1gOgRTa

1 2 3 4 5 6 7 8Why a toolkit?The right time The right insulin Mythsand barriersInsulin management:key factsCommissioning forpeople with Type 2diabetesMedicinesoptimisationteamsCommunitypharmacy9AcknowledgementsAims of insulin therapyThe overall aim of insulin treatment in Type 2diabetes is to mimic normal insulin secretion in orderto achieve normoglycaemia without causing weightgain or hypoglycaemia 20 . In order to decide whichinsulin regime may be best for your patient, it isimportant to consider a number of factors including:7060Normal insulin secretionShort-lived, rapidly generatedmeal-related insulin peaksPathophysiology factorsNormal insulin secretion and underlying defectsin Type 2 diabetesIn healthy adults, normal insulin secretion has twokey elements: rapidly secreted insulin in responseto food intake, alongside a low level of basal insulinto control glucose between meals. The amount ofinsulin secreted depends on a number of factorsincluding activity, eating, stress and hormones 52 .In Type 2 diabetes, there are problems with bothelements of insulin secretion: the rapidly secretedinsulin as well as the basal insulin secretion whichresults in hyperglycaemia 53 .Insulin (! U/ml)504030201006:0010:00 14:00 18:00 22:00 2:00 6:00Polonsky KS et al. J Clin Invest. 1988;81: 442-8Time of dayLow, steady, basalinsulin profileBack to contentsReferencesRight Insulin, Right Time, Right Dose 33