European Committee on Antimicrobial Susceptibility Testing

Recommendations

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Dosages EUCAST Clinical Breakpoint Tables v. 7.0, valid from 2017-01-01 Cephalosporins Standard dose High dose Cefaclor 0.25-1 g x 3 oral None Cefadroxil 0.5-1 g x 2 oral None Cefalexin 0.25-1 g x 2-3 oral None Cefazolin 1-2 g x 3 None Cefepime 2 g x 2 iv 2 g x 3 iv Cefixime 0.2-0.4 g x 2 (0.4 g as single dose for Neisseria gonorrhoeae ) Cefotaxime 1 g x 3 iv 2 g x 3 iv Cefoxitin Clinical breakpoints not available Clinical breakpoints not available Cefpodoxime 0.1-0.2 g x 2 oral None Ceftaroline 0.6 g x 2 iv over 1 hour 0.6 g x 3 iv over 2 hours Ceftazidime 1 g x 3 iv 2 g x 3 iv Ceftazidime-avibactam (2 g ceftazidime + 0.5 g avibactam) x 3 over 2 hours (2 g ceftazidime + 0.5 g avibactam) x 3 over 2 hours Ceftibuten 0.4 g x 1 oral None Ceftobiprole 0.5 g x 3 iv over 2 hours None Ceftolozane-tazobactam (1 g ceftolozane + 0.5 g tazobactam) x 3 iv over 1 hour None Ceftriaxone 1 g x 1 iv 2 g x 1 iv Cefuroxime iv 0.75 g x 3 iv 1.5 g x 3 iv Cefuroxime oral 0.25-0.5 g x 2 oral None None Carbapenems Standard dose High dose Doripenem 0.5 g x 3 iv over 1 hour 1 g x 3 iv over 4 hours Ertapenem 1 g x 1 iv over 30 minutes None Imipenem 0.5 g x 4 iv over 30 minutes 1 g x 4 iv over 30 minutes Meropenem 1 g x 3 iv over 30 minutes 2 g x 3 iv over 30 minutes Monobactams Standard dose High dose Aztreonam 1 g x 3 iv 2 g x 4 iv 91
Dosages EUCAST Clinical Breakpoint Tables v. 7.0, valid from 2017-01-01 Fluoroquinolones Standard dose High dose Ciprofloxacin 0.5 g x 2 oral or 0.4 g x 2 iv 0.75 g x 2 oral or 0.4 g x 3 iv Levofloxacin 0.5 g x 1 oral or 0.5 g x 1 iv 0.5 g x 2 oral or 0.5 g x 2 iv Moxifloxacin 0.4 g x 1 oral or 0.4 g x 1 iv None Nalidixic acid Laboratory test reagent only Laboratory test reagent only Norfloxacin 0.4 g x 2 oral None Ofloxacin 0.2 g x 2 oral or 0.2 g x 2 iv 0.4 g x 2 oral or 0.4 g x 2 iv Aminoglycosides Standard dose High dose Amikacin 20 mg/kg x 1 iv 30 mg/kg x 1 iv Gentamicin 5 mg/kg x 1 iv 7 mg/kg x 1 iv Netilmicin 5 mg/kg x 1 iv 7 mg/kg x 1 iv Tobramycin 5 mg/kg x 1 iv 7 mg/kg x 1 iv Glycopeptides and lipoglycopeptides Standard dose High dose Dalbavancin 1 g x 1 iv over 30 minutes on day 1 None If needed, 0.5 g x 1 iv over 30 minutes on day 8 Oritavancin 1.2 g x 1 (single dose) iv over 3 hours None Teicoplanin 0.4 g x 1 iv 0.8 g x 1 iv or 0.4 g x 2 iv Telavancin 10 mg/kg x 1 iv over 1 hour None Vancomycin 0.5 g x 4 iv or 1 g x 2 iv or 2 g x 1 by continuous infusion None Macrolides, lincosamides and streptogramins Standard dose High dose Azithromycin 0.5 g x 1 oral or 0.5 g x 1 iv (2 g as single dose for Neisseria gonorrhoeae ) Clarithromycin 0.25 g x 2 oral 0.5 g x 2 oral Erythromycin 0.5 g x 2-4 oral or 0.5 g x 2-4 iv 1 g x 4 oral or 1 g x 4 iv Roxithromycin 0.15 g x 2 oral None Telithromycin 0.8 g x 1 oral None None Clindamycin 0.3 g x 2 oral or 0.6 g x 3 iv 0.3 g x 4 oral or 1.2 g x 2 iv Quinupristin-dalfopristin 7.5 mg/kg x 2 7.5 mg/kg x 3 92
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European C
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Guidance on reading EUCAST Breakpoi
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Version 7.0, 2017-01-01 Acinetobact
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Enterobacteriaceae EUCAST Clinical
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Pseudomonas spp. EUCAST Clinical Br
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Pseudomonas spp. EUCAST Clinical Br
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Acinetobacter spp. EUCAST Clinical
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Acinetobacter spp. EUCAST Clinical
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Staphylococcus spp. EUCAST Clinical
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Enterococcus spp. EUCAST Clinical B
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Enterococcus spp. EUCAST Clinical B
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Streptococcus groups A, B, C and G
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Streptococcus pneumoniae EUCAST Cli
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Streptococcus pneumoniae EUCAST Cli
Page 41 and 42: Streptococcus pneumoniae EUCAST Cli
Page 43 and 44: Viridans group streptococci EUCAST
Page 45 and 46: Viridans group streptococci EUCAST
Page 47 and 48: Haemophilus influenzae EUCAST Clini
Page 53 and 54: Moraxella catarrhalis EUCAST Clinic
Page 55 and 56: Moraxella catarrhalis EUCAST Clinic
Page 57 and 58: Neisseria gonorrhoeae EUCAST Clinic
Page 59 and 60: Neisseria gonorrhoeae EUCAST Clinic
Page 61 and 62: Neisseria meningitidis EUCAST Clini
Page 63 and 64: Neisseria meningitidis EUCAST Clini
Page 65 and 66: Gram-positive anaerobes except Clos
Page 67 and 68: Gram-positive anaerobes except Clos
Page 69 and 70: Clostridium difficile EUCAST Clinic
Page 71 and 72: Gram-negative anaerobes EUCAST Clin
Page 73 and 74: Gram-negative anaerobes EUCAST Clin
Page 75 and 76: Listeria monocytogenes EUCAST Clini
Page 77 and 78: Pasteurella multocida EUCAST Clinic
Page 79 and 80: Corynebacterium spp. EUCAST Clinica
Page 81 and 82: Aerococcus sanguinicola and urinae
Page 83 and 84: Kingella kingae EUCAST Clinical Bre
Page 85 and 86: Mycobacterium tuberculosis EUCAST C
Page 87 and 88: PK/PD (Non-species related) breakpo
Page 89 and 90: PK/PD (Non-species related) breakpo
Page 91: Dosages EUCAST Clinical Breakpoint
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European Committee on Antimicrobial Susceptibility Testing

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