Hospital Genten

Prescribing informationComposition and DescriPtionULFARET for Iniection 0.5 and 1 g. are preparations cf whitetd light yellow crystals or crystalline powder, each vial containing0.5 g. lpotency) and 1 g. (potency) of cefsulodin sodium,respeclverv.Actions'1. Unlike conventional cephalosporin, ULFARET is markedlyactive against Pseudomonas aeruginosa.2. The antibaclerial activity against Pseudomonas aeruginosais nearly equivalent to the aminoglycoside antibiotics, sucha5, gentamlcln.3. Since r1s mode of actron differs Jrom that of the aminoglycosideantibiotics, ULFARET has been proven to have positiveantibacterial activity against aminoglycoside-resistantstrains of Pseudomonas aeruginosa.4. lts action is bactericidal even at minimum inhibitory concentration(MlC)5. ULFARET displavs a strong resistance to beta-lactamaseproduce bV Pseudomonas aeruginosa.6. The potent antibacterial action of ULFARET against Pseudomonasaeruginosa is believed attributable to its prominentextracellular membrane permeability.lndicationslnfections due to ce{sulodin sensitive Pseudomonas aeruginosa :- Septicemia- Pneumonia, bronchitis and primary infection withbronchiectasis- Pyelonephritis, urocystitis and prostatitis- Secondary infectionsafter inlury or burn- PeritonitisDosage and AdministrationUsually, for adults, 0.5 to 1 g. dailv intramusculary, intravenouslvor by intravenous drip, divided into 2 to 4 doses.The dosage range should be adjusted according to age andseverity ol in{ection. Daily doses may be increased up to 4 g{or the treatment of sePticemia.In children, usually 100mg/kg. daily, divided 3-4 doses. Forsevere and intractable infections, such as septicemla, up to200 mg./kg. dailV, divided 3-4doses.For patients wrth impaired renal function, the initial dose is thesame as for those with sound kidneys. The maintenance dosemust be adiusted with the creatinine-clearance. The recommendeddosages therebY areCreatinine-clearance Recommende dose inof initialdoseDosage interval(ml/min)8 hrs5030201052.5In the case of acute renal failure (creatinine-clearance o ml/min),75olof the initial dose is recommended over 24 hrsULFARET can be administeredthe form ofi.m. :0.5 g. of ULFARET dissolved in a solution of localanesthetic such as 0.5-2olo lidocaine or mepivacaine.i.v. : 0.5 and 1 g. of ULFARET diluted in 20 ml of diluent(isotonic saline solution or dextrose injectio.n)i.v.drip : Single doses of 0.5 to 2 g. of ULFARET diluted in areptenishing fluid, such as glucose solution, electrolytesolution or amino acid preparation, may be used forintra venous drip inf usion over 30 minutes to 2 hrsPrecautionqnBO7Q605545Please refer to package insert959080706560o/o