PHILADELPHIA SPINE RESEARCH SYMPOSIUM

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3:05 p.m. S1.12: Aging Enhances the Degradative Response to Tail Compression and the Compression-induced Reduction of Wnt Signaling in the Nucleus Pulposus Contributes to Degeneration N Holguin, Washington University, St. Louis 3:20 p.m. D I S C U S S I O N 3:30 – 4:00 p.m. B R E A K 4:00 p.m. I N T R O D U C T I O N O F T H E P L E N A RY SPEAKER: Jill P. Urban, Oxford University M Risbud, Thomas Jefferson University, Philadelphia 4:15 p.m. P L E N A RY LEC T U R E : Regulation of Disc Cell Behaviour by the Physico-Chemical Environment J Urban, Oxford University 5:00 p.m. D I S C U S S I O N 5:20 – 7:30 p.m. W E LCO M E R E C E P T I O N A N D P O S T E R S E S S I O N I T U E S D AY • N O V E M B E R 10, 2015 <strong>SYMPOSIUM</strong> 2 7:00 a.m. B R E A K FA S T BIOMECHANICS, MODELING, AND DISEASE MECHANISMS Discussion Leader: D Elliott, University of Delaware 7:55 a.m. Introduction D Elliott, University of Delaware 8:00 a.m. S2.1: Invited Talk: Intervertebral Disc Degeneration: Osmolarity, Inflammation, and Regeneration K Ito, University of Eindhoven, Netherlands 8:30 a.m. S2.2: Invited Talk: Solving Low Back Pain – If We Can’t Measure It, We Can’t Improve It J Lotz, University of California, San Francisco 9:00 a.m. S2.3: Biomechanical Effects of Intervertebral Disc Degeneration on Vertebral Body Mineral Density: A Finite Element Analysis W Gu, University of Miami, Florida 9:15 a.m. S2.4: Finite Element Model Development and Validation of Healthy Human Lumbar Spines R Haddas, Texas Tech University, Lubbock, Texas 9:30 a.m. S2.5: In-vivo Characterization of Human Lumbar Intervertebral Discs by Magnetic Resonance Elastography: Diurnal Changes in Shear Stiffness and Relationship with Degeneration B Walter, Ohio State University, Columbus 9:45 a.m. D I S C U S S I O N 10:00 a.m. – 10:15 a.m. B R E A K 10:15 a.m. S2.6: Invited Talk: Mechanobiology of the Intervertebral Disc: Characterization of the Tissue-specific Effects of Whole-body Vibration in a Mouse Model C Seguin, University of Western Ontario, London, Canada 10:45 a.m. S2.7: Progressive Spinal Kyphosis in Perlecan Deficient Mice A Parajuli, University of Delaware 11:00 a.m. S2.8: Inflammatory Stimulation Alters Hydraulic Permeability and Compressive Moduli of Nucleus Pulposus Cells in a Manner Dependent on F-actin Function T Jacobsen, The Feinstein Institute for Medical Research, New York 11:15 a.m. D I S C U S S I O N 11:30 a.m. B OX E D LU N C H 12:00 p.m. – 2:00 p.m. O P T I O N A L TO U R O F CO N S T I T U T I O N C E N T E R (fee applies)
TISSUE ENGINEERING AND REGENERATIVE MEDICINE I Discussion Leader: R Kandel, Mount Sinai Hospital, Toronto 2:00 p.m. Introduction R Kandel, Mount Sinai Hospital, Toronto 2:05 p.m. S2.9: Invited Talk: Biological-basis of Designing Biomaterials for the Degenerated Disc A Pandit, University of Galway, Ireland 2:30 p.m. S2.10: Invited Talk: Using Functionalized Peptides to Control Disc Cell Behavior and Biosynthesis L Setton, Washington University, St. Louis 3:00 p.m. S2.11: Invited Talk: Exploration of Annulus Fibrosus Progenitor Cells D Sakai, Tokai University, Japan 3:30 p.m. S2.12: Nucleus Pulposus Phenotypic Markers to Determine Stem Cell Differentiation: Fact or Fiction? A Thorpe, Sheffield Hallam University, UK 3:45 p.m. S2.13: Efficacy of Demineralized Bone Sponges and Concentrated Bone Marrow in Posterolateral Lumbar Fusion BJ Yoon, Hospital for Special Surgery, New York 4:00 p.m. D I S C U S S I O N 4:10 p.m. P O S T E R S E S S I O N I I 5:30 – 6:15 p.m. R I S I N G S TA R S E S S I O N – O R S S P I N E S E C T I O N : Building Bridges in Disc Research: The Way Forward R Hartman, University of Pittsburgh The Role of the IVD Microenvironment on Neurovascular Ingrowth D Purmessur, Ohio State University, Columbus W E D N E S D AY • N O V E M B E R 11, 2015 <strong>SYMPOSIUM</strong> 3 7:00 a.m. B R E A K FA S T ( CO F F E E & PA S T R I E S ) MECHANISMS OF DISC DEGENERATION II Discussion Leader: J Hoyland, University of Manchester, UK 7:25 a.m. Introduction J Hoyland, University of Manchester, UK 7:30 a.m. S3.1: Invited Talk: Biology of Intervertebral Disc Aging: Age-related Alterations in Cellular Senescence and Bioenergetics N Vo, University of Pittsburgh 8:00 a.m. S3.2: Invited Talk: Inflammation in Intervertebral Disc Degeneration L Creemers, University Medical Center Utrecht 8:30 a.m. S3.3: Invited Talk: Prolyl Hydroxylase 2 Controls Inflammatory Actions of TNF-α on Nucleus Pulposus Cells M Risbud, Thomas Jefferson University, Philadelphia 9:00 a.m. S3.4: Disc Cells Respond to Propionibacterium Acnes and Release Cytokines which Activate Bone Marrow Leukocytes S Dudli, University of California, San Francisco 9:15 a.m. S3.5: Degenerative IVDs Sensitize Sensory Neurons to Heat Stimuli via IL-6/AKAP/TRPV1 pathway J Stover, University of Utah, Salt Lake Citys 9:30 a.m. S3.6: Excessive Reactive Oxygen Species are Therapeutic Targets for Intervertebral Disc Degeneration S Suzuki, Keio University, Japan 9:45 a.m. D I S C U S S I O N 9:55 a.m. – 10:15 a.m. B R E A K
Page 1 and 2: 3 rd International PHILADELPHIA SPI
Page 3 and 4: 2015 PLENARY SPEAKER Dr. Jill P. Ur
Page 5: M O N D AY • N O V E M B E R 9, 2
Page 9 and 10: T H U R S D AY • N O V E M B E R
Page 11 and 12: POSTER SESSION II - POSTER # 13 The
Page 13 and 14: POSTER SESSION I - POSTER # 46 Pred
Page 15 and 16: POSTER SESSION I - POSTER # 78 Post
Page 17: C O N F E R E N C E S P O N S O R S

PHILADELPHIA SPINE RESEARCH SYMPOSIUM

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