cystic Fibrosis Therapy 

Italian CF Foundation Research Grant (R Loi PI University of Perugia, 

Sardinia) DJ Weiss Co-investigator 7/1/10-6/30/12 50,000 Euros/yr 1 

An induced pluripotent stem cell (iPS)-based approach for the repopulation and 

phenotypic correction of cystic fibrosis airway epithelium 

Arizona State University/Mayo Clinic Scottsdale seed grant (C Nickerson PhD, 

PI) DJ Weiss Co-investigator 1/1/11-12/31/11 $40,000 direct 

Re-cellularization of de-celluarized human lung scaffolds using rotating 

bioreactor technology 

NHLBI R21HL108689 (DJ Weiss PI) 9/1/11-8/30/13 

NHLBI $250,000 total direct 

De-Cellularized Human Lungs for Ex Vivo Lung Regeneration 

Study section 3/11: Score 2.6 Anticipated funding as of September 2011 

Stem Cell Conference Grants and Support 2005 2007 2009 2011 

(DJ Weiss PI on all) 

NHBLI R13 25K 25K 25K pending 

Alpha 1 Antitrypsin Foundation Grant n/a 5K 5K 5K 

American Thoracic Society Assembly Project 12K 12K 12K pending 

Cystic Fibrosis Foundation 10K n/a n/a n/a 

Emory Center for Respiratory Health Grant n/a n/a 5K n/a 

LAM Foundation Research Grant n/a 5K 2K 1.5K 

Pulmonary Fibrosis Foundation n/a 5K 20K 15K 

VLC/UVM 5K 15K 10K 10K 

144



Lugogo NL, Kraft M & Dixon AE. Does Obesity produce a distinct asthma phenotype, 

J Appl Physiol. 2010; 108(3):729-34. PMID: 19875708 

Stapleton RD, Dixon AE, Parsons PE, Ware LB, Suratt BT. The Association between 

Body Mass Index and Plasma Cytokine Levels in Patients with Acute Lung Injury. Chest 

2010 Sep; 138(3):568-77. 

Dixon AE, Holguin F, Sood A, Salome CM, Pratley RE, Beuther DB, Celedón JC & 

Shore SA An Official American Thoracic Society Workshop Report: Obesity and 

Asthma. Proc Am Thorac Soc. 2010 Sep; 7(5):325-35. 

Raviv S, Dixon AE, Kalhan R, Shade D, Smith LJ. Effect of Obesity on Asthma 

Phenotype is dependent on asthma severity. Journal of Asthma, 2011; 48(1):98-104. 

Dixon AE, Pratley RE, Forgione PM, Kaminsky DA, Whittaker-Leclair LA, Griffes LA, 

Garudathri J, Raymond D, Poynter ME, Bunn JY, Irvin CG. Effects of obesity and 

bariatric surgery on airway hyperresponsiveness, asthma control and inflammation. 

Journal of Allergy and Clinical Immunology, accepted for publication 


BL Schwartz, RC Anafi, M Aliyeva, JA Thompson-Figueroa, GB Allen, LK Lundblad, 

JHT Bates. Effects of central airway shunting on the mechanical impedance of the 

mouse lung. Ann Biomed Eng 2010; 39: 497-507. 

AS Seah, KA Grant, M Aliyeva, GB Allen, and JHT Bates. Quantifying the Roles of 

Tidal Volume and PEEP in the Pathogenesis of Ventilator-Induced Lung Injury. Ann 

Biomed Eng, 2011; 39: 1505–1516 

MJ Wargo, MJ Gross, S Rajamani, JL Allard, LKA Lundblad, GB Allen, ML Vasil, LW 

Leclair, and DA Hogan. Hemolytic Phospholipase C Inhibition Protects Lung Function 

During Pseudomonas Aeruginosa Infection. Am J Respir Crit Care Med (in press) May, 

2011, doi:10.1164/rccm.201103-0374OC. 


M.A. Khan, R. Ellis, M.D. Inman, J. H.T. Bates, M.J. Sanderson, and L.J. Janssen. The 

influence of airway wall stiffness and parenchymal tethering on the dynamics of 

bronchoconstriction. American Journal of Physiology - Lung Cellular and Molecular 

Physiology. 299: L98-L108, 2010. 

A. Z. Politia, G.M. Donovan, M.H. Tawhai, M.J. Sanderson, A.-M. Lauzon, J.H. T. 

Bates, and J. Sneyd. A multiscale, spatially-distributed model of asthmatic airway hyperresponsiveness. 

Journal of Theoretical Biology. 266: 614-624, 2010. 

145

B. Ma, and J.H.T. Bates. Modeling the complex dynamics of derecruitment in the lung. 

Annals of Biomedical Engineering. 38: 3466-3477, 2010. 

G.M. Donovan, S.R. Bullimore, A.J. Elvin, M.H. Tawhai, J.H.T. Bates, A.-M.Lauzon, 

and J. Sneyd. A continuous-binding cross-linker model for passive airway smooth 

muscle. Biophysical Journal. 99: 3164-3171, 2010. 

RC. Anafi, and J.H.T. Bates. Balancing robustness against the dangers of multiple 

attractors in a Hopfield-type model of biological networks. PLoS ONE 5(12): e14413. 

doi:10.1371/journal.pone.0014413, 2010. 

B.L. Schwartz, R.C. Anafi, M. Aliyeva, J.A. Thompson-Figueroa, G.B. Allen, L.K.A. 

Lundblad, and J.H.T. Bates. Effects of central airway shunting on the mechanical 

impedance of the mouse lung. Annals of Biomedical Engineering. 39: 497-507, 2011. 

S.R. Bullimore, S. Siddiqui, G.M. Donovan, J.G. Martin, J. Sneyd, J. H.T. Bates and A.- 

M. Lauzon. Could an Increase in Airway Smooth Muscle Shortening Velocity Cause 

Airway Hyperresponsiveness?. American Journal of Physiology - Lung Cellular and 

Molecular Physiology. 300: L121-L131, 2011. 

D.W. Kaczka, K. Cao, G.E. Christensen, J.H.T. Bates, and B.A. Simon. Analysis of 

regional mechanics in canine lung injury using forced oscillations and 3-D image 

registration. Annals of Biomedical Engineering. 39: 1112-1124, 2011. 

L.K.A. Lundblad, L.M. Rinaldi, M.E. Poynter, E.P. Riesenfeld, M. Wu, S. Aimi, L.M. 

Barone, J.H.T. Bates, and C.G. Irvin. Detrimental effects of albuterol on airway 

responsiveness requires airway inflammation and is independent of beta-receptor affinity 

in murine models of asthma. Respiratory Research. 12: 27, 2011. 

A.S. Seah, K.A. Grant, M. Aliyeva, G.B. Allen, and J.H.T. Bates. Quantifying the roles 

of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injury. Annals 

of Biomedical Engineering. 39: 1505-1516, 2011. 

B. Suki and J.H.T. Bates. Lung tissue mechanics as an emergent phenomenon. Journal of 

Applied Physiology. 110: 1111-1118, 2011. 

B. Ma, B. Suki, and J.H.T. Bates. Effects of recruitment/derecruitment dynamics on the 

efficacy of variable ventilation. Journal of Applied Physiology. 110: 1319-1326, 2011. 

M. Tawhai and J.H.T. Bates. Multi-scale lung modeling. Journal of Applied Physiology. 

110: 1466-1472, 2011. 

B. Suki, J.H.T. Bates, and U. Frey. Complexity and Emergent Phenomena. Handbook of 

Physiology. J.J. Fredberg, Ed. American Physiological Society, 2011, Vol. 1, pp. 995 - 

1029. 

146


Davis GS Inhalation diseases of the lung, in “Netter’s Collection of Medical 

Illustrations: The Respiratory System” (2 nd Edition). D Kaminsky (Ed), Elsevier, Inc., 

Philadelphia, PA. 2011. 


Riesenfeld EP, Sullivan MJ, Thompson-Figueroa JA, Haverkamp HC, Lundblad LK, 

Bates JH, Irvin CG, Inhaled salmeterol and/or fluticasone alters structure/function in a 

murine model of allergic airways disease. Respir Res;11: 22, 2010. PMID: 20181256 

Neveu WA, Allard JL, Raymond DM, Bourassa LM, Burns SM, Bunn JY, Irvin CG, 

Kaminsky DA, Rincon M. Elevation of IL-6 in the allergic asthmatic airway is 

independent of inflammation but associates with loss of central airway function. Respir 

Res;11:28, 2010. PMID: 20205953 

Wu AC, Himes BE, Lasky-SU J, Litonjua A, Li L, Lange C, Lima J, Irvin CG, Weiss S. 

Development of a Pharmacogenetic Predictive Test for Asthma: Proof of Concept. 

Pharmacogenet Genomics 20:86-93, 2010.PMID: 20032818 

Cohen RT, Raby BA, Van Steen K, Fuhlbrigge AL, Celedon JC, Rosner BA, Strunk RC, 

Zeiger RS, Weiss CT Childhood Management Program Research Group. In Utero smoke 

exposure and impaired response to inhaled corticosteroids in children with asthma. J 

Allergy Clin Immunol 126(3):491-7, 2010. PMID: 20673983 

Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RSWEiss CT, 

Litonjua AA.. Serum vitamin D levels and severe asthma exacerbations in the Childhood 

Asthma Management Program study. J Allergy Clin Immunol 126(1):52-8 e5, 2010. 

PMID: 20538327 

Bosse Y, Riesenfeld EP, Pare PD, Irvin CG. It's not all smooth muscle: non-smoothmuscle 

elements in control of resistance to airflow. Annu Rev Physiol;72:437-62, 2010. 

PMID: 20148684 

Lundblad LK, Rinaldi LM, Poynter ME, Riesenfeld EP, Wu M, Aimi S, Barone LM, 

Bates JH, Irvin,C G. Detrimental effects of albuterol on airway responsiveness requires 

airway inflammation and is independent of beta-receptor affinity in murine models of 

asthma. Respir Res 2011;12:27. 

Meyers DA, Hanrahan JP, Lima JJ, Litonjua AA, Tantisira KG, Liggett SB. Regulatory 

haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir 

Crit Care Med 15;183(4): 449-454, 2011. PMID: 20851928 

Hantos Z, Bates JH, Irvin CG, Lundblad LK, Sly PD. Airway resistance: synonyms, 

surrogates, and precision. Am J Physiol Lung Cell Mol Physiol 2011;300(3):L506; author 

reply L07.PMID: 21368020 

147

Fifth Avenue Effect: how drug presentation style influences adherence and outcome in 

patients with asthma. J Allergy Clin Immunol 2011;127(2):406-11. 

Dweik RA, Boggs PB, Erzurum SC, Irvin, CG, Leigh MW, Lundberg JO, Olin A-C, 

Plummer AL, Taylor DR. Interpretation of Exhaled Nitric Oxide Levels (FENO) for 

Clinical Application. American Thoracic Society. Accepted for publication 

Kaminsky DA, Irvin CG, Sterk PJ. Complex Systems in Pulmonary Medicine: A Systems 

Biology Approach to Lung Disease. J Appl Physiol 2010. 

Hyde DM, Hamid Q, Irvin CG. Anatomy, pathology, and physiology of the 

tracheobronchial tree: emphasis on the distal airways. J Allergy Clin Immunol 124(6 

Suppl):S72-7, 2009. PMID: 19962039 

Hensen PM, Downey GP, Irvin CG. It’s Much More than Just Pretty Pictures. Am J 

Respir Cell Mol Biol 42:1-2, 2010. PMID: 20393072 

Irvin CG. Airways hyperresponsiveness: A perspective from 15,000 ft. J Appl Physiol, 

2010. PMID: 20133442 

Irvin CG. The nose: A window into the asthmatic lung? Clin Exp Allergy 40:839-840, 

2010. PMID: 20557548 

Le groupe Pulmonaire, Quanjer PH, Enright PL, Stocks J, Ruppel G, Swanney MP.Crapo 

RO, Pedersen OF, Falaschetti E, Schouten JP, Jensen, RL. [Open letter to the members of 

the GOLD committee]. Rev Mal Respir 27(9):1003-7, 2010. 

Clerisme-Beaty EM, Bartlett SJ, Teague WG, Lima J, Irvin CG, Cohen R, et al. The 

Madison Avenue effect: how drug presentation style influences adherence and outcome 

in patients with asthma. J Allergy Clin Immunol 2011;127(2):406-11. 

Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, et al. 

Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am 

J Respir Crit Care Med 2011;183(4):449-54. 

David Kaminsky, MD 

Kaminsky, DA, Savage P, Callas P, Ades P. Lung Function and Cardiovascular Risk: 

Effect of Cardiac Rehabilitation. J Cardiopulm Rehab Prevent. 2010;30:384-90. 

Kaminsky DA. Peripheral lung mechanics in asthma: Exploring the outer limits. Pulm 

Pharmacol Ther. 2010 Dec 10. [Epub ahead of print]. 

Kaminsky DA, Irvin CG, Sterk PJ. Complex systems in pulmonary medicine: 

A systems biology approach to lung disease. J Appl Physiol. 2010 Dec 23. [Epub ahead 

of print]. 

148

Gardner ZS, Ruppel, GL, Kaminsky DA. Grading the Severity of Obstruction in Mixed 

Obstructive-Restrictive Lung Disease. Chest 2011. March 7. [Epub ahead of print]. 

Kaminsky DA, Marcy T, Dorwaldt A, Pinckney R, DeSarno M, Solomon L, Hughes, J. 

Motivating smokers in the hospital pulmonary function lab to quit 

smoking by use of the lung age concept. Nicot and Tob Research 2011. [Epub ahead of 

print]. 

Kaminsky DA. Ed. Netter Collection of Medical Illustrations, 2 nd ed. Volume 3: 

Respiratory System. Philadelphia: Elsevier, Inc. 2010. 




138:568-577 2010; (epub April, 2010) 

Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR. 

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressordependent 

septic shock. Crit Care Med. 2010 Jun; 38(6):1436-41.PMID: 20386309 

Stapleton RD, Martin TR, Weiss NS, Crowley JJ, Gundel SJ, Nathens AB, Akhtar SS, 

Ruzinski JT, Caldwell E, Curtis JR, Heyland DK, Watkins TR, Martin JM, Parsons PE, 

Wurfel MM, Hallstrand TS, Sims KA, Neff MJ. A Phase II Randomized Placebo- 

Controlled Trial of Omega-3 Fatty Acids for the Treatment of Acute Lung Injury. Crit 

Care Med 2011. March 17 (epub ahead of print) 

Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay; 

National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome 

Network. Crit Care Med 2011, Jan 28 (epub ahead of print) 

Allen GB and Parsons PE. Acute respiratory failure due to Acute Respiratory Distress 

Syndrome and Pulmonary Edema in: Intensive Care Medicine, Irwin and Rippe, 7thth 

Edition, (in press) 

Parsons PE, Acute Lung Injury in: The Netter Collection of Medical Illustrations, 

volume 3: Respiratory System, DA Kaminsky, editor, Elsevier, Philadelphia PA, 2011 


Scanlon TC, Teneback CC, Gill A, Bement JL, Weiner JA, Lamppa JW, Leclair LW, 

Griswold K. Enhanced antimicrobial activity of engineered human lysozyme. ACS 

Chem Biol. Volume 5(9):809-18, 2010. 

149

Hodgkins SR, Ather JL, Paveglio SA, Allard JL, Leclair LW, Suratt BT, Boyson JE, 

Poynter ME. NO2 inhalation induces maturation of pulmonary CD11c+ cells that 

promote antigenspecific CD4+ T cell polarization. Respir Res. Volume 11: 102, 2010. 


Inhaled salmeterol and/or fluticasone and structure/function in airway inflammation. Erik 

P. Riesenfeld MD, Michael A. Sullivan BS, John A. Thompson-Figueroa MSE, Hans C. 

Haverkamp PhD, Lennart K Lundblad PhD, Jason H.T. Bates PhD, DSc, and Charles G. 

Irvin PhD. Respir Res, 2010. 11(1): 22 

Effects of central airway shunting on the mechanical impedance of the mouse lung. 

Benjamin L. Schwartz, Ron C. Anafi, Minara Aliyeva, John A. Thompson-Figueroa, 

Gilman B. Allen, Lennart K.A. Lundblad, and Jason H. T. Bates. Ann Biomed Eng. 2010 

Jul 17. [Epub ahead of print]PMID: 20640513. 

The ability of albuterol isomers to alter the immediate airway response to inhaled antigen 

and airway hyperresponsiveness. Lennart KA Lundblad, Lisa M Rinaldi, Matthew E. 

Poynter, Erik P Riesenfeld, Min Wu, Steven Aimi, Leesa M Barone, Jason HT Bates and 

Charles G Irvin Respiratory Research 2011, 12:27 (7 March 2011) 

Hemolytic phospholipase C inhibition protects lung function during Pseudomonas 

aeruginosa infection. Matthew J. Wargo, Maegan J. Gross, Sathish Rajamani, Jenna L. 

Allard, Lennart K.A. Lundblad, Gilman B. Allen, Michael L. Vasil, Laurie W. Leclair, 

and Deborah A. Hogan. AJRCCM Articles in Press. Published on May 11, 2011 as 

doi:10.1164/rccm.201103-0374OC 

Translational Medicine Approaches to the Study of Pulmonary Diseases. Editorial. 

Lennart K.A. Lundblad, Ph.D, Leesa M. Barone, Ph.D. and Lynne Murray, Ph.D. Pulm 

Pharmacol Ther. 2011 Apr;24(2):185-6. 


Kaminsky D, Marcy T, Dorwaldt A, Pinckney R, Desarno M, Solomon L, Hughes J. 

Motivating Smokers in the Hospital Pulmonary Function Lab to Quit Smoking by Use of 

the Lung Age Concept Nicotine and Tobacco Research 2011 in press 

Martino J, Marcy T. Discontinuation of Mechanical Ventilation. In Parsons PE, and 

Wiener-Kronish JP, eds., Critical Care Secrets, 5th Ed. In press 

Marcy TW. Mechanical Ventilation. In Kaminsky D (ed) The Netter Collection of 

Medical Illustrations: Respiratory System. Elsevier Inc, Philadelphia 2011 

Marcy TW. Pulmonary Edema. In Kaminsky D (ed) The Netter Collection of Medical 

Illustrations: Respiratory System. Elsevier Inc, Philadelphia 2011 

150


Aktan, I., Chant, A., Borg, Z.D., Damby, D.E., Leenstra, P.C., Lilley, G.W., Petty, J., 

Suratt, B.T., Teuscher, C., Wakeland, E.K., Poynter, M.E., and J.E. Boyson. Slam 

haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT 

cell number and function. Journal of Immunology, June 7, 2010 [Epub ahead of print], 

PMID: 20530260. 

Ather, J.L., Hodgkins, S.R., Janssen-Heininger, Y.M.W., and M.E. Poynter. Airway 

epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled 

antigen. American Journal of Respiratory Cell and Molecular Biology, June 2, 2010. 

[Epub ahead of print], PMID: 20581095. 

Hodgkins, S.R., Ather, J.A., Paveglio, S.A., Allard, J.L., Whittaker LeClair, L.A., Suratt, 

B.T., Boyson, J.E., and M.E. Poynter. NO2 inhalation induces maturation of pulmonary 

CD11c+ cells that promote antigen-specific CD4+ T cell polarization in the lung. 

Respiratory Research, 2010, 11:102, PMC2918560. 

Lundblad, L.K.A., Rinaldi, L.M., Poynter, M.E., Riesenfeld, E.P., Wu, M., Aimi, S., 

Barone, L.M., Bates, J.H.T., and C.G. Irvin. Detrimental effects of albuterol on airway 

responsiveness requires airway inflammation and is independent of β-receptor affinity. 

Respiratory Research 12:27 (2011). 

Paveglio, S.A., Allard, J., Foster, S.R., Ather, J., Bevelander, M., Mayette, J., Whittaker, 

L.A., McCarthy, S.M., van der Vliet, A., Suratt, B.T., Boyson, J.E., and M.E. Poynter. 

Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus 

fumigatus antigen exposure. American Journal of Respiratory Cell and Molecular 

Biology, 2011 Jan;44(1):11-23. Epub 2010 Jan 29, PMID 20118221. 

Goodwin, M., Sueblinvong, V., Eisenhauer, P., Ziats, N.P., Leclair, L., Poynter, M.E., 

Steele, C., Rincon, M., and D.J. Weiss. Bone marrow derived mesenchymal stromal cells 

inhibit Th2-mediated allergic airways inflammation in mice. Stem Cells May (2011). 

PMID:21544902. 

Ckless, K., Hodgkins, S.R., Ather, J.L., and M.E. Poynter. Epithelial, dendritic, and 

CD4+ T cell regulation of and by reactive oxygen and nitrogen species in allergic 

sensitization. Biochemica et Biophysica Acta – General Subjects March 2011 [Epub 

ahead of print]. 

Ather, J.L., Ckless, K., Martin, R., Foley, K.L., Suratt, B.T., Boyson, J.E., Fitzgerald, 

K.A., Flavell, R.A., Eisenbarth, S.C., and M.E. Poynter. Serum amyloid A (SAA) 

activates the NLRP3 inflammasome and promotes TH17 allergic asthma in mice. Journal 

of Immunology May 27, 2011 [Epub ahead of print]. 

151




2010;138:568-77. 

Stapleton RD, Martin TR, Weiss NS, Crowley JJ, Gundel SJ, Nathens AB, Akhtar SS, 

Ruzinski JT, Caldwell E, Curtis JR, Heyland DK, Watkins TR, Martin JM, Parsons PE, 

Wurfel MM, Hallstrand TS, Sims KA, Neff MJ. A Phase II Randomized Placebo- 

Controlled Trial of Omega-3 Fatty Acids for the Treatment of Acute Lung Injury. Crit 

Care Med 2011. In Press. 

Bhadra K, Stapleton RD. Enteral Nutrition. In: Vincent JL and Hall JB, eds. 

Encyclopedia of Intensive Care Medicine. New York, NY, Springer (In press). 

Stapleton RD, Martin JM, Mayer K. Fish oil in critical illness: mechanisms and clinical 

applications. Crit Care Clin 2010;26:501-14. 

Martin JM, Stapleton RD. Omega-3 Fatty Acids in Critical Illness. Nutr Rev 

2010;68:531-41. 


JL Ather, JF Alcorn, AL Brown, AS Guala, BT Suratt, YM Janssen-Heininger, ME 

Poynter, Distinct functions of airway epithelial NF-kB activity regulate nitrogen dioxideinduced 

acute lung injury. Am J Resp Cell Mol Biol, 43:443-51, 2010. 

RD Stapleton, AE Dixon, PE Parsons, L Ware, *BT Suratt, Association between body 

mass index and plasma cytokine levels in patients with acute lung injury. CHEST, 

138:568-77, 2010. 

JH Madenspacher, KA Smoak, DW Draper, S Ward, BT Suratt, MD Wilson, LL Rudel, 

MB Fessler. Dyslipidemia exerts opposing effects upon intrapulmonary and 

extrapulmonary host defense in mice. J Immunol, 185:1660-9, 2010. 

I Aktan, A Chant, DE Damby, ZD Borg, J Petty, ME Poynter, BT Suratt, C Teuscher, and 

JE Boyson. Slam haplotypes modulate the response to LPS in vivo through control of 

NKT cell number and function. J Immunol, 185:144-56, 2010. 

SR Hodgkins, JL Ather, SA Paveglio, JL Allard, LW Leclair, BT Suratt, JE Boyson, and 

ME Poynter. NO2 inhalation induces maturation of pulmonary CD11c+ cells and 

promotes a TH2- and TH17- polarizing environment in the lung. Resp Research, 11:102- 

20, 2010. 

SA Paveglio, J Allard, SR Foster, J Ather, M Bevelander, J Mayette, LA Whittaker, SM 

McCarthy, A van der Vliet, BT Suratt, JE Boyson, and ME Poynter. Airway epithelial 

Indoleamine 2,3-Dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus 

antigen exposure. Am J Resp Cell Mol Biol, 44:11-23, 2011. 

152

BT Suratt, Haematopoietic Transplantation and Pulmonary Chimerism, In: J Polak, 

editor. Cell Therapy for Lung Disease. 1st edition. London: Imperial College Press, 

2010. 


Scanlon T, Teneback C, Gill A, Bement J, Weiner J, Lamppa J, Leclair L, Griswold K. 

Enhanced antimicrobial activity of engineered human lysozyme. ACS Chemical Biology, 

17: 809-818, 2010. 


Somers A. Jean JC. Sommer CA. Omari A. Ford CC. Mills JA. Ying L. Sommer AG. 

Jean JM. Smith BW. Lafyatis R. Demierre MF. Weiss DJ. French DL. Gadue P. Murphy 

GJ. Mostoslavsky G. Kotton DN. Generation of transgene-free lung disease-specific 

human induced pluripotent stem cells using a single excisable lentiviral stem cell 

cassette. Stem Cells. 28(10):1728-40, 2010 

Panoskaltsis-Mortari A. Weiss DJ. Breathing new life into lung transplantation therapy. 

Molecular Therapy. 18(9):1581-3, 2010 

Weiss DJ, Finck C. Embryonic stem cells and repair of lung injury. 

Molecular Therapy. 18(3):460-1, 2010 

Sueblinvong V, Weiss DJ. Stem cells and cell therapy approaches in lung biology and 

diseases. Translational Research: The Journal of Laboratory & Clinical Medicine. 

156(3):188-205, 2010 

Grove D, Weiss DJ, Sueblinvong V. Mesenchymal stem cells: promise for chronic 

obstructive pulmonary disease therapy? Therapy 6:1-4 2010. 

Manuscripts in press 

Hillegass JM, Blumen SR, Cheng K, MacPherson MB, Aleexeva V, Lathrop SA, 

Beuschel SL, Steinbacher JL, Butnor KL, Ramos-Niño ME, Shukla ME, James TA, 

Weiss DJ, Taatjes DJ, Pass H, Carbone M, Landry CC, and Mossman BT. Increased 

Efficacy of Doxorubicin Delivered in Multifunctional Microparticles for Mesothelioma 

Therapy. International Journal of Cancer Research 2011. 

Moodley Y, Manuelpillai U, Weiss DJ. Cellular Therapies for Lung Disease-A Distant 

Future? Respirology 2011. 

Weiss DJ, Bertoncello I, Borok Z, Kim C, Panoskaltsis-Mortari A, Reynolds S, Rojas M, 

Stripp B, Warburton D, Prockop DJ. Stem Cells and Cell Therapies in Lung Biology and 

Lung Diseases: Conference Report. Proceedings of the American Thoracic Society 2011. 

153

Goodwin M, Sueblinvong V, Eisenhauer P, Ziats NP, Leclair L, Poynter ME, Steele C, 

Rincon M, Weiss DJ. Bone Marrow Derived Mesenchymal Stromal Cells Inhibit Th2- 

Mediated Allergic Airways Inflammation in Mice. Stem Cells 2011 

Bozyk PD, Popova AP, Bentley JK, Goldsmith AM, Linn MJ, Weiss DJ, Hershenson 

MB. Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern 

of lung-specific gene expression. Stem Cells and Development 2011 

Submitted Manuscripts 

Jensen T, Roszell B, Zang F, Matson A, Thrall R, Claffey K, Weiss DJ, Finck C. Rapid 

Lung De-cellularization Process: Preservation of Lung Architecture, Ability to Support 

Differentiated mESC, and in vivo Implantation. 

Mantell LL, Zaher TE, Weiss DJ, Sitpara R, Phan B, Leclair L, Wargo MJ, Li J, Yang H, 

Javdan M, Miller EJ, Tracey KJ. HMGB1 Impairs Elimination of P. aeruginosa from the 

Lung in Cystic Fibrosis 

Gil S, Weiss DJ, Matute-Bello G. Resident murine lung mesenchymal stromal cells 

modulate the lung response to acute inflammatory injury in a strain-dependent manner. 

Daly A, Wallis J, Borg Z, Laquer P, Allen GB, Weiss DJ. Growth and differentiation of 

mesenchymal stromal cells seeded into whole de-cellularized mouse lungs. 

Manuscripts in Revision (will be re-submitted over next month) 

Van Heeckeren AM, Hsu DP, Wilson AG, Fulton SA, Loi R, Perez A, Ziats NP, Xue W, 

Schlucter M, Weiss DJ, Davis PB. Inflammatory Cells Contribute to Pseudomonas 

aeruginosa Lung Hyperinflammation in Cystic Fibrosis Mice. 

Sueblinvong V, Eisenhauer PL, Goodwin M, Bates JHT, Iatridis JC, Weiss DJ. Cyclic 

Uniaxial Stretch Induces Expression of Airway and Alveolar Epithelial Proteins in 

Mesenchymal Stem Cells. 

Eisenhauer PE, Loi R, Sueblinvong V, Goodwin M, Mazan MR, Allen GB, Hoffman 

AM, Weiss DJ. Endogenous Lung Progenitor Cells are not Replenished by Bone 

Marrow-Derived Cells in Long Term Post-Pneumonectomy Lung Growth in Mice. 

Book Chapters 2010 

Repair of the Lung Epithelium in Cystic Fibrosis 

V Sueblinvong and DJ Weiss 

Cell Therapy for Lung Repair Dame Julia Polak, Editor. Imperial Press London, 2010 

A General Review of the Current Status of Cell Therapies for Lung Disorders 

DJ Weiss 

Cell Therapy for Lung Repair Dame Julia Polak, Editor. Imperial Press London, 2010 

154

Mesenchymal Stem Cells for Lung Repair and Regeneration 

DJ Weiss 

Stem Cells and Cell Therapies in Lung Biology and Diseases Mauricio Rojas, Editor, 

Springer, 2010 

155

156

Division of Rheumatology and Clinical Immunology 

Edward Leib, M.D., Interim Director 

http://www.med.uvm.edu/medicine/rheumatology 

Our division of Rheumatology and Clinical Immunology provides high 

quality and multidisciplinary patient care through our daily outpatient 

clinics, infusion center (located within the rheumatology clinic), and 

bone density facility. Our division provides excellent teaching to our 

fellows, residents and medical students and opportunities to participate 

in research from bench to bedside. Seven board certified 

rheumatologists see over 900 patients in our clinics each month with a 

wide variety of inflammatory and non-inflammatory rheumatic diseases. We have 24-7 

coverage for inpatient consultations and have several outreach clinics throughout 

northern and central Vermont. The Osteoporosis Center performs over 250 bone density 

studies monthly and a metabolic bone clinic, held jointly with endocrinology, provides 

additional outpatient care and expertise. In our infusion center we are able to deliver 

point of care therapies for rheumatoid arthritis, other rheumatic disease and metabolic 

bone disease. Our infusion center is also used for clinical and basic research trials. In 

collaboration with our pulmonary division, we have an interstitial lung disease program. 

An ultrasound unit to image joints and tendons has recently been purchased for onsite 

diagnosis and treatment of musculoskeletal disease. We have a fellowship training 

program with two full time rheumatology fellows in existence for 29 years that has 

received ACGME accreditation for a full 6 years, the maximum that can be awarded. For 

the past two years we have been awarded two highly competitive grants from the 

American College of Rheumatology Research and Education Foundation to support the 

fellowship training program. All medical residents, generally during their 3 rd year, have a 

one month mandatory rotation where they learn rheumatology and experience an 

efficient, service oriented and productive outpatient practice. UVM medical students may 

spend a one month rotation in our clinic as part of their elective selection. The faculty 

collaboratively introduce rheumatology and metabolic bone disease to the 2 nd year 

medical students with one week of didactics as part of the Vermont Integrated 

Curriculum. Clinical research is presently being conducted on the treatment of 

rheumatoid arthritis and on analysis of our bone density database. We also are working 

collaboratively with other departments and divisions such as Orthopedics, Oncology, 

Physiology, and Immunobiology on clinical projects. Our experienced faculty consists of 

four full professors, one associate professor and two assistant professors. 

157

Faculty 

Edward Leib, M.D. 


Interim Director, Rheumatology Division, UVM and FAHC 

Director, The Osteoporosis Center, FAHC 

� Member at large, UVMMG Board 

� Member, UVMMG Care and Operations Committee, FAHC 

� Member, Physician Satisfaction Committee, FAHC 

� Member, Search Committee, Unit Director, Rheumatology & Clinical 

Immunology, UVM and FAHC 

� Chair, Search Committee, Faculty Position, Assistant/Associate Professor, 

Rheumatologist, UVM and FAHC 

� Research Interest: Bone densitometry and risk factors for osteoporosis and 

fractures utilizing our database of over 15,000 patients 

Areas of interest are Osteoporosis and Metabolic Bone Disease 


Dr. Leib serves on several committees for the International Society for Clinical 

Densitometry (ISCD): Accreditation Committee, Publications Committee, Scientific 

Advisory Committee, Faculty Committee and Bone Density Course. He is Former Chair 

of Education Council Committee. 


Dr. Leib serves on the Editorial Board, Journal of Clinical Densitometry. 

Publications – peer reviewed, chapters, etc., (no abstracts) 

Blank RD, Bilezikian JP, Bonnick SL, Laster AJ, Leib ES, Lewiecki EM, Miller, PD, 

Watts NB, Binkley N. “Evidence Based” or “Logic Based” Medicine? Osteoporos Int. 

21(10):1681-1683, 2010. Epub 2010 May 13. 

Kung AW, Wu CH, Itabashi A, Lee JK, Park HM, Zhao Y, Chan WP, Kendler DL, Leib 

ES, Lewiecki EM, Bilezikian JP, Baim S. Asia Pacific Panel of ISCD.International 

Society for Clinical Densitometry Official Positions: Asia-Pacific Region Consensus. J 

Clin Densitom. 13(4):336-351, 2010. Epub 2010 Jul 21. 

Leib ES, Saag KG, Adachi JD, Geusens PP, Binkley N, McCloskey EV, Hans DB. The 

Impact of the Use of Glucocorticoids on the Estimate by Frax of the 10 Year Risk of 

Fracture. J Clin Densitom. In Press. 

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Ralph Budd, M.D. 


Director, Immunobiology Program; Associate Chair of Medicine for Research 

Director, Vermont Center of Immunology & Infectious Diseases 

� Key Research Interests: Death receptors, caspases and metabolism in T cell 

growth, gamma/delta T cells in Lyme arthritis 


Andreas Koenig, PhD 

Phan Thai (MD/PhD student) 


Editor for “Textbook of Rheumatology”, Elsevier 


Chairman of the Immunity and Host Defense NIH study section 


University Scholar designation by UVM Graduate College for 2009-2010 


Title: Role of Fas in T Cell Development and Function 


Role: PI 



Title: Role of Fas in T Cell Development and Function (Supplement) 


Role: PI 



Title: Gamma Delta Cells in Lyme Arthritis 


Role: PI 



Title: Gamma Delta Cells in Lyme Arthritis (ARRA Supplement) 


Role: PI 



159

Title: Vermont Immunology / Infectious Diseases Center 


Role: PI 

Current Yr funding: $2,166,699 


Title: Vermont Immunology / Infectious Diseases Center (Pilot ARRA 

Supplement) 


Role: PI 



Title: Vermont Immunology / Infectious Diseases Center (BSL3 ARRA 

Supplement) 


Role: PI 



Title: Regulation of Effector CD4 T Cells During Infection 


Role: PI 

Current Yr funding: $1,683,578 (no cost extension, effective 08/01/11) 





Sep 21. PMID: 20979227 



Nov;40(11):3043-53. doi: 10.1002/eji.201040577. Epub 2010 Oct 27. PMID: 21061436 

Fortner KA, Lees RK, MacDonald HR, Budd RC. Fas (CD95/APO-1) limits the 

expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC 

contacts. Int Immunol. 2011 Feb;23(2):75-88. Epub 2011 Jan 25. PMID: 21266499 

Janssen-Heininger YM, Aesif SW, van der Velden J, Guala AS, Reiss JN, Roberson EC, 

Budd RC, Reynaert NL, Anathy V. Regulation of apoptosis through cysteine oxidation: 

implications for fibrotic lung disease. Ann N Y Acad Sci. 2010 Aug;1203:23-8. Review. 

PMID: 20716279 

160

Sheldon M. Cooper, M.D. 


Former Unit Director, Rheumatology and Clinical Immunology 

� Areas of Interest: Rheumatoid Arthritis, Biological Therapies, Clinical Research. 

� Areas of Expertise: Lupus, Osteoarthritis, Psoriatic Arthritis, Rheumatoid 

Arthritis. 

Research Studies 

He is a full time clinician, who is presently conducting several clinical trials testing the 

benefit of anti-rheumatic medications including tocilizumab, certolizumab and an anti- 

BAFF agent. 


Master, American College of Rheumatology 

Nicole R. Hynes, M.D. 


� Areas of interest: General Rheumatology, Rheumatoid Arthritis, Fibromyalgia 

Nicole Hynes, M.D., a recent graduate of our fellowship program, participates in many of 

our outreach programs. She did her internal medicine residency at FAHC. Dr. Hynes 

graduated University of Vermont College of Medicine. She participates in many of our 

outreach programs. 

Christine Haas Jones, M.D. 


Director, Rheumatology Clinic (2011) 

� Co-founder, Interstitial Lung Disease Clinic (with Yolanda Mageto) 

� ISCD Certified Bone Densitometrist 

Areas of interest: Rheumatic Diseases with Pulmonary Manifestation, Dermatomyositis, 

Rheumatoid Arthritis, and Vasculitis 

Dr. Jones is on academic leave until July 2012. She is working in a rural hospital in New 

Zealand, where she is supervising house officers and conducting fortnightly 

rheumatology clinics. She is gaining experience in managing diverse medical problems 

within a single-payer system (the NHS). She is particularly interested in learning more 

about the Maori culture and its relationship to the health care system. 

161

Publications – peer reviewed, chapters, etc. (no abstracts): 

Dr. Jones, and 2 nd year fellow, Dr. Tilluckdharry co-authored “Rheumatic Disease in the 

ICU” in the 5 th edition of Critical Care Secrets, which is due for publication July. 

ChiChi Lau, M.D. 


Director CME, Rheumatology 

Curriculum Committee Member, Rheumatology Fellowship Program 

Area of interest: Adult Rheumatology. 

Areas of expertise: Lupus and other Connective Tissue Disorders. 

Dr. Lau has expanded rheumatologic services at the St. Albans Outreach Clinic. 

Bonita S. Libman, M.D. 


Director, Fellowship Program, Rheumatology and Clinical Immunology, UVM 

� Chair, Medical Records Committee, FAHC 

� Chair, UVM College of Medicine Nominating Committee 

� Member, UVM Medical Group Nominating and Governance Committee 

� Member FAHC Medical Executive Committee 

� Member, Department of Medicine Operational Efficiency Committee 

Areas of interest: Teaching Rheumatology and Clinical Practice of Rheumatology 


Dr. Libman is a member of several American College of Rheumatology Committees and 

subcommittees, most recently In-Training Examination Item Writing Committee. 

Grants - list all active by faculty member, PI: 

Dr. Libman is the recipient of the American College of Rheumatology Research and 

Education Foundation/Amgen/Wyeth Fellowship Training Award, which awarded 

$25,000 for 2010-2011 and $25,000 for 2011-2012. 

Fellows: 

� Tristan Blackburn, M.D. is our first year fellow. She did her residency at 

FAHC. Her abstract was selected to be an oral presentation at the ISCD 

Annual Meeting in April. 

� Lynda Tilluckdharry M.D. will complete the program in July 2011,. Dr. 

Tilluckdharry also did her residency at FAHC. Drs. Jones and Tilluckdharry 

co-authored “Rheumatic Disease in the ICU” in the 5 th edition of Critical Care 

Secrets, which is due to be published in July. She has an abstract accepted on 

162

� Gustavo Carbone, M.D. completed his fellowship in June 2010. He is a now 

a board certified rheumatologist practicing in New York State. 


Jennifer D. McGill, PA-C will begin working with us in August. 

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Chair page: - UVM College of Medicine - University of Vermont

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