PharmaPoint: Peripheral Artery Disease - Global Drug Forecast and Market Analysis to 2024

Research focused on the PharmaPoint: Peripheral Artery Disease ­ Global
Drug Forecast and Market Analysis to 2024
"The Report PharmaPoint: Peripheral Artery Disease ­ Global Drug Forecast and
Market Analysis to 2024 provides information on pricing, market analysis, shares,
forecast, and company profiles for key industry participants. ­
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In the 2014 base year, the global PAD market was worth approximately $543.4m, including
both branded and generic drugs. By 2024, GlobalData expects that the global PAD market
will experience significant expansion, with a Compound Annual Growth Rate (CAGR) of
approximately 4.15%, equating to around $816.3m. The dramatic increase in the value of
the overall global PAD therapeutics market will be partly attributable to the launch of
several PAD drugs currently in late­stage pipeline development, which GlobalData believes
have extraordinary potential. These include the novel antithrombotic pharmacological
agents, Merck & Co.s Zontivity (vorapaxar), AstraZenecas Brilinta (ticagrelor), and Bayer
and Janssens (a subsidiary of Johnson & Johnson) Xarelto (rivaroxaban), which have the
capacity to reform the antiplatelet and anticoagulatory PAD treatment landscape.
GlobalData believes that the size of the market for pharmacological agents designed to
alleviate PAD symptoms, including cilostazol, naftidrofuryl, and pentoxifylline, will
diminish throughout the forecast period. GlobalData accredits this diminishing to three
factors: first, the advent of advanced revascularization procedures, as characterized by
gradual, incremental improvements in success rates over time; second, the fact that current
drug treatments, such as the ones mentioned above, display lackluster efficacy, perturbing
safety attributes, and inconvenient dosing regimens; and third, the lack of novel, superior,
premium­priced, drug therapies in the late stages of the PAD pipeline that could encroach
on the patient shares of existing, rival pharmacological treatments.
The overall level of unmet need in the PAD market is high, resulting in a generous amount
of room for new entrants to capitalize on. With respect to the first three traditional pillars
of PAD treatment ­ antithrombotic pharmacological agents, lipid­lowering medical
therapies, and antihypertensive drugs ­ the level of unmet need will fall once the current
crop of late­phase PAD therapies portrayed in this report arrives onto the market. With
respect to drugs that allay the symptoms of PAD, the level of unmet need here is
astronomical. Present medical treatments are limited, archaic, and some have restricted
availability.
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Highlights
Key Questions Answered
­ From a clinical standpoint, there is a demand for novel medical therapies that target and
relieve the symptoms of PAD in IC and CLI patients. KOLs interviewed by GlobalData
expressed a desire for second­generation drug treatments that display superior efficacy and
favorable safety profiles compared to existing pharmacological. Environmental unmet needs
for this particular indication include physician education, patient awareness, greater
screening, and improved guidelines. What other unmet needs exist in this market? Will the
drugs under development fulfil the unmet needs of the PAD market?
­ The current late­stage PAD pipeline encompasses AstraZenecas Brillinta, Bayer/Janssens
Xarelto and Mercks Zontivity. Will the late­stage drugs make a significant impact on the
PAD market? Which of these drugs will have the highest peak sales at the highest CAGR,
and why?
Key Findings
­ The major drivers of this expansion in the PAD market will be the advent of novel
antithrombotic agents, such as Brilinta and Xarelto, onto the PAD stage, and the increasing
prevalence of PAD across all of the 8MM.
­ The major global barrier to growth in the PAD market will be the losses of patent
protection and market exclusivity on marketed and key pipeline drugs during the forecast
period, such as AstraZenecas Crestor (rosuvastatin), Sanofis Plavix (clopidogrel), Brilinta,
and Xarelto.
­ The overall level of unmet need in the PAD market is high, resulting in a generous amount
of room for new entrants to capitalize on. GlobalData forecasts that once Brilinta and
Xarelto, pipeline pharmacological agents currently in late­stage clinical trials for PAD,
navigate their way through the regulatory landscape and secure approval for the PAD
indication, they will address some of the unmet needs in this area.
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Scope
­ Overview of peripheral artery disease (PAD), including epidemiology, etiology,
pathophysiology, symptoms, diagnosis, and treatment guidelines.
­ Annualized PAD therapeutics market revenue, annual cost of therapy and treatment usage
pattern data from 2014 and forecast for ten years to 2024.
­ Key topics covered include strategic competitor assessment, market characterization,
unmet needs, clinical trial mapping and implications for the PAD therapeutics market.
­ Pipeline analysis: comprehensive data split across different phases, emerging novel trends
under development, and detailed analysis of late­stage pipeline drugs.
­ Analysis of the current and future market competition in the global PAD therapeutics
market. Insightful review of the key industry drivers, restraints and challenges. Each trend
is independently researched to provide qualitative analysis of its implications.
Reasons to buy

The report will enable you to ­
­ Develop and design your in­licensing and out­licensing strategies through a review of
pipeline products and technologies, and by identifying the companies with the most robust
pipeline. Additionally a list of acquisition targets included in the pipeline product company
list.
­ Develop business strategies by understanding the trends shaping and driving the global
PAD therapeutics market.
­ Drive revenues by understanding the key trends, innovative products and technologies,
market segments, and companies likely to impact the global PAD therapeutics market in
future.
­ Formulate effective sales and marketing strategies by understanding the competitive
landscape and by analysing the performance of various competitors.
­ Identify emerging players with potentially strong product portfolios and create effective
counter­strategies to gain a competitive advantage.
­ Track drug sales in the global PAD therapeutics market from 2014­2024.
­ Organize your sales and marketing efforts by identifying the market categories and
segments that present maximum opportunities for consolidations, investments and strategic
partnerships.
Table Of Content
1 Table of Contents 12
1.1 List of Tables 18
1.2 List of Figures 22
2 Introduction 25
2.1 Catalyst 25
2.2 Related Reports 26
2.3 Upcoming Related Reports 26
3 Disease Overview 27
3.1 Etiology and Pathophysiology 28
3.1.1 Etiology 28
3.1.2 Pathophysiology 30
3.2 Classification and Staging Systems 31
3.3 Symptoms and Clinical Presentation 33
3.4 Prognosis 37
3.5 Quality of Life 41
4 Epidemiology 43
4.1 Disease Background 43
4.2 Risk Factors and Comorbidities 44
4.3 Global Trends 46
4.4 Forecast Methodology 47
4.4.1 Sources Used 48
4.4.2 Sources Not Used 61
4.4.3 Forecast Assumptions and Methods 61
4.5 Epidemiological Forecast of Total Prevalent Cases of PAD (2014­2024) 67
4.5.1 Total Prevalent Cases of PAD 67
4.5.2 Age­Specific Total Prevalent Cases of PAD 68
4.5.3 Sex­Specific Total Prevalent Cases of PAD 70
4.5.4 Age­Adjusted Total Prevalence of PAD 72

4.5.5 Total Prevalent Asymptomatic and Symptomatic Cases of PAD 73
4.5.6 Total Prevalent Cases of PAD with Intermittent Claudication and PAD with Critical
Limb Ischemia 75
4.5.7 Proportion of Total PAD Cases that Present as Asymptomatic, PAD with Intermittent
Claudication, and PAD with Critical Limb Ischemia 77
4.5.8 Total Prevalent Cases of PAD with Hypertension and PAD with Diabetes 78
4.6 Epidemiological Forecast of Diagnosed Prevalent Cases of PAD (2014­2024) 80
4.6.1 Diagnosed Prevalent Cases of PAD 80
4.6.2 Age­Specific Diagnosed Prevalent Cases of PAD 82
4.6.3 Sex­Specific Diagnosed Prevalent Cases of PAD 84
4.6.4 Diagnosed Prevalent Asymptomatic and Symptomatic Cases of PAD 86
4.6.5 Diagnosed Prevalent Cases of PAD with Intermittent Claudication and PAD with
Critical Limb Ischemia 88
4.6.6 Proportion of Diagnosed PAD Cases that Present as Symptomatic, PAD with
Intermittent Claudication, and PAD with Critical Limb Ischemia 90
4.6.7 Diagnosed Prevalent Cases of PAD with Hypertension and PAD Cases with Diabetes
91
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