Virucidal Activity of Disinfectants Against Parvoviruses - American ...

ArticlesTable 1List of cleaning products and biocides tested against viruses in this study.ProductCategory ofProductMain Compoundsin the FormulationCIP-100 Alkaline Detergent potassium hydroxideProKlenz-One Alkaline Detergent sodium hydroxidePAA-basedFormulationSporklenzRTUAtmosphericVHPSurface BiocideSurface BiocideAerial BiocidePAA 0.085%,H2O2 1%PAA 0.08%, H2O2 1%,acetic acid < 10%gaseous hydrogenperoxidepH12.4(1% solution)12.5(1% solution)Recommended Use ConditionsConcentrationsTemperatures1 to 6% 20°C to 55°C1 to 6% 20°C to 55°C1.5 to 2.0 na room temperature1.5 to 2.0 na room temperaturena250 (room) to 5,000 ppm(small volumes)na: not applicableBiocidalTreatmentCleaningProductsna: not applicableConcentrationTable 2TCID50 Log10 reductions observed after treatment of viruses dried onstainless steel coupons with or without the presence of organic soils.ContactTimeInterferingSubstanceTemp. VacciniaVirusAdenovirus PoliovirusPorcineParvovirusMinuteVirus ofMiceCIP-100 0.9% 10 min BSA+blood 20°C >4.0 >4.0 >4.0 >4.0 >4.0ProKlenz-OneLiquidDisinfectantsPAA-basedFormulationSporklenzRTUGaseousDisinfectantAtmosphericVHP0.9% 5 min none 45°C >4.0 >4.0 >4.0 >4.0 >4.01.9 ± 3.9 ±0.9% 10 min BSA+blood 20°C >4.0 >4.0 >4.00.4 0.50.9% 5 min none 45°C >4.0 >4.0 >4.0 >4.0 >4.0na 10 min BSA+blood 20°C >4.0 >4.0 >4.0 >4.0na 10 min BSA+blood 20°C >4.0 >4.0 >4.0 >4.0500 ppm 3 hr BSA+blood 20°C >4.0 >4.0 >4.0 >4.01000 ppm 2 hr BSA+blood 20°C >4.0 >4.01200 ppm 1 hr BSA+blood 20°C >4.0 >4.02000 ppm 30 min BSA+blood 20°C >4.0 >4.03.7 ±0.13.8 ±0.13.5 ±0.13.7 ±0.13.6 ±0.23.3 ±0.41.9 ±0.23.2 ±0.14.0 ±0.23.4 ±0.23.1 ±0.23.1 ±0.1www.absa.org Applied Biosafety Vol. 15, No. 4, 2010167