Chronic Progressive Lymphedema

CHRONIC PROGRESSIVE LYMPHEDEMA
TREATMENT CASE STUDY

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CYTOWAVE EQUINE THERAPY PROPOSAL
FOR CHRONIC PROGRESSIVE LYMPHEDEMA
I).
II).
III).
IV).
V).
What is Cytowave Equine Therapy?
CPL Treatment Case Study Timel ine
Cytowave Equine Therapy treatments for CPL
Interview with Emily Jewell
Cytowave Equine Equipment for CPL
VI). Cytowave Equipment Purchase Price
VII). Cytowave Rent to Own Program

Special Feature • Cytowave
Cytowave – A new medical therapy technology
Reliably reduces recovery times from serious tendon and ligament injuries by 5 months
By Richard Parker, Chief Technical Officer, CytoWave
Cytowave is a patented,
non-invasive treatment based
on tissue specific signals.
While other devices in the
equine market use generic
electromagnetic waveforms,
Cytowave offers a tissue
specific analytic method
based on the biology of
the injury. The tissue signal
is derived based upon the
difference in biomagnetic
signals from normal and
injured tissues. This
proprietary SQUID Therapy
Signal (STS) is amplified and
delivered via a mild magnetic
field. This new technology
has been embraced by many
top veterinarians and is being
used as an adjunct to stem
cell therapy or PRP.
The Basics of CytoWave Technology
Equine tendon and ligament injuries occur frequently in both competitive and companion
animals. Unfortunately, this type of trauma does not lend itself to fast, non-invasive recovery
techniques. Disorders of these tendons often become chronic and are difficult to manage
successfully. In most cases, recovery is prolonged for many months and even years.
It is theorized that the mechanism for accelerating the closure of ligament and tendon lesions
is found in the nature of the electromagnetic signals impressed on the subject. The specific
and complex activity known as the “healing process” is an expression of the local activity of
electromagnetic fields, as their generation is spontaneous and inevitable due to ionic and
charged particle flow.
CytoWave Therapy technology takes
an actual electromagnetic signal
given off by the body at an injury site,
stores and then amplifies that signal
before re-admitting to the subject so
as to accelerate the healing process.
This “jump-start” occurs because
the signal applied to the injury is very
similar to the same signal the horse
produces. That signal, therefore, is
readily accepted on a cellular level
and processed in such a manner as
to accelerate the recovery.
Opposing coils held by a boot apparatus deliver
the CytoWave STSTM signal
Thus, we have a targeted, tissue specific physical therapy which can be used for soft (muscle
and nerve), dense (tendons and ligaments) and hard (bone splinters or hairline fractures) tissue
injuries.
Cytowave derived signals contrasted with the much older PEMF technology.
“We’ve used Cytowave
most effectively for
tendon injuries, some
suspensory branch
injuries, it’s been very
helpful.”
— Dr. Tim Ober,
United States Equestrian Team
Simple older PEMF signals
very common in the industry
Actual physiological waveform
which looks nothing like PEMF
Cytowave signals from actual
measurements accelerating repair
These signals have been reported to operate about four times faster than PEMF systems and
obtain consistent results in the 90% range; instead of the 60% range such as is the case with
other popular technologies. As Cytowave uses tissue-specific signals, it is able to achieve
consistent results unlike other technologies which treat every injury the same. In fact, we very
rarely have a failure to close a serious lesion, reduce deep tissue inflammation, relieve sore
back discomfort or accelerate bone fracture repair.
http://bit.ly/EQS2015Summer
16 | Henry Schein Animal Health ph: (855) HSAH-EQ1 (472-4371) | fx: (888) 329-3861 | www.henryscheinvet.com

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Below are a set of images from two severe injuries. The first set of
images show a fracture of the C4 vertebrae in a horse that slipped
on ice. The first scan, taken at the time of the injury shows the
severity of the fracture. The second image was taken after 8 weeks
of treatment using the Cytowave fracture program.
We have found that the Normalizing Signal Waveform (the
mathematical difference between the injury waveform and healthy
waveform) contains information about therapeutic recovery
representing the biological activity of the body in affecting the
injury repair. This signal can be applied using an external complex
signal generator which contains the recorded waveform patterns,
connected to a coil applicator delivery system, as shown in the
process diagram of patent 7,361,136 (2):
Figure 1 – Development of the STS signal
The second set of images below is from a 24 year old horse that
suffered a lesion covering 75% of a tendon. Typically, Cytowave
can close a serious lesion in 3 to 5 weeks in a young, healthy horse
but given the advanced age of the subject, the healing process
was much longer. The horse has begun rehabilitation after 13
weeks of treatment that closed the lesion and substantially reduced
inflammation.
This patented technology is now being routinely implemented by
CytoWave LLC (3, 4, 5, 6,) in a series of studies and production
installations for equine applications in preparation for an FDA filing.
This technique described as SQUID Signal Therapy (STSTM) has
the effect of rapidly accelerating the closure of ligament and tendon
lesions from a typical 6-12 months healing time to a nominal 3-5
weeks (4).
Both cases represent severe and difficult to heal injuries but the
images clearly illustrate that Cytowave technology, utilizing Squid
Therapy Signals , can effectively influence normal and injury
currents, thus contributing to, and accelerating the healing.
STS (Squid Therapy Signal)
The development of the SQUID (Superconducting QUantum
Interference Device) makes it possible to discover natural magnetic
field waveforms as a further extension of magnetic field therapy
technology. As the waveform is theorized to contain the intelligence
of the biological functions taking place locally, it is also proposed
that detection and generation of the proper waveform associated
with a given healing process would be an essential component of an
optimal waveform delivery device designed to accelerate the healing
process by delivering that same waveform, in an amplified form.
This proposition was addressed in the paper of Parker and Markov
SQUID-Based Electromagnetic Fields – a Plausible Tool for
Treatment of Tendon Injuries (1). This paper included procedures in
identifying, extracting and isolating characteristics of magnetic fields
emanating from both healthy and injured or diseased portions of the
body. The goal is to discover the pattern revealed in signals which
are expressed by the ”healing component”, and then delivering
those same magnetic field patterns which have a therapeutic effect,
as described in the patent “Method and Apparatus for Generating a
Therapeutic Magnetic Field”, 7,361,136 (2).
NOTE: this material extracted from the paper “The Treatment of Tendon Injury with
Electromagnetic Fields Evidenced by Advanced Ultrasound Image Processing”, Richard
Parker, Marko Markov, 2014 obtained through CytoWave LLC
References
1. Parker R., and M. Markov, (2014) SQUID-Based Electromagnetic Fields – A Plausible Tool
for Treatment of Tendon Injuries at the Karolinska Institut, Department of Molecular Medicine
and Surgery Stockholm, Sweden, May 2014
2. Parker R.F. (2008) Patent #7,361,136, “Method and Apparatus for Generating a
Therapeutic Magnetic Field”.
3. Parker R., M. Markov, and J. Allen (in press) 30-Day Ligament/Tendon Lesion Closure: A
24-Horse Case Report Study. submitted to the American Association of Equine Practitioners
(AAEP) for the Salt Lake City Conference, December 2014.
4. Parker R. and M. Markov (2015) Electromagnetic Fields in Treatment of Tendon Injury
in Human And Veterinary Medicine. in Markov M (ed) Biological Effects of Electromagnetic
Fields, CRC Press, Boca Raton FL 435-454
5. Markov M. and R. Parker (2012) Electromagnetic Fields in Sports Injuries. Karolinska
Conference on Sports Medicine, Stockholm.
6. Markov M. and R. Parker (2012) Analytical Versus Empirical Design of EMF devices.
BEMS Annual meeting, Halifax, June 16-19, 2012
Cytowave’s technology was granted protection from the US patent office. This technology
was presented at various international meetings such as Scandinavian Congress of Sports
Medicine, VI International Workshop on Biological Effects of Electromagnetic Fields, XXXIIIth
Annual meeting of BEMS and published in peer-reviewed scientific journals.
Call us today at (844) 298-9283 or visit us at
www.cytowave.com to learn more about our programs.
About the Author Chief Technical Officer Richard Parker
has over 35 years of business experience and has been awarded
the central patent on the CytoWave process. Richard is a former
computer microprocessor designer and has also sponsored his own
successful companies in real estate development, and in the energy
field. Richard has focused his attention on the field of biomagnetic
therapy for the past 20 years, where he is a frequently invited speaker
at international venues and has published 14 papers in refereed
scientific journals. Richard earned a B.S. in Electrical Engineering
from the University of Florida and an M.S. in Electrical Engineering
from the Georgia Institute of Technology.
Summer 2015 | eqs | 17

Chronic Progressive Lymphedema
Treatment Case Study TIME LINE
On April, 27th 2016, Cytowave treatments were started on a Friesian stallion for Chronic Progressive Lymphedema
(CPL). The following therapy report represents the first ninety (90) day case study period.
All documentation was reported by Emily Jewell, owner of Keegan and Grace & Beauty Farms, and John Dovenmuehle,
Cytowave Equine Therapy representative. Photographs taken by Emily Jewell.
HISTORY OF SUBJECT:
Horse: Keegan, Friesian stallion
Age: 13 years old
Height: 16.3 hands
Weight: 1400 Lbs.
Owners: Emily and Mike Jewell
Grace and Beauty Farms
Carlisle, IN.
Environmental Conditions:
Keegan kept in dry stall area. Stall is exceptionally neat and cleaned every day.
Treatments are in the Farrier area of barn with Keegan standing on rubber pads.
Exercise: Daily exercise in round pen. Clean dry area.
Emily has owned Keegan since his birth and has trained him for show events and movies. He is considered a
member of her family, which of course he is. Emily first noticed signs of CPL when Keegan was around 5-6 years
old. Small nodules had appeared on Keegan’s rear legs, behind the hoofs. The symptoms spread from the right
rear leg to the left rear leg, then progressed to the two front legs.
The right rear leg has three (3) larger nodules and a large fold under the nodules. The left rear leg has two (2)
larger nodules and a smaller fold under the nodules.
The two front legs have small lesions with small nodules on both legs. The front legs are not in the trial program
but we are observing them to see if there are improvements without treatment.
OBJECTIVE:
We determined that Keegan was in the second stages of the disease. Our first objective was to reduce inflammation
by increasing circulation and lymphatic flow. We also wanted to relieve any soreness and pain in the rear
legs and to make Keegan comfortable and give his body a chance to begin healing naturally.
Currently Cytowave therapy does not have a pre-set program for CPL so we determined the best program would
be aimed at controlling CPL by reducing inflammation. Treatments for this objective are to run continuously
for two (2) weeks. We discussed the results of the treatments daily and based off of our results, set up the next
treatments.

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TREATMENTS:
We started Cytowave Inflammation/Maintenance treatments on Keegan’s rear legs where the CPL was most
severe. The Inflammation/ Maintenance treatment is a thirty minute noninvasive treatment. We treated the rear
legs, using a dual application with foreleg therapy boots. The boots were placed on top of the coronary band
with coils on the side of the legs. The therapy boots, coils and Cytowave equipment were applied and administered
by Emily.
RESULTS:
DAYS 1-7
▶ A noted decrease in inflammation / swelling in the rear legs was observed after four (4) days of treatments.
▶ Circulation and lymph flow appeared to have increased and there was a marked decrease in the size of the
cannon bone.
▶ The nodules and folds are softer, and more pliable, not as hard to touch. There is a little dampness and oily
feeling in the back of the hoof.
▶ The therapy boots are easier to apply, due to the swelling in the legs subsiding.
At the end of first week of treatments, Keegan was more relaxed and visibly comfortable. He is more active when
Emily turns him out in the pen to exercise and Keegan, has started to canter for the first time in 4 years.
Note the shaved area on the hoof on the image to the left. This is where the canon bone was measured daily. The
other two images show the nodule formation and the swollen cannon bone on Keegans leg.

These images show the affected areas - note the shave areas to the right that show the reduction in the folds
DAYS 7-21
Cytowave treatments used: Tendon / Ligament treatment program.
▶ The continued reduction in inflammation and swelling indicates lymphatic vessels are opening.
▶ Cannon bone swelling also continues to reduce in size.
▶ Folds in the rear of the legs are not has thick and are separating. Folds and nodules are softer and more pliable.
▶ Still some dampness and oily feeling in the crease of the back of the hoof area. Lesions continue to heal and are
drier and smaller.
▶ Keegan’s rear legs are not as sensitive in the area of the nodules. Emily is able to massage his legs without any
discomfort.
▶ Keegan is noticeably feeling better. He is more active, and runs and bucks in the open pen area.
This series of images show the shrunken nodules and folds on Keegan’s legs.

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DAYS 22-36
Changed Cytowave treatment program to Buck Shins. Lesions on rear legs continue to heal
▶ Swelling and inflammation continue to reduce in size and lymphatic vessels have opened. The cannon bone
measures at 10 ½” down from 12 ½”.
▶ Keegan is running in the arena after treatments and for the first time in four years he is cantering.
DAYS 37-51
Cytowave treatment program changed to bone fracture.
▶ Reduction in swelling continues which we believe is due to decreasing inflammatory response of the lymphatic
vessel.
▶ Folds are decreasing in size and feel softer and more pliable. Nodules are smaller. Emily massages Keegan’s
pastern areas which also helps increase the Lymphatic flow and circulation.
▶ Dampness and oily feeling decreases. The area under the feathers feels drier.
▶ Keegan continues to be more active, running and jumping in the lunging arena.
DAYS 52-66
Continuing with Bone Fracture treatment based on Keenan’s continued progress.
▶ Nodules and folds continue to decrease in size.
▶ Emily continues to manually massage rear legs and continues to exercise Keegan after treatments, which helps
keep the lymphatic vessels and circulation flowing.
DAYS 67-81
Emily continued Cytowave Bone Fracture treatments. Due to a heavy summer schedule, the treatments were
limited to three (3) per week. Of note, Keegan’s condition stayed the same even after reducing the number of treatments.
Swelling and inflammation did not increase, which indicates the quality of healing is substantial.
DAYS 81- 95
Based on Keenan’s condition, the three (3) treatments per week are continued.
▶ There is no increase with inflammation and swelling or in the size of the nodules and folds during this period.
▶ Rear legs and cannon bone size remains the same.
Note: Keegan is in the Breyer Fest Show in Kentucky and his trainer mentions that Keegan’s control is better than
it has been in many years and there is a significant difference in Keegan’s performance.
95 DAYS
Emily has started treating Keegan with Cytowave Bone Fracture treatments every day.
▶ To date, Keegan has not relapsed as his treatments continue.
▶ There is no further inflammation, or swelling on Keegan’s legs.

Keegan continues to enjoy his treatments and his energy level is high.
VETERINARIAN EVALUATION
Dr. Royal visits periodically during treatment sessions. He notes that the swelling and inflammation has drastically
reduced. Keegan is in very good health.
▶ Keegan’s HR = 36, RR=18 and Weight is 1400#
▶ His BAR, (Bright, Alert, Responsive), is excellent.
▶ He is sound with little sensitivity in the folds of his legs.
“Nodule’s are shrinking because of better Lymph flow. Inflammatory response up the leg is getting better because of
decreasing inflammatory response of the lymphatic vessel...From a clinical standpoint, the Cytowave treatment’s are
significant.”
Dr. Royal
Royal Veterinary Service
Odon, IN.

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CYTOWAVE EQUINE THERAPY
TREATMENTS FOR CPL
This is the first documented case of CPL being treated with Cytowave therapy. These are our recommendations
based on the outcome of this case study in which Cytowave seems to have stopped the progression of the CPL
and resulted in reversing the condition. To date, the subject has not relapsed and his Cytowave treatments
continue.
There are three (3) different Cytowave treatment programs that were used to control the progression of CPL in
Keegan:
1) Inflammation
2) Tendon / Ligament
3) Bone Fracture
As with any injury, the inflammation treatment program should always be used first. One of the strengths of
Cytowave therapy is the ability to quickly reduce pain and inflammation. Results are more noticeable with an
“edema” based disease such as CPL. Starting with the 30 minute inflammation also allows a horse to get used to
wearing the treatment applicators and gives the owner a chance to observe how the horse responds to the
treatments.
With stage 1 CPL, the Tendon / Ligament treatments can be used after starting with the Inflammation treatment
program. The Cytowave Tendon/Ligament treatment programs can have a very positive effect on reducing
soreness, pain and swelling.
For stage 2 & 3, it is recommended to follow the same process as you would with stage 1 CPL. Start with the
inflammation treatment for 2 - 3 days, then to the Tendon/Ligament program for approximately one week. If
there are continued signs of healing, you can progress to the Bone Fracture treatment program. The Bone
Fracture treatment program is recommended for use when nodules and folds are present in the legs.
As with all Cytowave treatment programs, your horse will tell you if the program is having a positive outcome.
If you use the Tendon/Ligament program for several days and notice that the healing progress has plateaued,
return to using the inflammation program.
The inflammation program appears to help control CPL. The number of maintenance treatments needed depend
on the condition of the CPL and how the horse responds to the treatments. It is safe to use the inflammation (30
minutes) up to three times a day.
Before the start of any Cytowave treatment programs, it is recommended you consult your veterinarian. The
Cytowave Representatives will also consult with your veterinarian and explain the Cytowave technology,
treatments and results that we are trying to achieve. The Cytowave Corporate office staff are available to assist
with any questions regarding the treatments as well.

AN INTERVIEW WITH EMILY JEWELL
Emily and Mike Jewell own a small farm in southern Indiana and they breed and raise Friesian and Andalusian
horses. At any given time they care for 10 or more horses, a few of which are Friesian and Andalusian mares.
They stand two stallions, an Andalusian and their pride and joy Friesian stallion Keegan. Keegan is the celebrity
in their area and has appeared in several magazines such as Horse Illustrated and Horse and Rider. Keegan and
some of their other horses have been used in several Farnam ads. Keegan has really made a name for himself and
Grace and Beauty farms with all of his accomplishments.
Emily understands that when it comes to horses, there is no shortage of maladies that they can suffer from. For
example, Emily noticed something was wrong with one of her Freisians when they were around 5 or 6 years old.
Small nodules had appeared on the horse’s rear legs, just behind the hoofs. At first Emily thought the horse
had scratches, but when the condition worsened, she researched and discovered that this was the early stage of
Chronic Progressive Lymphedema (CPL), a lymphatic disorder that many draft horses, including Friesians are
predisposed to.
Emily began treating her Friesian horse to slow the advancement of CPL but results were not positive. In spite of
her efforts, the symptoms spread from the right rear leg to the left rear leg, then progressed to the two front legs.
She began to fear the inevitable - since there is no known cure, most heavy bodied horses with CPL have to be
euthanized around 15 years old.
By chance, Emily was approached at a horse show by John Dovenmuehle who told her about Cytowave. “When
he said “inflammation reduction” I really perked up,” Emily said.
At this point, she was ready to try anything to slow down the progress of this relentless, inflammation based disease.
Cytowave did not have a specific CPL based set of therapy signals, but it did have a robust pain/inflammation
program that had proven effective with other inflammation based conditions, including cellulitis. “At first,
I didn’t know what to think. We had tried everything up to this point but really didn’t have anything to lose.”
Emily stated.
On April 27th, 2016, Emily began to use Cytowave treatments exclusively on her horse. After only 4 days of
treatments, Emily noticed the inflammation had decreased. After the first week, the inflammation in the rear legs
and the Cannon bone size had decreased as well. The nodules and the folds were softer, not as hard to the touch
and the Cytowave boots were easier to wrap around his legs
due to the decreased swelling.
The shift in her horse’s demeanor underscored that positive
physical changes were taking place. “He was more relaxed and
comfortable. When I let him out in the pen, he was more active,
running and bucking,” Emily said.
After eight (8) days, the inflammation and Canon bone swelling
continued to decrease. The folds in the rear legs were not
as thick and were separating. Folds and nodules were softer and
more pliable. There was still some dampness and oily feeling in
the creases of the back hoof area but overall, the lesions were
drier and reducing in size. And for the first time in weeks she
was able to massage his legs without any discomfort.

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“He really began enjoying getting his legs massaged after his treatments,” Emily continued. “Overall he just seems
really happy. I did not realize how much the disease had slowly robbed him of his spirit over the years because it
was so gradual. Once he started feeling better, I realized I was getting my old horse back!”
In the span of 10 days, measurements showed that the swelling had been substantially reduced. The Canon bone
showed the most dramatic reduction in size, with the left leg going from 12 ½” to 10 ½”.
On May 11th, Dr. Royal evaluated her horse and he noted that the Cytowave treatments had drastically reduced
the swelling and inflammation. He said her horse seemed to be in very good health and his BAR (Bright, Alert,
Responsive) was excellent. He was in very good health, sound, with little sensitivity in the folds of his legs.
After twenty one (21) days of treatments, Emily continued to see positive results in slowing the progression of
the CPL condition. The size of the folds and nodules decreased and lesions in the rear legs were drier and smaller.
Pain and sensitivity in the folds of his legs lessened. His overall health improved and it was apparent that her
horse felt much better.
“At first he stamped his feet and was a bit agitated until he got used to the boots,” Emily said. “Now it’s a walk in
the park for him and he really enjoys the treatments.”
Her horse will continue with treatments and hopefully completely recover. As for Emily? She was so impressed
with the results that she is now working for Cytowave to help promote their new technology.
CONTACT INFORMATION:
Emily Jewell - Grace and Beauty Farms
Carlisle IN
812-691-1839

EQUIPMENT COST FOR CPL
Controller/ Computer - $4,500.00 (Refurbished)
➢With three programs, and one maintenance/inflammation program
➢Includes, 25’ extension cable, 12’ break away cable and test magnet
➢Included treatment program (Maintenance/Inflammation) and client picks an
➢additional 2 treatments: choice of –
Fracture
Ligament/Tendon
Bucked Shins
Hock/Knee/Joint
Complete Leg Applicator Kit- $675.00 (value of $710.00)
➢Includes one therapy boot, oblong coils (set), belt pockets (set)
➢two belts and two snaps
Additional-$650.00 (value of $710.00)
➢One therapy boot, oblong coils (set), boot pockets (set), two belts and two snaps.
➢One 20” “Y” connector (value of $80.00)
Warranty
➢3 years, on Controller/Computer
➢1 year, on Coils
➢3 months, Applicators
Replacement/Repair
➢Advance Replacement/Repair of all, applicators and accessories
➢Optional, loaner available for advanced replacement of controller/computer. No
➢Charge if determined purchased controller/computer os covered by warranty.
Insurance
➢$1800.00/ one year, (equivalent to $150.00/month), can only purchase at onset of
Agreement.
➢Must be paid in full, with payment of purchased agreement
All Cytowave products are made in the USA. All products are assembled for each order individual order.

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CPL - RENT TO OWN PROGRAM
1. $550.00 paid monthly
2. $550.00 deposit one-time payment
3. After 6 months client can either return items or all monies can be applied to purchase
including deposit. If client decided to keep unit longer than 6 months at 9 months 75% of
rental monies can be applied towards purchase. At 1yr client can apply 50% of rental money
towards purchase, or property must be returned to company
4. $5,525.00 total purchase price, excluding tax.
Rent to Own Program provides the following Cytowave Equipment:
➢Controller/ Computer - (Refurbished)
➢With two programs, and maintenance/inflammation program
➢Includes, 25’ extension cable, 12’ break away cable and test magnet
➢Ligament/Tendon program
➢Bone Fracture program
➢Retail purchase price is over, $13,500.00
Complete Leg Applicator Kit-
➢Includes one therapy boot, oblong coils (set), belt pockets (set)
➢two belts and two snaps.
Retail purchase price is, $710.00
Additional Cytowave equipment, add $40.00/ month
➢One therapy boot, oblong coils (set), boot pockets (set), two belts and
two snaps.
➢One 20”, “Y” connector
Regular retail price is, $795.00

CYTOWAVE EQUIPMENT FOR CPL
Cytowave Equine therapy equipment includes:
➢Controller/Computer-
➢Pre set programs for CPL treatments
Inflammation
Tendon/Ligament
Fracture Bone
➢25’ Extension cable, 12’ breakaway cable
➢Foreleg therapy boots (2)
➢Foreleg Therapy Boot Pockets
➢Leg coil Belts (4), used for stabilization
➢Boot snaps- (4) extra, attaches to coil pockets
➢Oblong Coils (2) sets, fits Foreleg Boot Pockets
➢20” “Y” cable
➢Test Magnet