Accelerated Atherosclerosis Introduction

Syndromes of accelerated atherosclerosis• In contrast to spontaneous atherosclerosis, amore significant denuding endothelial injuryappears to be the critical initiating event,followed by intense platelet involvement andthrombus formation, leading to an initialpredominant process of smooth muscle cellproliferationDiabetes‐accelerated accelerated atherosclerosis• There is increasing i evidence that advanceddglycation end‐products(AGE) and theirinteraction ti with the receptor RAGE play a pivotalrole in atherosclerosis, in particular in the settingof diabetes.• Previous studies have shown that inhibition ofAGE accumulation and RAGE expression indiabetes by either reduction of the formation ofAGEs or cross‐link breakers was associated itdwithreduced atherosclerosis and renal disease.