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HARVARD MEDICAL SCHOOL
MD-PhDProgram
newsletter
spring/summer 2006 ■ vol. 17 ■ no. 1
A Metaphor for the Graduates
Relationships in
Science as in Life
BY DR. CHRIS A. WALSH
Director’s remarks to the graduates at the Annual
Spring Dinner held on June 6, 2006
It always amazes me to look over the
thesis topic of the graduating MD-PhD
students, to see how diverse a group it
is, and how their work resonates with
what is the finest and most exciting
stuff in biomedical science. I guess that
is said partly out of a sense of pride,
because a lot of the papers published
by this particular group of graduating
students are in fact among the finest
work of the last few years. In
the tremendous diversity of topics, some common
themes emerge, especially in the areas
IN THIS EDITION, of development and regulatory control.
we celebrate the end of a For instance, we have Victoria Wang’s
busy and productive acade- studies of how the transcription factor,
mic year in which enrollment Oct-1 controls so many diverse aspects
includes 148 MD-PhD students of organ development, or David
in various stages of training Miyamoto’s work on how kinesins
working towards completion function in the cell cycle. Or Sunny
of their dual degrees at Harvard Haparvat’s studies of how the devel-
and/or MIT. While we welcomed opment of the retina is controlled
12 new students last July (see by thyroid hormone, starting to put
page 2), we congratulated 13 a developmental perspective on the
graduates leaving the program widely known importance of thy-
this June with the 20th anniroid hormone to brain developversary
celebratory dinner with ment. Some students might have
special remarks by Dr. Chris considered collaborating, since Tom
Walsh and Dr. Vassilios
Deuel and Vassilios Bezzerides were
Bezzerides speaking on
both studying the elongation of axons
behalf of his class.
— Linda Burnley, editor
in the developing brain, and Eric
The MD-PhD Class of 2006 with Dr. Chris Walsh (far left) at the program’s annual spring dinner held on June 6, 2006. Front
row (left) Emanuela Binello, Jay Chyung, David Miyamoto, Victoria Wang, Eric Osborn, Jacob Ulm; Back row (left) David
Berry, Thomas Deuel, Vassilios Bezzerides, Yonatan Grad, Jason Camander. Not pictured: Sanjiv Harpavat and Arlo Miller.
Osborn’s studies of actin dynamics in endothelial cells would probably
have given important information to both of them, and maybe
Eric and Jason Commander had some interesting conversations,
given Jason’s interest in the function of endothelial cells in the
inflammatory response.
The theme of regulatory control connects Emanuela Binello’s
studies of immune regulation and cardiac rejection, and Jay
Chyung’s studies of regulation of the
proteins that cause Alzheimer’s disease,
as well as Wes Ulm’s analysis of viral
restriction and the retroviral proteins Contents
that cause this phenomenon. Arlo
2
Miller also defined how the melanoma
A YEAR OF BONDING
proteins are regulated by the microph-
4
thalmai protein, David Berry focused
BREAD AND CIRCUS
on how glycosaminoglycans regulate so
5
many diverse aspects of cellular func- MENTORING DINNER SERIES
tion, and Yonatan Grad took a bioinfor-
6
matics approach to hunt through entire
PROGRAM NOTES
genomes to identify sequences that reg-
9
FOR THE RECORD
continued on page 5

IN THEIR OWN WORDS
A Year of Bonding
First-Year MD-PhDs Now
Ready for Next Step
Aseemingly disparate group of aspiring scientists and clinicians,
this year’s MD-PhD class brings with it a variety of
interests, both academic and extracurricular. From the
moment our summer course began, there was excitement all
around. We quickly came together through Sunday night Vanderbilt
Hall potlucks, daytrips around Boston, and late night treks for ice
cream. In the coming years, we expect this bond to grow stronger
and to be a source of support within our group. Despite our varied
obsession with the Red Sox or Yankees, 9 pm bedtimes versus midnight
Minipreps, and love for warm weather compared to the frigid
chills of Boston, our group shares a strong common interest in the
pursuit of free food and, of course, a little bit of research if time permits.
Below are short descriptions of each of the members of the firstyear
class. These blurbs highlight the diverse backgrounds of the
group, and the tremendous contribution that such diversity is sure
to make in our future development as physician-scientists.
Katrina Abuabara, a native of Northern California, stayed true to
her roots and graduated from Stanford University in 2001 with a BA
in human biology and a MA in sociology. She then migrated south
to Mexico City, where she worked on reproductive health epidemiology
in Latin America. She has since focused on disease modeling
and decision analysis at UCSF and the Harvard School of Public
Health, and is currently interested in infectious disease and international
health policy. Even after two years in Boston, she still isn’t convinced
that winter is a time to be indoors, and you may just find her
bundled in down, biking along the Charles or jogging in Brookline.
MD-PhD
PROGRAM
newsletter
Editor
Linda Burnley
Assistant Editor
Janelle McCluskey
Designer
Kathleen Sayre
PHOTO CREDITS: LINDA BURNLEY,
MOSHE JAKUBOWSKI, LIZA GREEN
This newsletter is published twice a year
since it was first published in 1990.
©COPYRIGHT 2006
BY THE PRESIDENT AND FELLOWS OF
HARVARD COLLEGE
www.hms.harvard.edu/md_phd
2 HARVARD MD-PHD PROGRAM newsletter
Joseph Franses was born in
West Lafayette, Indiana, and
attended Purdue University,
where he earned bachelors
degrees in chemistry and chemical
engineering in 2005. After
college, he married his high
school and college sweetheart,
Nicole Waples, before coming to
HMS. In his spare time he enjoys
playing on the dominant HST
intramural basketball team,
reading, trying to not forget how
to play the piano, and finding
more things that need to be fixed
in his new condo. Joseph’s past
research interests included interfacial
chemistry and engineering,
organometallic chemistry,
and biochemical engineering;
his current research interests
Erin Loeliger and Marie Hollenhorst at the first Joslin/MD-PhD Program poster
symposium in August 2005.
include cardiovascular drug delivery, biomaterials, and vascular
biology. He hopes to, in chronological order: own a dog, have some
kids, and become a cardiologist and researcher. Joseph is very honored
to be part of such a fantastic group of colleagues.
Vijay Ganesh was born and raised in upstate New York. As he headed
to Harvard to pursue a degree in biology, his prescient mother
told him that his good fortunes would follow him to Boston.
Unfortunately, this has come to mean that in the six years since he
left his hometown, the N.Y. Yankees and N.Y. Giants have failed to
win a single championship, while the historically inept Red Sox and
Patriots have experienced unprecedented luck. Perhaps as a testament
to his emotional fortitude, Vijay decided to remain in Boston
for his MD-PhD. He is excited to continue his research training in
neuroscience. Though he knows that a career as a physician-scientist
is difficult to craft, what he has witnessed in Boston and abroad
tells him that anything is possible. This delusion keeps him motivated,
and his first-rate classmates in HST keep him happy—both
in class, and on the tennis, basketball, and squash courts.
Marie Hollenhorst is from Saratoga, California. She attended
Stanford University, where she studied biology and did research on
the molecular mechanism of T cell anergy. After graduating, she
made the strange choice to trade Palo Alto’s palm-tree-lined streets
for the gray skies of Boston. Luckily, in Boston she found a group of
friendly and smart MD/PhD students who proved to be just crazy
enough to merit spending 7-8 years with. In the future, Marie hopes
to combine her passions for chemistry, biology, and medicine into a
successful career that will still allow her to have time for her favorite
activity: sleeping!
Honor Hsin graduated from Harvard College in 2005 with a degree
in biochemical sciences. She currently aspires to pursue her interests
in molecular neuroscience and forensic psychiatry at MIT and

Harvard, respectively. In her spare time she
enjoys running in the gym before class and
reading books and articles on foreign affairs
and defense policy.
Erin Loeliger was raised on the fair shores of
Maryland’s Chesapeake Bay and attended
the University of Maryland Baltimore
County, graduating with a major in biochemistry
and a minor in philosophy for a
nice balanced academic diet. During her
time at UMBC, Erin worked in a structural
biochemistry lab studying viral proteins of
HIV. Her current research interests include
virology and stem cell biology. She spends
her free time pursuing her back-up career of
ballroom dancing, pondering the meaning
of life and other unanswerable questions
and trying to learn how to cook without
burning her kitchen down. Erin feels
immeasurably lucky to be a member of such
a fabulous class.
Athar Malik, a native of southeast Michigan,
graduated from the Johns Hopkins
University in 2005 with a degree in biomedical
engineering. Athar’s undergraduate
experiences investigating cartilage tissue
engineering excited him about the therapeutic
potential of stem cells and tissue engineering.
However, he recently became even
more excited by the field of neuroscience and
is now planning on working in a cellular and
molecular neuroscience laboratory.
Motivated principally by his faith as an
Ahmadi Muslim, Athar hopes to improve
understanding of normal and pathologic
processes in the human body through his
career as a physician-scientist. As an avid
athlete, Athar regularly makes time to play
pickup games of basketball and squash with
his colleagues.
Peter Miller is a “southern” lad from Atlanta,
GA, but has been in Boston for the past five
years. As a 2005 graduate of MIT with a dual
B.S. in chemical engineering and biology, he
is most interested in cancer research,
although he has also worked in biochemical
engineering and immunology in the past.
Outside of class he enjoys sports, “straight
chillin’ and illin’” with colleagues, and logging
onto MyCourses. Other than that, Peter
looks forward to many, many, many years of
education and hopes to run a lab, practice
pediatric oncology, and cure cancer by the
age of thirty four.
Sidharth Puram is perhaps the only one
who considers Boston a spring break destination.
Born and raised in Minnesota, he
views Boston as a pleasant escape from the
occasional minus-30-degree wind chills of
his home. As a former MIT student studying
biology and neuroscience, he worked in the
lab of Dr. Bob Langer on DNA delivery using
polymer microspheres. However, in the
upcoming years he hopes to “ditch the engineering,”
and pick up some good old-fashioned
biology, a.k.a. droning the days away
with Western Blots. In his copious amounts
of free time, Sid enjoys scuba diving, playing
squash, and participating in photo shoots
with his HST colleagues. Although a neuroscience
focused research career is his most
likely aspiration, he feels confident that if all
From left to right: Katrina Abuabara, Vijay Ganesh, Athar Malik, Marie Hollenhorst, Xavier
Rios, Erin Loeliger, Peter Miller, Honor Hsin, Joseph Franses, Taka Soda, and Sid Puram.
else fails, he can fall back on a career of professional
“car on frozen lake” driving and
snow football. You’ll know you’ve found him
when you see the guy without a jacket in the
dead of the Boston winter.
Xavier Rios-Villanueva used to live in
Puerto Rico, where he did his undergrad
studies in industrial biotechnology. He
enjoys explaining to people the “special”
relationship between Puerto Rico and the
US, and how he is not really an international
student. In addition, he wishes to become
a better salsa dancer and spends a considerable
amount of his free time learning about
the Japanese culture and language via anime.
Currently he is interested in applying systems
biology approaches to stem cells and
human metabolism and, as a pastime, wonders
why people decided to build cities in
places where winter lasts six months.
Takahiro Soda is a son of one of those
Japanese “salarymen” who thought he was
being sent to the USA for 2 or 3 years and
would soon return to Japan and live an average
life. However, his family ended up staying
here for a long time. As a result, Takahiro
graduated from UCLA with a degree in neuroscience.
He has taken part in research on
Huntington’s disease and is interested in psychiatric
illnesses. When Takahiro is not in
class, he is sleeping, playing soccer, or eating,
sometimes all at the same time. His drive in
life is to consume mass quantities of good
food. He somehow plans to achieve this end
through a career involving research and care
of psychiatric illness.
HARVARD MD-PHD PROGRAM newsletter
3

4
Bread and Circus
Some things never change
Since September, the first and second year
MD-PhD classes have gathered weekly
for the free exchange of ideas, and, of
course, free food. Our goal was to create a
forum for informal
peer advising and
social interaction; the
result was much camaraderie
and a fascinating
series of student
and guest presentations.
The topics varied
widely with our diverse
interests, encompassing
everything from
the conventional to the
unconventional, and
then the even less conventional.
Craig Mermel
began the series with an ethical debate on the
right of a pharmacist to refuse emergency
The author, Sol Schulman
We are happy
to introduce the
inaugural MD-PhD
Newsletter cartoon
by Ben Rapoport,
MD-PhD student now
entering his third
year in the program.
Ben began drawing
cartoons for elementary
school spelling
assignments and
eventually went on
to draw editorial
cartoons for the
Harvard Crimson.
HARVARD MD-PHD PROGRAM newsletter
contraception. Ben Rapoport later managed
to overcome his micrographia long enough to
present an analysis of crossword strategy using
an overhead projector. In October, first year
student Peter Miller stepped up to the
lunchtable with a truly novel topic: medicine.
Using the second years as an overzealous consult
service for the first year class, we collectively
cracked the case “A Five Day Old Girl
With Leukocytosis.”
Ben Rapoport set a new standard of entertainment
with his presentation “Exotic
Medical Images: Raw Food Diets,” a review of
strange but true vignettes from the photographic
archives of the New England Journal
that will make you think twice before ordering
sushi again.
Sol Schulman continued the foray into
pseudo-science with a talk on “Executive
Privilege: A Matter Of Life And Death,” surveying
the dark medical secrets of the US presidents.
After hearing circumstantial evidence
that our potent leader George ‘The Potomac
Stallion’ Washington may not have been so
potent, that president Harding likely suffered
from mumps orchitis, and that FDR was into
digital clubbing, we successfully completed a
quiz matching president with pathology.
Dr. Thomas Stossel, Professor of Medicine
at Harvard Medical School and the Brigham
and Women’s Hospital, engaged us in a lively
talk and subsequent discussion on the relationship
between publicly and privately funded
research. A strong believer in the benefits of
fostering a close relationship between academia
and industry, Dr. Stossel highlighted
recent government regulation of such interaction
and how we would be impacted as future
physician-scientists.
The weekly lunches also provide a means
by which to implement more formal advising.
Distinguished guests have included Dr. Walsh,
Dr. Blacklow, Dr. Rupnick, and Dr. Dienstag,
collectively covering topics ranging from lab
and graduate program selection to summer
clinical clerkship opportunities.
The ancient Romans knew the only true
way to placate an oppressed working class, and
some things never change. Our busy ways pull
our classes in many directions, but we continue
to look forward each week to our very own
bread and circus.

METAPHOR FOR GRADUATES
continued from page 1
ulate all different kinds of genes regardless of their
function.
And so it seems everything these days in science is
about relationships. How one thing regulates or relates
to another. As though the outer boundary lines of biomedical
science are becoming sketched in—after all,
we know how many base pairs of DNA there are in our
genome, how many genes there are (approximately),
and there are fewer and fewer proteins out there without
names or ascribable functions. Genome sequencing
projects are done with the big players humans and
mice and are now down to sequencing the nine-toed
hedgehog and the armadillo—no kidding—or to figuring
out how to sequence your genome or mine, and
not just Craig Ventor’s DNA or the DNA of Craig
Ventor’s pet dog. This maturity has led some people to
suggest that certain fields—like developmental genetics—are
becoming mature, and that tomorrow’s
Nature and Cell papers will have to come from somewhere
else. Increasingly this somewhere else involves
working with a finite group of parts and focusing on
how they relate, because even with a finite number of
elements, we know that their relationships will still be
almost infinite.
And I guess that’s a metaphor for where we are
tonight. Because even though we are a finite group of
people, our relationships are potentially infinite and
much more interesting: relationships to families, to
friends, to our science, and to the science that is done
by our colleagues. That is where the real interest lies,
the “Cell papers of our life-times” not inside ourselves
as one piece, but how we relate. This is something I
find I have always done a very bad job of remembering
myself, and that I have been thinking of this week as I
was at my old school—the University of Chicago—
helping to celebrate the career of one of my former
teachers, and catching up with some old fellow students.
So with that, congratulations, good luck, and
may you have successful relationships.
Dr. Walsh is the HMS Bullard Professor of Neurology;
Chief of Genetics and Professor of Pediatrics at Children’s
Hospital; Howard Hughes Investigator at BIDMC; and
the Director of the MD-PhD Program since 2003.
So, what do you want to be
when when you grow grow up?
BY SARAH E. HENRICKSON
MENTORS AND ROLE MODELS are important, as we’ve
been told all our lives. For many of us, that’s how we got
here (and why we wanted to) in the first place. However,
as we make our way through the MD-PhD Program, it may seem
hard to locate role models who are able to maintain a clinical practice
while successfully pursuing academic research. So, we worked with
Dr. David Hafler and our program director, Dr. Chris Walsh, to begin
a series of dinners this past June to help address this issue.
The plan was, we could have a small group of MD-PhD students in
their lab years of their MD-PhD visit the homes of faculty who would
open their living rooms and their lives to the students, invite a few faculty
friends, and chat with us over Thai food about how to make this
career path work. No powerpoint, no chalk talks—just straightforward
advice about the things you think about, but are never quite sure who
to ask—how do you move from your residency into a lab of your
own? How do you make time to have kids? How does tenure work?
How can you do all this and be happy and fulfilled?
So far, we’ve had four dinners. We began in June, 2005, with
Dr. Chris Walsh and his wife Dr. Ming Hui Chen and their lovely
daughters who invited Dr. Maria Rupnick to join us for Thai food and
a discussion of the proposed changes to the medical curriculum at
HMS. A few months later, Dr. Hafler and his wife Dr. Janet Hafler, and
their son Brian, who is a member of the MD-PhD Program, and their
younger son Jason, hosted a dinner in September, inviting us and Dr.
Laurie Glimcher, Dr. David Fisher and Dr. Michael Brenner out to West
Newton to enjoy a lovely fall day and conversation. We had a Chinese
New Year-themed dinner with Dr. Cynthia Morton in January, which
led to a great set of discussions about tenure, applying to residency and
the realities of the two academic-track parent families.
In April we were hosted by the Provost of Harvard University, Dr.
Steven Hyman and his wife Dr. Barbara Bierer, VP for Research at
BWH. It was a great opportunity to chat and get advice from a couple
who both hold key administrative positions. We’re also scheduling
dinners with Dr. David Altshuler and Dr. Joel Hirschhorn—if you
have any suggestions for dinners or if you’d like to help out, please
let me know!
HARVARD MD-PHD PROGRAM newsletter
5

6
Noted
Dr. Alan M. Michelson, MD-PhD class of 1986, and member of
the program’s faculty committees for the past 10 years, has accepted
a position as Associate Director for Basic Research at the National
Heart, Lung and Blood Institute. In this capacity, Dr. Michelson will
work with the NHLBI Director, Dr. Elizabeth Nabel, on extramural
basic science policy and the development of new research initiatives.
Dr. Michelson will also continue his own laboratory research as a
Senior Investigator in the NHLBI Division of Intramural Research.
Dr. Chris Walsh recognized Dr. Michelson’s role in the Program—
citing his outstanding contributions as chair of the Committee of
Advisors and member of the Executive Committee and
Subcommittee on Admissions—with a plaque presented to him at
the program’s dinner in honor of the graduates on June 6, 2006.
Parenthetically, Dr. Michelson was one of 8 graduates of the program
honored at the program’s first annual graduation dinner 20
years ago in 1986.
✓
✓
In the fall of 2004, the Executive Council of the AAMC approved a
proposal to establish a new MD-PhD Section of the Graduate
Research Education and Training (GREAT) Group. Membership
in this body includes the faculty who serve as the institutional leaders
of MD-PhD programs (MSTP and others) at medical schools.
The mission of the MD-PhD Section is to advance the education,
training and career development of physician-scientists, with an
emphasis on training in the MD-PhD programs of LCME accredited
medical schools. Both Dr. Chris Walsh and Ms. Linda Burnley are
members of the new MD-PhD Section with Linda serving as a
founding member of the MD-PhD Section’s Executive Committee as
well as co-chair of the data analysis committee.
✓
MD-PhD Alumnus Dr. Robert L. Satcher, Jr. (MIT ’93), (HMS ’94)
gave the Robert H. Ebert Lecture “From Harvard to NASA: An Alumni
Perspective on Space, Medicine, and Astronauts” on April 28, 2006 as
part of the Alliance Revisitation Weekend events. Dr. Satcher was selected
by NASA in May 2004 and completed Astronaut Candidate Training
this past February as part of preparation for future
flight assignments as a mission specialist. Prior
to NASA training, he was Assistant Professor at
the Feinberg School of Medicine, Northwestern
University, in Orthopaedic Surgery where he also
held appointments as an Attending Physician at
Children’s Memorial Hospital in Chicago specializing
in musculoskeletal oncology and an adjunct
appointment in the biomedical engineering
department at Northwestern University.
HARVARD MD-PHD PROGRAM newsletter
PROGRAM
Program Submits 5-Year Competitive Renewal to NIH
The Harvard MD-PhD Program submitted its five-year competitive
renewal of its training grant to the NIH last January.
The grant was composed of 1,531 pages containing a comprehensive
report on the program’s progress over the past five years, including supporting
data for the $17.1M budget
request. Carefully detailed data tables
and analysis of the program’s administration,
finances, faculty, alumni, current
students and applicant pools supported
the program’s request.
The program faculty and staff
worked for over two months to complete
the project. While the number of
MSTP trainee positions in the current
The finished grant before it
was shipped to the NIH.
grant is 44, the program director, Dr. Chris A. Walsh, felt strongly that the
grant justified a budget increase to 50 trainee slots. Review of the grant
was held at the NIH on June 20, 2006 and a council decision is anticipated
in October. The funding requested for the next five-year period is
anticipated to begin on July 1, 2007.
The Days of Molecular Medicine Conference
this past May in Stockholm, Sweden focused on Chronic
Inflammation. Marlys Fassett and Sarah Henrickson (below)
both fourth years in the program, traveled across the Atlantic
to hear great lectures, including those from HMS professors
Laurie Glimcher and Diane Mathis, and chat with colleagues over
posters from across the world. The conference showcased fantastic
science, from basic mechanisms of NFkB and innate immuni
ty to the clinical trials for therapies
for rheumatoid arthritis and
other autoimmune disorders. A
panel on the regulatory challenges
in the US and Europe for new
drugs generated spirited discussion,
as did the banquet at the
Vasa Museum, home to a 17th
century Swedish ship that made it
less than half an hour out of the
harbor on its maiden voyage
before sinking, only to be resurrected
in the 1950s from
Stockholm Harbor. A wonderful
trip! Next year, the DMM conference
will be at MGH and will
focus on Emerging Technology
and Human Disease.

notes
Annual MD-PhD Program
and Joslin Diabetes
Poster Symposium
Last August, Dr. Joel Hirschhorn,
assistant professor of pediatrics
and genetics, associate director of
graduate education, collaborated
with Dr. Diane J. Mathis, professor
of medicine at Joslin Diabetes
Center, to co-sponsor the first
annual MD-PhD Poster Symposium for the first and second year
students to present research done during their summer labs. Other
MD-PhD and summer undergraduate students on campus were
invited to attend, as were investigators at the Joslin, who described
research opportunities in their labs. There was a great turnout and a
very enthusiastic response to this initial event. We look forward to
the 2nd annual poster session to be held on August 3, 2006.
Annual Retreat
The program’s 23rd annual weekend student/faculty
retreat was held last October, 2005 at
Waterville Valley, NH. Over 100 participants
attended the retreat in which Gary Nabel, MD,
PhD (left) delivered the 6th Annual Eva Neer
Memorial Lecture: “When Bad Viruses Kill Good
Cells: From Mechanisms to Prevention.” Dr.
Nabel, a 1982 graduate of the MD-PhD
Program, is Director of the Vaccine Research
Center in the National Institute of allergy and Infectious Diseases at
NIH. He is well known as a molecular virologist and immunologist
for his work in the fields of HIV, Ebola virus, and cancer research.
Several senior students (Anna Farago, John Hanna, Christina Mills,
Cullen Taniguchi, Ram Srinivasan, Junne Kamihara, Phillip Erwin,
Ashutosh Jadhav) gave oral presentations of their thesis research. A
joint poster session highlighted research results from 25 different
labs followed by a special guest lecture by Elizabeth G. Nabel, MD,
Director of National Heart, Lung, and Blood Institute on “Genomic
Medicine and Cardiovascular Disease.” Retreat sponsors included by
Merck Research Laboratories, Chiron BioPharmaceuticals, Pfizer,
Inc, Abbott Laboratories, Genzyme Corporation, the NIH-MSTP
grant, and Harvard Medical School.
The program is now planning the next retreat to be held
October 13-15, 2006 at Waterville Valley. Cancer research pioneer
Dr. M. Judah Folkman, Julia Dyckman Andrus Professor of
Pediatric Surgery, has accepted our invitation to give the Eva Neer
Memorial Lecture. Save the date!
Awards and Honors
Amma Agymang, Phillip Erwin, and Carlos Ponce each received
individual Ruth L. Kirschstein National Research Services Awards
sponsored by the National Institutues of Health following submission
of individual fellowship applications.
Hannah Chang was awarded the Ashford Fellowship as MD-PhD
graduate student in the Biophysics Program.
Marlys Fassett and Sarah Henrickson were awarded travel
fellowships to present abstracts at the Days of Molecular Medicine
Conference "Inflammation in Chronic Disease" sponsored by
Massachusetts General Hospital, Karolinska Institutet and Nature
Medicine May 24-27, 2006, Stockholm, Sweden.
Sarah Henrickson received Outstanding Poster Award last fall at the
CBR Institute for Biomedical Research Annual Retreat. Sarah also was
selected to present a plenary lecture at HMS Medical Education Day
last fall; promoted to “Instructor-G” status as teaching assistant.
Todd Herrington now finishing his thesis in the lab of John Assad
was named as a recipient of the Stuart H.Q. and Victoria Quan
Fellowship, an intra-Harvard fellowship for neuroscience graduate
students.
The first recipient of this Harvard Stem Cell Institute’s Medical
Scientist Training Fellowship is Ashutosh Jadhav, whose thesis
work has been carried out in the lab of Professor Constance Cepko
where he has been studying the development of the mammalian
retina. The title of his thesis is “Regulation of vertebrate retinal
development by the Notch signaling pathway.”
Ryan Lanning was awarded the Department of Defense Breast Cancer
Research Program 2005 Predoctoral Traineeship Award. He was also
named an Athinoula A. Martinos Research Scholar for biomedical
imaging in 2005.
Arindel Maharaj was named an Albert J. Ryan Fellow in November,
2005 and was awarded a European Commission travel award to attend
the Euroconference on Angiogenesis in France in May 2006.
Christina Mills received the Keystone Symposia scholarship ($1000
to help defray travel and lodging expenses associated with attendance)
for the Advances in Influenza Research: From Birds to Bench to
Bedside conference held March 28 - April 2, 2006.
Benjamin Rapoport has been awarded the Hugh Hampton Young
Memorial Fellowship, a competitive graduate fellowship at MIT.
Sashank Reddy won a CUE teaching award last fall. The award
recognized his work as a TF for Chem285 taught at Harvard.
Benjamin Sommers won the annual Academy Health Dissertation
Award. The Dissertation Award honors an outstanding scientific contribution
from a doctoral thesis in health services research and the candidate
showing exceptional promise as a health services researcher. This
year's dissertation award will be featured in a special session at the
Annual Research Meeting on Tuesday, June 25, 2006.
HARVARD MD-PHD PROGRAM newsletter
7

Newest Class for 2006-07
The MD-PhD Program received 477 applications (63% men;
37% women) from undergraduates applying for admission
and funding from the MSTP grant. About 17% were invited
for competitive interviews for MSTP funding offers. The new
MSTP class includes: Mr. Jonathan Abraham (Harvard), Ms.
Milena Andzelm (Harvard), Ms. Erin Chen (U-Chicago), Mr.
Mark Lee (Yale), Ms. Devarati Mitra (Stanford), Mr. Yin Ren
(MIT), Mr. Cameron Sadegh (MIT); and Ms. Yawei Yang
(UCLA); and 2 deferrals from 2005 applicant pool: Ms. Sarah
Hill (Harvard) and Ms. Karolina Maciag (Harvard); Mr.
David Konieczkowski (Princeton) deferred until 2007.
In August, Ms. Amy Saltzman (Princeton), also a deferral
from 2005, will join the program in the social sciences track
along with Mr. Stephen Huffaker (U-Wisconsin), a recipient
of the new NIH-Graduate Partners Program. The program
also welcomed Ms. Aurore Halkovich and Mr. Xavier Moisset,
visiting French MD-PhD students sponsored by INSERM,
who are participating in the summer course.
8 HARVARD MD-PHD PROGRAM newsletter
PROGRAM notes
Above: Students gather
at the annual summer
barbeque in 2005 on
HMS Quad.
Left: Jason Comander
at the Match Day on
March 23, 2006.
CONTINUED FROM PAGE 7
Gallery
Spring Dinner on June 6 honored the
MD-PhD Class of 2006 and brought together,
pictured from top:
• Drs. Alan Michelson, Yonatan Grad, and
Ms. Linda Burnley
• Dr. Vassilous Bezzerides, center, gave remarks
on behalf of his graduating class. Shown with
him are his parents, Bandel and Elizabeth
Bezzerides, and his wife, Ann Mitsakos.
• Graduate Thomas Deuel shown here with
his mother Dr. Ruthmary K. Deuel.
• Getting together at the Spring Dinner.

PhDs Completed
Andrew J. Aguirre, Health Sciences and Technology, BBS-Genetics (DMS) at Harvard University. [Ronald A. Depinho,
M.D.] Genetic Determinants of Pancreatic Ductal Adenocarcinoma (9/05).
Siraj M. Ali, Health Sciences and Technology, Biophysics (GSAS) at Harvard University. [David Sabatini, M.D., Ph.D.] A
Tale of Two mTor Complexes (6/05).
Zarine R. Balsara, Health Sciences and Technology, Immunology (DMS) at Harvard University. [Michael N. Starnbach,
Ph.D.] The interaction of Chlamydia trachomatis with mammalian host cells (5/06).
Jakob Begun, Health Sciences and Technology, BBS Microbiology and Molecular Genetics (DMS) at Harvard University.
[Frederick M. Ausubel, Ph.D.] Investigating the host-pathogen interaction using a Staphylococcus-Caenorhabditis elegans
model system (5/05).
Irene A. Chen, Health Sciences and Technology, Biophysics (GSAS) at Harvard University. [Jack W. Szostak, Ph.D.]
Building a Protocell: Physical Aspects and Emergent Behaviors (9/05).
Savita V. Dandapani, Castle, BBS-Cell and Developmental Biology (DMS) at Harvard University. [Martin R. Pollak, M.D.]
Role of alpha-actinin-4 in the kidney (7/06).
John P. Dekker, Cannon, Neuroscience (DMS) at Harvard University. [Gary I. Yellen, Ph.D.] Molecular Analysis of Gating
in Voltage - Dependent Ion Channels (5/06).
Phillip A. Erwin, Cannon, BBS-Cell and Developmental Biology (DMS) at Harvard University. [Thomas Michel, M.D.,
Ph.D.] Dynamic S-Nitrosylation of Endothelial Nitric Oxide Synthase in Vascular Endothelial Cells (9/05).
Anna F. Farago, Castle, BBS-Microbiology and Molecular Genetics (DMS) at Harvard University. [Susan Dymecki, M.D.,
Ph.D.] Uncovering Molecular and Spatial Predictors of Brainstem Identity (6/06).
John R. Greenland, HST, Virology (DMS) at Harvard University. [Norman Letvin, M.D.] Vaccine antigen expression and
immune responses (6/06).
Robert S. Griffin, Health Sciences and Technology, Neuroscience (DMS) at Harvard University. [Clifford Woolf, Ph.D.]
Gene expression associated with neuropathic pain (9/05).
Robert S. Hagan, Health Sciences and Technology, Biology at MIT. [Peter Sorger, Ph.D.] Regulation of the Spindle
Checkpoint by Mad2 Binding Proteins (7/05).
David H. Jung, Castle, BBS-Genetics (DMS) at Harvard University. [Frederick W. Alt, Ph.D.] Cis-acting elements controlling
antigen receptor gene assembly (6/05).
Junne Kamihara, Health Sciences and Technology, Biology at MIT. [David E. Houseman, Ph.D.] Studies at the
Hemochromatosis (HFE) Locus: Gene conversions, Haplotypes, and an Association Analysis (12/05).
Rita Khodosh, Health Sciences and Technology, Biology at MIT. [Paul A. Garrity, Ph.D.] Beach1 Functionally Antagonizes
Rab11 During Development and in Regulating Synaptic Morphology (7/05).
Christina E. Mills, Health Sciences and Technology, Infectious Disease at Harvard School of Public Health. [Marc
Lipsitch, D.Phil] Transmission and Control of Pandemic Influenza (3/06).
Bradley J. Molyneaux, Cannon, Neuroscience (DMS) at Harvard University. [Jeffrey D. Macklis, M.D.] Molecular
Development of Corticospinal Motor Neurons (9/05).
Carlos F. Paz, Cannon, BBS-Cell and Developmental Biology (DMS) at Harvard University [Charles J. Wietz, M.D.,
Ph.D.] Circadian Clock Function in the Mammalian Retina (10/05).
Robert S. Ohgami, Health Sciences and Technology, BBS- Cell and Developmental Biology (DMS) at Harvard University.
[Mark D. Fleming, M.D., D. Phil] Identification and characterization of the Steap family of metalloreductases (5/06).
James Rhee, Health Sciences and Technology, BBS-Genetics (DMS) at Harvard University [Bruce M. Spiegelman,
Ph.D.] Partnership of HNF4a with the transcriptional coactivator PGC-1a in the regulation of hepatic glucose and lipid
homeostasis (9/05).
Douglas Rubinson, Health Sciences and Technology, Biology at MIT. [Frank B. Gertler, Ph.D.] Knocked Down and
Knocked Out: A lentiviral system for RNAi transgenesis and the Ena/VASP triple-knockout uncovers functions in
mouse development (5/05).
Safa A. Sadeghpour, Health Sciences and Technology, Brain & Cognitive Sciences at MIT. [Guosong Liu, M.D., Ph.D.]
NMDA Normalization in Hippocampal Neurons: Activity-Dependent, Temporal, and Spatial Properties (8/05).
Patrick Safo, Cannon, Neuroscience (DMS) at Harvard University. [Wade G. Regehr, Ph.D.] The Role of
Endocannabinoids in Synaptic Plasticity as the Granule Cell to Purkinje Cell Synapse (6/06).
Jay A. Shendure, Peabody, BBS-Genetics (DMS) at Harvard University [George M. Church, Ph.D.] Multiplex Genome
Sequencing and Analysis (8/05).
Bryan K-H. Sun, Holmes, BBS-Genetics (DMS) at Harvard University. [Jeannie T. Lee, M.D., Ph.D.] Mechanisms of Tsixmediated
repression of Xist (4/06).
David Y. Takeda, Health Sciences and Technology, Pathology (DMS) at Harvard University. [Anindya Dutta, Ph.D.]
Regulation of Mammalian Replication Initiators During the Cell Cycle (6/05).
Cullen M. Taniguchi, Castle, BBS-Cell and Developmental Biology (DMS) at Harvard University [C. Ronald Kahn, M.D.,
D.Sc.] The Dissection of Insulin Signaling Isoforms In Vivo: Molecular Mechanisms of Hepatic Insulin Action (11/05).
Vesselin T. Tomov, Health Sciences and Technology, BBS-Genetics (DMS) at Harvard University. [Brian Seed, Ph.D.]
Codon-Optimized and Reporter-Packaging Strains of HIV-1 (6/06).
Griffin M. Weber, Health Sciences and Technology, Engineering & Applied Sciences (GSAS) at Harvard University. [Lucila
Ohno-Machado, M.D., Ph.D.] Data representation and algorithms for biomedical informatics applications (5/05).
Ernest N. Yeh, Health Sciences and Technology, Electrical Engineering and Computer Science at MIT. [Daniel K.
Sodickson, M.D., Ph.D.] Advanced Image Reconstruction in Parallel Magnetic Resonance Imaging: Constraints and
Solutions (5/05).
Glenn C-W. Yiu, Health Sciences and Technology, Neuroscience (DMS) at Harvard University. [Zhigang He, Ph.D.,
B.M.] Signaling Mechanisms Limiting Axon Regeneration in the Adult Central Nervous System (5/06).
For the Record
GSAS = Graduate School of Arts and Sciences BBS = Biological and Biomedical Sciences DMS = Division of Medical Sciences
New Publications
Grossman D, Ellertson C, Abuabara K, Blanchard K, Rivas FT. Do Product Labeling and Practice
Guidelines Deter Contraceptive Use? Am J Public Health. 2006 Jan 31
Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ,
Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles of
human lung cancer. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30.
Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson
C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control
of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15;202(4):529-39.
Sarbassov dos D, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Prolonged
Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB. Mol Cell. 2006 Apr 21;22(2):159-68.
Bailey SN, Ali SM, Carpenter AE, Higgins CO, Sabatini DM. Microarrays of lentiviruses for gene
function screens in immortalized and primary cells. Nat Methods. 2006 Feb;3(2):117-22.
Sarbassov dos D, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol.
2005 Dec;17(6):596-603. Epub 2005 Oct 13. Review.
Ali SM, Sabatini DM. Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates
its hydrophobic motif site. J Biol Chem. 2005 Apr 4.
Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW,
Orr-Weaver TL. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb
as a cell cycle regulator. Dev Cell. 2005 Mar;8(3):435-42.
Dulay MT, Baca QJ, Zare RN. Enhanced proteolytic activity of covalently bound enzymes in photopolymerized
sol gel. Anal Chem. 2005 Jul 15;77(14):4604-10.
O'Hara FP, Beck E, Barr LK, Wong LL, Kessler DS, Riddle RD. Zebrafish Lmx1b.1 and Lmx1b.2 are
required for maintenance of the isthmic organizer. Development. 2005 Jul;132(14):3163-73.
Bernstein-Hanley I, Balsara ZR, Ulmer W, Coers J, Starnbach MN, Dietrich WF. Genetic analysis of
susceptibility to Chlamydia trachomatis in mouse. Genes Immun. 2006 Jan 5.
Sifri CD, Begun J, Ausubel FM. The worm has turned—microbial virulence modeled in
Caenorhabditis elegans. Trends Microbiol. 2005 Mar;13(3):119-27. Review.
Berry D, Ren J, Kwan CP, Sietsma DK, Sasisekharan R, Finklestein SP. Dimeric fibroblast growth factor-2
enhances functional recovery after focal cerebral ischemia. Restor Neurol Neurosci. 2005;23(3-
4):251-6.
Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J,
Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, Calvert VS, Petricoin EF 3rd, Liotta L,
Dadachova E, Pestell RG, Lisanti MP, Bonaldo P, Scherer PE.Adipocyte-derived collagen VI affects
early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma
microenvironment. J Clin Invest. 2005 May;115(5):1163-76.
Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P. Genetic replacement of cyclin
D1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb;25(3):1081-8.
Chang HH, Oh PY, Ingber DE, Huang S. Multistable and multistep dynamics in neutrophil differentiation.
BMC Cell Biol. 2006 Feb 28;7(1):11
Ohki K, Chung S, Ch'ng YH, Kara P, Reid RC. Functional imaging with cellular resolution reveals
precise micro-architecture in visual cortex. Nature. 2005 Feb 10;433(7026):597-603.
Fujikawa SM, Chen IA, Szostak JW. Shrink-wrap vesicles. Langmuir. 2005 Dec 20;21(26):12124-9.
Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles. J Am Chem Soc.
2005 Sep 28;127(38):13213-9.
Vining MS, Bradley PL, Comeaux CA, Andrew DJ. Organ positioning in Drosophila requires complex
tissue-tissue interactions. Dev Biol. 2005 Nov 1;287(1):19-34. Epub 2005 Sep 19.
Deuel TA, Liu JS, Corbo JC, Yoo SY, Rorke-Adams LB, Walsh CA. Genetic interactions between doublecortin
and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006 Jan
5;49(1):41-53.
Erwin PA, Mitchell DA, Sartoretto J, Marletta MA, Michel T. Subcellular targeting and differential Snitrosylation
of endothelial nitric-oxide synthase. J Biol Chem. 2006 Jan 6;281(1):151-7.
Erwin PA, Lin AJ, Golan DE, Michel T. Receptor-regulated dynamic S-nitrosylation of endothelial
nitric-oxide synthase in vascular endothelial cells. J Biol Chem. 2005 May 20;280(20):19888-94.
Mitchell DA, Erwin PA, Michel T, Marletta MA. S-Nitrosation and regulation of inducible nitric
oxide synthase. Biochemistry. 2005 Mar 29;44(12):4636-47.
HARVARD MD-PHD PROGRAM newsletter
9

Farago AF, Awatramani RB, Dymecki SM. Assembly of the brainstem cochlear nuclear complex is revealed
by intersectional and subtractive genetic fate maps. Neuron. 2006 Apr 20;50(2):205-18.
Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki
SM. Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.
Neuron. 2005 Dec 22;48(6):933-47.
Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP.The widespread
impact of mammalian MicroRNAs on mRNA repression and evolution. Science. 2005 Dec
16;310(5755):1817-21.
Tompers DM, Foreman RK, Wang Q, Kumanova M, Labosky PA. Foxd3 is required in the trophoblast
progenitor cell lineage of the mouse embryo. Dev Biol. 2005 Sep 1;285(1):126-37.
Sheen VL, Jansen A, Chen MH, Parrini E, Morgan T, Ravenscroft R, Ganesh V, Underwood T, Wiley J,
Leventer R, Vaid RR, Ruiz DE, Hutchins GM, Menasha J, Willner J, Geng Y, Gripp KW, Nicholson L,
Berry-Kravis E, Bodell A, Apse K, Hill RS, Dubeau F, Andermann F, Barkovich J, Andermann E,
Shugart YY, Thomas P, Viri M, Veggiotti P, Robertson S, Guerrini R, Walsh CA. Filamin A mutations
cause periventricular heterotopia with Ehlers-Danlos syndrome. Neurology. 2005 Jan 25;64(2):254-62.
van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks
FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of
lipid antigen presentation. Nature. 2005 Oct 6;437(7060):906-10.
Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS.TACI is mutant in common
variable immunodeficiency and IgA deficiency. Nat Genet. 2005 Aug;37(8):829-34.
Shamri R, Grabovsky V, Gauguet JM, Feigelson S, Manevich E, Kolanus W, Robinson MK, Staunton
DE, von Andrian UH, Alon R. Lymphocyte arrest requires instantaneous induction of an extended
LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol. 2005
May;6(5):497-506.
Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S,
von Andrian UH.The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cellexpressed
S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.
Blood. 2005 Aug 15;106(4):1314-22.
Uchimura K, Gauguet JM, Singer MS, Tsay D, Kannagi R, Muramatsu T, von Andrian UH, Rosen SD.
A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in
high endothelial venules. Nat Immunol. 2005 Nov;6(11):1105-13.
Greenland JR,Liu H,Berry D, Anderson DG, Kim WK, Irvine DJ, Langer R, Letvin NL. Beta-amino
ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Mol
Ther. 2005 Jul;12(1):164-70.
Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH.
Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol.
2006 Feb 6.
Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S,
Sattler M, Musacchio A. Determinants of conformational dimerization of Mad2 and its inhibition by
p31(comet). EMBO J. 2006 Mar 9; [Epub ahead of print]
Hagan RS, Sorger PK. Cell biology: the more MAD, the merrier. Nature. 2005 Mar 31;434(7033):575-7.
Schmidt M, Hanna J, Elsasser S, Finley D. Proteasome-associated proteins: regulation of a proteolytic
machine. Biol Chem. 2005 Aug;386(8):725-37.
Harpavat S, Cepko CL. RCAS-RNAi: a loss-of-function method for the developing chick retina. BMC
Dev Biol. 2006 Jan 22;6:2.
Sen J, Harpavat S, Peters MA, Cepko CL. Retinoic acid regulates the expression of dorsoventral topographic
guidance molecules in the chick retina. Development. 2005 Dec;132(23):5147-59.
Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J,
Zhang X, Shyr Y, Kinney MC. Differential gene expression in anaplastic lymphoma kinase-positive
and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. Hum Pathol. 2005
May;36(5):494-504.
Henrickson SE, EM Hartmann, G. Ott and A. Rosenwald. “Gene Expression Profiling in Malignant
Lymphomas.” In Microarray Technology and Cancer Gene Profiling ed. Simone Mocellin (2005).
Jadhav AP, Mason HA, Cepko CL. Notch 1 inhibits photoreceptor production in the developing
mammalian retina. Development. 2006 Mar;133(5):913-23.
Jung D, Giallourakis C, Mostoslavsky R, Alt FW. Mechanism and Control of V(D)J Recombination at
the Immunoglobulin Heavy Chain Locus. Annu Rev Immunol. 2006 Jan 16
Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.
J Biol Chem. 2005 Jun 3;280(22):21313-20.
10 HARVARD MD-PHD PROGRAM newsletter
For the Record
Mahajan VS, Leskov IB, Chen JZ.Homeostasis of T cell diversity. Cell Mol Immunol. 2005
Feb;2(1):1-10. Review.
Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systemic drug competition in drug-eluting
stent tissue deposition properties. J Control Release. 2005 Dec 5;109(1-3):236-43.
Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Thrombosis modulates arterial drug distribution
for drug-eluting stents. Circulation. 2005 Apr 5;111(13):1619-26.
Maharaj AS, Saint-Geniez M, Maldonado AE, D'Amore PA. Vascular endothelial growth factor localization
in the adult. Am J Pathol. 2006 Feb;168(2):639-48.
Loureiro RM, Maharaj AS, Dankort D, Muller WJ, D'Amore PA. ErbB2 overexpression in mammary
cells upregulates VEGF through the core promoter. Biochem Biophys Res Commun. 2005 Jan
14;326(2):455-65.
Engelman JA, Janne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE,
Cantley LC. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell
lung cancer cell lines. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3788-93.
Miller AJ, Levy C, Davis IJ, Razin E, Fisher DE. Sumoylation of MITF and its related family members
TFE3 and TFEB. J Biol Chem. 2005 Jan 7;280(1):146-55.
Mills CE, Robins JM, Bergstrom CT, Lipsitch M. Pandemic Influenza: Risk of Multiple Introductions
and the Need to Prepare for Them. PLoS Biol. 2006 Feb 21;3(6):e135
Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification
of corticospinal motor neurons. Neuron. 2005 Sep 15;47(6):817-31.
Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S,Mornon
JP, Zavacki AM, Zeold A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC.
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and
PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul;7(7):698-705.
Ohgami RS, Campagna DR, Antiochos B, Wood EB, Sharp JJ, Barker JE, Fleming MD. nm1054: a
spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood. 2005 Nov
15;106(10):3625-31.
Ohgami RS, Campagna DR, McDonald A, Fleming MD. The Steap proteins are metalloreductases.
Blood. 2006 Apr 11.
Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker
JE, Fleming MD. Identification of a ferrireductase required for efficient transferrin-dependent iron
uptake in erythroid cells. Nat Genet. 2005 Nov;37(11):1264-9.
Ohliger MA, Greenman RL, Giaquinto R, McKenzie CA, Wiggins G, Sodickson DK. Concentric coil
arrays for parallel MRI. Magn Reson Med. 2005 Nov;54(5):1248-60.
Willig-Onwuachi JD, Yeh EN, Grant AK, Ohliger MA, McKenzie CA, Sodickson DK. Phase-constrained
parallel MR image reconstruction. J Magn Reson. 2005 Oct;176(2):187-98.
Yeh EN, Stuber M, McKenzie CA, Botnar RM, Leiner T, Ohliger MA, Grant AK, Willig-Onwuachi
JD, Sodickson DK. Inherently self-calibrating non-Cartesian parallel imaging. Magn Reson Med.
2005 Jul;54(1):1-8.
Yeh EN, McKenzie CA, Ohliger MA, Sodickson DK. Parallel magnetic resonance imaging with adaptive
radius in k-space (PARS): constrained image reconstruction using k-space locality in radiofrequency
coil encoded data. Magn Reson Med. 2005 Jun;53(6):1383-92.
Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H,
McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging
with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications.
Acad Radiol. 2005 May;12(5):626-35.
Osborn EA, Rabodzey A, Dewey CF Jr, Hartwig JH. Endothelial actin cytoskeleton remodeling during
mechanostimulation with fluid shear stress. Am J Physiol Cell Physiol. 2006 Feb;290(2):C444-52.
Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK,
Gimbrone MA Jr, Garcia-Cardena G. Integration of flow-dependent endothelial phenotypes by
Kruppel-like factor 2. J Clin Invest. 2006 Jan;116(1):49-58.
Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA Jr, Garcia-Cardena G. Statins exert
endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem. 2005 Jul
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Philippakis AA, He FS, Bulyk ML. Modulefinder: a tool for computational discovery of cis regulatory
modules. Pac Symp Biocomput. 2005;:519-30
Born RT, Pack CC, Ponce CR, Yi S. Temporal evolution of 2-dimensional direction signals used to
guide eye movements. J Neurophysiol. 2006 Jan;95(1):284-300.

Rape M, Reddy SK, Kirschner MW. The processivity of multiubiquitination by the APC determines the
order of substrate degradation. Cell. 2006 Jan 13;124(1):89-103
Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM. Nutritional regulation
of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 2005 Aug 26;122(4):505-15.
Song B, Diaz-Griffero F, Park do H, Rogers T, Stremlau M, Sodroski J. TRIM5alpha association with
cytoplasmic bodies is not required for antiretroviral activity. Virology. 2005 Dec 20;343(2):201-11.
Dillon CP, Sandy P, Nencioni A, Kissler S, Rubinson DA, Van Parijs L. Rnai as an experimental and
therapeutic tool to study and regulate physiological and disease processes. Annu Rev Physiol.
2005;67:147-73.
Sanders GD, Bayoumi AM, Sundaram V, Bilir SP, Neukermans CP, Rydzak CE, Douglass LR, Lazzeroni
LC, Holodniy M, Owens DK. Cost-effectiveness of screening for HIV in the era of highly active antiretroviral
therapy. N Engl J Med. 2005 Feb 10;352(6):570-85.
Ryu J, Liu L, Wong TP, Wu DC, Burette A, Weinberg R, Wang YT, Sheng M. A critical role for myosin IIb
in dendritic spine morphology and synaptic function. Neuron. 2006 Jan 19;49(2):175-82.
Safo PK, Regehr WG. Endocannabinoids control the induction of cerebellar LTD. Neuron. 2005 Nov
23;48(4):647-59.
Arnoult D, Rismanchi N, Grodet A, Roberts RG, Seeburg DP, Estaquier J, Sheng M, Blackstone C.
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and
mitoptosis during programmed cell death. Curr Biol. 2005 Dec 6;15(23):2112-8.
Jaworski J, Spangler S, Seeburg DP, Hoogenraad CC, Sheng M. Control of dendritic arborization by the
phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci. 2005 Dec
7;25(49):11300-12.
Seiguer E, Smith JJ. Perception and process at the Food and Drug Administration: obligations and
trade-offs in rules and guidances. Food Drug Law J. 2005;60(1):17-32.
Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of Secreted Oligomers of Amyloid
{beta}-Protein on Hippocampal Synaptic Plasticity: A Potent Role for Trimers. J Physiol. 2006 Feb 9;
[Epub ahead of print]
Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe
KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and
avenues for therapeutic intervention. Biochem Soc Trans. 2005 Nov;33(Pt 5):1087-90.
Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R,
Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt
synaptic plasticity in vivo. Nat Med. 2005 Apr 17.
Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, Agnaf OE, Hartley DM, Selkoe DJ.
Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of
natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 9;25(10):2455-62.
Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of
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HARVARD MD-PHD PROGRAM newsletter
11

Class of 2006 Internship/Residency and Postgraduate Appointments
David A. Berry, Principal, Flagship Ventures -
Cambridge, MA.
Vassilios J. Bezzerides, Pediatrics, Children’s
Hospital - Boston, MA.
Emanuela Binello, Surgery Preliminary, Mt. Sinai
Hospital - New York, NY; Neurological Surgery,
Mt. Sinai School of Medicine - New York, NY.
Jay H. Chyung, Consultant - HCNR, Boston
Consulting Group - Boston, MA.
Jason I. Comander, Preliminary Medicine,
Brigham & Women’s Hospital - Boston, MA;
Ophthalmology, Massachusetts Eye & Ear
Infirmary - Boston, MA.
Thomas A.S. Deuel, Preliminary Medicine, Yale-
New Haven Hospital - New Haven, CT; Neurology,
Partners Neurology (Massachusetts General/
Brigham & Women’s Hospitals) - Boston, MA.
Yonatan H. Grad, Internal Medicine, Brigham &
Womens’ Hospital - Boston, MA.
HARVARD MEDICAL SCHOOL
MD-PhD
PROGRAM
newsletter
TOSTESON MEDICAL EDUCATION CENTER
260 LONGWOOD AVENUE,ROOM 168
BOSTON,MASSACHUSETTS 02115-5720
mdphd@hms.harvard.edu
www.hms.harvard.edu/md_phd
TEL 617-432-0991
FAX 617-432-2791
For the Record
CONTINUED FROM PAGE 11
Sanjiv Harpavat, Pediatrics, Baylor College of
Medicine - Houston, TX.
Arlo J. Miller, Transitional, Virginia Mason Medical
Center - Seattle, WA; Dermatology, Mayo Graduate
School of Medicine - Rochester, MN.
David T. Miyamoto, Preliminary Medicine -
Brigham & Women’s Hospital - Boston, MA;
Radiation Oncology, Harvard/ Brigham &
Women’s/Massachusetts General Hospitals -
Boston, MA.
Eric A. Osborn, Internal Medicine, Beth Israel
Deaconess Medical Center - Boston, MA.
Jacob W. Ulm, Pediatrics, UCLA Medical Center -
Los Angeles, CA.
Victoria E. Wang, Preliminary Medicine-, Stanford
University Programs - Stanford, CA; Radiation
Oncology, Harvard/ Brigham &
Women’s/Massachusetts General Hospitals -
Boston, MA..
Save the Date
Note these upcoming program events
Summer Course starts July 5
MSTP National Meeting July 7-10
Summer BBQ July 27
Poster Symposium Aug 3
24th Annual Retreat Oct 13-15
visit our website at www.hms.harvard.edu/md_phd
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