Anatomic Molecular Pathology: An Emerging Field

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COLORECTAL ADENOCARCINOMA:‣High Level MicrosatelliteInstability (MSIH)‣Loss of hMLH1 ProteinExpressionN N N NGologan & Sepulveda et al.Arch Pathol Lab Med 2005;129: 13901397T T T TBAT25 BAT26 D5S346 D17S250
Incidence and functional consequences ofhMLH1 promoter hypermethylation in colorectalcarcinoma11 of 13 (84%) MSIpositive cancersexhibited prominent methylation,compared with 2 of 21 MSInegative cancers (P =0.0001).Methylation specific PCR (MSP)James G. Herman et al. and Stephen B. BaylinPNAS, Vol. 95, Issue 12, 68706875, 6875, 1998
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