Handbook of clinical drug data.pdf - Me and My Life

SELECTIVE SEROTONIN AGONISTS COMPARISON CHARTDOSAGE ADULT ONSET HALF-LIFEDRUG FORMS DOSAGE (HR) (HR) COMMENTSAlmotriptan Tab 6.25, PO 12.5 mg. 1–2 3–3.7 Low headache recurrence rate. Similar efficacyAxert 12.5 mg. to oral sumatriptan, but better tolerated. Nopropranolol interaction.Eletriptan — PO 20–80 mg. 1–2 4–7 An 80 mg dose is superior to 100 mg of oralRelpaxsumatriptan. Does not induce CYP3A4.(Investigational—Pfizer)Frovatriptan — PO 2.5 mg. 2–4 25 Lowest recurrence rate.(Investigational—Elan)Naratriptan Tab 1, 2.5 mg. PO 1–2.5 mg, may repeat in 2 hr; may repeat 1–3 6 Low headache recurrence rate. More specificAmerge sequence once in 4 hr, to a maximum of than other agents for 5HT 1B. Smoking increases5 mg/day. and oral contraceptives decrease clearance.Rizatriptan Tab 5, 10 mg PO 5–10 mg; may repeat in 2 hr, to a maximum 0.5–2 2–3 Onset of rapidly dissolving tablet is slightlyMaxalt (conventional and of 30 mg/day. slower than conventional. Reduce dose whenMaxalt-MLT rapidly dissolving). used with propranolol.Sumatriptan Inj 6 mg SC 6 mg, may repeat once in 1 hr, to a maximum 0.2 (SC) 2.5 Headache recurrence rate of 40%; relativelyImitrex Tab 25, 50 mg of 12 mg/day. PO 25–100 mg, may repeat q 2 hr 0.5–1 (PO) high (5%) frequency of chest pain andNasal Spray 5, to a maximum of 200 mg/day. Nasal 5–20 mg, may