Where are we on the path to eliminate hepatitis C virus ?

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HCV is not JUST a liver virus ‣People with HCV infection <strong>are</strong> not just “livers on legs” ‣People with HCV infection have MANY health concerns 17
Change in Summary PRO Score From BL to EOT (scale: 0-100)* Pt-Reported Outcomes Improve With DAA Therapy • End-of-treatment changes from baseline in summary pt-reported outcomes among 818 pts treated with SOF/VEL or SOF + RBV in ASTRAL-2 (GT2) and ASTRAL-3 (GT3) 10 8 6 4 2 0 -2 -4 -6 -8 P = .16 SF-36: Physical Component Summary SOF + RBV P = .0001 SF-36: Mental Component Summary SOF/VEL P = .0001 P = .0009 FACIT-F: Fatigue FACIT-F: Total P = .0012 CLDQ- HCV: Total P = .0024 WPAI:SHP: Work Productivity P = .0002 WPAI:SHP: Activity *Changes of > 2 points represent significant difference from BL within treatment group (P < .05). Younossi ZM, et al. Clin Infect Dis. 2016;63:1042-1048. 18
Page 2 and 3: Are we on the path
Page 4 and 5: Control vs. Elimination vs. Eradica
Page 6 and 7: Why HCV Is A Tractable Target For E
Page 8 and 9: Nearly Everyone With HCV Can Now Be
Page 10 and 11: 9
Page 12 and 13: Viremic Infections (by Stage) Impac
Page 14 and 15: Focusing on Cirrhosis Rapid reducti
Page 16 and 17: Pts (%) HCV in the US: Gaps in Curr
Page 20 and 21: Pts (%) HCV Affects Pts’ Lives No
Page 22 and 23: Treating Everyone ‣Encourages tes
Page 24 and 25: Increasing SVR >90% with increase i
Page 26 and 27: Eliminating HCV Is Everyone’s Job
Page 28 and 29: WHAT needs to be done? 1 • Innova
Page 30 and 31: 29
Page 32 and 33: Could HCV Be Eliminated Through Ant
Page 34 and 35: Impact Of Prevention On Outcome Of
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Where are we on the path to eliminate hepatitis C virus ?

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