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Global Postmenopausal Hormone Therapy Market

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<strong>Postmenopausal</strong> <strong>Hormone</strong> <strong>Therapy</strong> <strong>Market</strong><br />

- <strong>Global</strong> Industry Analysis, Size, Share,<br />

Growth, Trends and Forecast 2016 - 2024<br />

Transparency <strong>Market</strong> Research Reports incorporated a definite<br />

business overview and investigation inclines on<br />

"<strong>Postmenopausal</strong> <strong>Hormone</strong> <strong>Therapy</strong> <strong>Market</strong>". This report<br />

likewise incorporates more illumination about fundamental<br />

review of the business including definitions, requisitions and<br />

worldwide business sector industry structure.<br />

Tropical spastic paraparesis (TSP) also called as HTLV-1–<br />

associated myelopathy (HAM) is a type of tropical<br />

myeloneuropathies caused by the human T-lymphotrophic virus<br />

1 (HTLV-1). Although initially described in tropical countries,<br />

TSP has also been found in temperate regions such as southern<br />

Japan. HTLV-1 virus belongs to the Retroviridae family, and<br />

preferentially infects CD4 lymphoid cells.<br />

The virus has been known to cause certain kinds of leukemia<br />

and lymphoma and is transmitted through exposure to infected<br />

blood, sexual contact, and use of illegal intravenous drugs. As<br />

the virus is also known to spread through breast milk, mothers<br />

infected with HTLV-1 virus must avoid breast feeding.


According to an article published in the journal Frontiers in<br />

Microbiology in 2012, the HTLV-1 virus is prevalent in certain<br />

regions including the Southwestern part of Japan, sub-Saharan<br />

Africa and South America, the Caribbean area, and certain areas<br />

of Middle East and Australo-Melanesia.<br />

Browse Full Research Report on <strong>Postmenopausal</strong> <strong>Hormone</strong><br />

<strong>Therapy</strong> <strong>Market</strong>:<br />

http://www.transparencymarketresearch.com/postmenopausal-hormonetherapy-market.html<br />

The study also estimates that 5 million to 10 million individuals<br />

have been affected globally with HTLV1 virus, however various<br />

other publications estimate the global prevalence of 10 million<br />

to 20 million.<br />

HTLV-1-associated myelopathy mostly affects the spinal cord,<br />

and results in an upper motor neurone syndrome, that usually<br />

affects lower limbs. Spastic paraparesis or paraplegia is the main<br />

characteristic of the infection. Tropical spastic paraparesis<br />

results in demyelination, inflammation and necrotic lesions in<br />

spinal cord. The progressive disease is associated with<br />

degeneration of neurons in the spinal cord, and results in gradual<br />

paralysis of the lower limbs.<br />

Other rare symptoms include optic atrophy, reduced ankle reflex<br />

and cranial nerve lesions. An article published in journal Revue


Neurologique in 2012, more than 90% of the tropical spastic<br />

paraparesis cases, the neurological features involved urinary<br />

bladder disturbance, spasticity and/or hyperreflexia of the lower<br />

extremities, and lower extremity muscle weakness.<br />

Various immunoassay kits are available for diagnosis of HTLV-1<br />

virus. Companies manufacturing such diagnostic kits include<br />

MP Biomedicals LLC, Fujirebio, Inc., Quest Diagnostics,<br />

DiaSorin S.p.A. Although the disease cannot be cured<br />

completely, medications are available for management of<br />

symptoms. Corticosteroids such as methylprednisolone are<br />

prescribed to decrease the inflammation of the spinal cord, while<br />

pain is treated with non-steroidal anti-inflammatory<br />

medications.<br />

Symptoms of urinary dysfunction can be treated by prescribing<br />

darifenacin, oxybutynin, tamsulosin, terazosin, and other drugs<br />

which reduce the activity of bladder muscles. National Institute<br />

of Neurological Disorders and Stroke (NINDS) is currently<br />

conducting phase I clinical trials for Hu MiK-Beta-1.<br />

The investigational drug is monoclonal antibody directed toward<br />

IL-2/IL-15R-Beta Subunit which blocks IL-15 action.<br />

Washington University School of Medicine in association with<br />

Merck Sharp & Dohme Corp. is also conducting phase II trials<br />

for Raltegravir.


Various other institutes are also conducting research programs<br />

for discovering new and effective treatment options for Tropical<br />

spastic paraparesis. Scientists have also tried antiretroviral<br />

agents for treatment of HTLV-1 infections. Gradual progress in<br />

the research activities is expected to launch more treatment<br />

drugs and expand the market in the future.<br />

Due to low and restricted geographical prevalence of the<br />

disease, the market for tropical spastic paraparesis is small.<br />

Government initiative for increasing awareness of the disease<br />

and its available treatment may curb the spread of infections.<br />

Lack of sufficient information on geographical prevalence, and<br />

epidemiology has restricted the research activities. These factors<br />

will also be responsible for a slower global market growth.<br />

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TMR’s data repository is continuously updated and revised by a<br />

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trends and information. With extensive research and analysis<br />

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primary and secondary research techniques to develop<br />

distinctive data sets and research material for business reports.<br />

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