G2 (1) Metabolic syndrome

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• Adipocyte derives hormones called adipokinesplay a key role in adipose tissue metabolismand in development of insulin resistance• Beneficial adipokines are,• Leptin• Adiponectin• Harmful adipokines are,• Resistin• TNF-α• IL-6Adipocyte and MetS
OBJECTIVES• Definition and diagnosis• Pathophysiology: Insulin Resistance• Clinical significance and implications• Prevalence: MSSM study and MetS inPenisular Malaysia.• Management of MetS
Page 2 and 3: OBJECTIVES• Definition and diagno
Page 4 and 5: Diagnosis• The National Cholester
Page 6 and 7: Third Report of the Expert Panel on
Page 8 and 9: International Diabetes Federation (
Page 10 and 11: WHO definition of IRS, 1999AT LEAST
Page 12 and 13: DEFINITIONS OF METABOLIC SYNDROMERi
Page 18 and 19: Clinical importance of MSPresence o
Page 20 and 21: Impact of the Metabolic Syndrome on
Page 22 and 23: Metabolic Syndrome: Total and CV Mo
Page 26 and 27: HARMONIZING THE METABOLIC SYNDROME.
Page 28 and 29: SOCIODEMOGRAPHIC CHARACTERISTICS OF
Page 30 and 31: Prevalence (%)PREVALENCE OF METABOL
Page 32 and 33: Prevalence (%)PREVALENCE OF METABOL
Page 34 and 35: MetS - where is Malaysiacompared to
Page 36 and 37: Prevalence of MetS in other populat
Page 38 and 39: Status of Diabetes Mellitus inMalay
Page 42 and 43: Cardiovascular Risk Reducing Treatm
Page 44 and 45: LIFE STYLE MODIFICATIONS WORKS• P
Page 46 and 47: MET-hours/weekHbA1c (%): placebo: M
Page 48: LIPIDSRisk FactorsLDL-cholesterolRe
Page 52 and 53: Cardiovascular Risk Reducing Treatm
Page 54 and 55: CONCLUSIONS• Definition and diagn

G2 (1) Metabolic syndrome

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