Tibetan Terrier 2011 World Congress Agenda

Welcome to the 12th TibetanTerrier World CongressTable of Contents3 Tibetan Terrier 2011 World Congress Agenda4 Preface by Margareta Sundqvist5 Previous World Congresses7 DNA Research & Testing, presented by Liz Hansen9 “A Role for Adult Stem Cells in Treating Canine Diseases?”,presented by Dr. Richard VullietMember Country Reports15 Australia17 Belgium17 Canada21 Denmark23 Finland25 Germany — KTR27 Germany — ILT28 Norway30 Sweden32 United Kingdom34 United States

Tibetan Terrier World Congress, USA, 2003(Left to right)Best of Breed:Ch. Sunclipse Wrapped in RedBest of Winners:Hero chad Lamleh von Kamal-a-SchilaBest of Opposite Sex:Ch. Sumanshu Tri Me on CharSuTIBETAN TERRIERHEALTH & WELFAREFOUNDATIONThe TTHWF is a non-profit organization dedicated tothe protection and advancement of the Tibetan Terrierin the areas of health and rescue. Your generousdonations have saved ailing TTs, found loving homes,helped discover vital genetic markers, and furtheredvaluable research. Your donations directly benefit thebreed. If the Tibetan Terrier is special to you, whatbetter way to express your appreciation then througha tax-deductible donation.PLEASE GIVE TODAYMaclains Tintinnabulation doingAgility at the TTCA Specialty 2003Donations accepted by check to:TTHWFP.O. Box 1001Southport, CT 06890or through Paypal at:http://www.tibetanterriersfoundation.org/Donations.html

Tibetan Terrier 2011 World Congress Agenda8:00 – 9:00 AM Light breakfast and beverages.9:00 AM Welcome – Ken Edmonds, TTCA PresidentAnd Jackie Faust, TT World Congress Chair9:00 – 11:00 AM Liz HansenAnimal Molecular Genetics Laboratory,University of Missouri, College of Veterinary MedicineEmail: HansenL@missouri.edu11:15 AM Question & Answer Discussion period12:00 – 1:00 PM Lunch1:00 PM Report about the Tibetan Terrier Health and WelfareFoundation by Brenda Brown1:15 – 3:15 PM Richard Vulliet, PhD, DVMProfessor Laboratory of VeterinaryCytotherapeutics, University of California, DavisReGena-Vet LaboratoriesEmail: regenavetlabs@gmail.com3:15 – 3:45 PM Question & Answer Discussion periodBreak4:00 – 5:00 PM Country Reports and where to hold the2013 TT World Congress.5:00 PM World Congress adjournment7:00 PM World Congress BanquetIf a country representative wants to speak to the Congress, please contact Jackie Faustor Ken Edmonds before 1:00 PM.5

Preface by Margareta SundqvistWhen I was showing at the World Winner show in Amsterdam in 1985 it was like it always is,everyone was brushing their dogs, getting in and out of the ring. Then everyone leaves. After theshow many people thought it was a pity that they did not have the time to speak to other people orif they had known a certain person was there they would have liked to speak with him/her etc.When the World Winner Show was going to be arranged in Copenhagen in 1989, I thoughtsomething should be arranged so everyone could get together and talk . So the first Tibetan WorldCongress was arranged for the 17 th of June, 1989 in Copenhagen, Denmark.At the same time, people were discussing the changes in the standard in FCI-countries, and thatit was hard to follow-up on exams in other countries.Having a Congress for the Tibetan Terrier would give an opportunity not only to get togetherand talk but also to discuss the changes in the standard and how to get information about eyeexams without being a member of every foreign club.It was hard to make the practical arrangements in Copenhagen from Stockholm, so I spoketo Marianne Delholm-Dons. She loved the idea of a Congress, and said she could arrange all thepractical things if I did the administration.Since I knew that different countries had very different systems for reporting exam results, Iasked the breed clubs to have one person discuss how they solved the problem with the hereditarydiseases.Sixty-eight people came to the first Tibetan Terrier World Congress. They came from America,Australia, Denmark, England, Finland, Germany, the Netherlands, Norway and Sweden.We decided to start a worldwide list with Tibetan Terriers diagnosed with PRA or lens luxationsince it was difficult to know what happened in other countries, and very often a case in onecountry affected the breeding in other countries when dogs were imported and exported betweenthe countries. The Tibetan Terrier International Information System, TIIS, was started and I waschosen to handle it. First the list was sent to the clubs that contributed to it and also paid an amounteach year for the administration. The total list was sent once a year, and when there was a case onlythe information about that case was sent. The breed clubs then informed their members.With new technology it is today up on the net, on www.tibetanterrierinternational.seEveryone had enjoyed themselves so much at the first Congress that it was decided it should bearranged every second year. The Tibetan World Congress has been held in these countries:1991 — Germany1993 — England1995 — Belgium1997 — The Netherlands1999 — Austria2001 — Sweden2003 — USA2005 — Germany2007 — England2009 — Norway2011 — USA6

Previous World Congresses1989 DenmarkThe first World Congress was held on the 17th of June 1989 in Copenhagen,Denmark. The subject discussed was the new FCI-standard and the need of havingan international list over cases of lens luxation and PRA. The TIIS-list was decidedto be done.1991 GermanyThe discussion over the standard continued and photos from Tibet were shown.1993 EnglandEye defects in the Tibetan Terrier, by Professor Peter Bedford.Genetics and the inheritance of defects in the Tibetan Terrier, by Dr. MalcolmWillisWhat are the essential breed characteristics that contribute to the Tibetan Terriertype? followed by open discussion about breed type.1995 BelgiumLectures over eye defects by Belgian veterinarians1997 The NetherlandsGenetics in connection with breeding, by Mike Tempest.Auction for Animal Health Trust/Joan Cain Memorial Fund1999 AustriaThe Tibetan Terrier in their homeland, by Juliette CunliffeReport about the mentality tests of Tibetan Terriers in Switzerland,by Dr. Kaspar SpörriNews about the standardStud dogs and mating problems due to the male, by Dr. Holzman2001 SwedenPresentation of a data based program for breeding, by Margareta SundqvistInsemination, sending semen and the cycle of the heat, by Professor CatharinaLinde-ForsbergThe misprint on size in the standard, by Mike Tempest2003 USAInherited genetic diseases, by Dr. Mark Neff, PhD, geneticistCanine Ceroid Lipofuscinosis (“CCL”) in Tibetan Terriers, by Martin Katz, PhDSeveral of the countries displayed posters graphically evidencing their healthactivities.7

The TIIS-list covering Lens Luxation and PRA is to be posted on the Internet.A procedure for removal of a dog from this list upon presentation of certificationfrom a qualified professional was approved.The TTCA, with the approval of the artist Linda Nagao, offered the World Congressthe use of the 8th World Congress logo as a permanent logo for future WorldCongresses.After a spirited discussion of the height standard currently applicable in theUK and Europe, it was decided that it would be more appropriate to vote inEurope at the next World Congress in Germany on the issue of whether or notWorld Congress participants are in favor of reverting to the language of the 1934standard.2005 GermanyCCL disease of the Tibetan Terrier, by Dr. Rolf BrahmHereditary course and gene test for CCL, by Dr. Anna WöhlkeThyroid disease of the Tibetan Terrier, by Dr. Reinhard SchrammMovement system, by Dr. Martin S. FischerResults of the height measuring at the TTWC 2001 in Sweden, by Dr. MikeTempest2007 EnglandMovement system, by Prof. Dr. Martin S. FischerGenetics — an approach to breeding healthier Tibetan Terriers, by Jeff SampsonLatest in DNA research at Animal Health Trust in England, by Cathryn MellershCanine Ceroid Lipfucinosis, PRA, Lens Luxation and Cataracts, by Professor PeterBedfordGlobal view on Tibetan Terriers, by Paul Stanton and Sheryl RuthledgeTrip to Tibet and the dogs in Tibet, by Primoz Peer, Margareta Sundqvist andAnna Lorenzon2009 NorwayAllergic dermatitis, by leg veterinarian Katarina VarjonenMammary gland tumors in dogs, by veterinarian Veronica M. KristiansenThe balance between selecting the best and maintaining genetic variation,by the veterinary advisor to the Norwegian Kennel Club, Kristin PrestrudReproduction and reproductive problems in the dogs and bitch, including canineherpes virus infection in kennels, by professor Wenche FarstadVideo with an interview with Angela MullinerVideo of Dr. Grieg and some of her Tibetan Terriers from the 1950sInformation by Pat Tempest about a suggestion of change in standard from theEnglish Kennel Club8

DNA Research & Testing:Opportunities & Benefits for Tibetan Terrier FanciersPresentation for the Tibetan Terrier World Congress – Harrisburg, PA May 16, 2011Presenter: Liz Hansen, Animal Molecular Genetics Laboratory, University of MissouriCollege of Veterinary Medicine, Columbia, MOTopics to be covered:• DNA basics and mapping inherited diseases• DNA tests now available for Tibetan Terriers – disease basics and testing stats• Wise use of current and future DNA tests• Banking DNA and data for future research & testing++++++++++++++++++++++++++++++++++++++++++++++++++++++++DNA Basics & Mapping Inherited Diseases• The building blocks of DNA – A,C,G,T• Nucleotides, codons, genes, chromosomes – how to build a dog!• Genome sequence, chromosomes, markers• Mapping markers – microsatellites, SNP’s• Polymorphisms and alleles• How do these alleles get from one generation to the next? The basic patterns ofinheritance, evaluating family groups where traits appear• Molecular genetics and the Canine Genome Project• Whole genome sequencing now – a new & very promising mutation discoverystrategy• Mapping data and what it means• Tracking down a mutation – how do we find a mutation for a recessive disease?• Are we there yet? How do we prove we’ve found the correct mutation.DNA Tests Now Available For Tibetan Terriers• Primary Lens Luxation (PLL)• Neuronal Ceroid Lipofuscinosis (NCL)• Degenerative Myelopathy (DM)9

For each disease:• Basics of the disease• Breeds known to have some form of the disease• How was the mutation found?• Current testing statistics overall, & specifically for Tibetan TerriersUsing DNA Tests Wisely• Why test?• Where should we test?• Which dogs should be tested?• Making choices – what to do with the information from test results• Individual goals, and breed-wide goals• Breeding dogs vs breeding test resultsWhat’s Next?• Are there other heritable diseases of concern to Tibetan Terrier fanciers?• DNA Banking – CHIC, or other ways to bank.• Future research and testing from banked samplesQuestions & DiscussionWebsites and Contact information:Canine Genetic Diseases Network – www.CanineGeneticDiseases.netOrthopedic Foundation for Animals – www.OFFA.orgCanine Health Information Center (CHIC) – www.caninehealthinfo.orgAnimal Molecular Genetics Laboratory (AMGL) – University of Missouri College ofVeterinary Medicine – contact Liz Hansen – HansenL@missouri.edu, 573-884-371210

Richard Vulliet, PhD, DVMA Role for Adult Stem Cells inTreating Canine Diseases?Richard Vulliet, PhD, DVMLab of Veterinary CytotherapeuticsSchool of Veterinary MedicineUniversity of California-Davisprvulliet@ucdavis.eduReGena-Vet LaboratoriesDavis, CA 95616Chronology of Therapeutic InterventionSources/ Innovationsnatural productsand derivativesserendipitypenicillinssulphanamidesaspirinpsychotropicsreceptorsNSAIDSenzymesgeneticengineeringbiotechdrugslipid lowerers,ACE-inhibitorsH2-antagonistsbeta blockerscell pharmacology/molecular biologychronicdegenerativediseaseassociatedwith aging,inflammation,cancerNew Therapeutic Cycles1900 1950 1960 1970 1980 1990 2000 2010 2200 2030Source: Lehman Brothers Pharmaceutical Research.Father and Son Picture ?Sources of Stem Cells:Differentiation to Osteogenic PhenotypeFate of Bone Marrow Stem Cells:1. Fertilized Zygotes2. Embryonic Tissues3. Bone Marrow***4. Tissue Specific Cells5. Umbilical Cord Blood6. OtherAdapted from Alexander Freidenstein, ca 1976Tip of theIceberg?Manyapplications i forother projects inveterinarymedicineProperties of Veterinary Diseases forInvestigation for Rx with Stem Cells:• Must be a cell loss disease that has the potential tobenefit from MSC treatment as established inlaboratory animals testing• Must be terminal• Vet Med must lack an acceptablealternative treatment• Ease of administration of MSCs• Must have the “right” ownerVeterinary Diseases that can be treatedwith Adult Bone Marrow Stem CellsLipoprotein LipaseIdiopathicPulmonaryFibrosisDegenerativeMyelopathyDilated Cardiomyo.Neuro ceroid lipofuscinosis111

Richard Vulliet, PhD, DVMLPL-deficient Cats*Physiological Function of LPL:Injection Protocol for LPL Cats:Bone MarrowAspirateCell Culture14 days~300 million MSCs? LPL +/+I. Var. amts of MSCsII. Mult. dose of MSCsIII. Var. routes of MSCsBlood Chylo. &IV. Factors affectingTGl Level Assayengraftment of MSCsRadioactiveassay of LPL* A similar condition exists in MiniatureSchnauzers, Beagles and some mixedbreeds, although it is not known if it isa genetic condition in the dogLane A: Molecular Weight MarkersLane B: Negative control (water only + primers)Lane C: untreated fMSCLane D: fMSC treated with adipogenic media? LPL -/-Daily or weekly blood& BM samplesHistology &Immunocytochem.qPCR to quantitateY chromosomeAnimal Stem Cell Injections: RelativelyPainless with routine clinical proceduresControl Cat Injected with50 million MSCs two days priorLPL-/- CatSamplesCollectedat VariousTimes100%Percent Wild-type or Pre-i njection Values90%80%70%60%50%40%30%20%10%0%Injection 1 Injection 2LPL Baseline10 15 20 25 30 35 40 45 50Time (Days)Hep-releasableLPL ActivityAbsorbance 600Lipid Profile over longer period of time???Long-term follow-up on Alfie:• Before MSC injection:– Alfie was originally the seconddumbest cat I had ever worked on– I spent about three hours looking forreference articles on hyperlipidemiaand mental retardation– Was a fur-ball, while working with her shewould sit in our laps and drool and shed• After injection of 100 million stem cells– Cat is grooming herself– Cat exhibits far more complex behavior– Cat has gained weight– Totally different CatExtremely Important Concept:Allogeneic Donor Cells can Correct aHeritable Genetic Deficiency!122

Richard Vulliet, PhD, DVMSLIDEsVeterinary Diseases that can be treatedwith Adult Bone Marrow Stem CellsLipoprotein LipaseDegenerativeMyelopathyDilated Cardiomyo.DegenerativeMyelopathy ofGermanShepherd DogsNeuro ceroid lipofuscinosisIdiopathicPulmonaryFibrosisThe Conservative Medical Alternative?(A) Analysis of locomotor recovery as measured by BBB scores. Animals treated withMSC immediately after SCI do not differ from control animals. (B) Delayed MSCtreatment significantly improved locomotor recovery. *, P = 0.013. Data representmeans ± SEM. Arrowheads indicate the treatment timeHofstetter et al. (2002) Proc. Natl. Acad. Sci. USA 99 2199-2204.One-week-delayedtransplantation of MSC afterSCI. (A) MSC form bundlesbridging the epicenter of thelesion visualized by thetransgenic GFP marker. Arrowsindicate the location of theimpact injury. (B) Nestinimmunoreactiveimmatureastrocytes with longitudinallyaligned processes (red) arefound within MSC bundles(green). (C) GFAP-IR (red)marks astrocytic processespenetrating the grafted cellaggregates (green). (D) 5-HTpositivefibers (red) are presentamong the implanted MSC(green). (E) Robust NF-IR nervefiber bundles (red) are found atthe interface between MSC andhost tissue. (B, C, and E)Asterisks indicate macrophages.[Bars = 250 μm (A) and 25 μm(B–E).]Hofstetter et al. (2002)Dog with Ischemic Spinal Cord Injuryand treated with MSCs or GFs or GFs+ MSCsTurbo: First real success in DM ????All we can say for sure is that Turbo isdoing much better three months afterinjection and this started a month afterinjection of cells133

Richard Vulliet, PhD, DVMVeterinary Diseases that can be treatedwith Adult Bone Marrow Stem CellsDegenerativeMyelopathyLipoprotein LipaseDilated Cardiomyo.Neuro ceroid lipofuscinosisIdiopathicPulmonaryFibrosisMSCs improveDCM in rats:Homing of Iron Fluorescent Particle LabelledMesenchymal Stem CellsCells were injected via tail veinwithin 24 hours of myocardialinfarctionDobermanPinscherDilatedCardiomyopathyFrom Nagaya et al Circulation 2005Jonathan Sorger and Jonathan Hill NHLBI/NIH 2002Doberman pinscher Dilated Cardiomyopathy:Diagnosis of DP-Dilated Cardiomyopathy:Diagnosis of DP-Dilated Cardiomyopathy:144

Richard Vulliet, PhD, DVMNoah: First DP with DCMtreated with MSCs:Dog #2 is GunnerSo how is Gunner doing?Veterinary Diseases that can be treatedwith Adult Bone Marrow Stem CellsDegenerativeMyelopathy“Westie IPF”Lipoprotein LipaseDilated Cardiomyo.IdiopathicPulmonaryFibrosisNeuro ceroid lipofuscinosisPulmonary hypertension in idiopathicpulmonary fibrosis. Vascular intimalfibrosis with luminal obliteration (arrow) ina region involved by interstitial fibrosisand chronic inflammation. Courtesy of Dr.Rubin Tuder, Johns Hopkins University.MSCs reduce scaring and collagendeposition in Bleomycin-treated MouseWhere areWe Now?Where doWe GoFromHere?Veterinary Diseases that can be treatedwith Adult Bone Marrow Stem CellsLipoprotein LipaseDegenerativeMyelopathyDilated Cardiomyo.From Ortiz …..Phinney et al. PNAS 100: 8407-11, 2003from Weiss et(2006) Proc AmThorac Soc 3: 197-207.IdiopathicPulmonaryFibrosisNeuro Ceroid Lipofuscinosis155

Richard Vulliet, PhD, DVMLysosomal Storage Disease, NeuronalCeroid Lipofuscinosis “NCL” or Batten’sDisease •Many different genes in humans andmany different but related diseases(Tay-Sachs, Neimann-Pick, etc)•A terminal disease that is inherited asan autosomal recessive pattern due tothe breeding of two carriers.•In humans, at least six different geneshave been reported to be causative.•Is classified as an “in-born error ofmetabolism” diseaseGenetics of BattensDisease or NCL in dogs• The exact gene is not known inAustralian Shepherds and PolishOwczarek Nizinny• American Bulldogs (Cathepsin D;CTSD), Border Collies (CLN5),English Setters (CLN8) and MinitureLonghaired Dachshund (CLN2, TPP1or tripeptidyl peptidase), TibetanTerriers (ATP13A2)Signs and Symptoms of NCL in Dogs:• Loss of house training• Developing of aggressiveness toward people• Loss of ability to respond to verbal commands• Becomes upset by loud or unfamiliar sounds• Difficulty in movement• Impaired vision and characteristic deposits inretina; may be blind• Starts occuring at 4 to 6 yearsNCL or Batten’s Disease in TTs• Classified as a lysosomal storage diseaseswhich results from an abnormal metabolismand a build up of breakdown products.• Can best be thought of as a disease where“nobody takes out the trash”• Abnormal deposits contain GFAP and histoneH4From Katz et al (2007) J. Inherit. Metab. DisTreatments of NCL?• None Known in humans or dogs• First signs are extreme inappropriate anxiety oraggression• Advanced cases go blind and have seizures• So far we have treatedt four dogs with NCL• Three have shown definite improvement, thefourth is likely improved• This is Boots !Current Pattern for Therapeutic ImplementationBasic Science studies, invitro testing, evaluationLaboratory Animals usingstandard in vivo modelsLarge Animal &or PrimateTestingPhase I, II & III Testingin HumansTesting in Animals withTerminal Naturally--Occurring DiseaseApproval in HumansApproval in AnimalsSuggested Pattern for Cytotherapeutic ApprovalBasic Science studies, invitro testing, evaluationThe Future of (Veterinary)Therapeutics?Laboratory Animals usingstandard in vivo modelsLarge Animal &or PrimateTestingPhase I, II & III Testingin HumansApproval in HumansTesting in Animals withTerminal Naturally--Occurring DiseaseApproval in AnimalsThe Diseased Dog can be thehuman patient’s “best friend”166

Tibetan Terriers in AustraliaThe history of the breed in Australia began in 1974 when the Granton Kennels ownedby Frank and Sue Wilson who were already breeding and showing Lhasa Apsos becameinterested in Tibetan Terriers. After a great deal of correspondence, Anne Mathews ofHardacre Kennels sent the Wilsons “Hardacre Goodwish” and “Hardacre Evil Weevil”.“Hardacre Aurora” followed these two dogs in 1975. This was the beginning of the journeyto the present day. The journey however has not always been easy. It took quite some timefor judges to appreciate our wonderful dogs. But now we are winning on a regular basis atGroup and Show level.Like the United States, Australia is a large country but unlike the United States ourpopulation is small by comparison. A universal problem faced by us all in Australia is “thetyranny of distance.” Consequently, we have very little opportunity to meet with eachother and share our knowledge. Sometimes travelling hundreds, and in some instances,thousands of kilometres to get together with our dogs. Added to the distance problem,Australia is divided into six States and two Territories, each with their own jurisdiction overdog showing and breeding. There is an umbrella organization called the Australian NationalKennel Club, which handles the recognition of judges, breed clubs and changes to breedstandards throughout Australia.In April 2009, thanks mainly to the efforts of Peter and Joyce Mortimer, a TibetanTerrier Specialty Club was formed under the auspices of the New South Wales Kennel Cluband held its first committee that month. Unfortunately some restrictions were placed onwhat we could do. For example we were not to use the word ‘“Australia” in the name andcould only draw on members affiliated with the New South Wales Kennel Club to serve oncommittees. Also any shows that the club holds can take place only in New South Wales. Assome of us live up to 3,000 kms away from Sydney very few of us can attend the meeting,although we can forward items of interest to be discussed and a newsletter is circulated. Itis hoped that we can grow from these small beginnings.Presently the breed is doing well in Australia even though the numbers arecomparatively small to the United States. Even at the large metropolitan shows therewould be less then 10 Tibetan Terriers entered. Some Tibetan Terriers are competing andachieving high levels of success in Obedience and Agility Trials as well as Endurance Testsand Dances with Dogs. Their popularity is increasing as a companion dog with the generalpublic. In recent times having access to the DNA testing for various problems has helpedbreeders to make more informed decisions in their breeding programs.17

The future growth of the breed in Australia continues to rely on imports mainly fromthe United Kingdom and Europe. Some of the recent imports are from Alilah, Araki,Caerlaverock, Kyangs, Schaka-Ta’s and Waterley to name but a few kennels. These importshave helped to widen our gene pool. On the export side Tibetan Terriers are being exportedto India (Bakit Swarna Aakarshan, the first one to be registered, shown and titled there formany years), Hong Kong, Indonesia, New Zealand and Singapore.In conclusion Tibetan Terriers in Australia have progressed from their humblebeginnings some 50 years ago to a healthy population with acceptance ever widening in thegeneral community and with increasing success in the show ring.Gordon and Chris LawrenceBakit Tibetan Terriers Queensland, Australia18

Report fromBelgiumfor theWorld Congress 2011.My name is Marleen de Winter and I am here as president to represent the Belgian TibetanTerrier Club at this world congress.Our club was founded in 1992, which means we will be celebrating our 20th anniversary nextyear. The goal of our club was, and still is, to promote improvements in the breeding of theTibetan TerrierWe aim to achieve added value by giving useful information to and by organizing activities forowners of Tibetans.Our club magazine comes out 4 times a year with a wide variation of articles about First aid,an explanation about HD (hip dysplasia), puppy behavior etc. You will also find pictures andshort stories covering the past activitiesShow results, breeders news (information about the breeder and litter, etc.) are presented.Results of DNA tests for PLL (lens luxation) and NCL (neuronal ceroid lipofuscinoses) as well asof eye and hip research are also published in our club magazine.In this user friendly magazine our management aims to bring our members closer together byorganizing activities that will give the members the opportunity to exchange experiences.Following are some examples of activities:• Comb and brush workshop preceded by a Tellington Touch lecture on 10/17/2010.• Organization of a minimum of 4 annual walks in different areas of the country. Thelargest turnout is during our yearly walk along the coast with an average attendanceof 50 Tibetans. During such walks a lot of information is exchanged between Tibetanowners, and the breeders are given the opportunity to follow up on the offspring oftheir dogs in a pleasant and relaxing manner.• The annual Club Show from the BTTC – CAC in Evergem is the highlight of the year.Members and non-members are welcome to participate at this event.19

The club especially aims for quality and health when breeding our breed and therefore makesuse of the breeders’ agreement. The club protocol is much stricter than the Kennel Club KMSHprotocol.In order to receive a license to breed, the Kennel Club only requires that both Tibetan parentsachieve the mark of “good” on a CAC-CACIB or a Club Special, as well as having proof ofauthenticity of the parents through a DNA sample of both parents and one puppy of theirlitter (chosen by a KMSH official).The requirements that must be met for our club are the following:Before breeding, both dogs must meet the following requirements.• A one-time test for the hips (HD), D and E are not acceptable for breeding• Annual eye test, at least temporarily free• Show results :oomale : 3 x Very Good or 1 excellent+1 Very Goodbitch: 3 x Very Good or 1 excellent+1 Very Good• As of 2011 a mandatory DNA test for PLL and NCL is requiredofor all breeding dogs and the following combinations are allowed:free x freefree x carrier,all other combinations are prohibited.We also maintain our own website www.tibetanterrierclub.be where you will find a lot ofinformation and the possibility to apply for our newsletter.Since April 26, 2010, BTTC has been a group member of Facebook for which we have receivedmany positive reactions.It is our goal in the future to be even more informative for the club’s breeders and membersregarding the progress of DNA research for hereditary or genetic illnesses.In our country we are dealing with a powerful group of merchants whose only interest is theprofits made on the sale of dogs causing a lot of animal suffering. Puppies of supposedly purebreddogs are being imported and traded on a large scale. These puppies, some or many ofwhich have hereditary problems due to insufficient or lack of testing of their parents, causeof lot of problems for purebred clubs. Therefore it is our duty to inform people of this andhopefully spare them from a bad buy and therefore avoid a lot of misery and sadness.I thank you for your attention.20

DenmarkIn May 2007, the TT-club of Denmark celebrated their 30th anniversary as a club for the TibetanTerrier and owner. At the moment we have a bit more than 200 club members. Remember Denmarkis a small country. JIn 2010 Denmark hosted the World Dog Show in Herning with dogs from many differentcountries. The Danish TT-club also hosted a club special the day before. It was very nice to see somany people and friends of our breed. As one of the attendanees I would say that 2 and 4 legged hada great time.We publish the TT-magazine “Tibetaneren” four times a year and from that and from our webpage www.tibetanerklubben.dk we keep our members updated on activities and news in the breedand the club.Fifty-one puppies in 10 litters were registered in 2010 including six imports which came infrom Sweden, Norway, the Netherlands and Germany. At the moment we have 18 active breeders inDenmark, five breeders have attended the breeders education from The Danish Kennel Club.Dogs for breeding must be hip-X-rayed and the result must be evaluated and appointed withthe status of A (the best), B or C. Hip status D or E can not be breed from. We recommend that a dogwith hip-status C is only breed to a mate with status A, but this is up to the breeder.Also we advise all owners to have their TT’s hips X-rayed.An eye certificate stating that the dog is free from eye disease must not be older than 12 monthsat the time of mating. We also encourage all our members to have their TTs eye-examined whenthey are about 5-6 years old, even if they do not wish to breed from them.Results are published on the website of the Danish Kennel Club.We also advice our breeders to have their dogs DNA testedWe are pleased to say that our last LL- case was back in 2001 and PRA case even further back.Approximately half a year before the CCL DNA test was made available we had a report from anowner of a TT that suspected the dog might suffer from CCL. Despite the sad and difficult situation,the owner donated blood samples from the dog and also a post mortem biopsy was given andexamined. The Danish TT club also made sure to get samples from some of his offspring. We hopeand believe that this was a small help developing the final test and encourage TT people all aroundthe world to participate in the future work giving the breeders the best tool possible in our breeding23

Back in 2005 the TT-club decided to establish a board of health to help guide both new andolder breeders in their future breeding of our wonderful breed.We try to keep update on the latest news for the benefit of our Danish co-breedersOur goals are to ensure the genetic variation in the breed, type, health, temperament and be true tothe standard in order to honour the rare treasure we were given from the roof of the worldEvery year we celebrate most winning bitch and dog from the club. They both receive the titleclub-winner of the year.On behalf of the club and all the Danish TT fanciers we wish all of you all the best with your TTs.We are looking forward meeting many old and new friends at the CongressHave a nice Congress – see you thereLouise Nicklasen, Søren Therkelsen (kennel Lamlux) & Merethe Breilev (kennel Dawa’s)24

News From FinlandTibetan Terriers arrived to Finland in the early 1960s and the breed has hold a small but firmniche in the Finnish dog world ever since. In the recent years there have been approximately 120puppies born each year. The total number of registered TTs during the five decades in Finlandis close to 5,000. Tibetan Terrier breed club of Finland, Tiibetinterrierit ry (TTry, http://www.tiibetinterrierit.com/) was established 1981. Before that Tibetan Terriers formed a subsectionof Suomen Tiibettiläiset ry, which was established 1971 and governed all the Tibetan breeds inFinland.TTry organizes one official specialty show every year. First open show was organized 2010and this will also be yearly event from now on. Other yearly events are breeder-day and TT-funday. The program for these entail lectures and fun activities, like introductions to different dogsports. Breeding examinations are organized in connection with the different events according todemand. The breed club publishes a magazine for members, a yearbook, a champion book and showjudgements.Finland is a small country and dog breeding is usually a small scale business here. Almost all thebreeders and people actively involved in TTs know each other, which makes us a close community.There is also a problem with being a small breed in a small country; it is quite difficult to take careof the genetic diversity and find versatile breeding material. A stud can become a “popular-sire”with only four or five litters. Luckily Finnish breeders have been educated and active in finding andimporting quality breeding material form other countries.At the moment the only mandatory health check before breeding for TTs in Finland is an eyeexamination. It is valid for one year at a time. There is an on-going discussion about the relevance ofother tests and many breeders check the knees and hips for their breeding stock, some also elbows.The new PLL-gene test has been quickly adopted by breeders and almost all the parents of thelitters born last year were tested before breeding. NCL testing is slowly following.The breeding committee guidelines are just now being updated but already for several yearsthe committee has had recommendations concerning the age, temperament, health and structuralquality of dogs used in breeding as well as the inbreeding coefficient of the planned combinations.The stated aims of the breeding committee are: securing the genetic diversity, maintaining thecorrect and social temperament, preventing and decreasing the occurrence of severe hereditarydiseases and maintaining the breeds typical appearance and conformation without exaggeration. Inorder for a litter to be accepted to TTry puppy list it has to be approved by the breeding committeeFinnish TTs have been successful in the show rings around the world and the overall quality,temperament and health of Finnish TTs is excellent. Several individuals have been exported todifferent countries in Europe and couple even to the US. TTs are not generally regarded as aperformance breed in Finland, but there is a small number of people who practice agility,rally obedience and obedience with their dogs. Some are even trying their skills in trackingand rescue.25

The Finnish Kennel Club has established an excellent breeding database for all breeds in Finland(TTs: http://jalostus.kennelliitto.fi/frmEtusivu.aspx?R=209). This database holds all the officialinformation of all pedigreed dogs in Finland, including health results. The database is open andfree-of-charge to everybody. You can search dogs by name or registration number, make sure theparents of your puppy have all the relevant cheks, make trial pedigrees showing common ancestors,inbreeding coefficients and ancestor loss coeffiecient as well as get statistics about health, breedingand trial results. Also all the conformation results are listed. One downside for TTs is that forimported dogs only three or four generations are added to the database, making f.e. trial pedigreeswith these dogs rather insufficient. Currently the database is available only in Finnish.In 2006 Prof Hannes Lohi established a research group studying canine genetics in theUniversity of Helsinki. The group collects DNA samples from purebred dogs to reveal the geneticsmechanisms behind different hereditary characteristics as well as mutations behind seriousdiseases affecting dogs, including several eye diseases, autoimmune syndromes and epilepsy.The research group was involved in the discovery of the mutation causing PLL and has on-goingcollaborations with the research groups in AHT and the University of Missouri. Finnish TT ownershave been taking part in the DNA sample collection actively, already donating about 200 DNAsamples.The newest project involving TTs is the genetics of the smooth coat variety. The mutationcausing smooth coat has been recognized in the Bichon, Havanese and Lhasa Apso breeds andhopefully by the time of the World Congress, there will be information about the genetics of thisvariety in TTs.None of the members of the Finnish TTry are able to attend the World Congress but we wishyou an excellent meeting and fruitful discussions for the benefit of our wonderful breedOn behalf of the TTryElisa Nevalainen, PhDmember of the breeding committeekennel Nyyppiksen26

Internationaler Klub für Tibetische Hunderassen e.V.Weltweit ältester Förderverein für die Hunderassen Tibets - gegründet 1967Mitglied im Verband für das Deutsche Hundewesen e.V.und in der Fédération Cynologique InternationaleReport From The International Club for Tibetan Breeds Association (KTR GERMANY) for theTibetan Terrier World Congress 2011The KTR is the world’s oldest Tibetan Breeds Club dedicated to promoting Do Khyi, Lhasa Apso,Tibetan Spaniel and Tibetan Terrier. The KTR has about 740 members at home and abroad.In 2010, 408 Tibetan Terrier puppies were listed into the stud book VDH / KTR.Dogs, which are to be considered for breeding, have to be presented at a minimum age of 12months to an approved Club representative for evaluation. Here, the assessment of the physique, thebreed type and the functionality is documented in a report. In the 4 session organised in 2010 bythe KTR, there were 52 Tibetan Terrier, who were granted a breeding license.For approximately 25 years, the Tibetan Terriers from the KTR have had compulsory eye testing.All breeding dogs have to be x-rayed for HD, before mating:In the past 3 years, 250 Tibetan Terrier were X-rayed and about 85% had an HD-A (compare withexellent in USA) and 12% with HD-B (compare with very good in USA)Since early 2009, all breeding dogs had patella (PL) examinations . More than 100 Tibetan Terrierhave been examined so far. We had 90% PL 0 / 0 and the other with PL 1 / 1.Since November 2009, all Tibetan Terriers who are to be used in breeding programmes have to betested on CCL and PLL.A total result on 31 March 2011, 1480 Tibetan Terriers tested on CCL:Clear 1076 72.7%Carrier 357 24.1%At Risk 47 3.2%And 526 tested Tibetan Terrier PLL:Clear 454 86.3%Carrier 68 12.9%At Risk 4 0.8%27

Females may not be mated before the age of 18 months. The females may within 24 months,havenot more than 2 litters. No breeding can take place with a bitch over 8 years of ageAt 8 weeks old all litters must be examined by officials from the KTR. It is then noted in a report,that in males the testes are present, how correct the bite is at present and and the number of teeth.Whether the puppies have umbilical or inguinal hernia, whether the puppies are socialized and howthe bitch looks after her whelping etc .All puppies must be microchipped and vaccinated against parvo, distemper, hepatitis andleptospirosis.The chip numbers are entered and the vaccination certificates are checked .Only then can thepuppies be registered into the KTR studbook and then pedigrees are issuedThe KTR has several regional groups that organize for our members, dog walks, barbecues andsocial gatherings! There are many seminars organised for Tibetan Breeds!At least once a year there is a breeder meeting with different topics. We have invited geneticists,behavioral biologists or veterinarians.In the last 2 years the KTR has organized a day for young dogs. Here the puppies from the last twoyears were, presented to a judge in a very relaxed atmosphereTwice a year our club magazine “KTR Reporter is published. Here reports are posted by ourmembers about their dogs, as well as reports and pictures from past shows , medical reports andpublications of all current breeding data.We wish the visitors to the TT World Congress 2011 in Pennsylvania all the best and hope they havea very enjoyable yet educational congress in support of our wonderful breed.We would like to know what the delegates think on the new breed standard of the FCI and whetherit might be possible to rename the Tibetan Terrier (which as we all know is not a terrier) the“Tibetan Apso”.Sincerely,Anke PeineKTR Hauptzuchtwartin28

Germany — ILTIn 1986, the ILT, “Internationaler Club für Lhasa Apso und Tibet Terrier e.V.” was founded inMonschau/Eifel. As a member of the German Kennel Club, the ILT is authorized to carry its ownstudbook and to issue pedigrees for dogs bred or purchased under the club’s auspices. Over the 25-year history of ILT, the club has united friends and supporters of the Tibetan breeds Lhasa Apso andTibetan Terrier.Club members are devoted to giving these rare and exceptional animals a second home. ILTencourages members and breeders to protect and advance the continued existence of these breeds.The club urges its breeders to achieve this ambitious objective by:• Breeding as closely as possible to the accepted FCI standard• Maintaining high breeding standards and by discriminate breeding• Adhering to a strict code of ethics outlined in the clubs rules and regulationsILT is a member of the German Kennel Club and the FCI (Fédération Cynologique Internationale)in Bruxelles/Belgium. In addition, the club supports the GFK, a scientific society engaged in theprogress of cynological research. As of November 6, 2009, the club has been granted the non-profitmaking status by the tax authorities. We would like to express our appreciation of the fact that manylocal and foreign members support us in protecting and advancing the interests of these breeds.Mr. and Mrs. Winfried Nouc, two founding members, have bred Tibetan Terriers, Lhasa Apsosand Tibetan Spaniels under their world famous kennel prefix “Seng Kyi”, and the couple introducedthese breeds to Germany.In the fall of 2011, we are going to celebrate the club’s 25 th anniversary with an interesting3-day-program. Local and foreign members, their family members as well as breed fanciers areheartily invited and welcome to join the celebration.For further information please contact:The Chairwoman & Club Breeding OfficialMrs. Gudrun Menges-MohrMail: menges-mohr@ilt-tibet.dePhone ++49.2162.2959529

Norwegian Tibetan Terrier Club (NTTK)The Norwegian Tibetan Terrier Club (NTTK) is a small club. This year we will celebrate our 30thanniversary. We have about 200 members and 25 breeders.NTTK have a special magazine for Tibetan terriers called “Tibetaner’n”. “Tibetaner’n” ispublished four times every year. The magazine contains information from the management,breeding committee, regional contacts, reader’s letters, advertisements and general information. Asa member in the Norwegian Tibetan Terrier Club you receive the Norwegian Kennel Club magazine“Hundesport” 10 times a year.Norwegian Kennel Club (NKK) is an umbrella-organization for all breeds – and dog clubs inNorway. NKK has general and ethical rules regarding breeding. All members should follow theserules. NKK arranges 11 international dog-shows every year. NKK is organized at The FederationCynologique Interationale (FCI) in Belgium.NTTK arranges a dog show for all breed every year. We also have a special dog show only forTibetan terriers every year. Normally there are between 25-35 dogs entered. At the special dogshow we have a “trimmed class”and “child and dog” competition in additional to the ordinaryexhibition.In the evening we have a banquet with good food and we celebrate all the dogs. When wearrange the all breed show we do it together with the Norwegian Greyhound Club. This show lastfor two days, with approximately 1,000 dogs entered. This is a big show for a little club, but possibledue to heavy support from our members.We have 11 regional contacts scattered all over the country. The regional contacts arrange coatcare demonstrations, walking trips and they support new and old members. Since Norway is a longcountry and most of the Tibetan terriers are located in the southern part of the country, the regionalcontacts are great publicity for the breed.The breeding committee’s main goal is:To keep the breed typical according to the standardTo aim for good temperament within the breedTo reduce the number of affected dogs regarding hereditary diseases/conditionsTo keep a good gene-variation in the breed30

The breeding committee tries to reach NTTK’s main goal by keeping records of informationregarding all hereditary diseases – carriers / cases. We make official all results regarding HD, LLand PRA in our magazine. We are also sending all LL and PRA cases to the TIIS List. We educatebreeders and owners about the hereditary problems so they know the importance of followingNTTK’s advice. We recommend that all Tibetan terriers should be x-rayed after one year of age. Eyeexaminedwhen the dog is 2, 4, and 6 years old. We also recommend the DNA test for NCL and CLL.The dog has to have a permanent ID prior to these examinations. Most of our dogs are marked withID-chips.We have co-operation between NTTK and the breeders. We all think it’s important to be openand share our information with each other and keep them in official records. The main attitudeamong the breeders is that NTTK’s rules are positive and necessary for our breed, all seriousbreeders respect and follow them. We shall never forget that the goal is not to exclude any dog fromthe breeding, but sometimes necessary to keep our breed healthy.Best regardsSiri Wangen31

The Swedish TT ReportSince the last report to the WC in Norway, the breeding committee has been updating RAS(Rasspecifika Avelsstrategier = Breed-Specific Regulations), a form from all breed-clubs sent to theSKK (Swedish Kennelclub) to show what the clubs and breeders have to think about health andtemperament in their breed. It´s asked for from our government and shall be updated every 5thyear). In order to achive facts a survey was sent out to 150 new TT-owners. This survey and anotherone more suited for TT-breeders were published in the TT-clubs magazine and website.The conclusion is that the TT in Sweden appears to have generally good health and nicetemperament.Over the past years the number of registrations still drops. In 2009 and 2010 there where 156and 150 TTs registered in Sweden.We have a very low inbreeding rate, only 0.5% (looking at 5 generations).Since the last Congress a total amount of 58 TTs have been mentally described. We now havean average value for our TTs reactions towards the different situations tested. The differentcharacteristics described are curiosity, fearlessness, aggressions, sociability, hunting-interest andplayfulness.The test is done by the SBK (Swedish Club for Workingdogs).So far the TTs that have been described to show very much the same reactions and the sameway to solve problems. The results of MH are official and listed by the SKK (Swedish Kennelclub)During 2010 our club has followed up the measuring project from 2000. All dogs entered at TTSspeciality shows have been measured. The result shows that the males average size have increasedfrom 41,2 cm to 42 cm (16.2 in. to 16.5 in.), and the females have decreased from 38,9 cm to 38,3 cm(15,3 in. to 15,1 in.).Two Tibetan Terriers have been imported from a kennel in China.We have had no cases of PLL, PRA or RD since the last congress.Two cases of NCL are diagnosed by DNA-test.Following are the results from dogs hip x-rays the last years.(Our scale of hip-ray: A and B are good hips. C is ok, D and E are bad hips)Out of 205 dogs born in 2007, 72 were hip X-rayed:Out of 143 dogs born in 2008, 44 were hip X-rayed:38 A27 B5 C2 D26 A10 B6 C2 D32

All results from hip X-ray and eye-examinations are official and listed by the SKK (SwedishKennelclub). The number of dogs having eye-examinations and hip X-rays are decreasing.When it comes to RD, known cases are also listed by the SKK. However it´s up to the breeder/owner to send the pathology report to SKK in order to make it public.Most of the breeders in Sweden seem to think that the DNA-tests available for our breed arevery helpful when making breeding decisions. They also see the benefit in the possibility to usecarriers for breeding.TTS has not set up any guidelines regarding the use of DNA-tests.SKK does not list results from any of the DNA-test since they don´t approve of swab-test andthe test must also be validated for the Swedish population. The Swedish Kennelclub has very clearethical rules for DNA-tests (not to use two carriers or a case for breeding). Breeders must followthese rules even if the tests are not approved by the SKK.This was all from the breeding committee of Sweden.Hope you have an interesting congress and a lovely time!TTS Breeding Committee2011-03-22Kristina ForsbergMarina C AnderssonGunilla Albrigtsen33

The Breed Record Supplement also includes results of health checks for eyes, hips and latterlyfor DNA tests. All results are published. Breeders do not have the choice to withhold publication ofany results. Results of any individual dog can also be obtained on line at www.the-kennel-club.org.uk/services/ then chose the option Health Tests. Results published by the Kennel Club for 2009 and2010 are as follows:Eye Certificates 2009 – 532 dogs examined with 1 dog clinically affected for PLL2010 – 437 dogs examined no reported clinically affected dogs for PRA or PLLHip Certificates 2009 – 223 dogs with a range of 0-762010 – 179 dogs with a range of 0-74DNA-PLL results obtained from AHT April 2011Total Tests for UK Clear Carrier At risk774 511 247 16100% 66% 32% 2%DNA–NCL results obtained from OFA April 2011Total Tests for UK Clear Carrier At risk246 164 71 11100% 67% 29% 4%At Crufts in March 2011 the Kennel club launched the trial of their new on line breeders toolcalled ‘Mate Select Programme’. This will be available on the Kennel Club web site and will drawdirectly from information stored on The KC registration data base for assessing the outcome ofproposed matings by calculations of Estimated Breeding Values (EBV’s). It will be a valuable tool inhelping to assess the genetic risks involved.We have made donations to the AnimalHealth Trust to aid their research to find thegene responsible for PRA. We still need moresamples from affected dogs. If you are able tohelp please contact either of the breed clubsand we will supply you with research test kits.Pat TempestTibetan Terrier Association Chairmanttachairman@aol.comPhilippa GilbertTibetan Terrier Breeder andOwners Club Chairmanthechairman@ttboc.co.uk35

News from America — TTCA Health ReportThe Tibetan Terrier Club of America has been very active over the past two years with newhealth initiatives, as well as working with the Tibetan Terrier Health and Welfare Foundation toforward health research in the breed.We have been actively involved in research which helped lead to the 2009 announcement thatgeneticists at the University of Missouri had identified a mutation for PLL. Not long after, in 2010,the mutation for NCL was found. Tests for both diseases are now offered through OFA. Researchinto Progressive Retinal Atrophy is also ongoing. Dr. Simon Peterson-Jones of Michigan StateUniversity has been studying PRA in TTs; information on how to submit samples to aid his researchcan be found on the TTCA website.The TTCA health committee has introduced a Longevity Listing Program to recognize members’dogs that have lived to age 13 and beyond. We continue to track the health status of the breedthrough periodic Health Surveys. Our latest health survey was completed in 2009. The results canbe viewed here: http://www.offa.org/surveys/survey_tibetan.html. Cancer and skin disorderstopped the list as the most highly reported conditions. Through the AKC Canine Health Foundation,the TTWHF has helped to fund studies into Both Canine Non- Hodgkin Lymphoma as well as CanineAtopic Dermatitis (a skin disease in which dogs develop hypersensitivity to food or environmentalallergens.)The TTCA continues to work with the Tibetan Terrier Health and Welfare Foundation to supportongoing research in many other areas as well. For the past two years, the TTCA and TTHWF havesupported stem cell research for NCL affected dogs. Dr. Richard Vulliet, Veterinary Medical Directorat ReGena-Vet Laboratories and professor at UC Davis, has been conducting a trial with clinicallyaffected TTs to investigate the potential of adult bone marrow stem cells to treat neuronal ceroidlipofuscinosis. For more information about the trial, please contact Dr. Vulliet at regenavetlabs@gmail.com.The TTHWF continues to support Dr. Mary Whitely’s research into Renal Dysplasia. Testing hasbeen available at subsidized rates for TTCA members for the past two years. It is hoped that herstudy will determine the frequency of the RD mutation in the US Tibetan Terrier population.Through its Breeder Challenge Fund, the TTHWF is also helping to fund another AKC CHF studyfor the Investigation to Identify Genes Associated with Canine Hemolytic Anemia. This research isbeing conducted by Lorna Kennedy at the University of Manchester.The TTCA Health Committee is committed to the education our members about TT health,identification of potential health issues in the breed and the promotion of research in the hope ofminimizing and overcoming potential health problems our dogs. We look forward to the future, andhope that it brings the promise of even healthier lives for our TTs.Please feel free to contact me with any questions.Stacey La Forge, TTCA Health Committee Chairpersonlaforge-gross@comcast.net36