Lire l'intervention de Jean-Pol Tassin

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Receptor binding profile of antipsychoticsReceptor olanzapine risperidone quetiapine ziprasidone clozapine haloperidolD 1 31 430 455 525 85 210D 2 11 4 160 5 126 0.7D 3 49 10 7 473 2D 4 27 9 32 35 35-HT 1A >10000 210 2800 3 875 11005-HT 2A 4 0.5 295 0.4 16 455-HT 2C 23 25 1 16 >10000α 1 19 0.7 7 11 7 6H 1 7 20 11 50 6 440M 1 1.9 >10000 120 >1000 1.9 >1500aMoore et al., 1993; b Daniel et al., 1999
Page 1 and 2:
USAGEABUSDEPENDANCE
Page 5 and 6:
No predictionReward occurs(No CS)RR
Page 7 and 8:
POMPE D’INJECTIONORDINATEURTROUIN
Page 10:
CortexPré-FrontalGluNoyauAccumbens
Page 13 and 14:
150100500-40 0 40 80 120 160 200Tem
Page 15 and 16:
150100500-40 0 40 80 120 160 200Tem
Page 17 and 18: CortexPré-FrontalGluNoyauAccumbens
Page 19 and 20: 2500NA (% basal)200015001000Amphét
Page 21 and 22: GABAGluCPFD 1D 2AMPAGABA ANAccGABAG
Page 23: D 1GABAGluCPFD 2α 1b5-HT 2AAMPAGAB
Page 26 and 27: CPFGluNAccGABA5-HT 1A RRD5-HTDAATV5
Page 28 and 29: USAGEJus de pommeDAABUSNA / 5-HTDro
Page 42 and 43: Injection AIGUË Morphine / test Pr
Page 44 and 45: Injections REPETEES Morphine / test
Page 46 and 47: Amph.5-HT (% baseline)1250100075050
Page 48 and 49: 17501500125010007505002500Amph.5-HT
Page 50: 17501500125010007505002500Amph.5-HT
Page 53 and 54: d-amphetamineNE (% of baseline)1000
Page 55 and 56: AUTO-ADMINISTRATIONNR(NON RENFORCE)
Page 57 and 58: d-amphetamineNE (% of baseline)1000
Page 59 and 60: Locomotor activity(¼ turn / min)50
Page 62 and 63: 5-HT2A5-HT5-HT2AATV5-HTRDRM
Page 64 and 65: CONCLUSIONSLa nicotine n’est pas
Page 66 and 67: 25002000Arepeated salinerepeated am
Page 75 and 76: Locomotor activity(¼ turn / min)50
Page 77 and 78: outon synaptiquerécepteurspré-syn
Page 79 and 80: CONTROL6-OHDALESIONEDAB
Page 83: α1b+/+α1b -/-D-Amph (3 mg/kg, ip)
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Lire l'intervention de Jean-Pol Tassin

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