PharmaPoint: Human Immunodeficiency Virus (HIV) - Global Drug Forecast and Market Analysis to 2023

Report Overview On PharmaPoint Human Immunodeficiency Virus (HIV) ­ Global
Drug Forecast and Market Analysis to 2023
"The Report PharmaPoint: Human Immunodeficiency Virus (HIV) ­ Global Drug
Forecast and Market Analysis to 2023 provides information on pricing, market
analysis, shares, forecast, and company profiles for key industry participants. ­
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Human immunodeficiency virus (HIV) is a retrovirus that infects the cells of the immune
system, destroying or impairing their function. As the infection progresses, the immune
system becomes increasingly weaker, making the infected person more susceptible to other
infections. Since the first anti­HIV drug, GlaxoSmithKlines (GSKs) Retrovir
(azidothymidine), was approved in 1987, major improvements have been made in the field
of antiretroviral therapy (ART). This rapid progress has been headlined by the emergence
of once­daily, single­tablet regimens (STRs) such as Gilead Science's Atripla
(efavirenz/emtricitabine/tenofovir disoproxil fumarate [TDF]), which offer patients an
unparalleled level of convenience.
GlobalData projects the global HIV marketplace ­ which, for the purposes of this report,
comprises nine major pharmaceutical markets (US, France, Germany, Italy, Spain, UK,
Japan, Brazil, China) ­ to experience modest growth during the forecast period. This growth
will be driven primarily by the highly anticipated arrivals of novel integrase inhibitor­ (INI­)
and protease inhibitor­ (PI­) based STRs, which include ViiV Healthcares Triumeq
(dolutegravir/abacavir/lamivudine), Gileads Quad 2
(elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate [TAF]), and Gileads
and Janssens darunavir/cobicistat/emtricitabine/TAF. Nevertheless, looming patent
expiries of high­grossing branded drugs in the US, 5EU (France, Germany, Italy, Spain,
UK), and Japan, along with compulsory licensing and generic erosion in Brazil and China,
are expected to curtail market growth.
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Highlights
Key Questions Answered
­ How will the HIV market landscape in the 9MM (US, France, Germany, Italy, Spain, UK,
Japan, Brazil, China) change from 2013­2023?

­ What are the most promising late­stage pipeline drugs in HIV?
­ How do the clinical and commercial attributes of late­stage pipeline therapies compare
with one another, and against existing treatment options?
­ What are the unmet needs in HIV treatment management?
­ What drivers and barriers will affect HIV therapeutics sales in the 9MM over the forecast
period?
Key Findings
­ The global HIV therapeutics market was worth approximately $14 billion in 2013, and
GlobalData projects this market to reach a total of $15 billion in sales by 2023, at a
Compound Annual Growth Rate (CAGR) of 0.9%. These sales are expected to come
predominantly from the US market, as financial austerity measures remain a primary
barrier to the growth of the HIV market in the other countries covered in this report.
­ Over GlobalDatas 2013­2023 forecast period, the increased uptake of STRs is expected to
drive market growth. KOLs interviewed by GlobalData expect that INI­based STRs ­ led by
ViiVs Triumeq and Gileads Quad 2 ­ will dominate the marketplace for the duration of the
forecast period.
­ The most notable barriers of growth over the forecast period include patent expiries of key
HIV drugs in the seven major markets (7MM) (US, France, Germany, Italy, Spain, UK,
Japan) and compulsory licensing in Brazil and China.
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Scope
­ Overview of HIV, including epidemiology, etiology, pathophysiology, symptoms,
diagnosis, and current management strategies.
­ Topline HIV market revenue from 2013­2023. Annual cost of therapy (ACOT) and major
pipeline product sales in this forecast period are included.
­ Key topics covered include current treatment options, unmet needs and opportunities, and
the drivers and barriers affecting HIV therapeutics sales in the 9MM.
­ Pipeline analysis: comprehensive data split across different phases, emerging novel trends
under development, synopses of innovative early­stage projects, and detailed analysis of
late­stage pipeline products.
­ Analysis of the current and future market competition in the global HIV therapeutics
market. Insightful review of the key industry drivers, restraints and challenges. Each trend
is independently researched to provide qualitative analysis of its implications.
Reasons to buy
­ Develop and design your in­licensing and out­licensing strategies through a review of

pipeline products and technologies, and by identifying the companies with the most robust
pipeline.
­ Develop business strategies by understanding the trends shaping and driving the global
HIV therapeutics market.
­ Drive revenues by understanding the key trends, innovative products and technologies,
market segments, and companies likely to impact the HIV therapeutics market in the future.
­ Formulate effective sales and marketing strategies by understanding the competitive
landscape and by analyzing the performance of various competitors.
­ Identify emerging players with potentially strong product portfolios and create effective
counter­strategies to gain a competitive advantage.
­ Organize your sales and marketing efforts by identifying the market categories and
segments that present maximum opportunities for consolidations, investments, and
strategic partnerships.
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Table of Contents
1 Table of Contents
1 Table of Contents 11
1.1 List of Tables 19
1.2 List of Figures 26
2 Introduction 28
2.1 Catalyst 28
2.2 Related Reports 29
2.3 Upcoming Related Reports 29
3 Disease Overview 30
3.1 Etiology 30
3.1.1 Viral Lifecycle 30
3.2 Pathophysiology 33
3.3 Staging and Symptoms 34
3.3.1 Primary or Acute Infection 34
3.3.2 Chronic Infection 35
3.3.3 Advanced Infection/AIDS 35
3.4 Prognosis 37
3.5 Quality of Life 37
4 Epidemiology 39
4.1 Disease Background 39
4.2 Risk Factors and Comorbidities 39
4.3 Global Trends 41
4.3.1 US 42
4.3.2 5EU 42

4.3.3 Brazil, China, and Japan 43
4.4 Forecast Methodology 44
4.4.1 Sources Used 45
4.4.2 Sources Not Used 55
4.4.3 Forecast Assumptions and Methods 56
4.5 Epidemiological Forecast for HIV in the 8MM (2013­2023) 62
4.5.1 Total Prevalent Cases of HIV 62
4.5.2 Age­Specific Total Prevalent Cases of HIV 64
4.5.3 Sex­Specific Total Prevalent Cases of HIV 66
4.5.4 Age­Standardized Total Prevalence of HIV 68
4.5.5 HIV Cases Treated with ART 69
4.5.6 Cases of HIV in Pregnant Women 70
4.6 Epidemiological Forecast for HIV in Japan (2013­2023) 71
4.6.1 20­Year Diagnosed Prevalent Cases of HIV 71
4.6.2 Age­Specific 20­Year Diagnosed Prevalent Cases of HIV 72
4.6.3 Sex­Specific 20­Year Diagnosed Prevalent Cases of HIV 73
4.6.4 Age­Standardized 20­Year Diagnosed Prevalence of HIV 74
4.6.5 HIV Cases Treated with ART 75
4.6.6 Cases of HIV in Pregnant Women 76
4.7 Discussion 76
4.7.1 Epidemiological Forecast Insight 76
4.7.2 Limitations of the Analysis 77
4.7.3 Strengths of the Analysis 78
5 Disease Management 79
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