Lire l'intervention de Jean-Pol Tassin

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CONCLUSIONSLa nicotine n’est pas addictive par elle-même.Elle le <strong>de</strong>vient mélangée au tabac car les IMAOs qu’il contientdésensibilisent les récepteurs 5-HT 1A .Anne-Sophie Villégier (Fondation G. Lagrue)/ Lucas Salomon (MRT)/Christophe Lanteri (MILDT)
Amph.500400300200100saline + AmphSCH + AmphRS + AmphSCH + RS + AmphNE (% baseline)saline / SCH / SCH + RSsaline / SCHp-Chloroamph.A B0-40 0 40 80 120 160 200time (min)10007505002500saline + PCASCH + PCA-40 0 40 80 120 160 200time (min)5-HT (% baseline)
Page 1 and 2:
USAGEABUSDEPENDANCE
Page 5 and 6:
No predictionReward occurs(No CS)RR
Page 7 and 8:
POMPE D’INJECTIONORDINATEURTROUIN
Page 10:
CortexPré-FrontalGluNoyauAccumbens
Page 13 and 14: 150100500-40 0 40 80 120 160 200Tem
Page 15 and 16: 150100500-40 0 40 80 120 160 200Tem
Page 17 and 18: CortexPré-FrontalGluNoyauAccumbens
Page 19 and 20: 2500NA (% basal)200015001000Amphét
Page 21 and 22: GABAGluCPFD 1D 2AMPAGABA ANAccGABAG
Page 23: D 1GABAGluCPFD 2α 1b5-HT 2AAMPAGAB
Page 26 and 27: CPFGluNAccGABA5-HT 1A RRD5-HTDAATV5
Page 28 and 29: USAGEJus de pommeDAABUSNA / 5-HTDro
Page 42 and 43: Injection AIGUË Morphine / test Pr
Page 44 and 45: Injections REPETEES Morphine / test
Page 46 and 47: Amph.5-HT (% baseline)1250100075050
Page 48 and 49: 17501500125010007505002500Amph.5-HT
Page 50: 17501500125010007505002500Amph.5-HT
Page 53 and 54: d-amphetamineNE (% of baseline)1000
Page 55 and 56: AUTO-ADMINISTRATIONNR(NON RENFORCE)
Page 57 and 58: d-amphetamineNE (% of baseline)1000
Page 59 and 60: Locomotor activity(¼ turn / min)50
Page 62 and 63: 5-HT2A5-HT5-HT2AATV5-HTRDRM
Page 66 and 67: 25002000Arepeated salinerepeated am
Page 68: Receptor binding profile of antipsy
Page 72 and 73: NE (% baseline)12501000750500250Amp
Page 74 and 75: Amph.5-HT (% baseline)1250100075050
Page 76 and 77: Le système de récompenseJean-Pol
Page 78 and 79: RNic+Dopamine_RNicGABARNicR Nicotin
Page 80: 3000250020001500100050001 2 3 4 5 6
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