Hospital Genten

I-eukopenia due to radiation and/or chemotherapy.It is well known that the sctivity of oboxylaw in liver homogemte of albinorats grown on a VBr deficient regime cm be enhmced by adding VBt (or Thia'mine diphosphate, hereimfter abbrwiated TDP) to such deficient tegime or furthelincased by adding Adcnosine triphosPhate (her€inafter abbreviated ATP) to VB'(ot TDP).The exploitation of INOSIE-F has originated from a report bv BiochemicalR@m, Tokyo Agricultural Univtrsity, that when INOSTE F' instead of the rbovementioned ATP, is added to VBr (or TDP), the sme results will bt obtained'The study on clarifiotion of this mode of action is still kept going on and inpuallel thdewith, fundmental experiments have als been wnducted frompathohistologiel and biochemical viewPoints.lComposition ard PropcrtierlGensal name : InosineProptielay name : Hypoxmthine ribosideChemicalname : Hypoxanthineg-P'ribofurabinosid€?n t - o:--lStructuralformula ' UAn-1-- I THl\r'r/-N "c--c c -c-cH,gHtttllAaionslHOHOHH1. Ph.rmeologicrl rstionr(l ) Inqinr prrmrt.r lhroueh th. €llwlllt. r)12) Inqin. trk.t di?cl pr.i in tuglr mt$oli:m'l)'2)(31 lnqim raivrot .n:ym. orklizing pyruvic rid.3)There arc many reports akadymade on metabolism, its activating efiect on14) Inorinr rstivetr donely xanthinloxidu. rtc.?)heptaic function and its action on the maintemne of ATP leYel in the ells of theDone msrow md L-cells md moreovs, its action on the cirolating system has alsolreen proved sufficient, thus dtawing attraction flom the mediel profession by mdby in its application to clinics.eir uiu firJ :: n oul: n f, nrJ:i5) lnorinc trkar p.rt in tynthariring nucbotidd (or nsla6ktG) in th.cglnirm.2)llndicrtionl Lrukopenh due to radiation and/or chemotherryy.[Adminbtration and dongolUsually administer l,200ng - 1,800mg u lnoslne oraly in 3divided dorcs ps day for adults.The dosge may be incrasd or dereased suitably accotding tothc patient's agp md symptom.