Molecular docking studies of banana flower ... - Bioinformation

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Conclusions:
The docked conformations of all the flavonoids indicate that
the phosphorylated tyrosines namely PTR -1158, PTR -1162
and PTR – 1163 remain in the activation loop .PTR -1158 was
bound to ASP 1156, PTR-1162 was hydrogen bonded to THR
1160 ,ARG 1164 and PTR-1163 was bound to GLY 1166 all of
which are a part of the activation loop. This structural
orientation clearly suggests that insulin receptor tyrosine
kinase in its active state. Hence it can be concluded that
theses flavonoids can be considered as activators of Insulin
Receptor Tyrosine kinase. Based on Autodock binding
energies it can be hypothesized that Hesperitin
triacetate,Naringenin,Naringenin pelargonidin and
naringinen flavonone are potent activators of IR tyrosine
kinase.
Acknowledgements:
We wish to thank the management of Sreenidhi Institute of
Science and Technology for providing the necessary facilities
to carryout this work.
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Edited by P Kangueane
Citation: Ganugapati et al. Bioinformation 8(5): 216-220 (2012)
License statement: This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium,
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ISSN 0973-2063 (online) 0973-8894 (print)
Bioinformation 8(5): 216-220 (2012) 219 © 2012 Biomedical Informatics