M.Sc Chemistry - Skymount Distance Education

PAPER-IIMSCH/S/420 CHEMISTRY OF NATURALl PRODUCTS,BIOMOLECULES ANDBIOTECHNOLOGYNatural products and biomolecules:Classification of natural products: classification based on chemical structure,physiological activity, taxonomy and biogenesis.Steroids and hormones: definition and occurrence, detection and isolation of steroidsand hormones.Structure determination of, stereochemistry and synthesis of cholesterol,ergosterol,estrone,progesterone,androsterone,andcortisone.Prostaglandins,F21,andE2,thromboxaneTx,pencillins,cephalosporin, Puromysin. Tetracyclins,adriamycin anddaunomyinone.Vitamins: Definition,ocurrance, structural formulae and physiological functions of Vit.A1, A2, B1,B2,B6,nicotinic acid , Vit.C, D,and vitamin K..Alkaloids: qunine, morphine,thiophine,codine, nicotine, reserpine.Anthocyanins,flavonesand isoflavones, examples in each family.Terpinoids: monoterpines,syntesis of geraniol,citral, menthola and meHeterocyclics and synthetic drugs:Methods of synthesis,physical and chemical properties and aromatic character ofpyrazole, imidazole,oxazole,thiazole, pyridizine,pyrmidine and pyrazine. Coumarine andchromones Synthesis of pyrimidine and purine bases – uric acid , caffeine,theobromineand theophylline.Synthetic drugs-chemotherpy, classification of drugs,synthesis of – benadryl ( antiallergic), beta methasone ( anti inflammatory steroid), diazeoam (tranquilizer), ibuprofen,piroxican and indomethacin(non steroidal anti inflammatory), 5-fluorouracil and 2-deoxyribonuceside(anti cancer), micanzole (anti fungal).Chloroquine andpyrethramine(anti malarials).Concepts in biotechnology:Bioprocesses technology, microbial growth dynamic, bioreactor concepts, immobilizationof cells and enzymes, enzyme technology and applications, principles of DNAtechnology,monoclonal antibodies, and concepts in agricultural and other industrialbiotechnology.