CURRICULUM VITAE - The Pancreapedia

2. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP 4th, Pan FC, Akiyama H, Wright CV, JensenK, Hebrok M, Sander M.(2012). Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming asthe Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma. Cancer Cell. S1535-6108(12)00449-7.Contribution: Characterization of the major tool in this study, Ptf1a CreER knock-in allele. We have presentedlineage-tracing data obtained using Ptf1a CreER in various conferences and have convinced Dr. Sander to obtainPtf1a CreER line to perform these experiments prior to publication. We also helped in manuscript editing.3. Cai Q, Brissova M, Reinert RB, Pan FC, Brahmachary P, Shostak A, Radhika A, Poffenberger G, JeromeWG, Dumont DJ, Powers AC.(2012) Enhanced expression of VEGF-A in cells increases endothelialcell number but impairs islet morphogenesis and cell proliferation. Developmental Biology 367: 40-54.Contribution: Perform immunofluorescence analysis in Figure 2. I also helped in manuscript editing.4. Kopinke D, Brailsford M, Pan FC, Wright CV, Murtaugh LC. (2012) Ongoing Notch Signaling maintainsphenotypic fidelity in the adult exocrine pancreas. Developmental Biology. 362: 57-64.Contribution: Characterization and provide Ptf1a CreER line for deletion of RBJ knock out in adult acinar cells priorto publication. We also helped in manuscript editing.5. Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR,Grompe M. (2011) Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cellsurface markers. Mol Cell Endocrinol. 339: 144-150.Contribution: I helped to characterize ~50 monoclonal antibodies by immunofluorescence analysis onembryonic and adult pancreatic tissues. These monoclonal antibodies were generated by the Grompe’s lab aspart of the collaboration within the Beta Cell Biology Consortium. Contribute to data in Figure 5. We also helpedin manuscript editing.6. Pan FC. Wright CV. (2011) Pancreas organogenesis: from bud to plexus to gland. DevelopmentalDynamics. 240: 530-565.7. Loeber J, Pan FC, Pieler T. (2009). Generation of transgenics frogs. Method in Molecular Biology. 561:65-72.8. Pan FC, Chen Y, Bayha E, Pieler T. (2007). Retinoic acid-mediated patterning of the pre-pancreaticendoderm in Xenopus operates via direct and indirect mechanisms. Mechanisms of Development.124(7-8):518-319. Pieler T, Pan FC, Afelik S, Chen Y. (2006). Molecular genetics of liver and pancreas development. InCell Signaling and Growth Factors in Development: From Molecules to Organogenesis (ed. K.Unsicker and K. Krieglstein), Vol. 2. pp. 823-840. Wiley-vch, Weinheim.10. Pan FC, Chen Y, Loeber J, Henningfeld K, Pieler T. (2005) I-SceI mediated transgenesis in Xenopus. .Developmental Dynamics 235: 247-252.11. Chen Y*, Pan FC*, Brandes N, Afelik S, Soelter M, Pieler T. (2004). Retinoic acid is essential forpancreas development and promotes endocrine at the expense of exocrine cell differentiation inXenopus. Developmental Biology 271: 144-160. (* equal contribution).12. Xu Y*, Pan FC*, Wright CV, Gu G. (2013). Adult pancreatic duct cells transdifferentiate to -like cellduring PDL-induced regeneration in the mouse. (* equal contribution) (Submitted to PLos One).2