Global Postmenopausal Hormone Therapy Market
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<strong>Postmenopausal</strong> <strong>Hormone</strong> <strong>Therapy</strong> <strong>Market</strong><br />
- <strong>Global</strong> Industry Analysis, Size, Share,<br />
Growth, Trends and Forecast 2016 - 2024<br />
Transparency <strong>Market</strong> Research Reports incorporated a definite<br />
business overview and investigation inclines on<br />
"<strong>Postmenopausal</strong> <strong>Hormone</strong> <strong>Therapy</strong> <strong>Market</strong>". This report<br />
likewise incorporates more illumination about fundamental<br />
review of the business including definitions, requisitions and<br />
worldwide business sector industry structure.<br />
Tropical spastic paraparesis (TSP) also called as HTLV-1–<br />
associated myelopathy (HAM) is a type of tropical<br />
myeloneuropathies caused by the human T-lymphotrophic virus<br />
1 (HTLV-1). Although initially described in tropical countries,<br />
TSP has also been found in temperate regions such as southern<br />
Japan. HTLV-1 virus belongs to the Retroviridae family, and<br />
preferentially infects CD4 lymphoid cells.<br />
The virus has been known to cause certain kinds of leukemia<br />
and lymphoma and is transmitted through exposure to infected<br />
blood, sexual contact, and use of illegal intravenous drugs. As<br />
the virus is also known to spread through breast milk, mothers<br />
infected with HTLV-1 virus must avoid breast feeding.
According to an article published in the journal Frontiers in<br />
Microbiology in 2012, the HTLV-1 virus is prevalent in certain<br />
regions including the Southwestern part of Japan, sub-Saharan<br />
Africa and South America, the Caribbean area, and certain areas<br />
of Middle East and Australo-Melanesia.<br />
Browse Full Research Report on <strong>Postmenopausal</strong> <strong>Hormone</strong><br />
<strong>Therapy</strong> <strong>Market</strong>:<br />
http://www.transparencymarketresearch.com/postmenopausal-hormonetherapy-market.html<br />
The study also estimates that 5 million to 10 million individuals<br />
have been affected globally with HTLV1 virus, however various<br />
other publications estimate the global prevalence of 10 million<br />
to 20 million.<br />
HTLV-1-associated myelopathy mostly affects the spinal cord,<br />
and results in an upper motor neurone syndrome, that usually<br />
affects lower limbs. Spastic paraparesis or paraplegia is the main<br />
characteristic of the infection. Tropical spastic paraparesis<br />
results in demyelination, inflammation and necrotic lesions in<br />
spinal cord. The progressive disease is associated with<br />
degeneration of neurons in the spinal cord, and results in gradual<br />
paralysis of the lower limbs.<br />
Other rare symptoms include optic atrophy, reduced ankle reflex<br />
and cranial nerve lesions. An article published in journal Revue
Neurologique in 2012, more than 90% of the tropical spastic<br />
paraparesis cases, the neurological features involved urinary<br />
bladder disturbance, spasticity and/or hyperreflexia of the lower<br />
extremities, and lower extremity muscle weakness.<br />
Various immunoassay kits are available for diagnosis of HTLV-1<br />
virus. Companies manufacturing such diagnostic kits include<br />
MP Biomedicals LLC, Fujirebio, Inc., Quest Diagnostics,<br />
DiaSorin S.p.A. Although the disease cannot be cured<br />
completely, medications are available for management of<br />
symptoms. Corticosteroids such as methylprednisolone are<br />
prescribed to decrease the inflammation of the spinal cord, while<br />
pain is treated with non-steroidal anti-inflammatory<br />
medications.<br />
Symptoms of urinary dysfunction can be treated by prescribing<br />
darifenacin, oxybutynin, tamsulosin, terazosin, and other drugs<br />
which reduce the activity of bladder muscles. National Institute<br />
of Neurological Disorders and Stroke (NINDS) is currently<br />
conducting phase I clinical trials for Hu MiK-Beta-1.<br />
The investigational drug is monoclonal antibody directed toward<br />
IL-2/IL-15R-Beta Subunit which blocks IL-15 action.<br />
Washington University School of Medicine in association with<br />
Merck Sharp & Dohme Corp. is also conducting phase II trials<br />
for Raltegravir.
Various other institutes are also conducting research programs<br />
for discovering new and effective treatment options for Tropical<br />
spastic paraparesis. Scientists have also tried antiretroviral<br />
agents for treatment of HTLV-1 infections. Gradual progress in<br />
the research activities is expected to launch more treatment<br />
drugs and expand the market in the future.<br />
Due to low and restricted geographical prevalence of the<br />
disease, the market for tropical spastic paraparesis is small.<br />
Government initiative for increasing awareness of the disease<br />
and its available treatment may curb the spread of infections.<br />
Lack of sufficient information on geographical prevalence, and<br />
epidemiology has restricted the research activities. These factors<br />
will also be responsible for a slower global market growth.<br />
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