Hydrogel drug delivery
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HYDROGEL OCULAR DRUG DELIVERY<br />
<strong>Hydrogel</strong> Contact Lenses
Treatment of Ocular Disease<br />
LOAD ‘em<br />
Alexa Fluor 488<br />
Dye<br />
Vitamin E<br />
Timolol<br />
Brimonidine
Ingredients loaded into pHEMA<br />
hydrogel contact lenses<br />
Function<br />
Vitamin E • Increase duration of <strong>drug</strong> release.<br />
• Increase loading of hydrophilic<br />
<strong>drug</strong>s.<br />
Alexa Fluor 488 dye<br />
Timolol<br />
Cyan green colouration<br />
Treats open angle glaucoma<br />
Brimonidine • Treats open angle glaucoma<br />
• Treats ocular hypertension<br />
• Decrease synthesis of aqueous<br />
humour.
HYDROGEL PARENTERAL DRUG DELIVERY
ATRIGEL DRUG DELIVERY<br />
•Parenteral administration of <strong>drug</strong>.<br />
•For localized effect.<br />
•Is less invasive (painful) due to use of gel.
PHARMACEUTICAL PRODUCTS<br />
1.Atridox<br />
• 85% Doxycycline<br />
•Periodontal treatment<br />
2. Atrisorb D<br />
•4 % Doxycycline<br />
•Periodontal tissue regeneration
PROCEDURE<br />
1.Drug is combined into atrigel<br />
2.Sterilised by γ radiation<br />
3.Injected. Sub gingival<br />
4.Endogenous water causes <strong>drug</strong> to solidify<br />
5.Traps <strong>drug</strong> to produce regional effect
HARIVIN NATHAN A/L RAMESH ANAND<br />
A156854<br />
FFAR/2
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