3.4-Breast cancer subtypes (Newman) - Breast Health Global Initiative

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Research Project: KATH-UMInternational Breast Cancer RegistryTo systematically evaluate African ancestry as arisk factor for ER/triple-negative, early onsetbreast cancer• Multicenter/international study– African Americans (UM; Henry Ford Hospital)– White Americans (UM; Henry Ford Hospital)– Ghanaians (Komfo Anoyke Teaching Hospital)• Document correlation between quantifiedextent of ancestry (via genotyping) and riskfor ER-negative/triple-negative breast cancer(via tumor studies)
Preliminary Results(in press, Cancer)HFH WAN=1,008HFH AAN=581GhanaN=75PValueMean Age 62.4 60.7 48.0 0.002Mean TumorSize1.95 2.30 3.20
Page 1 and 2: BREAST CANCER SUBTYPES:Association
Page 3 and 4: Breast Cancer Treatment• All brea
Page 5 and 6: Systemic Therapy for Breast Cancer
Page 8 and 9: “Basal-like” breast cancerGene
Page 10 and 11: Triple-Positive Breast CancerH&EER-
Page 12 and 13: BREAST CANCER SUBTYPES:Association
Page 14 and 15: NCDB: Frequency of ER-Negative Tumo
Page 16 and 17: Frequency of ER-Negative Breast Can
Page 18 and 19: High-Risk Breast Cancer andAfrican
Page 22 and 23: HFH WAN=1,008HFH AAN=581GhanaianN=7
Page 24 and 25: Other African Datasets• Huo et al
Page 26 and 27: ALDH1 as a Breast CancerStem Cell M
Page 28 and 29: ALDH1/Breast CA Stem Cell Marker:Gh

3.4-Breast cancer subtypes (Newman) - Breast Health Global Initiative

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