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EuroPneumo Special Issue / pneumonia 2015 Oct 21;7:I–72 P1.17 Pneumolysin-induced nitric oxide contributes to lysosomal membrane permeabilisation in Streptococcus pneumoniae-infected macrophages 12 Joseph Ford, Martin Bewley, Simon Johnston, David Dockrell P1.18 Structure of the pneumococcal L,D-carboxypeptidase DacB and impact of DacB on pathophysiological processes 12 Mohammed R. Abdullah, Javier Gutiérrez-Fernández, Thomas Pribyl, Nicolas Gisch, Malek Saleh, Manfred Rohde, Lothar Petruschka, Gerhard Burchhardt, Dominik Schwudke, Juan Hermoso, Sven Hammerschmidt P1.19 Blockade of Streptococcus pneumoniae adhesion receptors of the blood-brain barrier endothelium: a new therapeutic approach for the prevention and cure of pneumococcal meningitis 13 Federico Iovino, Birgitta Henriques-Normark P1.20 Pneumococcal nasopharyngeal carriage in Nepalese children prior to pneumococcal conjugate vaccine introduction 13 Rama Kandasamy, Meeru Gurung, Stephen Thorson, Shrijana Shrestha, Imran Ansari, Katherine L. O’Brien, Sarah Kelly, Dominic F. Kelly, Andrew J. Pollard P1.21 Phosphoenol-pyruvate phospho-transferase A interactions with putative host target receptors and their derived peptides during Streptococcus pneumoniae adhesion 14 Tatyana Kushnir, Marilous Shagan, Anat Shahar, Raz Zarivach, Natali Elia, Ron Dagan, Yaffa Mizrachi Nebenzahl P1.22 Contribution of a temperate bacteriophage to the virulence of a Streptococcus pneumoniae serotype 1 strain 14 Martin Norman, Anna Syk, Sarah Browall, Birgitta Henriques-Normark P1.23 Streptococcus pneumoniae cardiac microlesions: pneumolysin-mediated immune evasion and biofilm growth 15 Ryan Gilley, Anukul Shenoy, Norberto Gonzalex-Juarbe, Carlos Orihuela P1.24 Polyamine transport in the pneumococcus is essential for evading early innate immune responses in pneumococcal pneumonia 15 Aswathy Rai, John Stokes, Justin Thornton, Edwin Swiatlo, Imran Sunesara, Bindu Nanduri P1.25 IL-22 contributes to recovery from pneumococcal pneumonia by reducing collagen deposition in lung 16 Neil Ritchie, Tom Evans P1.26 Pneumococcal colonisation and invasive disease studied in the porcine model 16 Astrid de Greeff, Saskia van Selm, Herma Buys, Jose Harders-Westerveen, Rahajeng Tunjungputri, Quirijn de Mast, Andre van der Ven, Norbert Stockhofe-Zurwieden, Marien de Jonge, Hilde Smith P1.27 Variome of the pneumococcal surface-exposed proteins and other virulence factors: a bioinformatics analysis 17 Andres Castro, Alejandro Gomez, Mauricio Gallego, Alejandro Bedoya, Sven Hammerschmidt, Gustavo Gamez P1.28 Global serotypes and genotypes for Streptococcus pneumoniae: a whole genome resource for assessing the impact of global pneumococcal immunisation 17 Rebecca Gladstone, Jukka Corander, Maaike Alaerts, Brenda Kwambana-adams, Mignon Du plessis, Paulina Hawkins, Dean Everett, Martin Antonio, Anne von Gottberg, Keith Klugman, Lesley McGee, Stephen Bentley, Robert Breiman pneumonia 2015 Volume 7 V
EuroPneumo Special Issue / pneumonia 2015 Oct 21;7:I–72 P1.29 Investigating the pneumococcal phageome using a diverse genome dataset 18 Caroline L Harrold, Andries J van Tonder, Angus McDonnell, Ben A Edwards, Angela B Brueggemann P1.31 Molecular pneumococcal capsular typing using whole genome sequencing: moving the Streptococcus pneumoniae reference service into the genomic era 18 Georgia Kapatai, Carmen Sheppard, Ali Al-Shahib, David Litt, Norman Fry, Anthony Underwood, Timothy Harrison P1.32 Streptococcus pneumoniae shows no overall systematic genetic adaptation over the course of infections leading to meningitis 19 John Lees, Diederik van der Beek, Julian Parkhill, Stephen Bentley P1.33 Genomic and virulence comparisons of non-human isolates of Streptococcus pneumoniae 19 Andrea Mitchell, Ashleigh Holmes, Patricia Romero, Jenny Herbert, Mark van der Linden, Andrew Waller, Tim Mitchell P1.34 Analysis into the recombination of the phase variable Type I restriction modification system spnD39III locus 20 Megan De Ste Croix, Ana Manso, Shehzan Dada, Richard Haigh, Marco Oggioni P1.35 Site matters: alternative insertion sites of integrative conjugative element Tn5253 can influence conjugation frequency in Streptococcus pneumoniae 20 Francesco Santoro, Alessandra Romeo, Gianni Pozzi, Francesco Iannelli P1.36 Mutagenesis of one Streptococcus pneumoniae serotype 1 strain 21 Vanessa Terra, Charles Plumptre, Emily Kay, Brendan Wren P1.37 Improving molecular detection, identification and serotyping of Streptococcus pneumoniae in complex samples 21 Laura Boelsen, Eileen Dunne, Katherine Gould, Fiona Russell, Kim Mulholland, Jason Hinds, Catherine Satzke P1.38 Genome-wide assessment of pneumococcal antigenic diversity 22 Nicholas Croucher, Lisa Kagedan, Claudette Thompson, Julian Parkhill, Stephen Bentley, Jonathan Finkelstein, Marc Lipsitch, William Hanage P1.39 An increase in negative supercoiling in Streptococcus pneumoniae induces a global transcriptomic response that regulates the DNA topoisomerase I gene 22 Maria-José Ferrándiz, Antonio-Javier Martín-Galiano, Isabel Camacho-Soguero, Cristina Arnanz, Adela G. de la Campa P1.41 Systematic nomenclature for the bacterial two-component regulatory systems, based on genomic, structural and functional analysis of the pan-genome of Streptococcus pneumoniae 23 Gustavo Gamez, Diego Sanchez, Frank Mona, Yully Betancur, Andres Castro, Alejandro Gomez, Jose Mediavilla, Mauricio Corredor, Sven Hammerschmidt P1.42 Optimisation of the expression of fluorescent proteins in Streptococcus pneumoniae 23 Maria Catalão, Joana Figueiredo, Mafalda Henriques, João Gomes, Sergio Filipe pneumonia 2015 Volume 7 VI
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