PDTE 2016 July Newsletter

A new preparation
called Sileo
BSAVA Small animal
Formulary
Causes diuresis by supressing ADH
secretion, a transient increase in blood
glucose by decreasing endogenous
insulin secretion, mydriasisand
decreased intraocular pressure.
Vomiting could be caused after i.m.
application. Due to effect on blood
glucose, use in diabetic animals is
not recommended. Spontaneous
arousal from deep sedation following
stimulation can occur with this
preparation. Aggressive animals
must be sedated with caution.
Moreover it is not working in stressed
animals with high adrenalin - this
medicine binds the same receptors
as adrenalin. When they are busy this
medicine does not work. That is why
it is not possible aroused animals fall
alseep with this preparation.
I am strongly against sedatives
beeing used by owners without
veterninary supervision. It could be
life threatening. I have the antidote
for this at my practice but owners at
home do not. If the animal develop
cardiac arrest at home they are not
able to do anything. I think it is my
duty to warn dog people before
using this at home. It is not safe.
Editorial correction: the original publication of this article listed the preparation as Silio rather than Sileo, which was corrected 18/07/16
Dr. Martina Nčeradská from Czech Republic explains the workings and side effects of Sileo and advices
against it’s unsupervised usage
One of my clients asked me
about a new preparation
Sileo. I decided to write
about this to inform dog people who
love their dogs and do not want to
harm them. This new preparation
is meant to “protect” dogs from
fireworks and sound.
European Medicines Agency
recommends this preparation
for medical use. Sileo contains
dexmedetomidine hydrochlorid,
which is selective alpha-2 adrenergic
receptor agonist (alpha-2 agonist)
that works by reducing the activity
of the sympathetic nervous system,
making the dog calm or sleepy.
I use this preparation in my practice
as a part of anaesthesia. It is good
sedative, but in my opinion it has
to be used under the supervision
of a veterinary doctor in case of
complications and the animal should
be carefully monitored. It is not a
preparation which could be allowed
for unsupervised use at home.
The letter from European Medicines
Agency states: “The benefits of Sileo
are its efficacy in the alleviation of
acute anxiety and fear associated
with noise in dogs. The most common
side effects are transient paleness of
mucous membranes at the application
site, sedation, emesis and urinary
incontinence. Detailed conditions
for the use of this product will be
described in the summary of product
characteristics (SPC) which will be
published in the European Public
Assessment Report (EPAR) and will
be available in all official European
Union languages after the marketing
authorisation has been granted by the
European Commission. The CVMP,
on the basis of quality, safety and
efficacy data submitted, considers
that there is a favourable benefit to
risk balance for Sileo and therefore
recommends the granting of the
marketing authorisation.“
I like dexmedetomidin for use in my
practice, but I am really scared of
what could this do in the hands of
owners not knowing how it works -
this medication is contraindicated in
many animals - vets should know that,
but owners do not.
Contraindications in
BSAVA Small animal
Formulary
Do not use in animals with
cardiovascularor other systemic
disease. Use of dexmedetomidine in
geriatric patients is not advisable. It
shuld not be used in pregnant animals,
nor in animals requiring or receiving
sympathomimetic amines.
Adverse reactions in
22
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